Naiem Nassiri, MD, RPVI
Associate Professor of Surgery (Vascular); Co-Director, Vascular Malformations Program (VaMP); Associate Professor of Surgery (Vascular), Vascular Surgery and Endovascular Therapy; Chief, Vascular & Endovascular Surgery, VA Connecticut Healthcare System
Research & Publications
Biography
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Research Summary
My research interest focuses in part on biomolecular pathways involved in the pathogenesis and propagation of vascular malformations. In particular, I am interested in the endovascular delivery of sustained, targeted pharmacotherapy for less invasive management of these complex lesions.
I am also actively involved in clinical trials involving novel aortic endograft technologies.
I serve as the Director of Site-Based Clinical research for Vascular Surgery for the Yale Heart & Vascular Center (HVC)
Coauthors
Research Interests
Embolization, Therapeutic; Klippel-Trenaunay-Weber Syndrome; Pulmonary Embolism; Aneurysm, Ruptured; Sirolimus; Limb Salvage; Vascular Malformations; Drug-Eluting Stents; Endovascular Procedures
Research Image
Arteriovenous malformation of the hand before and after embolization
Multimodal embolotherapy of a high-flow arteriovenous malformation of the hand via retrograde transvenous, antegrade transarterial, and direct stick embolization.
Selected Publications
- Endovascular Reconstruction for Chronic Infrarenal Aortoiliac Occlusive Disease.Pepe RJ, Patel P, Huntress LA, Nassiri N. Endovascular Reconstruction for Chronic Infrarenal Aortoiliac Occlusive Disease. Annals Of Vascular Surgery 2017, 45: 263.e11-263.e17. PMID: 28648656, DOI: 10.1016/j.avsg.2017.06.053.
- Palliative Endovascular Techniques for Management of Peripheral Vascular Blowout Syndrome in End-Stage Malignancies.Huntress LA, Kogan S, Nagarsheth K, Nassiri N. Palliative Endovascular Techniques for Management of Peripheral Vascular Blowout Syndrome in End-Stage Malignancies. Vascular And Endovascular Surgery 2017, 51: 394-399. PMID: 28535730, DOI: 10.1177/1538574417710600.
- Stent-Assisted Coil Embolization of a Symptomatic Renal Artery Aneurysm at a Bifurcation Point.Nassiri N, Huntress LA. Stent-Assisted Coil Embolization of a Symptomatic Renal Artery Aneurysm at a Bifurcation Point. Annals Of Vascular Surgery 2017, 42: 299.e11-299.e14. PMID: 28279720, DOI: 10.1016/j.avsg.2016.10.042.
- Direct stick embolization of extremity arteriovenous malformations with ethylene vinyl alcohol copolymer.Nassiri N, Cirillo-Penn NC, Crystal DT. Direct stick embolization of extremity arteriovenous malformations with ethylene vinyl alcohol copolymer. Journal Of Vascular Surgery 2017, 65: 1223-1228. PMID: 28189353, DOI: 10.1016/j.jvs.2016.12.062.
- Evaluation and management of peripheral venous and lymphatic malformations.Nassiri N, Thomas J, Cirillo-Penn NC. Evaluation and management of peripheral venous and lymphatic malformations. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2016, 4: 257-65. PMID: 26993876, DOI: 10.1016/j.jvsv.2015.09.001.
- Evaluation and management of congenital peripheral arteriovenous malformations.Nassiri N, Cirillo-Penn NC, Thomas J. Evaluation and management of congenital peripheral arteriovenous malformations. Journal Of Vascular Surgery 2015, 62: 1667-76. PMID: 26598124, DOI: 10.1016/j.jvs.2015.08.052.
- Transarterial treatment of congenital renal arteriovenous fistulas.Nassiri N, Dudiy Y, Carroccio A, Rosen RJ. Transarterial treatment of congenital renal arteriovenous fistulas. Journal Of Vascular Surgery 2013, 58: 1310-5. PMID: 23810295, DOI: 10.1016/j.jvs.2013.05.010.
- Interventional management of high-flow vascular malformations.Rosen RJ, Nassiri N, Drury JE. Interventional management of high-flow vascular malformations. Techniques In Vascular And Interventional Radiology 2013, 16: 22-38. PMID: 23499129, DOI: 10.1053/j.tvir.2013.01.004.
- Massive and submassive pulmonary embolism: experience with an algorithm for catheter-directed mechanical thrombectomy.Nassiri N, Jain A, McPhee D, Mina B, Rosen RJ, Giangola G, Carroccio A, Green RM. Massive and submassive pulmonary embolism: experience with an algorithm for catheter-directed mechanical thrombectomy. Annals Of Vascular Surgery 2012, 26: 18-24. PMID: 21885244, DOI: 10.1016/j.avsg.2011.05.026.
- Staged endovascular and surgical treatment of slow-flow vulvar venous malformations.Nassiri N, O TM, Rosen RJ, Moritz J, Waner M. Staged endovascular and surgical treatment of slow-flow vulvar venous malformations. American Journal Of Obstetrics And Gynecology 2013, 208: 366.e1-6. PMID: 23395642, DOI: 10.1016/j.ajog.2013.02.003.
- Pelvic Congestion Syndrome.Balica AC, Nassiri N, Horne J, Egan S, Wang XK. Pelvic Congestion Syndrome. Journal Of Minimally Invasive Gynecology 2015, 22: S152. PMID: 27678858, DOI: 10.1016/j.jmig.2015.08.561.
- Transcatheter embolization of persistent embryonic veins in venous malformation syndromes.Nassiri N, Crystal D, Huntress LA, Murphy S. Transcatheter embolization of persistent embryonic veins in venous malformation syndromes. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2017, 5: 749-755. PMID: 28818233, DOI: 10.1016/j.jvsv.2017.05.016.
- Evaluation and management of the lateral marginal vein in Klippel-Trénaunay and other PIK3CA-related overgrowth syndromes.Fereydooni A, Nassiri N. Evaluation and management of the lateral marginal vein in Klippel-Trénaunay and other PIK3CA-related overgrowth syndromes. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2020, 8: 482-493. PMID: 32089498, DOI: 10.1016/j.jvsv.2019.12.003.
- Endovascular Revascularization Incorporating Infrapopliteal Coronary Drug-Eluting Stents Improves Clinical Outcomes in Patients with Critical Limb Ischemia and Tissue Loss.Huntress LA, Fereydooni A, Dardik A, Nassiri N. Endovascular Revascularization Incorporating Infrapopliteal Coronary Drug-Eluting Stents Improves Clinical Outcomes in Patients with Critical Limb Ischemia and Tissue Loss. Annals Of Vascular Surgery 2020, 63: 234-240. PMID: 31563654, DOI: 10.1016/j.avsg.2019.07.011.
- Bifurcated unibody aortic endografts can overcome unfavorable aortoiliac anatomy for deployment of bilateral iliac branch endoprostheses.Fereydooni A, Deyholos C, Botta R, Nezami N, Dardik A, Nassiri N. Bifurcated unibody aortic endografts can overcome unfavorable aortoiliac anatomy for deployment of bilateral iliac branch endoprostheses. Journal Of Vascular Surgery Cases And Innovative Techniques 2019, 5: 174-178. PMID: 31193591, PMCID: PMC6536773, DOI: 10.1016/j.jvscit.2019.01.004.
- Molecular changes associated with vascular malformations.Fereydooni A, Dardik A, Nassiri N. Molecular changes associated with vascular malformations. Journal Of Vascular Surgery 2019, 70: 314-326.e1. PMID: 30922748, DOI: 10.1016/j.jvs.2018.12.033.
- An Academic Tertiary Referral Center's Experience with a Vascular Surgery-Based Uterine Artery Embolization Program.Nassiri N, Balica A, Cirillo-Penn NC, Crystal DT, Bachmann GA. An Academic Tertiary Referral Center's Experience with a Vascular Surgery-Based Uterine Artery Embolization Program. Annals Of Vascular Surgery 2018, 52: 90-95. PMID: 29777846, DOI: 10.1016/j.avsg.2018.03.008.
- An institution-wide algorithm for direct-stick embolization of peripheral venous malformations.Nassiri N, Huntress LA, Simon M, Murphy S. An institution-wide algorithm for direct-stick embolization of peripheral venous malformations. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2018, 6: 351-357. PMID: 29396158, DOI: 10.1016/j.jvsv.2017.12.011.
- Author Correction: Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency.Guo X, Fereydooni A, Isaji T, Gorecka J, Liu S, Hu H, Ono S, Alozie M, Lee SR, Taniguchi R, Yatsula B, Nassiri N, Zhang L, Dardik A. Author Correction: Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency. Scientific Reports 2020, 10: 8301. PMID: 32404972, PMCID: PMC7220925, DOI: 10.1038/s41598-020-65540-w.
- Discrepancy in Outcomes after Revascularization for Chronic Limb-Threatening Ischemia Warrants Separate Reporting of Rest Pain and Tissue Loss.Brahmandam A, Gholitabar N, Cardella J, Nassiri N, Dardik A, Georgi M, Ochoa Chaar CI. Discrepancy in Outcomes after Revascularization for Chronic Limb-Threatening Ischemia Warrants Separate Reporting of Rest Pain and Tissue Loss. Annals Of Vascular Surgery 2021, 70: 237-244. PMID: 32659417, DOI: 10.1016/j.avsg.2020.06.057.
- Endovascular abdominal aortic aneurysm repair in a centenarian.Bellamkonda KS, Kim T, Rosenthal R, Dardik A, Nassiri N. Endovascular abdominal aortic aneurysm repair in a centenarian. Journal Of Vascular Surgery Cases And Innovative Techniques 2020, 6: 361-364. PMID: 32715172, PMCID: PMC7371717, DOI: 10.1016/j.jvscit.2020.05.009.
- Mechanochemical and surgical ablation of an anomalous upper extremity marginal vein in CLOVES syndrome identifies PIK3CA as the culprit gene mutation.Lim Y, Fereydooni A, Brahmandam A, Dardik A, Choate K, Nassiri N. Mechanochemical and surgical ablation of an anomalous upper extremity marginal vein in CLOVES syndrome identifies PIK3CA as the culprit gene mutation. Journal Of Vascular Surgery Cases And Innovative Techniques 2020, 6: 438-442. PMID: 32775850, PMCID: PMC7396827, DOI: 10.1016/j.jvscit.2020.05.013.
- Trends and outcomes of thoracic endovascular aortic repair with open concomitant cervical debranching.Bellamkonda KS, Yousef S, Nassiri N, Dardik A, Guzman RJ, Geirsson A, Ochoa Chaar CI. Trends and outcomes of thoracic endovascular aortic repair with open concomitant cervical debranching. Journal Of Vascular Surgery 2021, 73: 1205-1212.e3. PMID: 32861861, DOI: 10.1016/j.jvs.2020.07.103.
- A hybrid approach for vascular control and repair of an expanding iatrogenic femoral artery pseudoaneurysm.Gorecka J, Chen JF, Shah S, Dardik A, Guzman RJ, Nassiri N. A hybrid approach for vascular control and repair of an expanding iatrogenic femoral artery pseudoaneurysm. Journal Of Vascular Surgery Cases And Innovative Techniques 2020, 6: 460-463. PMID: 32875180, PMCID: PMC7451709, DOI: 10.1016/j.jvscit.2020.07.010.
- Intraoperative retrograde TEVAR to control endoleak after emergent total arch replacement and frozen elephant trunk repair for ruptured Kommerell's diverticulum.Singh S, Chen JF, Assi R, Nassiri N, Vallabhajosyula P. Intraoperative retrograde TEVAR to control endoleak after emergent total arch replacement and frozen elephant trunk repair for ruptured Kommerell's diverticulum. Journal Of Cardiac Surgery 2020, 35: 3578-3580. PMID: 33085131, DOI: 10.1111/jocs.14950.
- Retreatment of a recanalized splenic artery aneurysm using a low-profile microembolization platform.Chen JF, Danahey J, Fischer U, Nassiri N. Retreatment of a recanalized splenic artery aneurysm using a low-profile microembolization platform. Journal Of Vascular Surgery Cases And Innovative Techniques 2020, 6: 553-556. PMID: 33134641, PMCID: PMC7588812, DOI: 10.1016/j.jvscit.2020.09.004.
- Snare-assisted thoracic endovascular aortic repair for redirection of a false lumen elephant trunk.Chen JF, Mangi A, Vallabhajosyula P, Nassiri N. Snare-assisted thoracic endovascular aortic repair for redirection of a false lumen elephant trunk. Journal Of Vascular Surgery Cases And Innovative Techniques 2020, 6: 566-570. PMID: 33134644, PMCID: PMC7588806, DOI: 10.1016/j.jvscit.2020.08.008.
- Assessment of quality of life changes in patients with lower extremity lymphedema using an advanced pneumatic compression device at home.Maldonado TS, Rokosh RS, Padberg F, Rotella V, Miller H, Nassiri N, Jacobowitz G, Berland T, Sadek M, Barfield ME. Assessment of quality of life changes in patients with lower extremity lymphedema using an advanced pneumatic compression device at home. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2021, 9: 745-752. PMID: 33137494, DOI: 10.1016/j.jvsv.2020.10.013.
- Correlation of venous symptoms with iliac vein stenosis on magnetic resonance imaging.Aurshina A, Huber S, Deng Y, Attaran R, Nassiri N, Dardik A, Ochoa Chaar CI. Correlation of venous symptoms with iliac vein stenosis on magnetic resonance imaging. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2021, 9: 1291-1296.e1. PMID: 33387666, DOI: 10.1016/j.jvsv.2020.12.077.
- Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database.Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74: 729-737. PMID: 33617982, DOI: 10.1016/j.jvs.2021.01.063.
- Superselective carotid body tumor embolization with platinum-based coils.Bellamkonda KS, Chen JF, Tonnessen B, Rahmati R, Nassiri N. Superselective carotid body tumor embolization with platinum-based coils. Journal Of Vascular Surgery Cases And Innovative Techniques 2021, 7: 1-5. PMID: 33665522, PMCID: PMC7902276, DOI: 10.1016/j.jvscit.2020.10.007.
- Endovascular repair of a dissecting pararenal abdominal aortic aneurysm in a patient with type III Loeys-Dietz syndrome.Bellamkonda KS, Dardik A, Nassiri N. Endovascular repair of a dissecting pararenal abdominal aortic aneurysm in a patient with type III Loeys-Dietz syndrome. Journal Of Vascular Surgery Cases And Innovative Techniques 2021, 7: 10-15. PMID: 33665524, PMCID: PMC7902277, DOI: 10.1016/j.jvscit.2020.09.017.
- Imaging of vascular malformations with a high-intensity focused ultrasound probe for treatment planning.Danahey J, Seip R, Lee B, Nassiri N, Dardik A, Guzman R, Nassiri N. Imaging of vascular malformations with a high-intensity focused ultrasound probe for treatment planning. Journal Of Vascular Surgery. Venous And Lymphatic Disorders 2021, 9: 1467-1472.e2. PMID: 33838310, DOI: 10.1016/j.jvsv.2021.03.011.
- Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation.Ugwu N, Atzmony L, Ellis KT, Panse G, Jain D, Ko CJ, Nassiri N, Choate KA. Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation. HGG Advances 2021, 2 PMID: 33912852, PMCID: PMC8078848, DOI: 10.1016/j.xhgg.2021.100028.
- Superselective intranidal delivery of platinum-based high-density packing coils for treatment of arteriovenous malformations.Bellamkonda KS, Fereydooni A, Trott K, Lee Y, Mehra S, Nassiri N. Superselective intranidal delivery of platinum-based high-density packing coils for treatment of arteriovenous malformations. Journal Of Vascular Surgery Cases And Innovative Techniques 2021, 7: 230-234. PMID: 33997560, PMCID: PMC8095044, DOI: 10.1016/j.jvscit.2021.01.005.
- Emergent percutaneous chimney endovascular aortic repair of a secondary aortoenteric fistula in the setting of a solitary kidney.Chen JF, Ochoa Chaar CI, Cardella J, Dardik A, Guzman RJ, Nassiri N. Emergent percutaneous chimney endovascular aortic repair of a secondary aortoenteric fistula in the setting of a solitary kidney. Journal Of Vascular Surgery Cases And Innovative Techniques 2021, 7: 253-257. PMID: 33997566, PMCID: PMC8095080, DOI: 10.1016/j.jvscit.2021.01.009.
- Alternative Endograft Aortoiliac Reconstruction for Iliac Branch Endoprostheses.Brahmandam A, Chen JF, Tonnessen BH, Chaar CIO, Fischer U, Dardik A, Guzman RJ, Nassiri N. Alternative Endograft Aortoiliac Reconstruction for Iliac Branch Endoprostheses. Annals Of Vascular Surgery 2021, 77: 38-46. PMID: 34455041, DOI: 10.1016/j.avsg.2021.05.065.
- All type B aortic dissections should undergo thoracic endovascular aneurysm repair.Singh S, Nassiri N, Vallabhajosyula P. All type B aortic dissections should undergo thoracic endovascular aneurysm repair. JTCVS Techniques 2021, 9: 17-24. PMID: 34647046, PMCID: PMC8501243, DOI: 10.1016/j.xjtc.2021.05.029.
- Erratum: Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation.Ugwu N, Atzmony L, Ellis KT, Panse G, Jain D, Ko CJ, Nassiri N, Choate KA. Erratum: Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation. HGG Advances 2022, 3: 100061. PMID: 35047851, PMCID: PMC8756555, DOI: 10.1016/j.xhgg.2021.100061.
- False lumen access for trans-septal thoracic endovascular aortic repair in a 10-cm dissecting thoracoabdominal aortic aneurysm.Chen JF, Vallabhajosyula P, Nassiri N. False lumen access for trans-septal thoracic endovascular aortic repair in a 10-cm dissecting thoracoabdominal aortic aneurysm. Journal Of Vascular Surgery Cases And Innovative Techniques 2022, 8: 93-97. PMID: 35128224, PMCID: PMC8804189, DOI: 10.1016/j.jvscit.2021.10.013.
- Elucidating the role of the AFX2 endograft in endovascular treatment of aortic pathology.Chen JF, Brahmandam A, Harris S, Fischer U, Nassiri N. Elucidating the role of the AFX2 endograft in endovascular treatment of aortic pathology. Annals Of Vascular Surgery 2022 PMID: 35589028, DOI: 10.1016/j.avsg.2022.04.042.
Clinical Trials
Conditions | Study Title |
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Diseases of the Cardiovascular System | Study of the Relay Pro® Thoracic Stent-Graft in Subjects With Traumatic Injury of the Descending Thoracic Aorta |