Neera Dahl, MD, PhD
Associate Professor of Medicine (Nephrology); Medical Director, Nephrology; Director, Nephrology Clinical Trials Program, Nephrology
Research & Publications
Biography
News
Research Summary
I am interested in research involving the diagnosis and management of ADPKD and related cystic kidney diseases. I also have a research interest in factors affecting the formation of kidney stones. As the director of the Yale Nephrology Clinical Trials Program I oversee studies in ADPKD, diabetic kidney disease, kidney stones and glomerulonephritis.
Extensive Research Description
In collaboration with Dr. Tinika Montgomery (nephrology), Drs. Dinesh Singh, Piruz Motamedinia, and Tim Tran (urology) we have created a Kidney Stone Registry to track important aspects of kidney stone management.
In the inherited kidney disease space I am most interested in those aspects of clinical research which improve care for ADPKD patients.
Coauthors
Research Interests
Kidney Diseases; Nephrology
Selected Publications
- Long-Term Safety of Tolvaptan in ADPKD: Where Do We Stand?Patel DM, Dahl NK. Long-Term Safety of Tolvaptan in ADPKD: Where Do We Stand? Clinical Journal Of The American Society Of Nephrology : CJASN 2020, 16: 3-5. PMID: 33376103, PMCID: PMC7792649, DOI: 10.2215/CJN.17981120.
- The AE gene family of Cl/HCO3- exchangers.Alper SL, Darman RB, Chernova MN, Dahl NK. The AE gene family of Cl/HCO3- exchangers. Journal Of Nephrology 2002, 15 Suppl 5: S41-53. PMID: 12027221.
- Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer.Dahl NK, Jiang L, Chernova MN, Stuart-Tilley AK, Shmukler BE, Alper SL. Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer. The Journal Of Biological Chemistry 2003, 278: 44949-58. PMID: 12933803, DOI: 10.1074/jbc.M308660200.
- Thrombotic microangiopathy and renal failure exacerbated by epsilon-aminocaproic acid.Mutter WP, Stillman IE, Dahl NK. Thrombotic microangiopathy and renal failure exacerbated by epsilon-aminocaproic acid. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2009, 53: 346-50. PMID: 18805613, DOI: 10.1053/j.ajkd.2008.07.023.
- Recurrent flank pain from 'lobster claw'.Singanamala S, Krishnamoorthy S, Perazella MA, Dahl NK. Recurrent flank pain from 'lobster claw'. NDT Plus 2011, 4: 274-5. PMID: 25949502, PMCID: PMC4421448, DOI: 10.1093/ndtplus/sfr032.
- Should living kidney donor candidates with impaired fasting glucose donate?Vigneault CB, Asch WS, Dahl NK, Bia MJ. Should living kidney donor candidates with impaired fasting glucose donate? Clinical Journal Of The American Society Of Nephrology : CJASN 2011, 6: 2054-9. PMID: 21784837, DOI: 10.2215/CJN.03370411.
- Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome.Hall IE, Kashgarian M, Moeckel GW, Dahl NK. Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. Clinical Nephrology 2012, 77: 62-5. PMID: 22185970, DOI: 10.5414/cn106859.
- Evaluation of urine biomarkers of kidney injury in polycystic kidney disease.Parikh CR, Dahl NK, Chapman AB, Bost JE, Edelstein CL, Comer DM, Zeltner R, Tian X, Grantham JJ, Somlo S. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Kidney International 2012, 81: 784-90. PMID: 22258321, PMCID: PMC3319327, DOI: 10.1038/ki.2011.465.
- Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition.Manjunath V, Moeckel G, Dahl NK. Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition. Clinical Nephrology 2013, 80: 151-5. PMID: 23845267, DOI: 10.5414/cn107258.
- Cystic kidney disease in a patient with systemic toxicity from long-term D-penicillamine use.Koraishy FM, Cohen RA, Israel GM, Dahl NK. Cystic kidney disease in a patient with systemic toxicity from long-term D-penicillamine use. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2013, 62: 806-9. PMID: 23796907, DOI: 10.1053/j.ajkd.2013.04.017.
- Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management.Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrology, Dialysis, Transplantation : Official Publication Of The European Dialysis And Transplant Association - European Renal Association 2014, 29: 247-54. PMID: 24215018, DOI: 10.1093/ndt/gft437.
- CT urography for the diagnosis of medullary sponge kidney.Koraishy FM, Ngo TT, Israel GM, Dahl NK. CT urography for the diagnosis of medullary sponge kidney. American Journal Of Nephrology 2014, 39: 165-70. PMID: 24531190, DOI: 10.1159/000358496.
- Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease: A Biomarker of Disease Progression and Therapeutic Efficacy.Alam A, Dahl NK, Lipschutz JH, Rossetti S, Smith P, Sapir D, Weinstein J, McFarlane P, Bichet DG. Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease: A Biomarker of Disease Progression and Therapeutic Efficacy. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2015, 66: 564-76. PMID: 25960302, DOI: 10.1053/j.ajkd.2015.01.030.
- Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis.Marsenic O, Anderson M, Couloures KG, Hong WS, Kevin Hall E, Dahl N. Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis. Hemodialysis International. International Symposium On Home Hemodialysis 2016, 20: 277-85. PMID: 26663617, DOI: 10.1111/hdi.12384.
- Simple Renal Cysts as Markers of Thoracic Aortic Disease.Ziganshin BA, Theodoropoulos P, Salloum MN, Zaza KJ, Tranquilli M, Mojibian HR, Dahl NK, Fang H, Rizzo JA, Elefteriades JA. Simple Renal Cysts as Markers of Thoracic Aortic Disease. Journal Of The American Heart Association 2016, 5 PMID: 26746998, PMCID: PMC4859353, DOI: 10.1161/JAHA.115.002248.
- Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis.Vichot AA, Zsengellér ZK, Shmukler BE, Adams ND, Dahl NK, Alper SL. Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis. Clinical Kidney Journal 2017, 10: 135-140. PMID: 28638614, PMCID: PMC5469557, DOI: 10.1093/ckj/sfw074.
- Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring.Rauniyar N, Yu X, Cantley J, Voss EZ, Belcher J, Colangelo CM, Stone KL, Dahl N, Parikh C, Lam TT, Cantley LG. Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring. Proteomics. Clinical Applications 2018, 12: e1700157. PMID: 29573172, PMCID: PMC6736530, DOI: 10.1002/prca.201700157.
- Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment.Lee Y, Blount KL, Dai F, Thompson S, Scher JK, Bitterman S, Droher M, Herzog EL, Moeckel G, Karihaloo A, Dahl NK. Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment. Clinical And Experimental Nephrology 2018, 22: 906-916. PMID: 29453607, DOI: 10.1007/s10157-018-1542-x.
- Preimplantation Genetic Diagnosis Counseling in Autosomal Dominant Polycystic Kidney Disease.Murphy EL, Droher ML, DiMaio MS, Dahl NK. Preimplantation Genetic Diagnosis Counseling in Autosomal Dominant Polycystic Kidney Disease. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2018, 72: 866-872. PMID: 29606500, DOI: 10.1053/j.ajkd.2018.01.048.
- TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation.Gulati A, Bale AE, Dykas DJ, Bia MJ, Danovitch GM, Moeckel GW, Somlo S, Dahl NK. TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD-A Novel Presentation. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2018, 72: 895-899. PMID: 29941221, DOI: 10.1053/j.ajkd.2018.05.006.
- A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE. A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan. Journal Of The American Society Of Nephrology : JASN 2018, 29: 2458-2470. PMID: 30228150, PMCID: PMC6171265, DOI: 10.1681/ASN.2018060590.
- In Reply to 'TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD Is in Fact a Case of RVCL-S Presenting With Renal Features'.Gulati A, Dahl N. In Reply to 'TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD Is in Fact a Case of RVCL-S Presenting With Renal Features'. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2019, 73: 893-894. PMID: 30846257, DOI: 10.1053/j.ajkd.2019.01.014.
- Simple renal cysts and bovine aortic arch: markers for aortic disease.Brownstein AJ, Bin Mahmood SU, Saeyeldin A, Velasquez Mejia C, Zafar MA, Li Y, Rizzo JA, Dahl NK, Erben Y, Ziganshin BA, Elefteriades JA. Simple renal cysts and bovine aortic arch: markers for aortic disease. Open Heart 2019, 6: e000862. PMID: 30774963, PMCID: PMC6350752, DOI: 10.1136/openhrt-2018-000862.
- Revisiting racial differences in ESRD due to ADPKD in the United States.Murphy EL, Dai F, Blount KL, Droher ML, Liberti L, Crews DC, Dahl NK. Revisiting racial differences in ESRD due to ADPKD in the United States. BMC Nephrology 2019, 20: 55. PMID: 30764782, PMCID: PMC6376748, DOI: 10.1186/s12882-019-1241-1.
- Inherited glomerular diseases in the gilded age of genomic advancements.Gulati A, Dahl N, Tufro A. Inherited glomerular diseases in the gilded age of genomic advancements. Pediatric Nephrology (Berlin, Germany) 2020, 35: 959-968. PMID: 31049720, PMCID: PMC7184048, DOI: 10.1007/s00467-019-04266-y.
- Risk factors and safe contrast volume thresholds for postcontrast acute kidney injury after peripheral vascular interventions.Lee SR, Zhuo H, Zhang Y, Dahl N, Dardik A, Ochoa Chaar CI. Risk factors and safe contrast volume thresholds for postcontrast acute kidney injury after peripheral vascular interventions. Journal Of Vascular Surgery 2020, 72: 603-610.e1. PMID: 31843298, DOI: 10.1016/j.jvs.2019.09.059.
- Intraoperative Ultrasound Guidance for Banding of an Arteriovenous Fistula Causing High Cardiac Output Heart Failure.Turner AD, Chen M, Dahl N, Scoutt L, Dardik A, Ochoa Chaar CI. Intraoperative Ultrasound Guidance for Banding of an Arteriovenous Fistula Causing High Cardiac Output Heart Failure. Annals Of Vascular Surgery 2020, 66: 665.e5-665.e8. PMID: 31863947, DOI: 10.1016/j.avsg.2019.12.011.
- Collagen IV Gene Mutations in Adults With Bilateral Renal Cysts and CKD.Gulati A, Sevillano AM, Praga M, Gutierrez E, Alba I, Dahl NK, Besse W, Choi J, Somlo S. Collagen IV Gene Mutations in Adults With Bilateral Renal Cysts and CKD. Kidney International Reports 2020, 5: 103-108. PMID: 31922066, PMCID: PMC6943786, DOI: 10.1016/j.ekir.2019.09.004.
- IgA vasculitis complicated by acute kidney failure with thrombotic microangiopathy: successful use of eculizumab.Patel DM, Cantley L, Moeckel G, Dahl NK, Luciano R. IgA vasculitis complicated by acute kidney failure with thrombotic microangiopathy: successful use of eculizumab. Journal Of Nephrology 2021, 34: 2141-2145. PMID: 34019254, DOI: 10.1007/s40620-021-01028-8.
- Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol.Dahl NK, Reed KL, Daunais MA, Faust JR, Liscum L. Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. The Journal Of Biological Chemistry 1992, 267: 4889-96. PMID: 1537866.
- Hairpin and duplex formation in DNA fragments CCAATTTTGG, CCAATTTTTTGG, and CCATTTTTGG: a proton NMR study.Pramanik P, Kanhouwa N, Kan LS. Hairpin and duplex formation in DNA fragments CCAATTTTGG, CCAATTTTTTGG, and CCATTTTTGG: a proton NMR study. Biochemistry 1988, 27: 3024-31. PMID: 3401464, DOI: 10.1021/bi00408a054.
- A second complementation class of cholesterol transport mutants with a variant Niemann-Pick type C phenotype.Dahl NK, Daunais MA, Liscum L. A second complementation class of cholesterol transport mutants with a variant Niemann-Pick type C phenotype. Journal Of Lipid Research 1994, 35: 1839-49. PMID: 7852861.
- Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant.Dahl NK, Gutheil WG, Liscum L. Abnormal regulation of low density lipoprotein-sensitive events in a cholesterol transport mutant. The Journal Of Biological Chemistry 1993, 268: 16979-86. PMID: 8349588.
- Association of AKI-D with Urinary Findings and Baseline eGFR in Hospitalized COVID-19 Patients.Patel DM, Phadke M, Dai F, Simonov M, Dahl NK, Kodali R. Association of AKI-D with Urinary Findings and Baseline eGFR in Hospitalized COVID-19 Patients. Kidney360 2021, 2: 1215-1224. PMID: 35369662, PMCID: PMC8676386, DOI: 10.34067/KID.0001612021.
- Clinical Applications of Genetic Discoveries in Kidney Transplantation: a Review.Marin EP, Cohen E, Dahl N. Clinical Applications of Genetic Discoveries in Kidney Transplantation: a Review. Kidney360 2020, 1: 300-305. PMID: 35372915, PMCID: PMC8809267, DOI: 10.34067/KID.0000312019.
- An Unusual Cause of AKI in a Kidney Transplant Recipient.Malhotra D, Dahl NK. An Unusual Cause of AKI in a Kidney Transplant Recipient. Kidney360 2021, 2: 1869-1870. PMID: 35373005, PMCID: PMC8785853, DOI: 10.34067/KID.0004332021.
- Mayo Imaging Classification May Be Useful in Determining the Need for Nephrectomy in ADPKD.Rosenberg S, Virmani S, Klarman S, Santovasi S, Dai F, Dahl NK. Mayo Imaging Classification May Be Useful in Determining the Need for Nephrectomy in ADPKD. Kidney360 2021, 2: 325-330. PMID: 35373011, PMCID: PMC8740992, DOI: 10.34067/KID.0003902020.
- Examining the Role of Novel CKD Therapies for the ADPKD Patient.Patel DM, Dahl NK. Examining the Role of Novel CKD Therapies for the ADPKD Patient. Kidney360 2021, 2: 1036-1041. PMID: 35373079, PMCID: PMC8791369, DOI: 10.34067/KID.0007422020.
- An Unusual Cause of Peritoneal Dialysis Catheter Dysfunction.Sundararajan A, Dahl NK, Latich I. An Unusual Cause of Peritoneal Dialysis Catheter Dysfunction. Kidney360 2021, 2: 1540-1541. PMID: 35373106, PMCID: PMC8786129, DOI: 10.34067/KID.0001762021.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Cardiovascular System; Diseases of the Kidney & Urinary Tract; Genetics - Adult | Genetic Determinants of Aneurysms in Autosomal Dominant Polycystic Kidney Disease |
Diseases of the Digestive System - Small Intestines, Large Intestines & Rectum; Diseases of the Kidney & Urinary Tract | Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria |
Hepatitis; HIV/AIDS; Immune System; Infectious Diseases | Screening In Anticipation of Future Research |
Diseases of the Digestive System - Liver; Genetics - Adult | Genetic Studies of Polycystic Livers |