Research & Publications
Dr. Valentino’s main research interests include: bile duct complications in children with liver transplants, primary sclerosing cholangitis (PSC), an autoimmune bile duct disease, and advocacy for children waiting on the liver transplant wait-list.
The Yale New Haven Transplantation Center (YNHTC) is a member of the North American pediatric liver transplant group called the Society of Pediatric Liver Transplantation (SPLIT). This group has awarded Dr. Valentino and her colleagues funding to investigate the management of bile duct complications in children with liver transplants across the country.
Dr. Valentino is also investigating PSC, which occurs in 5% of children with inflammatory bowel disease (IBD). Unfortunately, 10-20% of children with PSC undergo liver transplantation. Dr. Valentino is investigating non-invasive means to identify PSC in children with IBD. Dr. Valentino is also involved in multicenter studies, supported by PSC Partners Seeking a Cure, to help us understand PSC as well as the medications we can use in the treatment of this condition.
Approximately 1 in 10 children die while waiting for a healthy liver on the US liver transplant wait-list. We have been investigating ways to increase organ transplantation. Through the Society of Pediatric Liver Transplantation (SPLIT) we are advocating for children on the liver transplant wait-list.
Dr. Valentino is also collaborating with Dr. Michael Schilsky at Yale University on the Wilson Disease (WD) Registry at WD Centers of Excellence to learn more about the spectrum of disease in patients with WD from infancy to adulthood.
Dr. Valentino is collaborating with Dr. Binita Kamath at the Hospital for Sick Children and University of Toronto on an international study of Alagille syndrome called the Global ALagille Alliance (GALA). We hope to better understand Alagille Syndrome in children and advance management strategies.
Dr. Valentino is the site principal investigator at Yale for the International Registry of Congenital Porto-Systemic Shunts (IRCPSS). This group, led by Dr. Valérie McLin, is studying vascular shunts of the liver to better identify patients who are at risk for developing complications and to offer them standardized care.
Biliary Tract Surgical Procedures; Gastroenterology; Liver; Pediatrics; Cholangitis, Sclerosing; Inflammatory Bowel Diseases; Liver Transplantation