Peili Gu, PhD
Research Scientist
Research & Publications
Biography
Research Summary
My interests include how dysfunctional telomeres activate DNA-damage responses to promote cancer or cellular senescence/premature aging in mouse models and use these models to understand tumorigenesis or pathogenesis of telomere-related gene mutations in human cancers and diseases
Coauthors
Selected Publications
- CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.Gu P, Min JN, Wang Y, Huang C, Peng T, Chai W, Chang S. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. The EMBO Journal 2012, 31:2309-21.
- Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres.Gu P, Deng W, Lei M, Chang S. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Cell Research 2013, 23:705-19.
- Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.Chen C, Gu P, Wu J, Chen X, Niu S, Sun H, Wu L, Li N, Peng J, Shi S, Fan C, Huang M, Wong CC, Gong Q, Kumar-Sinha C, Zhang R, Pusztai L, Rai R, Chang S, Lei M. Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nature Communications 2017, 8:14929.
- Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.Gu P, Wang Y, Bisht KK, Wu L, Kukova L, Smith EM, Xiao Y, Bailey SM, Lei M, Nandakumar J, Chang S. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis. Oncogene 2017, 36:1939-1951.