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Peter Schwartz, MD

John Slade Ely Professor Emeritus of Obstetrics, Gynecology, and Reproductive Sciences; Vice Chair, Gynecology

Contact Information

Peter Schwartz, MD

Office Location

Mailing Address

  • Obstetrics, Gynecology & Reproductive Sciences

    PO Box 208063

    New Haven, CT 06520-8063

    United States

Research Summary

Ovarian cancer is currently the fifth most common cancer in American women and the fourth most common cause of female cancer deaths. A lack of early warning symptoms and a lack of tests highly sensitive for detecting the disease are the major cause for the high death rate. My research is involved with early detection of ovarian cancer by screening a population of women who have at least one first degree relative with ovarian cancer, thereby making them at higher risk than the population at large for the disease.

My research is also involved with identifying tumor markers which may be useful in early detection of ovarian cancer and in monitoring women who have themselves experienced ovarian cancer. We are interested in new and innovative ways of treating patients with ovarian cancer and are enroll women in a prospective trial of neoadjuvant chemotherapy. Finally, we see a large number of women at Yale with an aggressive form of uterine cancer, uterine papillary serous cancer. I have developed new clinical approaches that have been very successful in the treatment of women with early stages of this disease and am collaborating with colleagues in studying the molecular biology of this disease in order to develop new treatment strategies.

Specialized Terms: Ovarian Cancer; Uterine; Vaginal; Cervical and vulvar cancer; Screening for ovarian cancer

Extensive Research Description

Ovarian cancer is currently the fifth most common cancer in American women and the fourth most common cause of female cancer deaths. A lack of early warning symptoms and a lack of tests highly sensitive for detecting the disease are the major cause for the high death rate. My research is involved with early detection of ovarian cancer by screening a population of women who have at least one first degree relative with ovarian cancer, thereby making them at higher risk than the population at large for the disease.

My research is also involved with identifying tumor markers which may be useful in early detection of ovarian cancer and in monitoring women who have themselves experienced ovarian cancer. We are interested in new and innovative ways of treating patients with ovarian cancer and are enroll women in a prospective trial of neoadjuvant chemotherapy. Finally, we see a large number of women at Yale with an aggressive form of uterine cancer, uterine papillary serous cancer. I have developed new clinical approaches that have been very successful in the treatment of women with early stages of this disease and am collaborating with colleagues in studying the molecular biology of this disease in order to develop new treatment strategies.

Neoadjuvant chemotherapy in the treatment of patients with advanced ovarian cancer

Management strategies for women with uterine papillary serous cancer

Early detection of ovarian cancer

Treatment of the elderly with ovarian and/or uterine cancer

Coauthors

Research Interests

Uterine Cervical Neoplasms; Gynecology; Ovarian Neoplasms; Uterine Neoplasms; Vaginal Neoplasms; Vulvar Neoplasms

Selected Publications

Clinical Trials

ConditionsStudy Title
Other Female Genital; OvaryA Phase II Study of Tazemetostat (EPZ-6438) (IND # 138671) in Recurrent or Persistent Endometrioid or Clear Cell Carcinoma of the Ovary, and Recurrent or Persistent Endometrioid Endometrial Adenocarcinoma
CervixA Phase 2 Study of Cemiplimab, an Anti-PD-1 Monoclonal Antibody, and ISA101b Vaccine in Patients With Recurrent/Metastatic HPV16 Cervical Cancer Who Have Experienced Disease Progression After First Line Chemotherapy
Corpus Uteri; OvaryA Phase 1 Open-Label, Safety, Pharmacokinetic and Preliminary Efficacy Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody-Drug Conjugate (ADC), in Patients With Advanced Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) and Endometrial Cancers
OvaryA Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) Alone and In Combination With Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)
Corpus UteriA Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination With Adjuvant Chemotherapy With or Without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Cancer After Surgery With Curative Intent (KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
OvaryA Multicenter Phase 3, Double-Blind, Placebo-Controlled Study Comparing Chemo-Immunotherapy (Paclitaxel-Carboplatin- Oregovomab) vs Chemotherapy (Paclitaxel-Carboplatin- Placebo) in Patients With Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma
CervixA Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer (KEYNOTE-A18 / ENGOT-cx11)
OvaryMIRASOL: A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression
Other Female GenitalA Phase III Randomized Trial of Radiation +/- MK-3475 (Pembrolizumab) for Newly Diagnosed Early Stage High Intermediate Risk Mismatch Repair Deficient (dMMR) Endometrioid Endometrial Cancer
Corpus UteriA Phase II Evaluation of the Safety and Efficacy of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Persistent or Recurrent Endometrial Cancer
Other Female Genital; OvaryA Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients With Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum
Corpus UteriA Phase II Evaluation of Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2-SN-38 Antibody-drug Conjugate, in Patients With Persistent or Recurrent Endometrial Carcinoma
Other Female GenitalA Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC #776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer
Corpus Uteri; Larynx; Lung; Soft Tissue; Unknown SitesA Phase 2 Open Label Study of Sacituzumab Govitecan (IMMU-132) in Subjects With Metastatic Solid Tumors
Corpus Uteri; Other Female GenitalA Phase II Evaluation of Afatinib