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Patrick G. O'Connor

MD, MPH, MACP
Dan Adams and Amanda Adams Professor of General Medicine; Chief, Section of General Internal Medicine

Contact Information

Patrick G. O'Connor, MD, MPH, MACP

Mailing Address

  • Internal Medicine

    PO Box 208056, 333 Cedar Street

    New Haven, CT, 06520-8056

    United States

Research Summary

Dr. O’Connor has focused his scholarly work on the interface between primary care and substance abuse. This has included research examining the transfer of substance abuse treatment strategies from “specialty” settings to primary care settings. His publications in this area include studies on the management of opioid withdrawal in primary care settings, opioid maintenance in primary care, and the use of naltrexsone for treating alcohol dependence in primary care patients. He has been active in medical education on substance abuse both nationally and internationally.

Specialized Terms: Interface between primary care and substance abuse

Coauthors

Research Interests

Alcoholism; Education, Medical; Internal Medicine; Opioid-Related Disorders; Substance-Related Disorders; Physicians, Primary Care

Selected Publications

  • Disturbance in heart rhythm-arrhythmias.O’Connor PG, Johnson GT. Disturbance in heart rhythm-arrhythmias. The Harvard Medical School Health Letter, 1982
  • Peptide T treatment of cognitive impairment in HIV and intravenous drug users.Rosen MI, Bridge TP, O’Malley SS, Pearsall HR, Martini B, O’Connor PG, Brett-Smith H, Thomas H, van Dyck C, Woods SW, Kosten TR. Peptide T treatment of cognitive impairment in HIV and intravenous drug users. The American Journal of the Addictions 1992, 1:1-7.
  • Medical complications of cocaine use.O’Connor PG, Chang G, Shi J. Medical complications of cocaine use. In Clinician’s Guide to Cocaine Addiction: Theory, Research and Treatment, eds. Kosten TR, Kleber HD, Guilford Press, New York, NY, 1992, pp. 241-72.
  • Primary care management of intravenous drug users.O’Connor PG, Samet JH. Primary care management of intravenous drug users. In Substance Abuse Education in General Internal Medicine: A Manual for Faculty, eds. Bigby J, Adger H, Bureau of Health Professions (HRSA) and Office of Treatment Improvement (ADAMHA), 1992.
  • Challenges in caring for injection-drug users with HIV infection: Lessons from the United States for Poland.O’Connor PG. Challenges in caring for injection-drug users with HIV infection: Lessons from the United States for Poland. Proceedings from the Conference on HIV/AIDS. Gdansk, Poland, March 23-25, 1993.
  • Opioid intoxication and withdrawal.O’Connor PG, Kosten TR. Opioid intoxication and withdrawal. In Principles of Addiction Medicine, ed. Miller N, American Society of Addiction Medicine. Chevy Chase, MD, 1994, pp.1-6.
  • Comprehensive care of injection drug users: The role of methadone maintenance and primary medical care.O’Connor PG. Comprehensive care of injection drug users: The role of methadone maintenance and primary medical care. Proceedings of Other IVDU Rehabilitative Programs in the Prevention of HIV/AIDS. Warsaw, Poland, September 12-14, 1994, pp. 107-19.
  • Methadone maintenance programs should be developed in Poland.O’Connor PG. Methadone maintenance programs should be developed in Poland. Proceedings of Other IVDU Rehabilitative Programs in the Prevention of HIV/AIDS. Warsaw, Poland, September 12-14, 1994, pp. 213-15.
  • Substance abuse issues.Williams AB, O’Connor PG. Substance abuse issues. In Primary Care of Women and Children with HIV Infection, eds. Kelly P, Holman S, Rothenberg R, Holzemer SP, Jones and Barlett, Inc., 1995, pp. 217-38.
  • Guidelines for the use of naltrexone in the treatment of alcoholism.Rounsaville BJ, O’Malley S, O’Connor PG. Guidelines for the use of naltrexone in the treatment of alcoholism. The APT Foundation, New Haven, CT, 1995.
  • HIV vaccine preparedness trials in injection-drug users: Are we prepared?O’Connor PG, Meandzija B, Poling J, Kosten T, Fitzgerald B, Rounsaville B. HIV vaccine preparedness trials in injection-drug users: Are we prepared? Substance Abuse 1995, 16:195-203
  • Models of medical care for HIV-infected drug users.Samet JH, Stein MD, O’Connor PG. Models of medical care for HIV-infected drug users. Substance Abuse 1995, 16(3):131-9.
  • Female drug users with HIV infection: Issues for medical care and substance abuse treatment.Selwyn PA, O’Connor PG, Schottenfeld RS. Female drug users with HIV infection: Issues for medical care and substance abuse treatment. In HIV Infection in Women, eds. Minkoff H, DeHovitz JA, Duerr A, Raven Press, 1995, pp. 241-62.
  • Challenges in caring for injection drug users with HIV infection: Lessons from the United States for Poland.O’Connor PG. Challenges in caring for injection drug users with HIV infection: Lessons from the United States for Poland. In HIV/AIDS: Social and Medical Aspects. The University of Gdansk Press, Gdansk, Poland, 1995, pp. 211-19.
  • Routine screening and initial assessment.O’Connor PG. Routine screening and initial assessment. In Clinical Manual of Substance Abuse, 2nd edition ed. Kinney J, Mosby-Year Book, Inc., 1996, pp. 40-56.
  • Engaging the patient in treatment.O’Connor PG. Engaging the patient in treatment. In Clinical Manual of Substance Abuse, 2nd edition, ed. Kinney J, Mosby-Year Book, Inc., 1996, pp. 57-73.
  • Medical and nutritional complications of alcoholism: Mechanisms and management.O’Connor PG. Medical and nutritional complications of alcoholism: Mechanisms and management. Substance Abuse, Plenum Publishing Corporations, New York, NY, 1996, 17(3):175.
  • HCFA Guidelines for teaching: The new world order.O’Connor PG. HCFA Guidelines for teaching: The new world order. Cortlandt Forum 1996, 9(10):72.
  • Glycosylated hemoglobin: A new look at an old friend.O’Connor PG. Glycosylated hemoglobin: A new look at an old friend. Cortlandt Forum 1996, 9(12):73.
  • Substance abuse and HIV/AIDS in Poland: Opportunities for educational exchange.O’Connor PG, Williams AB. Substance abuse and HIV/AIDS in Poland: Opportunities for educational exchange. Substance Abuse 1996, 17(2):101-9.
  • Identification and treatment of substance abuse in primary care settings. The general internist.O’Connor PG. Identification and treatment of substance abuse in primary care settings. The general internist. The American Journal on Addictions 1996, 5(4) Suppl 1:S9-S19.
  • Drug Impaired Professionals.O’Connor PG. Drug Impaired Professionals. The New England Journal of Medicine 1997, 337(15):1093-4.
  • The impact of the Yale faculty development program: Clinical alcohol and drug research and education (CADRE) on medical student teaching about substance abuse.O’Connor PG, Pearsall HR, Ball SA, Forsyth BWC, Faraclas WG, Schottenfeld RS. The impact of the Yale faculty development program: Clinical alcohol and drug research and education (CADRE) on medical student teaching about substance abuse. Substance Abuse 1997, 18(1):33-40.
  • Site accommodations and preceptor behavior valued by 3rd-year students in ambulatory internal medicine clerkships.Kernan WN, O’Connor PG. Site accommodations and preceptor behavior valued by 3rd-year students in ambulatory internal medicine clerkships. Teaching and Learning in Medicine 1997, 9(2):96-102.
  • Medical issues in the care of opioid dependent patients.O’Connor PG, Selwyn PA. Medical issues in the care of opioid dependent patients. In New Treatments for Opioid Dependence, eds. Stine SM, Kosten TR, Guilford Publications, Inc. New York, NY, 1997, pp. 199-227.
  • Substance Abuse and Internal Medicine.Samet JH, Stein MD, O’Connor PG. Substance Abuse and Internal Medicine. In Medical Clinics of North America: Alcohol and Other Substance Abuse, eds. Samet JH, Stein MD, O’Connor PG, W.B. Saunders Company. Philadelphia, 1997, 81(4), pp. xiii-xiv.
  • Effective medical treatment of heroin addiction.O’Connor PG. Effective medical treatment of heroin addiction. Abstracts of Clinical Care Guidelines, 1997.
  • Medical disorders in substance abuse patients.O’Connor PG. Medical disorders in substance abuse patients. In Dual Diagnosis Substance Abuse and Comorbid Medical and Psychiatric Disorders, eds. Kranzler HR, Rounsaville BJ, Marcel Dekker Inc., New York, NY, 1998, pp. 535-66.
  • Patient assessment.Gourevitch MN, Selwyn PA, O’Connor PG. Patient assessment. In Management of Drug Users in the Community A Practical Handbook, ed. Robertson R, Arnold, London, 1998, pp. 193-213.
  • Linkages of substance abuse with primary care and mental health treatment.O’Connor PG, Ziedonis DM. Linkages of substance abuse with primary care and mental health treatment. In Principles of Addiction Medicine, 2nd Edition, eds. Graham AW, Schultz TK, American Society of Addiction Medicine, Inc., Chevy Chase, MD, 1998, pp. 353-62.
  • Management of opioid intoxication and withdrawal.O’Connor PG, Kosten TR. Management of opioid intoxication and withdrawal. In Principles of Addiction Medicine, 2nd Edition., eds. Graham AW, Schultz TK, American Society of Addiction Medicine, Inc., Chevy Chase, MD, 1998, pp. 457-64.
  • A call for scholarly review articles in Substance Abuse.O’Connor PG. A call for scholarly review articles in Substance Abuse. Substance Abuse 1998, 19(2):47.
  • Complications of Drug Use.O’Connor PG. Complications of Drug Use. Proceedings of the American Academy of Addiction Psychiatry’s 10th Annual Meeting and Symposium, 1999.
  • Office-Based Methadone Maintenance Treatment of Opioid Dependence.Fiellin DA, O’Connor PG, eds. Office-Based Methadone Maintenance Treatment of Opioid Dependence. Instructors Guide. Yale University School of Medicine, 1999.
  • Primary care setting.78. O’Connor PG. Primary care setting. In Handbook of Alcoholism, eds. Zernig G, Saria A, Kurz M, O’Malley SS, CRC Press, New York, NY, 2000, pp. 165-72.
  • Methadone Medical Maintenance: A training and Resource Guide for Office-based PhysiciansFiellin DA, Storti SA, Schottenfeld RS, Biscoe JD, Pantalon MV, O’Connor PG. Methadone Medical Maintenance: A training and Resource Guide for Office-based Physicians, Addiction Technology Transfer Center of New England, Providence, 2000.
  • Methadone treatment for opioid dependence.O’Connor PG. Methadone treatment for opioid dependence. Journal of Substance Abuse Treatment. 2000, 12(6): 423-428.
  • Treating opioid dependence (Letter).O’Connor PG. Treating opioid dependence (Letter). The New England Journal of Medicine 2001, 344.
  • Prescription opioid abuse and potential role of office-based opioid maintenance treatment in integrating medical and substance abuse care.O’Connor PG. Prescription opioid abuse and potential role of office-based opioid maintenance treatment in integrating medical and substance abuse care. Topics in HIV Medicine. 2001, 9(5)10-14.
  • Primary Health Care Settings, Section IV, Treatment Settings.O’Connor PG and Fiellin DA. Primary Health Care Settings, Section IV, Treatment Settings. In Handbook of Clinical Alcoholism Treatment, 1st edition, Lippincott Williams & Wilkins, 2003.
  • Alcohol Abuse. PIER Clinical Guidance from American College of Physicians.Fiellin DA and O’Connor PG. Alcohol Abuse. PIER Clinical Guidance from ACP. American College of Physicians, 2003, pp. 1-34.
  • Alcohol Abuse and Dependence.O’Connor PG. Alcohol Abuse and Dependence. In Cecil Textbook of Medicine, 22nd Edition, W.B. Saunders Company, A Division of Harcourt Health Science, 2004.
  • Counseling requirements for buprenorphine maintenance in primary care: lessons learned from a preliminary study in a methadone maintenance program.Pantalon MV, Fiellin DA, O’Connor PG, Chawarski MC, Pakes JR, Schottenfeld RS. Counseling requirements for buprenorphine maintenance in primary care: lessons learned from a preliminary study in a methadone maintenance program. Addictive Disorders and Their Treatment 2004, 3(2):71-76.
  • Medical disorders in substance abuse patients.Sullivan LE, O’Connor PG. Medical disorders in substance abuse patients. In Dual Diagnosis and Psychiatric Treatment: Substance Abuse and Comorbid Disorders, 2nd edition, eds. Kranzler HR, Tinsley JA, Marcel Dekker Inc., New York, NY, 2004, pp. 515-553.
  • 2004 update on addiction medicine/psychiatry in the state of Connecticut.Kraus ML, Kirk TA, Savage B, Patrich S, O’Connor PG, Babor TF, D’Onofrio G, Kosten TR, Kranzler H, Fiellin D, Schottenfeld RS. 2004 update on addiction medicine/psychiatry in the state of Connecticut. Connecticut Medicine 2005, 69(4): 217-225.
  • Alcohol Abuse and Dependency.O’Connor PG. Alcohol Abuse and Dependency. In ACP Medicine Textbook. American College of Physicians, 2005, Vol. 2, pp. 2555-2563.
  • The Science of Addiction: From Neurobiology to Treatment, by Carlton K. Erickson (Book Review).O’Connor PG. The Science of Addiction: From Neurobiology to Treatment, by Carlton K. Erickson (Book Review). New England Journal of Medicine 2007, 357(16)1671-72.
  • Alcohol Abuse and Dependence.O’Connor PG. Alcohol Abuse and Dependence. In Goldman Cecil Medicine, 23rd Edition, W.B. Saunders Company, A Division of Harcourt Health Science, 2007.
  • Diagnosis and pharmacologic management of opioid dependency.Jones ES and O’Connor PG. Diagnosis and pharmacologic management of opioid dependency. Hospital Physician 2007, 43(10)15-24, 39.
  • Medical and Postgraduate Education in Substance Abuse.O’Connor PG. Medical and Postgraduate Education in Substance Abuse. 2008 Update on Addiction Medicine/Psychiatry in the State of Connecticut 2008, 72(4): 219-221.
  • Drug Use and Abuse.O'Connor PG. Drug Use and Abuse. In The Merck of Medical Information Home Edition, Merck & Co., Inc., Whitehouse Station, NJ and printed in The Merck Manual Home Health Handbook, Merck Research Laboratories, Division of Merck & Co., Inc., Whitehouse Station, NJ, 2009.
  • Management of Opioid Intoxication and Withdrawal.Tetrault JM, O’Connor PG. Management of Opioid Intoxication and Withdrawal. In Principles of Addiction Medicine, 4th Edition, Lippincott Williams & Wilkins, Inc., Philadelphia, PA, 2009, pp. 589-603.
  • Alcohol Abuse and Dependency.O’Connor PG. Section 13 / Chapter III Alcohol Abuse and Dependency. In ACP Medicine Textbook. American College of Physicians, 2009.
  • Drug Use and Dependence.O'Connor PG, "Drug Use and Dependence," In The Merck Manual of Diagnosis and Therapy, 19th Edition, 2011.
  • Alcohol Abuse and Dependence.O’Connor PG. Alcohol Abuse and Dependence. In Goldman’s Cecil Medicine, 24th Edition, 2012.
  • Alcohol use disorder.O’Connor PG. Alcohol use disorder. In Goldman-Cecil Medicine, 25th Edition, 2015:149-156.
  • Imput from the Field: Panel of Medical Leaders and Champions.O’Connor PG, et al. Medicine Responds to Addiction Proceedings, Executive Office of the President of the United States, Office of National Drug Control Policy, The American Board of Addiction Medicine Foundation. "Imput from the Field: Panel of Medical Leaders and Champions.” The White House, Washington, DC. September 2015.
  • The Fix Addiction and Recovery, Straight Up by John Lavitt.O’Connor, PG. The Fix Addiction and Recovery, Straight Up by John Lavitt, December 4, 2015. Ensuring High Quality Addiction Care for All: The Fix Q&A with the President of the American Board of Addiction Medicine.
  • Facing Addiction in America: The Surgeon General’s Report on Alcohol, Drugs, and Health.O’Connor, PG et al. U.S. Department of Health and Human Services (HHS), Office of the Surgeon General, Facing Addiction in America: The Surgeon General’s Report on Alcohol, Drugs, and Health. Washington, DC: HHS, November 2016.
  • Integrated Curriculum and Core Competencies on Prevention of Risky Substance Use and Treatment of Addiction.O’Connor PG, et al. Medicine Responds to Addiction Symposium II Proceedings, Executive Office of the President of the United States, Office of National Drug Control Policy, The American Board of Addiction Medicine Foundation. "Integrated Curriculum and Core Competencies on Prevention of Risky Substance Use and Treatment of Addiction.” The White House, Washington, DC. October 2016.
  • Unhealthy alcohol use, including alcohol use disorder: Epidemiology, pathogenesis, clinical manifestations, course assessment, and diagnosis.Tetrault JM, O’Connor PG. Unhealthy alcohol use, including alcohol use disorder: Epidemiology, pathogenesis, clinical manifestations, course assessment, and diagnosis. UpToDate 2015. Updated Sept 13, 2018.
  • The Opioid Crisis: Understanding the Complexities, Acknowledging the Challenges, and Exploring Possible Solutions.O'Connor, PG, et al. AHLA White Paper, The Opioid Crisis: Understanding the Complexities, Acknowledging the Challenges, and Exploring Possible Solutions. American Health Law Association. Feb 20, 2019.
  • Alcohol use disorder.O’Connor PG. Alcohol use disorder. In Goldman-Cecil Medicine, 26th edition, 2020, Chapter 30, pages 143-150.