Octavian Henegariu, MD, PhD
Associate Research Scientist in Neurosurgery
Research & Publications
Biography
News
Coauthors
Selected Publications
- Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomasKaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann D, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring J, Brors B, Sahm F, Wick W. Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas. Acta Neuropathologica 2023, 146: 499-514. PMID: 37495858, PMCID: PMC10412493, DOI: 10.1007/s00401-023-02613-w.
- Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung InjurySung E, Park M, Henegariu O, Sime P, Chae W. Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury. American Journal Of Pathology 2023, 193: 1130-1142. PMID: 37263344, PMCID: PMC10477954, DOI: 10.1016/j.ajpath.2023.05.009.
- Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart diseaseMishra-Gorur K, Barak T, Kaulen L, Henegariu O, Jin S, Aguilera S, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai D, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek A, Bilguvar K, Lifton R, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2214997120. PMID: 37043537, PMCID: PMC10120005, DOI: 10.1073/pnas.2214997120.
- P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphomaKaulen L, Erson-Omay E, Henegariu O, Karschnia P, Huttner A, Günel M, Baehring J. P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma. Neuro-Oncology 2022, 24: ii68-ii68. PMCID: PMC9443199, DOI: 10.1093/neuonc/noac174.235.
- Identification of Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 as a Disease Causing Gene in Intracranial Aneurysms and its Role in Vertebrate CNS Specific AngiogenesisBarak T, Sencicek A, Miyagishima D, Henegariu O, Gorur K, Bilguvar K, Gunel M. Identification of Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 as a Disease Causing Gene in Intracranial Aneurysms and its Role in Vertebrate CNS Specific Angiogenesis. Neurosurgery 2019, 66: 310-303. DOI: 10.1093/neuros/nyz310_303.
- HOW DOES THE SILENCING OF THE INFLAMMATION MEDIATOR GENE: FAT10, EXTEND LIFESPAN IN MICE?Canaan A, Arjona C, Gulez B, Seay M, Zhang J, Henegariu O, Garcia Milian R. HOW DOES THE SILENCING OF THE INFLAMMATION MEDIATOR GENE: FAT10, EXTEND LIFESPAN IN MICE? Innovation In Aging 2017, 1: 978-978. PMCID: PMC6185008, DOI: 10.1093/geroni/igx004.3533.
- Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitisChae W, Hao L, Henegariu O, Yilmaz S, Bothwell A. Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis. The Journal Of Immunology 2017, 198: 156.8-156.8. DOI: 10.4049/jimmunol.198.supp.156.8.
- Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes.Baldzizhar R, Fedorchuk C, Jha M, Rathinam C, Henegariu O, Czyzyk J. Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. Journal Of Biological Chemistry 2013, 288: 11506. PMCID: PMC3630857, DOI: 10.1074/jbc.a112.409664.
- Abstract 5324: Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesisChae W, Henegariu O, Zelterman D, Hao L, Gibson T, Bothwell A. Abstract 5324: Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Cancer Research 2010, 70: 5324-5324. DOI: 10.1158/1538-7445.am10-5324.
- Synergy of IL-1 Receptor Antagonist and Anti-CD3 Monoclonal Antibody in Reversal of Diabetes in NOD MiceAblamunits V, Opare-Addo L, Henegariu O, Mandrup-Poulsen T, Herold K. Synergy of IL-1 Receptor Antagonist and Anti-CD3 Monoclonal Antibody in Reversal of Diabetes in NOD Mice. Clinical Immunology 2010, 135: s31. DOI: 10.1016/j.clim.2010.03.095.
- The Mechanism of Spontaneous Intestinal Tumorigenesis Via CD4 T Cell-derived IL-17AChae W, Gibson T, Zelterman D, Hao L, Henegariu O, Bothwell A. The Mechanism of Spontaneous Intestinal Tumorigenesis Via CD4 T Cell-derived IL-17A. Clinical Immunology 2010, 135: s62-s63. DOI: 10.1016/j.clim.2010.03.191.
- P.1.i.040 Increased expression of diabetic autoantigen PTPR-N in basal ganglia of Tourette's syndrome patientsMorer A, Chae W, Tobiasova Z, Henegariu O, Vaccarino F, Bothwell A, Leckman J, Kawikova I. P.1.i.040 Increased expression of diabetic autoantigen PTPR-N in basal ganglia of Tourette's syndrome patients. European Neuropsychopharmacology 2009, 19: s357. DOI: 10.1016/s0924-977x(09)70543-7.
- Receptor for advanced glycation end products is required for normal T cell activation and development of T cell induced lung inflammation (36.10)Akirav E, Henegariu O, Clynes R, Schmidt A, Herold K. Receptor for advanced glycation end products is required for normal T cell activation and development of T cell induced lung inflammation (36.10). The Journal Of Immunology 2009, 182: 36.10-36.10. DOI: 10.4049/jimmunol.182.supp.36.10.
- Color-Changing Karyotyping (CCK), an M-FISH/SKY AlternativeHenegariu O. Color-Changing Karyotyping (CCK), an M-FISH/SKY Alternative. 2009, 217-230. DOI: 10.1007/978-3-540-70581-9_20.
- Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infectionAsnicar M, Henegariu O, Shaw M, Goheen M, Bartlett M, Smith J, Lee C. Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection. BMC Microbiology 2001, 1: 8. PMID: 11446902, PMCID: PMC34520, DOI: 10.1186/1471-2180-1-8.
- A triple color FISH technique for mouse chromosome identificationHenegariu O, Dunai J, Chen X, Korenberg J, Ward D, Greally J. A triple color FISH technique for mouse chromosome identification. Mammalian Genome 2001, 12: 462-465. PMID: 11353394, DOI: 10.1007/s003350020038.
- Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem CellKrause D, Theise N, Collector M, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis S. Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell. Cell 2001, 105: 369-377. PMID: 11348593, DOI: 10.1016/s0092-8674(01)00328-2.
- Cryptic Translocation Identification in Human and Mouse Using Several Telomeric Multiplex FISH (TM-FISH) StrategiesHenegariu O, Artan S, Greally J, Chen X, Korenberg J, Vance G, Stubbs L, Bray-Ward P, Ward D. Cryptic Translocation Identification in Human and Mouse Using Several Telomeric Multiplex FISH (TM-FISH) Strategies. Laboratory Investigation 2001, 81: 483-491. PMID: 11304567, DOI: 10.1038/labinvest.3780256.
- Small Marker Chromosome Identification in Metaphase and Interphase Using Centromeric Multiplex FISH (CM-FISH)Henegariu O, Bray-Ward P, Artan S, Vance G, Qumsyieh M, Ward D. Small Marker Chromosome Identification in Metaphase and Interphase Using Centromeric Multiplex FISH (CM-FISH). Laboratory Investigation 2001, 81: 475-481. PMID: 11304566, DOI: 10.1038/labinvest.3780255.
- Improvements in cytogenetic slide preparation: Controlled chromosome spreading, chemical aging and gradual denaturingHenegariu O, Heerema N, Wright L, Bray‐Ward P, Ward D, Vance G. Improvements in cytogenetic slide preparation: Controlled chromosome spreading, chemical aging and gradual denaturing. Cytometry 2001, 43: 101-109. PMID: 11169574, DOI: 10.1002/1097-0320(20010201)43:2<101::aid-cyto1024>3.0.co;2-8.
- Liver from bone marrow in humansTheise N, Nimmakayalu M, Gardner R, Illei P, Morgan G, Teperman L, Henegariu O, Krause D. Liver from bone marrow in humans. Hepatology 2000, 32: 11-16. PMID: 10869283, DOI: 10.1053/jhep.2000.9124.
- Chromosome instability contributes to loss of heterozygosity in mice lacking p53Shao C, Deng L, Henegariu O, Liang L, Stambrook P, Tischfield J. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7405-7410. PMID: 10861008, PMCID: PMC16558, DOI: 10.1073/pnas.97.13.7405.
- Simple Method for Preparation of Fluor/Hapten-Labeled dUTPNimmakayalu M, Henegariu O, Ward D, Bray-Ward P. Simple Method for Preparation of Fluor/Hapten-Labeled dUTP. BioTechniques 2000, 28: 518-522. PMID: 10723566, DOI: 10.2144/00283st11.
- Custom fluorescent-nucleotide synthesis as an alternative method for nucleic acid labelingHenegariu O, Bray-Ward P, Ward D. Custom fluorescent-nucleotide synthesis as an alternative method for nucleic acid labeling. Nature Biotechnology 2000, 18: 345-348. PMID: 10700155, DOI: 10.1038/73815.
- Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablationTheise N, Badve S, Saxena R, Henegariu O, Sell S, Crawford J, Krause D. Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablation. Hepatology 2000, 31: 235-240. PMID: 10613752, DOI: 10.1002/hep.510310135.
- Colour-changing karyotyping: an alternative to M-FISH/SKYHenegariu O, Heerema N, Bray-Ward P, Ward D. Colour-changing karyotyping: an alternative to M-FISH/SKY. Nature Genetics 1999, 23: 263-264. PMID: 10545937, DOI: 10.1038/15437.
- Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous miceShao C, Deng L, Henegariu O, Liang L, Raikwar N, Sahota A, Stambrook P, Tischfield J. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 9230-9235. PMID: 10430925, PMCID: PMC17762, DOI: 10.1073/pnas.96.16.9230.
- p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic CellsMantel C, Braun S, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer H. p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells. Blood 1999, 93: 1390-1398. DOI: 10.1182/blood.v93.4.1390.
- p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells.Mantel C, Braun S, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer H. p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 1999, 93: 1390-8. PMID: 9949183, DOI: 10.1182/blood.v93.4.1390.404k25_1390_1398.
- Characterization of Multiple 12p Rearrangements in Testicular Germ Cell Tumor Cell Line 833K and Its Subclone 64CP by Chromosome MicrodissectionBlough R, Vance G, Henegariu O, Smolarek T, Sledge G, Heerema N. Characterization of Multiple 12p Rearrangements in Testicular Germ Cell Tumor Cell Line 833K and Its Subclone 64CP by Chromosome Microdissection. Cancer Genetics 1998, 106: 24-29. PMID: 9772905, DOI: 10.1016/s0165-4608(98)00042-9.
- Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion*Yu D, Qu C, Henegariu O, Lu X, Feng G. Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion*. Journal Of Biological Chemistry 1998, 273: 21125-21131. PMID: 9694867, DOI: 10.1074/jbc.273.33.21125.
- Triple-color FISH analysis of 12p amplification in testicular germ-cell tumors using 12p band-specific painting probesHenegariu O, Vance G, Heiber D, Pera M, Heerema N. Triple-color FISH analysis of 12p amplification in testicular germ-cell tumors using 12p band-specific painting probes. Journal Of Molecular Medicine 1998, 76: 648-655. PMID: 9725767, DOI: 10.1007/s001090050262.
- Molecular cytogenetic analysis of patients with holoprosencephaly and structural rearrangements of 7qVance G, Nickerson C, Sarnat L, Zhang A, Henegariu O, Morichon‐Delvallez N, Butler M, Palmer C. Molecular cytogenetic analysis of patients with holoprosencephaly and structural rearrangements of 7q. American Journal Of Medical Genetics 1998, 76: 51-57. PMID: 9508065, PMCID: PMC6775641, DOI: 10.1002/(sici)1096-8628(19980226)76:1<51::aid-ajmg9>3.0.co;2-s.
- A case with mosaic di‐, tetra‐, and octacentric ring Y chromosomesHenegariu O, Pescovitz O, Vance G, Verbrugge J, Heerema N. A case with mosaic di‐, tetra‐, and octacentric ring Y chromosomes. American Journal Of Medical Genetics 1997, 71: 426-429. PMID: 9286449, DOI: 10.1002/(sici)1096-8628(19970905)71:4<426::aid-ajmg10>3.0.co;2-i.
- Multiplex PCR: Critical Parameters and Step-by-Step ProtocolHenegariu O, Heerema N, Dlouhy S, Vance G, Vogt P. Multiplex PCR: Critical Parameters and Step-by-Step Protocol. BioTechniques 1997, 23: 504-511. PMID: 9298224, DOI: 10.2144/97233rr01.
- PCR and FISH analysis of a ring Y chromosomeHenegariu O, Kernek S, Keating M, Palmer C, Heerema N. PCR and FISH analysis of a ring Y chromosome. American Journal Of Medical Genetics 1997, 69: 171-176. PMID: 9056556, DOI: 10.1002/(sici)1096-8628(19970317)69:2<171::aid-ajmg11>3.0.co;2-i.
- Mild “duplication 6q syndrome”: A case with partial trisomy (6)(q23.3q25.3)Henegariu O, Heerema N, Vance G. Mild “duplication 6q syndrome”: A case with partial trisomy (6)(q23.3q25.3). American Journal Of Medical Genetics 1997, 68: 450-454. PMID: 9021020, DOI: 10.1002/(sici)1096-8628(19970211)68:4<450::aid-ajmg15>3.0.co;2-r.
- Human Y Chromosome Azoospermia Factors (AZF) Mapped to Different Subregions in Yq11Vog P, Edelmann A, Kirsch S, Henegariu O, Hirschmann P, Kiesewetter F, Köhn F, Schill W, Farah S, Ramos C, Hartmann M, Hartschuh W, Meschede D, Behre H, Castel A, Nieschlag E, Weidner W, Gröne H, Jung A, Engel W, Haidl G. Human Y Chromosome Azoospermia Factors (AZF) Mapped to Different Subregions in Yq11. Human Molecular Genetics 1996, 5: 933-943. PMID: 8817327, DOI: 10.1093/hmg/5.7.933.
- Molecular analysis of the genomic structure of the human Y chromosome in the euchromatic part of its long arm (Yq11)Kirsch S, Keil R, Edelmann A, Henegariu O, Hirschmann P, LePaslier D, Vogt P. Molecular analysis of the genomic structure of the human Y chromosome in the euchromatic part of its long arm (Yq11). Cytogenetic And Genome Research 1996, 75: 197-206. PMID: 9040791, DOI: 10.1159/000134481.
- The human A1 adenosine receptor: ligand binding properties, sites of somatic expression and chromosomal localizationRivkees S, Lasbury M, Stiles G, Henegariu O, Curtis C, Vance G. The human A1 adenosine receptor: ligand binding properties, sites of somatic expression and chromosomal localization. Endocrine 1995, 3: 623-629. PMID: 21153220, DOI: 10.1007/bf02746338.
- Rapid screening of the Y chromosome in idiopathic sterile men, diagnostic for deletions in AZF, a genetic Y factor expressed during spermatogenesisHenegariu O, Hirschmann P, Kilian K, Kirsch S, Lengauer C, Maiwald R, Mielke K, Vogt P. Rapid screening of the Y chromosome in idiopathic sterile men, diagnostic for deletions in AZF, a genetic Y factor expressed during spermatogenesis. Andrologia 1994, 26: 97-106. PMID: 8042776, DOI: 10.1111/j.1439-0272.1994.tb00765.x.