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Monique Hinchcliff, MD, MS

Associate Professor; Director of Yale Scleroderma Program, Rheumatology, Allergy, & Immunology

Research Summary

My research program includes clinical, interventional and observational studies in patients, as well as mechanistic studies in animal models and human tissue, with the overarching goal of better understanding the epidemiology, risk factors, mechanisms, treatment, and prognosis of systemic sclerosis (SSc). A major goal of my research is to combine patient-reported data with high-throughput approaches, including imaging modalities, to understand SSc heterogeneity and identify the deregulated molecular programs that underlie disease and its various organ-based complications.


Research Interests

Artificial Intelligence; Pulmonary Fibrosis; Raynaud Disease; Scleroderma, Localized; Scleroderma, Systemic; Scleroderma, Diffuse; Scleroderma, Limited; Microvascular Rarefaction

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Selected Publications

  • Scleroderma: From Pathogenesis to Comprehensive Management, 2e.Hinchcliff M, Whitfield M. Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis. 2016. Invited book chapter.
  • Generic Patient –Reported Outcome Instruments In Systemic Sclerosis: Patient-Reported Outcomes Information System (PROMIS) and Functional Assessment of Chronic Illness Therapy (FACIT). Book Chapter in Scleroderma: From Pathogenesis to Comprehensive Management.Hinchcliff M, Cella D. Editors Varga J, Denton C, Wigley F. Invited review and peer-reviewed.
  • Managing Systemic Sclerosis and Its Complications.Hinchcliff M, Varga J. The Journal of Musculoskeletal Medicine. October 2011, pp 380-387.
  • Managing Systemic Sclerosis and its Complications.Hinchcliff M, Varga J. The Journal of Musculoskeletal Medicine, October 2007

Clinical Trials