Research & Publications
Over the past 25+ years, the vast majority of Dr. Heerdt's research has been within 3 broad categories: a) cardiopulmonary adaptation to the stresses of anesthesia and surgery; b) evaluation of hemodynamic monitoring devices; and c) development of novel neuromuscular blocking drugs. Studies involving cardiopulmonary physiology have been conducted in both the laboratory and clinic, with an emphasis on a systems biology approach that incorporates functional and molecular aspects of adaptation. Most recently, Dr. Heerdt's laboratory has been incorporating aging and working with analytic approaches for quantifying the efficiency of mechanical coupling between the heart and circulation during acute and chronic pulmonary hypertension. Device evaluations have been largely focused upon methods for monitoring blood flow and tissue perfusion; recent studies have involved experimental models of shock. Dr. Heerdt's drug development work also involved both laboratory and clinical work, with investigation focused on a novel class of drugs that undergo “molecular inactivation” by the amino acid cysteine. This research resulted in the design and synthesis of a series of molecules that have now been licensed to pharma for further development.
Research funding and salary support have been provided by multiple foundations, industry sponsors, the Society of Cardiovascular Anesthesiologists, the American Heart Association, and the National Institutes of Health.
Cardiovascular Diseases; Heart Diseases; Chemicals and Drugs; Analytical, Diagnostic and Therapeutic Techniques and Equipment
Public Health Interests