Oscar Colegio, MD, PhD
Research & Publications
Biography
News
Research Summary
The focus of our lab is to characterize the role of immune cells called macrophages in tumor progression. The focus of these studies has been to identify pathways of tumorigenesis critical to a variety of murine tumor types including lung carcinoma, melanoma, colon carcinoma and cutaneous squamous cell carcinoma. In addition, we are performing parallel studies in identifying tumor-promoting pathways produced by infiltrating macrophages in human squamous cell carcinomas from immunosuppressed transplant recipients vs non-immunosuppressed patients.
Specialized Terms: Squamous cell carcinoma; Casal cell carcinoma; Melanoma; Tumor-associated macrophages; Immunology; Hypoxia; Epithelial-mesenchymal transitions; Solid organ transplantation
Extensive Research Description
- The role of macrophages in progression of cutaneous squamous cell carcinomas
Coauthors
Research Interests
Allergy and Immunology; Carcinoma, Squamous Cell; Dermatology; Melanoma; Epithelial-Mesenchymal Transition
Research Images
Tumor-associated Macrophages in Human Melanoma
Selected Publications
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 2014, 513:559-63.
- Palmoplantar peeling secondary to sirolimus therapy.Liu LS, McNiff JM, Colegio OR. Palmoplantar peeling secondary to sirolimus therapy. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2014, 14:221-5.
- Molecularly targeted therapies for nonmelanoma skin cancers.Liu LS, Colegio OR. Molecularly targeted therapies for nonmelanoma skin cancers. International Journal Of Dermatology 2013, 52:654-65.