Nancy Carrasco, MD

Anions; Organelle Biogenesis; Biological Assay; Breast Neoplasms; Hypothyroidism; Kinetics; Medical Oncology; Neoplasm Metastasis; Thyroid Neoplasms; Amino Acid Substitution

• Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter.Nicola JP, Carrasco N, Amzel LM. Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter. Nature Communications 2014, 5: 3948. PMID: 24888603, PMCID: PMC4248369, DOI: 10.1038/ncomms4948.
• Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS).Li W, Nicola JP, Amzel LM, Carrasco N. Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS). FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2013, 27: 3229-38. PMID: 23650190, PMCID: PMC3714583, DOI: 10.1096/fj.13-229138.
• The iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter.Paroder V, Nicola JP, Ginter CS, Carrasco N. The iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter. Journal Of Cell Science 2013, 126: 3305-13. PMID: 23690546, PMCID: PMC3730242, DOI: 10.1242/jcs.120246.
• Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS).Paroder-Belenitsky M, Maestas MJ, Dohán O, Nicola JP, Reyna-Neyra A, Follenzi A, Dadachova E, Eskandari S, Amzel LM, Carrasco N. Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS). Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 17933-8. PMID: 22011571, PMCID: PMC3207644, DOI: 10.1073/pnas.1108278108.
• Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nature Medicine 2009, 15: 1186-94. PMID: 19767733, PMCID: PMC2790327, DOI: 10.1038/nm.2029.
• The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate.Dohán O, Portulano C, Basquin C, Reyna-Neyra A, Amzel LM, Carrasco N. The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20250-5. PMID: 18077370, PMCID: PMC2154417, DOI: 10.1073/pnas.0707207104.
• Amino acid residues in transmembrane segment IX of the Na+/I- symporter play a role in its Na+ dependence and are critical for transport activity.De la Vieja A, Reed MD, Ginter CS, Carrasco N. Amino acid residues in transmembrane segment IX of the Na+/I- symporter play a role in its Na+ dependence and are critical for transport activity. The Journal Of Biological Chemistry 2007, 282: 25290-8. PMID: 17606623, DOI: 10.1074/jbc.M700147200.
• Na+ coordination at the Na2 site of the Na+/I- symporter.Ferrandino G, Nicola JP, Sánchez YE, Echeverria I, Liu Y, Amzel LM, Carrasco N. Na+ coordination at the Na2 site of the Na+/I- symporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: E5379-88. PMID: 27562170, PMCID: PMC5027462, DOI: 10.1073/pnas.1607231113.
• Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.Nagarajah J, Le M, Knauf JA, Ferrandino G, Montero-Conde C, Pillarsetty N, Bolaender A, Irwin C, Krishnamoorthy GP, Saqcena M, Larson SM, Ho AL, Seshan V, Ishii N, Carrasco N, Rosen N, Weber WA, Fagin JA. Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine. The Journal Of Clinical Investigation 2016, 126: 4119-4124. PMID: 27669459, PMCID: PMC5096947, DOI: 10.1172/JCI89067.