Peter A Humphrey, MD, PhD
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Research Summary
I am currently engaged in translational research on genitourinary malignancies, with a focus on prostate and kidney cancer.
Extensive Research Description
I am a urologic pathologist with extensive experience and a large number of publications in prostate pathology and prostate cancer research. The focus of my research has mainly been on prostate cancer, with emphasis on diagnostic surgical pathology of the prostate, clinico-pathological investigations, and molecular biomarkers of clinical relevance.
The early phase of my research career, at Duke University, reflected my interest in molecular pathology and membrane-bound polypeptide growth factor receptors and was devoted to study of the epidermal growth factor (EGF) receptor in a brain tumor model system. We characterized the protein products of amplified and rearranged epidermal growth factor genes in gliomas, and defined a series of mutant proteins. As a junior faculty member at Duke I obtained extramural funding from several sources and concentrated on one specific deletion mutant epidermal growth factor receptor, which we named variant III (vIII). I designed and had synthesized a peptide that spanned the fusion junction of the mutant vIII, and demonstrated, as we reported in a PNAS paper, that antibodies reactive with this peptide bound specifically to the mutant and not wild-type EGF receptor.
My main clinical and research interests are in prostate cancer. After moving to Washington University, I explored the expression and functional significance of the polypeptide growth factor hepatocyte growth factor and its receptor, c-met in prostate cancer. We documented, in a series of papers, how overexpression of these two proteins is linked to aggressive prostate cancer. We specifically showed, for the first time, that c-met expression is associated with the high-stage prostate cancer and the development of androgen-independence.
My research efforts in surgical pathology of the prostate gland have aimed to refine the diagnosis of prostate cancer through definition of the diagnostic and clinico-pathologic features of structural variants, such as deceptively benign-appearing pseudohyperplastic, atrophic, microcystic, PIN-like, and foamy gland variants. Diagnostic awareness of these variants is critical in establishing a diagnosis of malignancy for these patients. The papers on the pseudohyperplastic, microcystic, and PIN-like (stratified epithelial) variants were the first in the literature. I have also sought quantitative prognostic attributes for prostate cancer, such as percentage of prostate chips with cancer, prostate cancer size in needle core and radical prostatectomy tissues, and length of prostate cancer surgical margin involvement. Additional clinico-pathologic investigations on prognostic factors have generated publications on quantification of the frequency and admixture of high histological Gleason grade patterns, that represent the most aggressive form of prostate cancer, and the prognostic significance of grade at the surgical margin. Another major research initiative has been the development and validation of tissue biomarkers in prostate cancer. These functionally significant biomarkers include hepsin, NKX3.1, prolactin receptor, cytoglobin, alpha-methylacyl-CoA racemase (AMACR), and ERG. Several of these biomarkers (hepsin, prolactin receptor, and cytoglobin) were discovered by our gene expression profiling and publications on them highlight potentially novel functional roles for them in prostate cancer. The published work on AMACR and ERG immunohistochemistry has defined their comparative diagnostic utility in foamy gland and minimal adenocarcinomas of the prostate. This is of significance since AMACR is one of the most widely used tissue biomarkers in diagnosis of prostate cancer.
Translational research efforts have also focused on testis and kidney cancer. A biomarker study that has had great impact on diagnostic urologic surgical pathology is the development of SALL4, a zinc finger transcription factor involved in stem cell character maintenance, as an excellent diagnostic marker for testicular germ cell tumors. It is now widely used as a diagnostic tool in surgical pathology. In kidney cancer research we have characterized the clinico-pathologic and genetic features of rhabdoid renal cell carcinoma, a particularly aggressive form of kidncy cancer.
Currently, my research is focused on definition and utilization of new technologies in the tissue diagnosis of prostate cancer, including multiphoton microscopy (in collaboration with Dr. Rick Torres) and artificial intelligence/machine learning.
Coauthors
Research Interests
Precancerous Conditions; Pathological Conditions, Signs and Symptoms; Urogenital Neoplasms; Pathological Conditions, Anatomical
Research Image
Ductal adenocarcinoma of the prostate
Selected Publications
- Abstract B050: Human interpretation of 3D histopathology image datasets of whole prostate biopsies reveals more cribriform pattern (Gleason pattern 4) carcinoma than is seen in standard 2D histology imagesTrue L, Humphrey P, Roybal V, Chow S, Xie W, Liu J. Abstract B050: Human interpretation of 3D histopathology image datasets of whole prostate biopsies reveals more cribriform pattern (Gleason pattern 4) carcinoma than is seen in standard 2D histology images. Cancer Research 2023, 83: b050-b050. DOI: 10.1158/1538-7445.prca2023-b050.
- Pathologic concordance rate and outcomes by histologic subtype in advanced papillary renal cell (pRCC) carcinoma: An analysis from the SWOG S1500 (PAPMET) trial.Tripathi A, Tangen C, Li X, Tretiakova M, Humphrey P, Adeniran A, Barata P, Gulati S, Bergerot C, Pruthi D, Thompson I, Lara P, Pal S, Shuch B. Pathologic concordance rate and outcomes by histologic subtype in advanced papillary renal cell (pRCC) carcinoma: An analysis from the SWOG S1500 (PAPMET) trial. Journal Of Clinical Oncology 2023, 41: 4562-4562. DOI: 10.1200/jco.2023.41.16_suppl.4562.
- An update on computational pathology tools for genitourinary pathology practice: A review paper from the Genitourinary Pathology Society (GUPS)Parwani A, Patel A, Zhou M, Cheville J, Tizhoosh H, Humphrey P, Reuter V, True L. An update on computational pathology tools for genitourinary pathology practice: A review paper from the Genitourinary Pathology Society (GUPS). Journal Of Pathology Informatics 2022, 14: 100177. PMID: 36654741, PMCID: PMC9841212, DOI: 10.1016/j.jpi.2022.100177.
- Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted BiopsiesMartin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.
- Genomic Heterogeneity and the Small Renal MassUeno D, Xie Z, Boeke M, Syed J, Nguyen KA, McGillivray P, Adeniran A, Humphrey P, Dancik GM, Kluger Y, Liu Z, Kluger H, Shuch B. Genomic Heterogeneity and the Small Renal Mass. Clinical Cancer Research 2018, 24: 4137-4144. PMID: 29760223, PMCID: PMC6125159, DOI: 10.1158/1078-0432.ccr-18-0214.
- Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate BiopsyLu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.
- TestisBrimo F, Srigley J, Ryan C, Choyke P, Humphrey P, Barocas D, Brookland R, Buyyounouski M, Fine S, Halabi S, Hamstra D, Kattan M, McKenney J, Mason M, Oh W, Pettaway C, Touijer K, Zelefsky M, Sandler H, Amin M, Lin D. Testis. 2016, 735-743. DOI: 10.1007/978-3-319-40618-3_59.
- Konsenskonferenz 2014 der ISUP zur Gleason-Graduierung des ProstatakarzinomsKristiansen G, Egevad L, Amin M, Delahunt B, Srigley J, Humphrey P, Epstein J, Graduierungskommittee. Konsenskonferenz 2014 der ISUP zur Gleason-Graduierung des Prostatakarzinoms. Die Pathologie 2016, 37: 17-26. PMID: 26809207, DOI: 10.1007/s00292-015-0136-6.
- The incidence of adverse pathologic characteristics in small renal masses as size increases.Nawaf C, Rosoff J, Adeniran A, Humphrey P, Shuch B. The incidence of adverse pathologic characteristics in small renal masses as size increases. Journal Of Clinical Oncology 2016, 34: 596-596. DOI: 10.1200/jco.2016.34.2_suppl.596.
- MRI-US fusion targeted biopsy results in patients with a history of a prior negative biopsy.Nawaf C, Lu A, Rosoff J, Weinreb J, Schulam P, Humphrey P, Levi A, Sprenkle P. MRI-US fusion targeted biopsy results in patients with a history of a prior negative biopsy. Journal Of Clinical Oncology 2016, 34: 90-90. DOI: 10.1200/jco.2016.34.2_suppl.90.
- NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescenceManda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, Bailey M, Zhang H, Maher C, Humphrey P, Andriole G, Ding L, You Z, Chen F. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene 2015, 35: 3282-3292. PMID: 26477312, PMCID: PMC5012433, DOI: 10.1038/onc.2015.389.
- PD19-12 MODIFIED GLEASON GRADE OF PROSTATIC ADENOCARCINOMAS DETECTED IN THE PROSTATE, LUNG, COLORECTAL, AND OVARIAN CANCER SCREENING TRIALHumphrey P, Strother M, Grubb R, Hickey T, Korch M, Riley T, Mabie J, Bellinger A, Andriole G. PD19-12 MODIFIED GLEASON GRADE OF PROSTATIC ADENOCARCINOMAS DETECTED IN THE PROSTATE, LUNG, COLORECTAL, AND OVARIAN CANCER SCREENING TRIAL. Investigative Urology 2014, 191: e550. DOI: 10.1016/j.juro.2014.02.1531.
- Foamy Gland Adenocarcinoma of the Prostate: Incidence, Gleason Grade, and Clinical OutcomeHudson J, Cao D, Vollmer R, Kibel A, Grewal S, Humphrey P. Foamy Gland Adenocarcinoma of the Prostate: Incidence, Gleason Grade, and Clinical Outcome. American Journal Of Clinical Pathology 2012, 138: a108-a108. DOI: 10.1093/ajcp/138.suppl1.103.
- Protocol for the Examination of Specimens From Patients With Carcinoma of the PenisVelazquez E, Amin M, Epstein J, Grignon D, Humphrey P, Pettaway C, Renshaw A, Reuter V, Srigley J, Cubilla A. Protocol for the Examination of Specimens From Patients With Carcinoma of the Penis. Archives Of Pathology & Laboratory Medicine 2010, 134: 923-929. DOI: 10.5858/134.6.923.
- Protocol for the Examination of Specimens From Patients With Invasive Carcinoma of Renal Tubular OriginSrigley J, Amin M, Delahunt B, Campbell S, Chang A, Grignon D, Humphrey P, Leibovich B, Montironi R, Renshaw A, Reuter V. Protocol for the Examination of Specimens From Patients With Invasive Carcinoma of Renal Tubular Origin. Archives Of Pathology & Laboratory Medicine 2010, 134: e25-e30. DOI: 10.5858/134.4.e25.
- Protocol for the Examination of Specimens From Patients With Carcinoma of the UrethraMcKenney J, Amin M, Epstein J, Grignon D, Oliva E, Reuter V, Srigley J, Humphrey P. Protocol for the Examination of Specimens From Patients With Carcinoma of the Urethra. Archives Of Pathology & Laboratory Medicine 2010, 134: 345-350. DOI: 10.5858/134.3.345.
- Pseudoneoplastic Mimics of Prostate and Bladder CarcinomasHameed O, Humphrey P. Pseudoneoplastic Mimics of Prostate and Bladder Carcinomas. Archives Of Pathology & Laboratory Medicine 2010, 134: 427-443. DOI: 10.5858/134.3.427.
- Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate GlandSrigley J, Humphrey P, Amin M, Chang S, Egevad L, Epstein J, Grignon D, McKiernan J, Montironi R, Renshaw A, Reuter V, Wheeler T. Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland. Archives Of Pathology & Laboratory Medicine 2009, 133: 1568-1576. DOI: 10.5858/133.10.1568.
- Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesisSong H, Zhang B, Watson M, Humphrey P, Lim H, Milbrandt J. Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 2009, 28: 3307-3319. PMID: 19597465, PMCID: PMC2746257, DOI: 10.1038/onc.2009.181.
- A PROSPECTIVE STUDY OF FDG-PET/CT FOR DETECTING OCCULT METASTATIC BLADDER CARCINOMAKatz M, Dehdashti F, Grubb R, Humphrey P, Gao F, Siegel C, Klim A, Siegel B, Kibel A. A PROSPECTIVE STUDY OF FDG-PET/CT FOR DETECTING OCCULT METASTATIC BLADDER CARCINOMA. Investigative Urology 2009, 181: 376. DOI: 10.1016/s0022-5347(09)61063-6.
- EVALUATION OF URETERAL PHYSIOLOGIC CHANGES WITH A NOVEL “RIBBON STENT” DESIGN USING ELECTROMYOGRAPHIC AND GIANT MAGNETORESISTIVE SENSORSNatalin R, Hruby G, Okhunov Z, Singh H, Phillips C, Humphrey P, Gupta M, Landman J. EVALUATION OF URETERAL PHYSIOLOGIC CHANGES WITH A NOVEL “RIBBON STENT” DESIGN USING ELECTROMYOGRAPHIC AND GIANT MAGNETORESISTIVE SENSORS. Investigative Urology 2009, 181: 663-664. DOI: 10.1016/s0022-5347(09)61861-9.
- Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissueBrimo F, Vollmer R, Corcos J, Kotar K, Bégin L, Humphrey P, Bismar T. Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue. Histopathology 2008, 53: 177-183. PMID: 18752501, DOI: 10.1111/j.1365-2559.2008.03087.x.
- HISTOLOGIC RECLASSIFICATION OF BENIGN AND MALIGNANT RENAL TUMORS USING 2004 WHO CRITERIASkolarus T, Serrano M, Bullock T, Grubb R, Gao F, Humphrey P, Kibel A. HISTOLOGIC RECLASSIFICATION OF BENIGN AND MALIGNANT RENAL TUMORS USING 2004 WHO CRITERIA. Investigative Urology 2008, 179: 380. DOI: 10.1016/s0022-5347(08)61113-1.
- Editorial CommentHumphrey P. Editorial Comment. Investigative Urology 2008, 179: 1338-1339. DOI: 10.1016/j.juro.2007.11.140.
- Segmental disorders of the nephron: histopathological and imaging perspectivePrasad S, Narra V, Shah R, Humphrey P, Jagirdar J, Catena J, Dalrymple N, Siegel C. Segmental disorders of the nephron: histopathological and imaging perspective. British Journal Of Radiology 2007, 80: 593-602. PMID: 17621606, DOI: 10.1259/bjr/20129205.
- Immunohistochemistry in the diagnosis of minimal prostate cancerHameed O, Humphrey P. Immunohistochemistry in the diagnosis of minimal prostate cancer. Diagnostic Histopathology 2006, 12: 279-291. DOI: 10.1016/j.cdip.2006.05.003.
- Genomic aberrations are rare in urothelial neoplasms of patients 19 years or youngerWild P, Giedl J, Stoehr R, Junker K, Boehm S, van Oers J, Zwarthoff E, Blaszyk H, Fine S, Humphrey P, Dehner L, Amin M, Epstein J, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. The Journal Of Pathology 2006, 211: 18-25. PMID: 17072825, DOI: 10.1002/path.2075.
- EFFECT OF THE DUAL 5&agr;-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCERANDRIOLE G, HUMPHREY P, RAY P, GLEAVE M, TRACHTENBERG J, THOMAS L, LAZIER C, RITTMASTER R. EFFECT OF THE DUAL 5&agr;-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER. Investigative Urology 2004, 172: 915-919. PMID: 15310997, DOI: 10.1097/01.ju.0000136430.37245.b9.
- Scatter factor/hepatocyte growth factor as a prognostic indicator in metastatic prostate cancer: A plasma study in CALGB 9480Humphrey P, Halabi S, Picus J, Vogelzang N, Small E, Kantoff P. Scatter factor/hepatocyte growth factor as a prognostic indicator in metastatic prostate cancer: A plasma study in CALGB 9480. Journal Of Clinical Oncology 2004, 22: 9613-9613. DOI: 10.1200/jco.2004.22.14_suppl.9613.
- Scatter factor/hepatocyte growth factor as a prognostic indicator in metastatic prostate cancer: A plasma study in CALGB 9480Humphrey P, Halabi S, Picus J, Vogelzang N, Small E, Kantoff P. Scatter factor/hepatocyte growth factor as a prognostic indicator in metastatic prostate cancer: A plasma study in CALGB 9480. Journal Of Clinical Oncology 2004, 22: 9613-9613. DOI: 10.1200/jco.2004.22.90140.9613.
- Renal sinus haemangioma with inferior vena cava involvementBHAYANI S, HUMPHREY P, KIBEL A. Renal sinus haemangioma with inferior vena cava involvement. BJU International 2003, 92: e53-e53. PMID: 19127684, DOI: 10.1111/j.1464-410x.2003.04195.x.
- Evaluation of a Vessel Sealing System, Bipolar Electrosurgery, Harmonic Scalpel, Titanium Clips, Endoscopic Gastrointestinal Anastomosis Vascular Staples and Sutures for Arterial and Venous Ligation in a Porcine ModelLANDMAN J, KERBL K, REHMAN J, ANDREONI C, HUMPHREY P, COLLYER W, OLWENY E, SUNDARAM C, CLAYMAN R. Evaluation of a Vessel Sealing System, Bipolar Electrosurgery, Harmonic Scalpel, Titanium Clips, Endoscopic Gastrointestinal Anastomosis Vascular Staples and Sutures for Arterial and Venous Ligation in a Porcine Model. Investigative Urology 2003, 169: 697-700. DOI: 10.1097/00005392-200302000-00067.
- The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate CancerVollmer R, Humphrey P. The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer. American Journal Of Clinical Pathology 2001, 116: 864-870. PMID: 11764075, DOI: 10.1309/7mq7-mwar-4w8a-r75f.
- Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular studyO'Sullivan M, Perlman E, Furman J, Humphrey P, Dehner L, Pfeifer J. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Human Pathology 2001, 32: 1109-1115. PMID: 11679946, DOI: 10.1053/hupa.2001.28247.
- Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic?Fuller C, Pfeifer J, Humphrey P, Bruch L, Dehner L, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic? Human Pathology 2001, 32: 1102-1108. PMID: 11679945, DOI: 10.1053/hupa.2001.28252.
- Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinomaAbdulkadir S, Carbone J, Naughton C, Humphrey P, Catalona W, Milbrandt J. Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. Human Pathology 2001, 32: 935-939. PMID: 11567222, DOI: 10.1053/hupa.2001.27102.
- Latent Prostate Carcinoma in a Screened PopulationKibel A, Humphrey P. Latent Prostate Carcinoma in a Screened Population. European Urology 2001, 39: 35-36. PMID: 11340287, DOI: 10.1159/000052583.
- SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCERNAUGHTON M, PICUS J, ZHU X, CATALONA W, VOLLMER R, HUMPHREY P. SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER. Investigative Urology 2001, 165: 1325-1328. PMID: 11257710, DOI: 10.1016/s0022-5347(01)69893-8.
- SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCERNAUGHTON M, PICUS J, ZHU X, CATALONA W, VOLLMER R, HUMPHREY P. SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER. Investigative Urology 2001, 165: 1325-1328. DOI: 10.1097/00005392-200104000-00078.
- Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two CasesSarangarajan R, Hill D, Humphrey P, Hitchcock M, Dehner L, Pfeifer J. Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases. Pediatric And Developmental Pathology 2001, 4: 185-191. PMID: 11178636, DOI: 10.1007/s100240010141.
- Impaired prostate tumorigenesis in Egr1-deficient miceAbdulkadir S, Qu Z, Garabedian E, Song S, Peters T, Svaren J, Carbone J, Naughton C, Catalona W, Ackerman J, Gordon J, Humphrey P, Milbrandt J. Impaired prostate tumorigenesis in Egr1-deficient mice. Nature Medicine 2001, 7: 101-107. PMID: 11135623, DOI: 10.1038/83231.
- Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologistsAllsbrook W, Mangold K, Johnson M, Lane R, Lane C, Amin M, Bostwick D, Humphrey P, Jones E, Reuter V, Sakr W, Sesterhenn I, Troncoso P, Wheeler T, Epstein J. Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists. Human Pathology 2001, 32: 74-80. PMID: 11172298, DOI: 10.1053/hupa.2001.21134.
- Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinomaZhu X, Humphrey P. Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma. Urology 2000, 56: 1071-1074. PMID: 11113771, DOI: 10.1016/s0090-4295(00)00795-0.
- Minimal Adenocarcinoma in Prostate Needle Biopsy TissueThorson P, Humphrey P. Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue. American Journal Of Clinical Pathology 2000, 114: 896-909. PMID: 11338479, DOI: 10.1309/kvpx-c1em-142l-1m6w.
- Evaluation of a chronic indwelling prototype mesh ureteral stent in a porcine modelOlweny E, Portis A, Sundaram C, Afane J, Humphrey P, Ewers R, McDougall E, Clayman R. Evaluation of a chronic indwelling prototype mesh ureteral stent in a porcine model. Urology 2000, 56: 857-862. PMID: 11068323, DOI: 10.1016/s0090-4295(00)00734-2.
- Renal Cell Carcinoma With Rhabdoid FeaturesGökden N, Nappi O, Swanson P, Pfeifer J, Vollmer R, Wick M, Humphrey P. Renal Cell Carcinoma With Rhabdoid Features. The American Journal Of Surgical Pathology 2000, 24: 1329-1338. PMID: 11023094, DOI: 10.1097/00000478-200010000-00002.
- LAPAROSCOPIC AUGMENTATION CYSTOPLASTY WITH DIFFERENT BIODEGRADABLE GRAFTS IN AN ANIMAL MODELPORTIS A, ELBAHNASY A, SHALHAV A, BREWER A, HUMPHREY P, MCDOUGALL E, CLAYMAN R. LAPAROSCOPIC AUGMENTATION CYSTOPLASTY WITH DIFFERENT BIODEGRADABLE GRAFTS IN AN ANIMAL MODEL. Investigative Urology 2000, 164: 1405-1411. PMID: 10992423, DOI: 10.1016/s0022-5347(05)67207-2.
- LAPAROSCOPIC AUGMENTATION CYSTOPLASTY WITH DIFFERENT BIODEGRADABLE GRAFTS IN AN ANIMAL MODELPORTIS A, ELBAHNASY A, SHALHAV A, BREWER A, HUMPHREY P, MCDOUGALL E, CLAYMAN R. LAPAROSCOPIC AUGMENTATION CYSTOPLASTY WITH DIFFERENT BIODEGRADABLE GRAFTS IN AN ANIMAL MODEL. Investigative Urology 2000, 164: 1405-1411. DOI: 10.1097/00005392-200010000-00082.
- Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomyCarvalhal G, Humphrey P, Thorson P, Yan Y, Ramos C, Catalona W. Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy. Cancer 2000, 89: 1308-1314. PMID: 11002227, DOI: 10.1002/1097-0142(20000915)89:6<1308::aid-cncr16>3.0.co;2-3.
- WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal TumorAn Immunohistochemical and Molecular Diagnostic StudyHill D, Pfeifer J, Marley E, Dehner L, Humphrey P, Zhu X, Swanson P. WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal TumorAn Immunohistochemical and Molecular Diagnostic Study. American Journal Of Clinical Pathology 2000, 114: 345-353. PMID: 10989634, DOI: 10.1093/ajcp/114.3.345.
- Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype AssociationCook J, Hill D, Humphrey P, Pfeifer J, El-Mofty S. Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association. Modern Pathology 2000, 13: 914-918. PMID: 10955460, DOI: 10.1038/modpathol.3880164.
- Tissue factor expression and angiogenesisin human prostate carcinomaAbdulkadir S, Carvalhal G, Kaleem Z, Kisiel W, Humphrey P, Catalona W, Milbrandt J. Tissue factor expression and angiogenesisin human prostate carcinoma. Human Pathology 2000, 31: 443-447. PMID: 10821491, DOI: 10.1053/hp.2000.6547.
- Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?Kaleem Z, Lind A, Humphrey P, Sueper R, Swanson P, Ritter J, Wick M. Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas? Modern Pathology 2000, 13: 217-222. PMID: 10757331, DOI: 10.1038/modpathol.3880040.
- Genetic Analysis of Prostatic Atypical Adenomatous Hyperplasia (Adenosis)Doll J, Zhu X, Furman J, Kaleem Z, Torres C, Humphrey P, Donis-Keller H. Genetic Analysis of Prostatic Atypical Adenomatous Hyperplasia (Adenosis). American Journal Of Pathology 1999, 155: 967-971. PMID: 10487854, PMCID: PMC1866890, DOI: 10.1016/s0002-9440(10)65196-6.
- LAPAROSCOPIC BLADDER WALL SUBSTITUTION WITH A NONAUTOLOGOUS FREE GRAFTElbahnasy A, Portis A, Brewer A, Figenshau R, Elmatteet M, Shalhav A, Humphrey P, McDougall E, Clayman R. LAPAROSCOPIC BLADDER WALL SUBSTITUTION WITH A NONAUTOLOGOUS FREE GRAFT. Investigative Urology 1999, 161: 66.. DOI: 10.1097/00005392-199904010-00268.
- TOTAL PSA CUTOFF OF 2.5 NG./ML. CORRELATES WITH FAVORABLE PATHOLOGIC FEATURES OF PROSTATE CANCERKrumholtz J, Carvalhal G, Ramos C, Smith D, Thorson P, Yan Y, Humphrey P, Catalona W. TOTAL PSA CUTOFF OF 2.5 NG./ML. CORRELATES WITH FAVORABLE PATHOLOGIC FEATURES OF PROSTATE CANCER. Investigative Urology 1999, 161: 99.. DOI: 10.1097/00005392-199904010-00399.
- LAPAROSCOPIC SAGGITAL HEMICYSTECTOMY AND REPLACEMENT USING SIS WITH IPSILATERAL URETERAL REIMPLANTATIONElbahnasy A, Portis A, Brewer A, Shalhav A, Humphrey P, McDougall E, Clayman R. LAPAROSCOPIC SAGGITAL HEMICYSTECTOMY AND REPLACEMENT USING SIS WITH IPSILATERAL URETERAL REIMPLANTATION. Investigative Urology 1999, 161: 294.. DOI: 10.1097/00005392-199904020-00178.
- Improved instrumentation to facilitate laparoscopic ureteroureterostomyBrewer A, McDougall E, Elbahnasy A, Shalhav A, Maxwell K, Kovacs G, Hoenig D, Humphrey P, Clayman R. Improved instrumentation to facilitate laparoscopic ureteroureterostomy. Minimally Invasive Therapy & Allied Technologies 1999, 8: 19-24. DOI: 10.3109/13645709909153127.
- A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cellsGarabedian E, Humphrey P, Gordon J. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 15382-15387. PMID: 9860977, PMCID: PMC28051, DOI: 10.1073/pnas.95.26.15382.
- Clinical and pathologic tumor characteristics of prostate cancer as a function of the number of biopsy cores: a retrospective studyNaughton C, Smith D, Humphrey P, Catalona W, Keetch D. Clinical and pathologic tumor characteristics of prostate cancer as a function of the number of biopsy cores: a retrospective study. Urology 1998, 52: 808-813. PMID: 9801104, DOI: 10.1016/s0090-4295(98)00344-6.
- Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Investigative Urology 1998, 160: 1935-1936. DOI: 10.1016/s0022-5347(01)62455-8.
- Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Investigative Urology 1998, 160: 1935-1936.. DOI: 10.1097/00005392-199811000-00095.
- Predicting the pathology results of radical prostatectomy from preoperative informationVollmer R, Keetch D, Humphrey P. Predicting the pathology results of radical prostatectomy from preoperative information. Cancer 1998, 83: 1567-1580. PMID: 9781951, DOI: 10.1002/(sici)1097-0142(19981015)83:8<1567::aid-cncr12>3.0.co;2-e.
- Lymphoid Lesions of the Gastrointestinal Tract: A Histologic, Immunophenotypic, and Genotypic Analysis of 49 CasesO’Sullivan M, Ritter J, Humphrey P, Wick M. Lymphoid Lesions of the Gastrointestinal Tract: A Histologic, Immunophenotypic, and Genotypic Analysis of 49 Cases. American Journal Of Clinical Pathology 1998, 110: 471-477. PMID: 9763033, DOI: 10.1093/ajcp/110.4.471.
- Pseudohyperplastic Prostatic AdenocarcinomaHumphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.
- Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening PopulationArcangeli C, Humphrey P, Smith D, Harmon T, Shepherd D, Keetch D, Catalona W. Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population. Investigative Urology 1998, 160: 1580-1581. DOI: 10.1016/s0022-5347(01)62623-5.
- Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening PopulationArcangeli C, Humphrey P, Smith D, Harmon T, Shepherd D, Keetch D, Catalona W. Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population. Investigative Urology 1998, 160: 1580-1581.. DOI: 10.1097/00005392-199810000-00125.
- Prostatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy SpecimensKaleem Z, Swanson P, Vollmer R, Humphrey P. Prostatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens. American Journal Of Clinical Pathology 1998, 109: 695-703. PMID: 9620026, DOI: 10.1093/ajcp/109.6.695.
- Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey.Coffin C, Humphrey P, Dehner L. Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Seminars In Diagnostic Pathology 1998, 15: 85-101. PMID: 9606801.
- THE EFFECT OF PROSTATE VOLUME, AGE, TOTAL PROSTATE SPECIFIC ANTIGEN LEVEL AND ACUTE INFLAMMATION ON THE PERCENTAGE OF FREE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN MEN WITHOUT CLINICALLY DETECTABLE PROSTATE CANCERORNSTEIN D, SMITH D, HUMPHREY P, CATALONA W. THE EFFECT OF PROSTATE VOLUME, AGE, TOTAL PROSTATE SPECIFIC ANTIGEN LEVEL AND ACUTE INFLAMMATION ON THE PERCENTAGE OF FREE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN MEN WITHOUT CLINICALLY DETECTABLE PROSTATE CANCER. Investigative Urology 1998, 159: 1234-1237. PMID: 9507843, DOI: 10.1016/s0022-5347(01)63570-5.
- Diagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy SpecimensReyes A, Humphrey P. Diagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens. American Journal Of Clinical Pathology 1998, 109: 416-422. PMID: 9535395, DOI: 10.1093/ajcp/109.4.416.
- Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California.Arcangeli C, Humphrey P, Smith D, Harmon T, Shepherd D, Keetch D, Catalona W. Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California. Urology 1998, 51: 558-565. PMID: 9586607, DOI: 10.1016/s0090-4295(98)00035-1.
- CT of Cystic Renal Masses: Analysis of Diagnostic Performance and Interobserver VariationSiegel C, McFarland E, Brink J, Fisher A, Humphrey P, Heiken J. CT of Cystic Renal Masses: Analysis of Diagnostic Performance and Interobserver Variation. Investigative Urology 1998, 159: 1401. DOI: 10.1016/s0022-5347(01)63633-4.
- Immunohistologic Evaluation of Putatively Mutant p53 Protein in Cutaneous Melanocytic NeoplasmsKaleem Z, Lind A, Humphrey P, Swanson P, Sueper R, Ritter J, Wick M. Immunohistologic Evaluation of Putatively Mutant p53 Protein in Cutaneous Melanocytic Neoplasms. International Journal Of Surgical Pathology 1998, 6: 73-79. DOI: 10.1177/106689699800600203.
- THE EFFECT OF PROSTATE VOLUME, AGE, TOTAL PROSTATE SPECIFIC ANTIGEN LEVEL AND ACUTE INFLAMMATION ON THE PERCENTAGE OF FREE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN MEN WITHOUT CLINICALLY DETECTABLE PROSTATE CANCERORNSTEIN D, SMITH D, HUMPHREY P, CATALONA W. THE EFFECT OF PROSTATE VOLUME, AGE, TOTAL PROSTATE SPECIFIC ANTIGEN LEVEL AND ACUTE INFLAMMATION ON THE PERCENTAGE OF FREE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN MEN WITHOUT CLINICALLY DETECTABLE PROSTATE CANCER. Investigative Urology 1998, 159: 1234-1237.. DOI: 10.1097/00005392-199804000-00043.
- CT of Cystic Renal MassesSiegel C, McFarland E, Brink J, Fisher A, Humphrey P, Heiken J. CT of Cystic Renal Masses. Investigative Urology 1998, 159: 1401.. DOI: 10.1097/00005392-199804000-00106.
- Invasion of the bladder by transitional cell carcinomaVollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the bladder by transitional cell carcinoma. Cancer 1998, 82: 715-723. PMID: 9477105, DOI: 10.1002/(sici)1097-0142(19980215)82:4<715::aid-cncr15>3.0.co;2-0.
- Mass-Formative Atypical Adenomatous Hyperplasia of ProstateHumphrey P, Zhu X, Crouch E, Carbone J, Keetch D. Mass-Formative Atypical Adenomatous Hyperplasia of Prostate. Journal Of Urologic Pathology 1998, 9: 73-82. DOI: 10.1385/jup:9:1:73.
- The early detection of prostate carcinoma with prostate specific antigenSmith D, Humphrey P, Catalona W. The early detection of prostate carcinoma with prostate specific antigen. Cancer 1997, 80: 1852-1856. PMID: 9351559, DOI: 10.1002/(sici)1097-0142(19971101)80:9<1852::aid-cncr25>3.0.co;2-3.
- Unusual Histologic Types of High-Grade Prostatic Intraepithelial NeoplasiaReyes A, Swanson P, Carbone J, Humphrey P. Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1997, 21: 1215-1222. PMID: 9331295, DOI: 10.1097/00000478-199710000-00013.
- CT of cystic renal masses: analysis of diagnostic performance and interobserver variation.Siegel C, McFarland E, Brink J, Fisher A, Humphrey P, Heiken J. CT of cystic renal masses: analysis of diagnostic performance and interobserver variation. American Journal Of Roentgenology 1997, 169: 813-8. PMID: 9275902, DOI: 10.2214/ajr.169.3.9275902.
- Clear cell neoplasms of the endocrine system and thymus.Wick M, Ritter J, Humphrey P, Nappi O. Clear cell neoplasms of the endocrine system and thymus. Seminars In Diagnostic Pathology 1997, 14: 183-202. PMID: 9279975.
- Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene RearrangementRitter J, Wick M, Adesokan P, Fitzgibbon J, Zhu X, Humphrey P. Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement. American Journal Of Clinical Pathology 1997, 108: 60-68. PMID: 9208979, DOI: 10.1093/ajcp/108.1.60.
- The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle BiopsyHenneberry J, Kahane H, Humphrey P, Keetch D, Epstein J. The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy. The American Journal Of Surgical Pathology 1997, 21: 725-728. PMID: 9199652, DOI: 10.1097/00000478-199706000-00014.
- Comparison of Fibrin Glue, Laser Weld, and Mechanical Suturing Device for the Laparoscopic Closure of Ureterotomy in a Porcine ModelWolf S, Soble J, Nakada S, Rayala H, Humphrey P, Clayman R, Poppas D. Comparison of Fibrin Glue, Laser Weld, and Mechanical Suturing Device for the Laparoscopic Closure of Ureterotomy in a Porcine Model. Investigative Urology 1997, 157: 1487-1492. PMID: 9120988, DOI: 10.1016/s0022-5347(01)65029-8.
- Comparison of Fibrin Glue, Laser Weld, and Mechanical Suturing Device for the Laparoscopic Closure of Ureterotomy in a Porcine ModelWolf S, Soble J, Nakada S, Rayala H, Humphrey P, Clayman R, Poppas D. Comparison of Fibrin Glue, Laser Weld, and Mechanical Suturing Device for the Laparoscopic Closure of Ureterotomy in a Porcine Model. Investigative Urology 1997, 157: 1487-1492.. DOI: 10.1097/00005392-199704000-00109.
- Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor GrowthKawakita M, Rao G, Ritchey J, Ornstein D, Hudson M, Harmon T, Ratliff T, Humphrey P, Tartaglia J, Paoletti E. Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth. Journal Of The National Cancer Institute 1997, 89: 428-436. PMID: 9091644, DOI: 10.1093/jnci/89.6.428.
- Primitive Neuroectodermal Tumor of the Kidney-Another Enigma: a Pathologic, Immunohistochemical, and Molecular Diagnostic StudyMarley E, Liapis H, Humphrey P, Nadler R, Siegel C, Zhu X, Brandt J, Dehner L. Primitive Neuroectodermal Tumor of the Kidney-Another Enigma: a Pathologic, Immunohistochemical, and Molecular Diagnostic Study. The American Journal Of Surgical Pathology 1997, 21: 354-359. PMID: 9060607, DOI: 10.1097/00000478-199703000-00013.
- In Vivo Comparison of Electrosurgical Vaporization ElectrodesWolf J, Rayala H, Humphrey P, Clayman R. In Vivo Comparison of Electrosurgical Vaporization Electrodes. Journal Of Endourology 1997, 11: 83-87. PMID: 9048305, DOI: 10.1089/end.1997.11.83.
- Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal SamplesMallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.
- Laparoscopic pyeloplasty in the animal model.McDougall E, Elashry O, Clayman R, Humphrey P, Rayah H. Laparoscopic pyeloplasty in the animal model. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 1997, 1: 113-8. PMID: 9876657, PMCID: PMC3021264.
- The Unintubated Ureterotomy Endourologically RevisitedGardner S, Wolf S, Nakada S, Moon Y, Figenshau R, Pearle M, Soble J, Humphrey P, Clayman R. The Unintubated Ureterotomy Endourologically Revisited. Investigative Urology 1996, 156: 1160-1163. PMID: 8709338, DOI: 10.1016/s0022-5347(01)65742-2.
- The Unintubated Ureterotomy Endourologically RevisitedGardner S, Wolf S, Nakada S, Moon Y, Figenshau R, Pearle M, Soble J, Humphrey P, Clayman R. The Unintubated Ureterotomy Endourologically Revisited. Investigative Urology 1996, 156: 1160-1163.. DOI: 10.1097/00005392-199609000-00101.
- Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle BiopsyShepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy. Investigative Urology 1996, 156: 460-463. PMID: 8683703, DOI: 10.1016/s0022-5347(01)65881-6.
- Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle BiopsyShepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy. Investigative Urology 1996, 460-462. DOI: 10.1097/00005392-199608000-00038.
- Workgroup 4: Exploration of new pathologic factors in terms of potential for prognostic significance and future applicationsvon Eschenbach A, Brawer M, di Sant'Agnese P, Humphrey P, Mahran H, Murphy G, Sebo T, Veltri R. Workgroup 4: Exploration of new pathologic factors in terms of potential for prognostic significance and future applications. Cancer 1996, 78: 372-375. PMID: 8674021, DOI: 10.1002/(sici)1097-0142(19960715)78:2<372::aid-cncr31>3.0.co;2-r.
- Optimized microvessel density analysis improves prediction of cancer stage from prostate needle biopsiesBostwick D, Wheeler T, Blute M, Barrett D, MacLennan G, Sebo T, Scardino P, Humphrey P, Hudson M, Fradet Y, Miller G, Crawford E, Blumenstein B, Mahran H, Miles B. Optimized microvessel density analysis improves prediction of cancer stage from prostate needle biopsies. Urology 1996, 48: 47-57. PMID: 8693651, DOI: 10.1016/s0090-4295(96)00149-5.
- Clinical and Pathological Features of Hereditary Prostate CancerKeetch D, Humphrey P, Smith D, Stahl D, Catalona W. Clinical and Pathological Features of Hereditary Prostate Cancer. Investigative Urology 1996, 155: 1841-1843. PMID: 8618269, DOI: 10.1016/s0022-5347(01)66024-5.
- Clinical and Pathological Features of Hereditary Prostate CancerKeetch D, Humphrey P, Smith D, Stahl D, Catalona W. Clinical and Pathological Features of Hereditary Prostate Cancer. Investigative Urology 1996, 155: 1841-1842.. DOI: 10.1097/00005392-199606000-00004.
- Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based ScreeningHumphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Investigative Urology 1996, 155: 816-820. PMID: 8583583, DOI: 10.1016/s0022-5347(01)66316-x.
- Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based ScreeningHumphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Investigative Urology 1996, 155: 816-820.. DOI: 10.1097/00005392-199603000-00004.
- Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen LevelsNadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Investigative Urology 1995, 154: 407-413. PMID: 7541857, DOI: 10.1016/s0022-5347(01)67064-2.
- Laparoscopic Pneumodissection: A Unique Means of Tissue DissectionGardner S, Clayman R, McDougall E, Moon Y, Fadden P, Anderson K, Pearle M, Royal H, Humphrey P, Pingleton E, Roemer F. Laparoscopic Pneumodissection: A Unique Means of Tissue Dissection. Investigative Urology 1995, 154: 591-594. PMID: 7609143, DOI: 10.1016/s0022-5347(01)67117-9.
- Interobserver Reproducibility in the Diagnosis of Prostatic Intraepithelial NeoplasiaEpstein J, Grignon D, Humphrey P, McNeal J, Sesterhenn I, Troncoso P, Wheeler T. Interobserver Reproducibility in the Diagnosis of Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1995, 19: 873-886. PMID: 7611534, DOI: 10.1097/00000478-199508000-00002.
- Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the ProstateKeetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Investigative Urology 1995, 154: 347-351. PMID: 7541850, DOI: 10.1016/s0022-5347(01)67044-7.
- Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the ProstateKeetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Investigative Urology 1995, 154: 347-351.. DOI: 10.1097/00005392-199508000-00003.
- Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen LevelsNadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Investigative Urology 1995, 154: 407-413.. DOI: 10.1097/00005392-199508000-00023.
- Laparoscopic PneumodissectionGardner S, Clayman R, McDougall E, Moon Y, Fadden P, Anderson K, Pearle M, Royal H, Humphrey P, Pingleton E, Roemer F. Laparoscopic Pneumodissection. Investigative Urology 1995, 154: 591-594.. DOI: 10.1097/00005392-199508000-00076.
- Relationship between serum prostate specific antigen, needle biopsy findings, and histopathologic features of prostatic carcinoma in radical prostatectomy tissuesHumphrey P, Baty J, Keetch D. Relationship between serum prostate specific antigen, needle biopsy findings, and histopathologic features of prostatic carcinoma in radical prostatectomy tissues. Cancer 1995, 75: 1842-1849. DOI: 10.1002/1097-0142(19950401)75:7+<1842::aid-cncr2820751614>3.0.co;2-2.
- Evaluation of Optimal Stent Size After Endourologic Incision of Ureteral StricturesMoon Y, Kerbl K, Pearle M, Gardner S, McDougall E, Humphrey P, Clayman R. Evaluation of Optimal Stent Size After Endourologic Incision of Ureteral Strictures. Journal Of Endourology 1995, 9: 15-22. PMID: 7780426, DOI: 10.1089/end.1995.9.15.
- Comparison of Retrograde Endo-Pyelotomy and Endo-Balloon Rupture of the Ureteropelvic Junction in a Porcine ModelPearle M, Moon Y, Endicott R, Gardner S, Humphrey P, Clayman R. Comparison of Retrograde Endo-Pyelotomy and Endo-Balloon Rupture of the Ureteropelvic Junction in a Porcine Model. Investigative Urology 1994, 152: 2232-2239. PMID: 7966717, DOI: 10.1016/s0022-5347(17)31649-x.
- Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.Day M, Zhao X, Wu S, Swanson P, Humphrey P. Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Molecular Cancer Research 1994, 5: 735-41. PMID: 7947388.
- Development of a Mouse Model for Nonbacterial ProstatitisKeetch D, Humphrey P, Ratliff T. Development of a Mouse Model for Nonbacterial Prostatitis. Investigative Urology 1994, 152: 247-250. PMID: 8201676, DOI: 10.1016/s0022-5347(17)32871-9.
- Overexpression of p53 and HER-2/neu Proteins as Prognostic Markers in Early Stage Breast CancerMarks J, Humphrey P, Wu K, Berry D, Bandarenko N, Kerns B, Iglehart J. Overexpression of p53 and HER-2/neu Proteins as Prognostic Markers in Early Stage Breast Cancer. Annals Of Surgery 1994, 219: 332-341. PMID: 7909221, PMCID: PMC1243148, DOI: 10.1097/00000658-199404000-00002.
- Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian TumorsBerchuck A, Kohler M, Hopkins M, Humphrey P, Robboy S, Rodriguez G, Soper J, Clarke-Pearson D, Bast R. Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors. Gynecologic Oncology 1994, 52: 232-236. PMID: 7508877, DOI: 10.1006/gyno.1994.1037.
- Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinomaIbrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.
- Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasiasKohler M, Nishii H, Humphrey P, Saski H, Marks J, Bast R, Clarke-Pearson D, Boyd J, Berchuck A. Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias. American Journal Of Obstetrics And Gynecology 1993, 169: 690-694. PMID: 8372881, DOI: 10.1016/0002-9378(93)90644-x.
- Atypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinomaBostwick D, Srigley J, Grignon D, Maksem J, Humphrey P, van der Kwast T, Bose D, Harrison J, Young R. Atypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinoma. Human Pathology 1993, 24: 819-832. PMID: 8375853, DOI: 10.1016/0046-8177(93)90131-y.
- Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomasWikstrand C, Stanley S, Humphrey P, Pegram C, Archer G, Kurpad S, Shibuya M, Bigner D. Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas. Journal Of Neuroimmunology 1993, 46: 165-173. PMID: 8360327, DOI: 10.1016/0165-5728(93)90246-u.
- Complete Histologic Serial Sectioning of a Prostate Gland with AdenocarcinomaHumphrey P. Complete Histologic Serial Sectioning of a Prostate Gland with Adenocarcinoma. The American Journal Of Surgical Pathology 1993, 17: 468-472. PMID: 8470761, DOI: 10.1097/00000478-199305000-00005.
- Is Prostate Specific Antigen of Clinical Importance in Evaluating Outcome after Radical ProstatectomyFrazier H, Robertson J, Humphrey P, Paulson D. Is Prostate Specific Antigen of Clinical Importance in Evaluating Outcome after Radical Prostatectomy. Investigative Urology 1993, 149: 516-518. PMID: 7679755, DOI: 10.1016/s0022-5347(17)36132-3.
- Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levelsHumphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.
- Differential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic TissuesIbrahim G, Kerns B, MacDonald J, Ibrahim S, Kinney R, Humphrey P, Robertson C. Differential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues. Investigative Urology 1993, 149: 170-173. PMID: 7678041, DOI: 10.1016/s0022-5347(17)36032-9.
- Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation.Jacobs I, Kohler M, Wiseman R, Marks J, Whitaker R, Kerns B, Humphrey P, Berchuck A, Ponder B, Bast R. Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation. Journal Of The National Cancer Institute 1992, 84: 1793-8. PMID: 1433368, DOI: 10.1093/jnci/84.23.1793.
- Monoclonal antibodies to malignant human gliomasWikstrand C, Fredman P, Svennerholm L, Humphrey P, Bigner S, Bigner D. Monoclonal antibodies to malignant human gliomas. Journal Of Molecular Neuroscience 1992, 17: 137-146. PMID: 1384525, DOI: 10.1007/bf03159988.
- Prevalence of human papillomavirus types 16 and 18 in squamous‐cell carcinoma of the penis: A retrospective analysis of primary and metastatic lesions by differential polymerase chain reactionWiener J, Effert P, Humphrey P, Yu L, Liu E, Walther P. Prevalence of human papillomavirus types 16 and 18 in squamous‐cell carcinoma of the penis: A retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction. International Journal Of Cancer 1992, 50: 694-701. PMID: 1312062, DOI: 10.1002/ijc.2910500505.
- Immunoreactive Prostatic Specific Antigen in Male Periurethral GlandsFrazier H, Humphrey P, Burchette J, Paulson D. Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands. Investigative Urology 1992, 147: 246-248. PMID: 1370330, DOI: 10.1016/s0022-5347(17)37206-3.
- Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic CarcinomaHumphrey P, Walther P, Currin S, Vollmer R. Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma. The American Journal Of Surgical Pathology 1991, 15: 1165-1170. PMID: 1746683, DOI: 10.1097/00000478-199112000-00007.
- Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor functionHumphrey P, Gangarosa L, Wong A, Archer G, Lund-Johansen M, Bjerkvig R, Laerum O, Friedman H, Bigner D. Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function. Biochemical And Biophysical Research Communications 1991, 178: 1413-1420. PMID: 1678600, DOI: 10.1016/0006-291x(91)91051-d.
- Extramedullary Hematopoiesis in the ProstateHumphrey P, Vollmer R. Extramedullary Hematopoiesis in the Prostate. The American Journal Of Surgical Pathology 1991, 15: 486-490. PMID: 2035742, DOI: 10.1097/00000478-199105000-00009.
- Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimensHumphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.
- Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts.Colapinto E, Humphrey P, Zalutsky M, Groothuis D, Friedman H, de Tribolet N, Carrel S, Bigner D. Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts. Cancer Research 1988, 48: 5701-7. PMID: 3167830.
- The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosisHumphrey P, Vollmer R. The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis. Human Pathology 1988, 19: 411-418. PMID: 3366451, DOI: 10.1016/s0046-8177(88)80490-8.
- Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysisHumphrey P, Scroggs M, Roggli V, Shelburne J. Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis. Human Pathology 1988, 19: 155-165. PMID: 2449386, DOI: 10.1016/s0046-8177(88)80343-5.
- The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic MiceColapinto E, Lee Y, Humphrey P, Zalutsky M, Friedman H, Bullard D, Bigner D. The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice. British Journal Of Neurosurgery 1988, 2: 179-191. PMID: 3267302, DOI: 10.3109/02688698808992668.