Research & Publications
The Gopal lab is broadly interested in mRNA transport, RNA metabolism and its regulation in healthy and diseased neurons. As a physician-scientist, Dr. Gopal’s research aims to bridge neuronal cell biology and neuropathology of neurodegenerative disease. Her post-doctoral research provided new insight into the biophysical properties of neuronal ribonucleoprotein (RNP) granules and has shown that ALS-linked mutations fundamentally perturb the dynamic properties and transport of neuronal RNP complexes. The focus of the Gopal lab is to elucidate the molecular mechanisms driving neuronal RNP granule assembly, the spatiotemporal maturation and function of diverse RNP granules in neuronal physiology, and pathologic transitions in disease.
Amyotrophic Lateral Sclerosis; Autopsy; Cell Biology; Neurons; Ribonucleoproteins; Neurodegenerative Diseases; RNA Transport; Frontotemporal Lobar Degeneration; TDP-43 Proteinopathies