Paul Geha, MD
Research & Publications
Biography
News
Research Summary
Pain and Pleasure are mediated by overlapping neurochemical pathways; however, little is known about how the brain mediates the perception of pain and pleasure using very similar brain circuitry and neurochemicals. The interaction of pain and pleasure in the brain is reflected in co-morbid conditions such as chronic pain and obesity. Hence, pathological pain and overeating (due to disruption in perception of food pleasure) are good clinical examples of how we can tackle this question. We use functional magnetic resonance imaging (fMRI) as well as psychophysical (pain and food pleasure perception) and neuro-hormonal measures to address these questions.
Specialized Terms: Chronic pain, Obesity
Extensive Research Description
Neural Mechanisms of Obesity in Chronic Low Back Pain
Coauthors
Research Interests
Behavior and Behavior Mechanisms; Obesity; Chronic Pain; Psychiatry and Psychology
Selected Publications
- Decreased food pleasure and disrupted satiety signals in chronic low back painGeha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.
- Altered hypothalamic response to food in smokers 1 , 2 , 3Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM. Altered hypothalamic response to food in smokers 1 , 2 , 3 American Journal Of Clinical Nutrition 2012, 97: 15-22. PMID: 23235196, PMCID: PMC3522134, DOI: 10.3945/ajcn.112.043307.
- Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic PainBaliki MN, Geha PY, Fields HL, Apkarian AV. Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain Neuron 2010, 66: 149-160. PMID: 20399736, PMCID: PMC2873199, DOI: 10.1016/j.neuron.2010.03.002.
- The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic RegionsGeha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV. The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic Regions Neuron 2008, 60: 570-581. PMID: 19038215, PMCID: PMC2637446, DOI: 10.1016/j.neuron.2008.08.022.