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Mireille Serlie, MD, PhD

she/her/hers

Professor of Internal Medicine (Endocrinology)

Research & Publications
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Selected Publications

Tissue-specific inflammation and insulin sensitivity in subjects with obesity.Oussaada SM, Kilicarslan M, de Weijer BA, Gilijamse PW, Şekercan A, Virtue S, Janssen IMC, van de Laar A, Demirkiran A, van Wagensveld BA, Houdijk APJ, Jongejan A, Moerland PD, Verheij J, Geijtenbeek TB, Bloks VW, de Goffau MC, Romijn JA, Nieuwdorp M, Vidal-Puig A, Ter Horst KW, Serlie MJ. Tissue-specific inflammation and insulin sensitivity in subjects with obesity. Diabetes Res Clin Pract 2024, 111663. PMID: 38616042, DOI: 10.1016/j.diabres.2024.111663.
The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies.Slebe R, Wenker E, Schoonmade LJ, Bouman EJ, Blondin DP, Campbell DJT, Carpentier AC, Hoeks J, Raina P, Schrauwen P, Serlie MJ, Jan Stenvers D, de Mutsert R, Beulens JWJ, Rutters F. The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies. Diabetes Res Clin Pract 2024, 210: 111638. PMID: 38548105, DOI: 10.1016/j.diabres.2024.111638.
The science of micronutrients in clinical practice - Report on the ESPEN symposium.Berger MM, Amrein K, Barazzoni R, Bindels L, Bretón I, Calder PC, Cappa S, Cuerda C, D'Amelio P, de Man A, Delzenne NM, Forbes A, Genton L, Gombart AF, Joly F, Laviano A, Matthys C, Phyo PP, Ravasco P, Serlie MJ, Shenkin A, Stoffel NU, Talwar D, van Zanten ARH. The science of micronutrients in clinical practice - Report on the ESPEN symposium. Clin Nutr 2024, 43: 268-283. PMID: 38104489, DOI: 10.1016/j.clnu.2023.12.006.
Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents.Diepenbroek C, Rijnsburger M, van Irsen AAS, Eggels L, Kisner A, Foppen E, Unmehopa UA, Berland C, Dólleman S, Hardonk M, Cruciani-Guglielmacci C, Faust RP, Wenning R, Maya-Monteiro CM, Kalsbeek A, Aponte Y, Luquet S, Serlie MJM, la Fleur SE. Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents. Metabolism 2023, 155696. PMID: 37804881, DOI: 10.1016/j.metabol.2023.155696.
Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review.van der Meer R, Mohamed SA, Monpellier VM, Liem RSL, Hazebroek EJ, Franks PW, Frayling TM, Janssen IMC, Serlie MJ. Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review. Obes Rev 2023 PMID: 37632325, DOI: 10.1111/obr.13626.
Bariatric surgery improves postprandial VLDL kinetics and restores insulin mediated regulation of hepatic VLDL production.Yildirim V, Ter Horst KW, Gilijamse PW, van Harskamp D, Schierbeek H, Jansen H, Schimmel AW, Nieuwdorp M, Groen AK, Serlie MJ, van Riel NA, Dallinga-Thie GM. Bariatric surgery improves postprandial VLDL kinetics and restores insulin mediated regulation of hepatic VLDL production. JCI Insight 2023 PMID: 37432744, DOI: 10.1172/jci.insight.166905.
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover studyvan Galen K, Schrantee A, ter Horst K, la Fleur S, Booij J, Constable R, Schwartz G, DiLeone R, Serlie M. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nature Metabolism 2023, 5: 1059-1072. PMID: 37308722, DOI: 10.1038/s42255-023-00816-9.
Randomized clinical trial: Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition.Gompelman M, Wezendonk GTJ, Wouters Y, Beurskens-Meijerink J, Fragkos KC, Rahman FZ, Coolen JPM, van Weerdenburg IJM, Wertheim HFL, Kievit W, Akkermans RP, Serlie MJ, Bleeker-Rovers CP, Wanten GJA. Randomized clinical trial: Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition. Clin Nutr 2023, 42: 706-716. PMID: 36965196, DOI: 10.1016/j.clnu.2023.03.010.
Management of acute mesenteric ischaemia: Results of a worldwide survey.Hess B, Cahenzli M, Forbes A, Burgos R, Coccolini F, Corcos O, Holst M, Irtun Ø, Klek S, Pironi L, Rasmussen HH, Serlie MJ, Thibault R, Gabe S, Reintam Blaser A, ESPEN Special Interest Group on Acute Intestinal Failure ESPEN (European Society for Clinical Nutrition and Metabolism). Management of acute mesenteric ischaemia: Results of a worldwide survey. Clin Nutr ESPEN 2023, 54: 194-205. PMID: 36963863, DOI: 10.1016/j.clnesp.2022.12.022.
Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) - Proceedings from the SOGLI consortium meeting in rome November 2022.Gortan Cappellari G, Guillet C, Poggiogalle E, Ballesteros Pomar MD, Batsis JA, Boirie Y, Breton I, Frara S, Genton L, Gepner Y, Gonzalez MC, Heymsfield SB, Kiesswetter E, Laviano A, Prado CM, Santini F, Serlie MJ, Siervo M, Villareal DT, Volkert D, Voortman T, Weijs PJ, Zamboni M, Bischoff SC, Busetto L, Cederholm T, Barazzoni R, Donini LM, SOGLI Expert Panel. Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) - Proceedings from the SOGLI consortium meeting in rome November 2022. Clin Nutr 2023, 42: 687-699. PMID: 36947988, DOI: 10.1016/j.clnu.2023.02.018.
Serotonergic drugs for the treatment of obesity(in press): 5th Edition of the Handbook of Obesity. Chapter on serotonergic drugs for the treatment of obesity
Home Parenteral Nutrition(in press): Handbook of Nutrition, Chapter on Home Parenteral Nutrition
COVID-19: Lessons on malnutrition, nutritional care and public health from the ESPEN-WHO Europe call for papers.Barazzoni R, Breda J, Cuerda C, Schneider S, Deutz NE, Wickramasinghe K, COVID-19 Call Editorial Board. COVID-19: Lessons on malnutrition, nutritional care and public health from the ESPEN-WHO Europe call for papers. Clin Nutr 2022, 41: 2858-2868. PMID: 36075815, DOI: 10.1016/j.clnu.2022.07.033.
The Clash of Two Epidemics: the Relationship Between Opioids and Glucose Metabolism.Koekkoek LL, van der Gun LL, Serlie MJ, la Fleur SE. The Clash of Two Epidemics: the Relationship Between Opioids and Glucose Metabolism. Current Diabetes Reports 2022, 22: 301-310. PMID: 35593927, PMCID: PMC9188528, DOI: 10.1007/s11892-022-01473-0.
Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement.Donini LM, Busetto L, Bischoff SC, Cederholm T, Ballesteros-Pomar MD, Batsis JA, Bauer JM, Boirie Y, Cruz-Jentoft AJ, Dicker D, Frara S, Frühbeck G, Genton L, Gepner Y, Giustina A, Gonzalez MC, Han HS, Heymsfield SB, Higashiguchi T, Laviano A, Lenzi A, Nyulasi I, Parrinello E, Poggiogalle E, Prado CM, Salvador J, Rolland Y, Santini F, Serlie MJ, Shi H, Sieber CC, Siervo M, Vettor R, Villareal DT, Volkert D, Yu J, Zamboni M, Barazzoni R. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obesity Facts 2022, 15: 321-335. PMID: 35196654, PMCID: PMC9210010, DOI: 10.1159/000521241.
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. Arteriosclerosis, Thrombosis, And Vascular Biology 2021, 41: 2708-2725. PMID: 34551590, PMCID: PMC8551036, DOI: 10.1161/ATVBAHA.121.316615.
Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study.van Son J, van Galen KA, Bruijn AM, Koopman KE, Versteeg RI, la Fleur SE, Serlie MJ, Booij J. Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study. Brain Sciences 2021, 11 PMID: 34827426, PMCID: PMC8615750, DOI: 10.3390/brainsci11111428.
Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey.Pironi L, Steiger E, Joly F, Jeppesen PB, Wanten G, Sasdelli AS, Chambrier C, Aimasso U, Mundi MS, Szczepanek K, Jukes A, Theilla M, Kunecki M, Daniels J, Serlie M, Poullenot F, Cooper SC, Rasmussen HH, Compher C, Seguy D, Crivelli A, Santarpia L, Guglielmi FW, Kozjek NR, Schneider SM, Ellegard L, Thibault R, Matras P, Matysiak K, Van Gossum A, Forbes A, Wyer N, Taus M, Virgili NM, O'Callaghan M, Chapman B, Osland E, Cuerda C, Udvarhelyi G, Jones L, Won Lee AD, Masconale L, Orlandoni P, Spaggiari C, Díez MB, Doitchinova-Simeonova M, Serralde-Zúñiga AE, Olveira G, Krznaric Z, Czako L, Kekstas G, Sanz-Paris A, Jáuregui MEP, Murillo AZ, Schafer E, Arends J, Suárez-Llanos JP, Youssef NN, Brillanti G, Nardi E, Lal S. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey. Clinical Nutrition ESPEN 2021, 45: 433-441. PMID: 34620351, DOI: 10.1016/j.clnesp.2021.07.004.
Disruption of lateral hypothalamic calorie detection by a free choice high fat diet.Koekkoek LL, Slomp M, Castel J, Mutersbaugh M, Linville I, Serlie MJ, Luquet SH, la Fleur SE. Disruption of lateral hypothalamic calorie detection by a free choice high fat diet. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2021, 35: e21804. PMID: 34383974, DOI: 10.1096/fj.202100762R.
Activation of nucleus accumbens μ-opioid receptors enhances the response to a glycaemic challenge.Koekkoek LL, Kool T, Eggels L, van der Gun LL, Lamuadni K, Slomp M, Diepenbroek C, Serlie MJ, Kalsbeek A, la Fleur SE. Activation of nucleus accumbens μ-opioid receptors enhances the response to a glycaemic challenge. Journal Of Neuroendocrinology 2021, 33: e13036. PMID: 34528311, PMCID: PMC9286654, DOI: 10.1111/jne.13036.
Plasma Imidazole Propionate Is Positively Correlated with Blood Pressure in Overweight and Obese Humans.van Son J, Serlie MJ, Ståhlman M, Bäckhed F, Nieuwdorp M, Aron-Wisnewsky J. Plasma Imidazole Propionate Is Positively Correlated with Blood Pressure in Overweight and Obese Humans. Nutrients 2021, 13 PMID: 34444866, PMCID: PMC8399073, DOI: 10.3390/nu13082706.
The relation between postprandial glucagon-like peptide-1 release and insulin sensitivity before and after bariatric surgery in humans with class II/III obesity.Gilijamse PW, Demirkiran A, van Wagensveld BA, Ackermans MT, Romijn JA, Nieuwdorp M, Ter Horst KW, Serlie MJ. The relation between postprandial glucagon-like peptide-1 release and insulin sensitivity before and after bariatric surgery in humans with class II/III obesity. Surgery For Obesity And Related Diseases : Official Journal Of The American Society For Bariatric Surgery 2021, 17: 1440-1448. PMID: 34083134, DOI: 10.1016/j.soard.2021.04.022.
The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesityvan Galen KA, Booij J, Schrantee A, Adriaanse SM, Unmehopa UA, Fliers E, Schwartz GJ, DiLeone RJ, Horst K, la Fleur SE, Serlie MJ. The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity. Metabolism 2021, 123: 154839. PMID: 34331964, PMCID: PMC8994212, DOI: 10.1016/j.metabol.2021.154839.
Serotonin, food intake, and obesity.van Galen KA, Ter Horst KW, Serlie MJ. Serotonin, food intake, and obesity. Obesity Reviews : An Official Journal Of The International Association For The Study Of Obesity 2021, 22: e13210. PMID: 33559362, PMCID: PMC8243944, DOI: 10.1111/obr.13210.
Bridging-to-Surgery in Patients with Type 2 Intestinal Failure.de Vries FEE, Claessen JJM, van Hasselt-Gooijer EMS, van Ruler O, Jonkers C, Kuin W, van Arum I, van der Werf GM, Serlie MJ, Boermeester MA. Bridging-to-Surgery in Patients with Type 2 Intestinal Failure. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2021, 25: 1545-1555. PMID: 32700102, PMCID: PMC8203517, DOI: 10.1007/s11605-020-04741-0.
Metabolite Profile of Treatment-Naive Metabolic Syndrome Subjects in Relation to Cardiovascular Disease Risk.Warmbrunn MV, Koopen AM, de Clercq NC, de Groot PF, Kootte RS, Bouter KEC, Ter Horst KW, Hartstra AV, Serlie MJ, Ackermans MT, Soeters MR, van Raalte DH, Davids M, Nieuwdorp M, Groen AK. Metabolite Profile of Treatment-Naive Metabolic Syndrome Subjects in Relation to Cardiovascular Disease Risk. Metabolites 2021, 11 PMID: 33924347, PMCID: PMC8069178, DOI: 10.3390/metabo11040236.
The Role of the Gut Microbiota in the Gut-Brain Axis in Obesity: Mechanisms and Future Implications.van Son J, Koekkoek LL, La Fleur SE, Serlie MJ, Nieuwdorp M. The Role of the Gut Microbiota in the Gut-Brain Axis in Obesity: Mechanisms and Future Implications. International Journal Of Molecular Sciences 2021, 22 PMID: 33804250, PMCID: PMC7999163, DOI: 10.3390/ijms22062993.
STEP 4 Investigators. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical TrialRubino D, Abrahamsson N, Davies M, Hesse D, Greenway FL, Jensen C, Lingvay I, Mosenzon O, Rosenstock J, Rubio MA, Rudofsky G, Tadayon S, Wadden TA, Dicker D; STEP 4 Investigators. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021 Apr 13;325(14):1414-1425.
Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study.van Son J, Oussaada SM, Şekercan A, Beudel M, Dongelmans DA, van Assen S, Eland IA, Moeniralam HS, Dormans TPJ, van Kalkeren CAJ, Douma RA, Rusch D, Simsek S, Liu L, Kootte RS, Wyers CE, IJzerman RG, van den Bergh JP, Stehouwer CDA, Nieuwdorp M, Ter Horst KW, Serlie MJ. Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study. Frontiers In Endocrinology 2021, 12: 747732. PMID: 34970220, PMCID: PMC8713548, DOI: 10.3389/fendo.2021.747732.
Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease.Ter Horst KW, Vatner DF, Zhang D, Cline GW, Ackermans MT, Nederveen AJ, Verheij J, Demirkiran A, van Wagensveld BA, Dallinga-Thie GM, Nieuwdorp M, Romijn JA, Shulman GI, Serlie MJ. Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. Diabetes Care 2020, 44: 489-498. PMID: 33293347, PMCID: PMC7818337, DOI: 10.2337/dc20-1644.
Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome.Hartstra AV, Schüppel V, Imangaliyev S, Schrantee A, Prodan A, Collard D, Levin E, Dallinga-Thie G, Ackermans MT, Winkelmeijer M, Havik SR, Metwaly A, Lagkouvardos I, Nier A, Bergheim I, Heikenwalder M, Dunkel A, Nederveen AJ, Liebisch G, Mancano G, Claus SP, Benítez-Páez A, la Fleur SE, Bergman JJ, Gerdes V, Sanz Y, Booij J, Kemper E, Groen AK, Serlie MJ, Haller D, Nieuwdorp M. Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome. Molecular Metabolism 2020, 42: 101076. PMID: 32916306, PMCID: PMC7536740, DOI: 10.1016/j.molmet.2020.101076.
Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure.Pironi L, Steiger E, Joly F, Wanten GJA, Chambrier C, Aimasso U, Sasdelli AS, Szczepanek K, Jukes A, Theilla M, Kunecki M, Daniels J, Serlie MJ, Cooper SC, Poullenot F, Rasmussen HH, Compher CW, Crivelli A, Hughes SJ, Santarpia L, Guglielmi FW, Rotovnik Kozjek N, Ellegard L, Schneider SM, Matras P, Forbes A, Wyer N, Zmarzly A, Taus M, O'Callaghan M, Osland E, Thibault R, Cuerda C, Jones L, Chapman B, Sahin P, Virgili NM, Lee ADW, Orlandoni P, Matysiak K, Di Caro S, Doitchinova-Simeonova M, Masconale L, Spaggiari C, Garde C, Serralde-Zúñiga AE, Olveira G, Krznaric Z, Petrina Jáuregui E, Zugasti Murillo A, Suárez-Llanos JP, Nardi E, Van Gossum A, Lal S. Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure. Gut 2020, 69: 1787-1795. PMID: 31964752, DOI: 10.1136/gutjnl-2018-318172.
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin ResistanceLyu K, Zhang Y, Zhang D, Kahn M, Ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, Bogan JS, Cline GW, Samuel VT, Shulman GI. A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance. Cell Metabolism 2020, 32: 654-664.e5. PMID: 32882164, PMCID: PMC7544641, DOI: 10.1016/j.cmet.2020.08.001.
A free-choice high-fat diet modulates the effects of a sucrose bolus on the expression of genes involved in glucose handling in the hypothalamus and nucleus accumbens.Koekkoek LL, Unmehopa UA, Eggels L, Kool T, Lamuadni K, Diepenbroek C, Mul JD, Serlie MJ, la Fleur SE. A free-choice high-fat diet modulates the effects of a sucrose bolus on the expression of genes involved in glucose handling in the hypothalamus and nucleus accumbens. Physiology & Behavior 2020, 222: 112936. PMID: 32417644, DOI: 10.1016/j.physbeh.2020.112936.
Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders.Vos N, Oussaada SM, Cooiman MI, Kleinendorst L, Ter Horst KW, Hazebroek EJ, Romijn JA, Serlie MJ, Mannens MMAM, van Haelst MM. Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders. Current Diabetes Reports 2020, 20: 44. PMID: 32729070, PMCID: PMC7391392, DOI: 10.1007/s11892-020-01327-7.
Effects of a Hypercaloric and Hypocaloric Diet on Insulin-Induced Microvascular Recruitment, Glucose Uptake, and Lipolysis in Healthy Lean Men.Emanuel AL, Meijer RI, Woerdeman J, van Raalte DH, Diamant M, Kramer MHH, Serlie MJ, Eringa EC, Serné EH. Effects of a Hypercaloric and Hypocaloric Diet on Insulin-Induced Microvascular Recruitment, Glucose Uptake, and Lipolysis in Healthy Lean Men. Arteriosclerosis, Thrombosis, And Vascular Biology 2020, 40: 1695-1704. PMID: 32404008, DOI: 10.1161/ATVBAHA.120.314129.
Correlation of plasma metabolites with glucose and lipid fluxes in human insulin resistance.Hartstra AV, de Groot PF, Mendes Bastos D, Levin E, Serlie MJ, Soeters MR, Pekmez CT, Dragsted LO, Ackermans MT, Groen AK, Nieuwdorp M. Correlation of plasma metabolites with glucose and lipid fluxes in human insulin resistance. Obesity Science & Practice 2020, 6: 340-349. PMID: 32523723, PMCID: PMC7278901, DOI: 10.1002/osp4.402.
The effect of dapagliflozin on apolipoprotein B and glucose fluxes in patients with type 2 diabetes and well-controlled plasma LDL cholesterol.Bouter KEC, van Bommel EJM, Jansen H, van Harskamp D, Schierbeek H, Ackermans MT, Serlie MJ, Schimmel AWM, Nieuwdorp M, Dallinga-Thie GM, van Raalte DH. The effect of dapagliflozin on apolipoprotein B and glucose fluxes in patients with type 2 diabetes and well-controlled plasma LDL cholesterol. Diabetes, Obesity & Metabolism 2020, 22: 988-996. PMID: 32026592, PMCID: PMC7318266, DOI: 10.1111/dom.13990.
RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women.Kilicarslan M, de Weijer BA, Simonyté Sjödin K, Aryal P, Ter Horst KW, Cakir H, Romijn JA, Ackermans MT, Janssen IM, Berends FJ, van de Laar AW, Houdijk AP, Kahn BB, Serlie MJ. RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2020, 34: 6099-6110. PMID: 32167208, PMCID: PMC7317205, DOI: 10.1096/fj.201901979RR.
Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose-response effects on glucose metabolism in human subjects with metabolic syndrome.Gilijamse PW, Hartstra AV, Levin E, Wortelboer K, Serlie MJ, Ackermans MT, Herrema H, Nederveen AJ, Imangaliyev S, Aalvink S, Sommer M, Levels H, Stroes ESG, Groen AK, Kemper M, de Vos WM, Nieuwdorp M, Prodan A. Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose-response effects on glucose metabolism in human subjects with metabolic syndrome. NPJ Biofilms And Microbiomes 2020, 6: 16. PMID: 32221294, PMCID: PMC7101376, DOI: 10.1038/s41522-020-0127-0.
Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time.de Groot P, Scheithauer T, Bakker GJ, Prodan A, Levin E, Khan MT, Herrema H, Ackermans M, Serlie MJM, de Brauw M, Levels JHM, Sales A, Gerdes VE, Ståhlman M, Schimmel AWM, Dallinga-Thie G, Bergman JJ, Holleman F, Hoekstra JBL, Groen A, Bäckhed F, Nieuwdorp M. Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time. Gut 2020, 69: 502-512. PMID: 31147381, PMCID: PMC7034343, DOI: 10.1136/gutjnl-2019-318320.
Normalization of metabolic flux data during clamp studies in humans.Ter Horst KW, Serlie MJ. Normalization of metabolic flux data during clamp studies in humans. Metabolism: Clinical And Experimental 2020, 104: 154168. PMID: 31982479, DOI: 10.1016/j.metabol.2020.154168.
Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey.Pironi L, Steiger E, Brandt C, Joly F, Wanten G, Chambrier C, Aimasso U, Sasdelli AS, Zeraschi S, Kelly D, Szczepanek K, Jukes A, Di Caro S, Theilla M, Kunecki M, Daniels J, Serlie M, Poullenot F, Wu J, Cooper SC, Rasmussen HH, Compher C, Seguy D, Crivelli A, Pagano MC, Hughes SJ, Guglielmi FW, Kozjek NR, Schneider SM, Gillanders L, Ellegard L, Thibault R, Matras P, Zmarzly A, Matysiak K, Van Gossum A, Forbes A, Wyer N, Taus M, Virgili NM, O'Callaghan M, Chapman B, Osland E, Cuerda C, Sahin P, Jones L, Won Lee AD, Masconale L, Orlandoni P, Izbéki F, Spaggiari C, Bueno M, Doitchinova-Simeonova M, Garde C, Serralde-Zúñiga AE, Olveira G, Krznaric Z, Czako L, Kekstas G, Sanz-Paris A, Jáuregui EP, Murillo AZ, Schafer E, Arends J, Suárez-Llanos JP, Lal S. Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey. Clinical Nutrition (Edinburgh, Scotland) 2020, 39: 585-591. PMID: 30992207, DOI: 10.1016/j.clnu.2019.03.010.
Peripheral and central serotonin in the regulation of glucose metabolismHandbook of the Behavioural Neurobiology of Serotonin, Chapter 45; Peripheral and central serotonin in the regulation of glucose metabolism, Volume 31, 2020
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. ELife 2019, 8 PMID: 31418690, PMCID: PMC6748830, DOI: 10.7554/eLife.47990.
One-week exposure to a free-choice high-fat high-sugar diet does not disrupt blood-brain barrier permeability in fed or overnight fasted rats.Rijnsburger M, Unmehopa UA, Eggels L, Serlie MJ, la Fleur SE. One-week exposure to a free-choice high-fat high-sugar diet does not disrupt blood-brain barrier permeability in fed or overnight fasted rats. Nutritional Neuroscience 2019, 22: 541-550. PMID: 29284375, DOI: 10.1080/1028415X.2017.1418727.
The pathogenesis of obesity.Oussaada SM, van Galen KA, Cooiman MI, Kleinendorst L, Hazebroek EJ, van Haelst MM, Ter Horst KW, Serlie MJ. The pathogenesis of obesity. Metabolism: Clinical And Experimental 2019, 92: 26-36. PMID: 30639246, DOI: 10.1016/j.metabol.2018.12.012.
Iloprost infusion prevents the insulin-induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients.Emanuel AL, de Clercq NC, Koopen AM, van Poelgeest E, Serlie MJM, van Raalte DH, Kramer MHH, Nieuwdorp M, Eringa EC, Serné EH. Iloprost infusion prevents the insulin-induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients. Diabetes, Obesity & Metabolism 2018, 20: 2523-2531. PMID: 29885045, DOI: 10.1111/dom.13410.
The interrelation between FGF23 and glucose metabolism in humans.Ursem SR, Vervloet MG, Büttler RM, Ackermans MT, Oosterwerff MM, Eekhoff EMV, Lips P, Serlie MJ, la Fleur SE, Heijboer AC. The interrelation between FGF23 and glucose metabolism in humans. Journal Of Diabetes And Its Complications 2018, 32: 845-850. PMID: 29996975, DOI: 10.1016/j.jdiacomp.2018.06.013.
The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies.van Galen KA, Ter Horst KW, Booij J, la Fleur SE, Serlie MJ. The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies. Metabolism: Clinical And Experimental 2018, 85: 325-339. PMID: 28970033, DOI: 10.1016/j.metabol.2017.09.007.
The osteoblast: Linking glucocorticoid-induced osteoporosis and hyperglycaemia? A post-hoc analysis of a randomised clinical trial.van Bommel EJM, de Jongh RT, Brands M, Heijboer AC, den Heijer M, Serlie MJ, van Raalte DH. The osteoblast: Linking glucocorticoid-induced osteoporosis and hyperglycaemia? A post-hoc analysis of a randomised clinical trial. Bone 2018, 112: 173-176. PMID: 29729427, DOI: 10.1016/j.bone.2018.04.025.
Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects.Bouter K, Bakker GJ, Levin E, Hartstra AV, Kootte RS, Udayappan SD, Katiraei S, Bahler L, Gilijamse PW, Tremaroli V, Stahlman M, Holleman F, van Riel NAW, Verberne HJ, Romijn JA, Dallinga-Thie GM, Serlie MJ, Ackermans MT, Kemper EM, Willems van Dijk K, Backhed F, Groen AK, Nieuwdorp M. Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects. Clinical And Translational Gastroenterology 2018, 9: 155. PMID: 29799027, PMCID: PMC5968024, DOI: 10.1038/s41424-018-0025-4.
Striatal dopamine regulates systemic glucose metabolism in humans and miceTer Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ. Striatal dopamine regulates systemic glucose metabolism in humans and mice. Science Translational Medicine 2018, 10 PMID: 29794060, DOI: 10.1126/scitranslmed.aar3752.
Effects of a Carbohydrate-, Glutamine-, and Antioxidant-Enriched Oral Nutrition Supplement on Major Surgery-Induced Insulin Resistance: A Randomized Pilot Study.van Stijn MFM, Soeters MR, van Leeuwen PAM, Schreurs WH, Schoorl MG, Twisk JWR, De Bandt JP, Bonnefont-Rousselot D, Cynober L, Ackermans MT, Serlie MJ, Houdijk APJ. Effects of a Carbohydrate-, Glutamine-, and Antioxidant-Enriched Oral Nutrition Supplement on Major Surgery-Induced Insulin Resistance: A Randomized Pilot Study. JPEN. Journal Of Parenteral And Enteral Nutrition 2018, 42: 719-729. PMID: 28541810, DOI: 10.1177/0148607117711691.
Influence of prednisolone on parameters of de novo lipogenesis and indices for stearoyl-CoA- and Δ6- desaturase activity in healthy males: A Post-hoc analysis of a randomized, placebo-controlled, double-blind trial.Pranger IG, van Raalte DH, Brands M, Muskiet MHA, Kema IP, Serlie MJ, Diamant M, Bakker SJL, Muskiet FAJ. Influence of prednisolone on parameters of de novo lipogenesis and indices for stearoyl-CoA- and Δ6- desaturase activity in healthy males: A Post-hoc analysis of a randomized, placebo-controlled, double-blind trial. Prostaglandins, Leukotrienes, And Essential Fatty Acids 2018, 132: 8-15. PMID: 29735021, DOI: 10.1016/j.plefa.2018.03.009.
Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey.Pironi L, Konrad D, Brandt C, Joly F, Wanten G, Agostini F, Chambrier C, Aimasso U, Zeraschi S, Kelly D, Szczepanek K, Jukes A, Di Caro S, Theilla M, Kunecki M, Daniels J, Serlie M, Poullenot F, Wu J, Cooper SC, Rasmussen HH, Compher C, Seguy D, Crivelli A, Pagano MC, Hughes SJ, Guglielmi FW, Kozjek NR, Schneider SM, Gillanders L, Ellegard L, Thibault R, Matras P, Zmarzly A, Matysiak K, Van Gossum A, Forbes A, Wyer N, Taus M, Virgili NM, O'Callaghan M, Chapman B, Osland E, Cuerda C, Sahin P, Jones L, Lee ADW, Bertasi V, Orlandoni P, Izbéki F, Spaggiari C, Díez MB, Doitchinova-Simeonova M, Garde C, Serralde-Zúñiga AE, Olveira G, Krznaric Z, Czako L, Kekstas G, Sanz-Paris A, Jáuregui EP, Murillo AZ, Schafer E, Arends J, Suárez-Llanos JP, Shaffer J, Lal S. Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey. Clinical Nutrition (Edinburgh, Scotland) 2018, 37: 728-738. PMID: 28483328, DOI: 10.1016/j.clnu.2017.04.013.
A Systematic Review and Meta-analysis of Timing and Outcome of Intestinal Failure Surgery in Patients with Enteric Fistula.de Vries FEE, Atema JJ, van Ruler O, Vaizey CJ, Serlie MJ, Boermeester MA. A Systematic Review and Meta-analysis of Timing and Outcome of Intestinal Failure Surgery in Patients with Enteric Fistula. World Journal Of Surgery 2018, 42: 695-706. PMID: 28924879, PMCID: PMC5801381, DOI: 10.1007/s00268-017-4224-z.
Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss.Versteeg RI, Ackermans MT, Nederveen AJ, Fliers E, Serlie MJ, la Fleur SE. Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss. International Journal Of Obesity (2005) 2018, 42: 156-162. PMID: 28811653, DOI: 10.1038/ijo.2017.199.
Pharmacokinetic and Clinical Observations in PeoPle Over fiftY (POPPY) study and the AGEhIV Cohort Study. Patterns of Co- occurring Comorbidities in People Living With HIVDe Francesco D, Verboeket SO, Underwood J, Bagkeris E, Wit FW, Mallon PWG, Winston A, Reiss P, Sabin CA; Pharmacokinetic and Clinical Observations in PeoPle Over fiftY (POPPY) study and the AGEhIV Cohort Study. Patterns of Co- occurring Comorbidities in People Living With HIV. Open Forum Infect Dis. 2018 Oct 24;5(11):ofy272.
Pharmacokinetics of dabigatran etexilate and rivaroxaban in patients with short bowel syndrome requiring parenteral nutrition: The PDER PAN study.Cheung YW, Barco S, Mathôt RAA, van den Dool EJ, Stroobants AK, Serlie MJ, Middeldorp S, Coppens M. Pharmacokinetics of dabigatran etexilate and rivaroxaban in patients with short bowel syndrome requiring parenteral nutrition: The PDER PAN study. Thrombosis Research 2017, 160: 76-82. PMID: 29127863, DOI: 10.1016/j.thromres.2017.10.025.
The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans.Ter Horst KW, Gilijamse PW, Demirkiran A, van Wagensveld BA, Ackermans MT, Verheij J, Romijn JA, Nieuwdorp M, Maratos-Flier E, Herman MA, Serlie MJ. The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans. Molecular Metabolism 2017, 6: 1493-1502. PMID: 29107295, PMCID: PMC5681276, DOI: 10.1016/j.molmet.2017.08.014.
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.Kootte RS, Levin E, Salojärvi J, Smits LP, Hartstra AV, Udayappan SD, Hermes G, Bouter KE, Koopen AM, Holst JJ, Knop FK, Blaak EE, Zhao J, Smidt H, Harms AC, Hankemeijer T, Bergman JJGHM, Romijn HA, Schaap FG, Olde Damink SWM, Ackermans MT, Dallinga-Thie GM, Zoetendal E, de Vos WM, Serlie MJ, Stroes ESG, Groen AK, Nieuwdorp M. Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. Cell Metabolism 2017, 26: 611-619.e6. PMID: 28978426, DOI: 10.1016/j.cmet.2017.09.008.
Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding.Versteeg RI, Schrantee A, Adriaanse SM, Unmehopa UA, Booij J, Reneman L, Fliers E, la Fleur SE, Serlie MJ. Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2017, 31: 4545-4554. PMID: 28679529, DOI: 10.1096/fj.201601234R.
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease.Ter Horst KW, Serlie MJ. Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. Nutrients 2017, 9 PMID: 28878197, PMCID: PMC5622741, DOI: 10.3390/nu9090981.
Methods for quantifying adipose tissue insulin resistance in overweight/obese humans.Ter Horst KW, van Galen KA, Gilijamse PW, Hartstra AV, de Groot PF, van der Valk FM, Ackermans MT, Nieuwdorp M, Romijn JA, Serlie MJ. Methods for quantifying adipose tissue insulin resistance in overweight/obese humans. International Journal Of Obesity (2005) 2017, 41: 1288-1294. PMID: 28465607, DOI: 10.1038/ijo.2017.110.
Systematic review: pharmacotherapy for high-output enterostomies or enteral fistulas.de Vries FEE, Reeskamp LF, van Ruler O, van Arum I, Kuin W, Dijksta G, Haveman JW, Boermeester MA, Serlie MJ. Systematic review: pharmacotherapy for high-output enterostomies or enteral fistulas. Alimentary Pharmacology & Therapeutics 2017, 46: 266-273. PMID: 28613003, DOI: 10.1111/apt.14136.
Anticoagulants for the prevention and treatment of catheter-related thrombosis in adults and children on parenteral nutrition: a systematic review and critical appraisal.Barco S, Atema JJ, Coppens M, Serlie MJ, Middeldorp S. Anticoagulants for the prevention and treatment of catheter-related thrombosis in adults and children on parenteral nutrition: a systematic review and critical appraisal. Blood Transfusion = Trasfusione Del Sangue 2017, 15: 369-377. PMID: 27483479, PMCID: PMC5490734, DOI: 10.2450/2016.0031-16.
Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in HumansHorst K, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Reports 2017, 19: 1997-2004. PMID: 28591572, PMCID: PMC5469939, DOI: 10.1016/j.celrep.2017.05.035.
Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes.Versteeg RI, Stenvers DJ, Visintainer D, Linnenbank A, Tanck MW, Zwanenburg G, Smilde AK, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Bisschop PH. Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes. Journal Of Biological Rhythms 2017, 32: 130-142. PMID: 28470119, PMCID: PMC5423535, DOI: 10.1177/0748730417693480.
Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J. Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. Molecular Systems Biology 2017, 13: 916. PMID: 28254760, PMCID: PMC5371732, DOI: 10.15252/msb.20167422.
Blood pressure reduction after gastric bypass surgery is explained by a decrease in cardiac output.van Brussel PM, van den Bogaard B, de Weijer BA, Truijen J, Krediet CT, Janssen IM, van de Laar A, Kaasjager K, Fliers E, van Lieshout JJ, Serlie MJ, van den Born BH. Blood pressure reduction after gastric bypass surgery is explained by a decrease in cardiac output. Journal Of Applied Physiology (Bethesda, Md. : 1985) 2017, 122: 223-229. PMID: 27765843, DOI: 10.1152/japplphysiol.00362.2016.
Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats.Diepenbroek C, Rijnsburger M, Eggels L, van Megen KM, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE. Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats. Neuroscience Letters 2017, 637: 85-90. PMID: 27888043, DOI: 10.1016/j.neulet.2016.11.045.
Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans.Versteeg RI, Koopman KE, Booij J, Ackermans MT, Unmehopa UA, Fliers E, la Fleur SE, Serlie MJ. Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans. Neuroendocrinology 2017, 105: 141-149. PMID: 27626923, PMCID: PMC5637289, DOI: 10.1159/000450549.
Differential effects of hypercaloric choice diets on insulin sensitivity in rats.Diepenbroek C, Eggels L, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE. Differential effects of hypercaloric choice diets on insulin sensitivity in rats. The Journal Of Endocrinology 2017, 232: 49-57. PMID: 27754934, DOI: 10.1530/JOE-16-0265.
Guideline on Home Parenteral Nutritionhttps://www.farmacotherapie.org/
Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials.Ter Horst KW, Schene MR, Holman R, Romijn JA, Serlie MJ. Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials. The American Journal Of Clinical Nutrition 2016, 104: 1562-1576. PMID: 27935520, DOI: 10.3945/ajcn.116.137786.
Primary thromboprophylaxis for adult patients on home parenteral nutrition: A comment on the 2016 ESPEN guideline.Barco S, Serlie MJ, Coppens M. Primary thromboprophylaxis for adult patients on home parenteral nutrition: A comment on the 2016 ESPEN guideline. Clinical Nutrition (Edinburgh, Scotland) 2016, 35: 1579-1580. PMID: 27546797, DOI: 10.1016/j.clnu.2016.08.003.
Addendum: hypercaloric diets with high meal frequency, but not increased meal size, increase intrahepatic triglycerides: A randomized controlled trial.Serlie MJ, Ter Horst KW, Brown AW. Addendum: hypercaloric diets with high meal frequency, but not increased meal size, increase intrahepatic triglycerides: A randomized controlled trial. Hepatology (Baltimore, Md.) 2016, 64: 1814-1816. PMID: 27037642, PMCID: PMC5046189, DOI: 10.1002/hep.28588.
Nutrition in the spotlight: metabolic effects of environmental light.Versteeg RI, Stenvers DJ, Kalsbeek A, Bisschop PH, Serlie MJ, la Fleur SE. Nutrition in the spotlight: metabolic effects of environmental light. The Proceedings Of The Nutrition Society 2016, 75: 451-463. PMID: 27499509, DOI: 10.1017/S0029665116000707.
The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents.Rijnsburger M, Belegri E, Eggels L, Unmehopa UA, Boelen A, Serlie MJ, la Fleur SE. The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents. Physiology & Behavior 2016, 162: 61-8. PMID: 27083123, DOI: 10.1016/j.physbeh.2016.04.011.
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A. Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. Cell Metabolism 2016, 24: 172-84. PMID: 27345421, PMCID: PMC6666317, DOI: 10.1016/j.cmet.2016.05.026.
Home parenteral nutrition-associated thromboembolic and bleeding events: results of a cohort study of 236 individuals.Barco S, Heuschen CB, Salman B, Brekelmans MP, Serlie MJ, Middeldorp S, Coppens M. Home parenteral nutrition-associated thromboembolic and bleeding events: results of a cohort study of 236 individuals. Journal Of Thrombosis And Haemostasis : JTH 2016, 14: 1364-73. PMID: 27122107, DOI: 10.1111/jth.13351.
Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss.van der Zwaal EM, de Weijer BA, van de Giessen EM, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ. Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss. European Neuropsychopharmacology : The Journal Of The European College Of Neuropsychopharmacology 2016, 26: 1190-200. PMID: 27184782, DOI: 10.1016/j.euroneuro.2016.04.009.
Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men.Koopman KE, Roefs A, Elbers DC, Fliers E, Booij J, Serlie MJ, la Fleur SE. Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men. Psychological Medicine 2016, 46: 1707-17. PMID: 26984412, DOI: 10.1017/S0033291716000222.
The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese womenHorst K, Versteeg RI, Gilijamse PW, Ackermans MT, Heijboer AC, Romijn JA, la Fleur SE, Trinko R, DiLeone RJ, Serlie MJ. The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women. Diabetes & Metabolism 2016, 42: 416-423. PMID: 27262368, DOI: 10.1016/j.diabet.2016.04.011.
Impaired insulin action in the liver, but not in adipose tissue or muscle, is a distinct metabolic feature of impaired fasting glucose in obese humans.Ter Horst KW, Gilijamse PW, Ackermans MT, Soeters MR, Nieuwdorp M, Romijn JA, Serlie MJ. Impaired insulin action in the liver, but not in adipose tissue or muscle, is a distinct metabolic feature of impaired fasting glucose in obese humans. Metabolism: Clinical And Experimental 2016, 65: 757-763. PMID: 27085782, DOI: 10.1016/j.metabol.2016.02.010.
Outcome of acute intestinal failure.Atema JJ, Mirck B, Van Arum I, Ten Dam SM, Serlie MJ, Boermeester MA. Outcome of acute intestinal failure. The British Journal Of Surgery 2016, 103: 701-708. PMID: 26999497, DOI: 10.1002/bjs.10094.
Presentation of a nationwide multicenter registry of intestinal failure and intestinal transplantation.Neelis EG, Roskott AM, Dijkstra G, Wanten GJ, Serlie MJ, Tabbers MM, Damen G, Olthof ED, Jonkers CF, Kloeze JH, Ploeg RJ, Imhann F, Nieuwenhuijs VB, Rings EHHM. Presentation of a nationwide multicenter registry of intestinal failure and intestinal transplantation. Clinical Nutrition (Edinburgh, Scotland) 2016, 35: 225-229. PMID: 25660415, DOI: 10.1016/j.clnu.2015.01.010.
Determinants of reduced cognitive performance in HIV-1-infected middle-aged men on combination antiretroviral therapySchouten J, Su T, Wit FW, Kootstra NA, Caan MW, Geurtsen GJ, Schmand BA, Stolte IG, Prins M, Majoie CB, Portegies P, Reiss P; AGEhIV Study Group. Determinants of reduced cognitive performance in HIV-1-infected middle-aged men on combination antiretroviral therapy. AIDS. 2016 Apr 24;30(7):1027-38.
HIV-Associated Neuroretinal Disorder in Patients With Well-Suppressed HIV-Infection: A Comparative Cohort StudyDemirkaya N, Wit FW, van Den Berg TJ, Kooij KW, Prins M, Schlingemann RO, Abramoff MD, Reiss P, Verbraak FD; AGEhIV Cohort Study Group. HIV-Associated Neuroretinal Disorder in Patients With Well-Suppressed HIV-Infection: A Comparative Cohort Study. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1388-97.
T-Cell Activation Independently Associates With Immune Senescence in HIV- Infected Recipients of Long-term Antiretroviral TreatmentCobos Jiménez V, Wit FW, Joerink M, Maurer I, Harskamp AM, Schouten J, Prins M, van Leeuwen EM, Booiman T, Deeks SG, Reiss P, Kootstra NA; AGEhIV Study Group. T-Cell Activation Independently Associates With Immune Senescence in HIV- Infected Recipients of Long-term Antiretroviral Treatment. J Infect Dis. 2016 Jul 15;214(2):216-25.
Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected IndividualsKooij KW, Wit FW, Booiman T, van der Valk M, Schim van der Loeff MF, Kootstra NA, Reiss P; AGEhIV Cohort Study Group. Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals. J Infect Dis. 2016 Dec 15;214(12):1817-1821.
Addendum: hypercaloric diets with high meal frequency, but not increased meal size, increase intrahepatic triglycerides: A randomized controlled trialSerlie MJ, Ter Horst KW, Brown AW. Addendum: hypercaloric diets with high meal frequency, but not increased meal size, increase intrahepatic triglycerides: A randomized controlled trial. Hepatology. 2016 Nov;64(5):1814-1816.
Insulin resistance in obesity can be reliably identified from fasting plasma insulin.ter Horst KW, Gilijamse PW, Koopman KE, de Weijer BA, Brands M, Kootte RS, Romijn JA, Ackermans MT, Nieuwdorp M, Soeters MR, Serlie MJ. Insulin resistance in obesity can be reliably identified from fasting plasma insulin. International Journal Of Obesity (2005) 2015, 39: 1703-9. PMID: 26155920, DOI: 10.1038/ijo.2015.125.
Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease.Versteeg RI, Serlie MJ, Kalsbeek A, la Fleur SE. Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease. Neuroscience 2015, 301: 155-67. PMID: 26047725, DOI: 10.1016/j.neuroscience.2015.05.067.
Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A. Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. International Journal Of Obesity (2005) 2015, 39: 1151-60. PMID: 25801691, PMCID: PMC4486370, DOI: 10.1038/ijo.2015.34.
The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia.de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E. The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia. Endocrine Connections 2015, 4: 86-91. PMID: 25712898, PMCID: PMC4401105, DOI: 10.1530/EC-14-0113.
Sexual Dimorphism in Hepatic, Adipose Tissue, and Peripheral Tissue Insulin Sensitivity in Obese Humans.Ter Horst KW, Gilijamse PW, de Weijer BA, Kilicarslan M, Ackermans MT, Nederveen AJ, Nieuwdorp M, Romijn JA, Serlie MJ. Sexual Dimorphism in Hepatic, Adipose Tissue, and Peripheral Tissue Insulin Sensitivity in Obese Humans. Frontiers In Endocrinology 2015, 6: 182. PMID: 26635731, PMCID: PMC4659894, DOI: 10.3389/fendo.2015.00182.
Cost-effectiveness of intestinal transplantation for adult patients with intestinal failure: a simulation study.Roskott AM, Groen H, Rings EH, Haveman JW, Ploeg RJ, Serlie MJ, Wanten G, Krabbe PF, Dijkstra G. Cost-effectiveness of intestinal transplantation for adult patients with intestinal failure: a simulation study. The American Journal Of Clinical Nutrition 2015, 101: 79-86. PMID: 25527753, DOI: 10.3945/ajcn.114.083303.
Effects of T3 treatment on brown adipose tissue and energy expenditure in a patient with craniopharyngioma and hypothalamic obesity.van Santen HM, Schouten-Meeteren AY, Serlie M, Meijneke RW, van Trotsenburg AS, Verberne H, Holleman F, Fliers E. Effects of T3 treatment on brown adipose tissue and energy expenditure in a patient with craniopharyngioma and hypothalamic obesity. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2015, 28: 53-7. PMID: 25514327, DOI: 10.1515/jpem-2014-0337.
Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction.Gabriel TL, Tol MJ, Ottenhof R, van Roomen C, Aten J, Claessen N, Hooibrink B, de Weijer B, Serlie MJ, Argmann C, van Elsenburg L, Aerts JM, van Eijk M. Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction. Diabetes 2014, 63: 3310-23. PMID: 24789918, DOI: 10.2337/db13-1720.
The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men.la Fleur SE, Serlie MJ. The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men. Best Practice & Research. Clinical Endocrinology & Metabolism 2014, 28: 649-59. PMID: 25256761, DOI: 10.1016/j.beem.2014.06.001.
Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial.Koopman KE, Caan MW, Nederveen AJ, Pels A, Ackermans MT, Fliers E, la Fleur SE, Serlie MJ. Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. Hepatology (Baltimore, Md.) 2014, 60: 545-53. PMID: 24668862, PMCID: PMC4265261, DOI: 10.1002/hep.27149.
Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity.de Weijer BA, van de Giessen E, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ. Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity. Diabetologia 2014, 57: 1078-80. PMID: 24500343, PMCID: PMC3980032, DOI: 10.1007/s00125-014-3178-z.
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.Vrieze A, Out C, Fuentes S, Jonker L, Reuling I, Kootte RS, van Nood E, Holleman F, Knaapen M, Romijn JA, Soeters MR, Blaak EE, Dallinga-Thie GM, Reijnders D, Ackermans MT, Serlie MJ, Knop FK, Holst JJ, van der Ley C, Kema IP, Zoetendal EG, de Vos WM, Hoekstra JB, Stroes ES, Groen AK, Nieuwdorp M. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity. Journal Of Hepatology 2014, 60: 824-31. PMID: 24316517, DOI: 10.1016/j.jhep.2013.11.034.
Adaptation of glucose metabolism to fasting in young children with infectious diseases: a perspective.Zijlmans WC, van Kempen AA, Serlie MJ, Kager PA, Sauerwein HP. Adaptation of glucose metabolism to fasting in young children with infectious diseases: a perspective. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2014, 27: 5-13. PMID: 23813356, DOI: 10.1515/jpem-2013-0165.
Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects.Borgers AJ, Koopman KE, Bisschop PH, Serlie MJ, Swaab DF, Fliers E, la Fleur SE, Alkemade A. Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects. Frontiers In Neuroscience 2014, 8: 106. PMID: 24860418, PMCID: PMC4030197, DOI: 10.3389/fnins.2014.00106.
Subthalamic nucleus stimulation does not influence basal glucose metabolism or insulin sensitivity in patients with Parkinson's disease.Lammers NM, Sondermeijer BM, Twickler TB, de Bie RM, Ackermans MT, Fliers E, Schuurman PR, La Fleur SE, Serlie MJ. Subthalamic nucleus stimulation does not influence basal glucose metabolism or insulin sensitivity in patients with Parkinson's disease. Frontiers In Neuroscience 2014, 8: 95. PMID: 24860415, PMCID: PMC4018563, DOI: 10.3389/fnins.2014.00095.
Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV- infected and uninfected individuals: the AGEhIV cohort studySchouten J, Wit FW, Stolte IG, Kootstra NA, van der Valk M, Geerlings SE, Prins M, Reiss P; AGEhIV Cohort Study Group. Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV- infected and uninfected individuals: the AGEhIV cohort study. Clin Infect Dis. 2014 Dec 15;59(12):1787-97.
The effect of a diiodothyronine mimetic on insulin sensitivity in male cardiometabolic patients: a double-blind randomized controlled trial.van der Valk F, Hassing C, Visser M, Thakkar P, Mohanan A, Pathak K, Dutt C, Chauthaiwale V, Ackermans M, Nederveen A, Serlie M, Nieuwdorp M, Stroes E. The effect of a diiodothyronine mimetic on insulin sensitivity in male cardiometabolic patients: a double-blind randomized controlled trial. PloS One 2014, 9: e86890. PMID: 24586256, PMCID: PMC3931609, DOI: 10.1371/journal.pone.0086890.
Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic ActivationXu X, Grijalva A, Skowronski A, van Eijk M, Serlie MJ, Ferrante AW. Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation. Cell Metabolism 2013, 18: 816-830. PMID: 24315368, PMCID: PMC3939841, DOI: 10.1016/j.cmet.2013.11.001.
Brain areas and pathways in the regulation of glucose metabolism.Diepenbroek C, Serlie MJ, Fliers E, Kalsbeek A, la Fleur SE. Brain areas and pathways in the regulation of glucose metabolism. BioFactors (Oxford, England) 2013, 39: 505-13. PMID: 23913677, DOI: 10.1002/biof.1123.
Hepatic and peripheral insulin sensitivity do not improve 2 weeks after bariatric surgery.de Weijer BA, Aarts E, Janssen IM, Berends FJ, van de Laar A, Kaasjager K, Ackermans MT, Fliers E, Serlie MJ. Hepatic and peripheral insulin sensitivity do not improve 2 weeks after bariatric surgery. Obesity (Silver Spring, Md.) 2013, 21: 1143-7. PMID: 23913729, DOI: 10.1002/oby.20220.
Screening for psychosocial distress in patients with long-term home parenteral nutrition.Roskott AM, Huisman-de Waal G, Wanten GJ, Jonkers-Schuitema C, Serlie MJ, Baxter JP, Hoekstra-Weebers JE. Screening for psychosocial distress in patients with long-term home parenteral nutrition. Clinical Nutrition (Edinburgh, Scotland) 2013, 32: 396-403. PMID: 22981598, DOI: 10.1016/j.clnu.2012.08.023.
Lactate increases hepatic secretion of VLDL-triglycerides in humans.Sondermeijer BM, Battjes S, van Dijk TH, Ackermans MT, Serlie MJ, Nieuwdorp M, Groen AK, Dallinga-Thie GM, Stroes ES. Lactate increases hepatic secretion of VLDL-triglycerides in humans. Atherosclerosis 2013, 228: 443-50. PMID: 23540683, DOI: 10.1016/j.atherosclerosis.2013.02.040.
Omega-3 long-chain fatty acids strongly induce angiopoietin-like 4 in humans.Brands M, Sauerwein HP, Ackermans MT, Kersten S, Serlie MJ. Omega-3 long-chain fatty acids strongly induce angiopoietin-like 4 in humans. Journal Of Lipid Research 2013, 54: 615-621. PMID: 23319744, PMCID: PMC3617937, DOI: 10.1194/jlr.M030049.
No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men.Brands M, van Raalte DH, João Ferraz M, Sauerwein HP, Verhoeven AJ, Aerts JM, Diamant M, Serlie MJ. No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men. The Journal Of Clinical Endocrinology And Metabolism 2013, 98: 1219-25. PMID: 23386653, DOI: 10.1210/jc.2012-3266.
Effects of a hypercaloric diet on β-cell responsivity in lean healthy men.Brands M, Swat M, Lammers NM, Sauerwein HP, Endert E, Ackermans MT, Verhoeven AJ, Serlie MJ. Effects of a hypercaloric diet on β-cell responsivity in lean healthy men. Clinical Endocrinology 2013, 78: 217-25. PMID: 22324306, DOI: 10.1111/j.1365-2265.2012.04364.x.
Bariatric surgery is an effective treatment for morbid obesity.Schigt A, Gerdes VE, Cense HA, Berends FJ, van Dielen FM, Janssen I, van der Laar A, van Wagensveld BA, Romijn JA, Serlie MJ. Bariatric surgery is an effective treatment for morbid obesity. The Netherlands Journal Of Medicine 2013, 71: 4-9. PMID: 23482295.
Type of infectious disease affects glucose metabolism and liver glycogen content in Surinamese children: malaria vs. pneumonia.Zijlmans W, Jitan J, Ackermans MT, Serlie MJ, van Kempen AA, Sauerwein HP. Type of infectious disease affects glucose metabolism and liver glycogen content in Surinamese children: malaria vs. pneumonia. Journal Of Pediatric Endocrinology & Metabolism : JPEM 2013, 26: 293-9. PMID: 23327825, DOI: 10.1515/jpem-2012-0288.
Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region.Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE. Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. Molecular Metabolism 2013, 2: 417-22. PMID: 24327957, PMCID: PMC3855045, DOI: 10.1016/j.molmet.2013.07.006.
Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats.Diepenbroek C, van der Plasse G, Eggels L, Rijnsburger M, Feenstra MG, Kalsbeek A, Denys D, Fliers E, Serlie MJ, la Fleur SE. Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats. Frontiers In Neuroscience 2013, 7: 226. PMID: 24339800, PMCID: PMC3857552, DOI: 10.3389/fnins.2013.00226.
Angiopoietin-like protein 4 is differentially regulated by glucocorticoids and insulin in vitro and in vivo in healthy humans.van Raalte DH, Brands M, Serlie MJ, Mudde K, Stienstra R, Sauerwein HP, Kersten S, Diamant M. Angiopoietin-like protein 4 is differentially regulated by glucocorticoids and insulin in vitro and in vivo in healthy humans. Experimental And Clinical Endocrinology & Diabetes : Official Journal, German Society Of Endocrinology [and] German Diabetes Association 2012, 120: 598-603. PMID: 22972030, DOI: 10.1055/s-0032-1321864.
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JF, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, Derrien M, Druesne A, Van Hylckama Vlieg JE, Bloks VW, Groen AK, Heilig HG, Zoetendal EG, Stroes ES, de Vos WM, Hoekstra JB, Nieuwdorp M. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012, 143: 913-6.e7. PMID: 22728514, DOI: 10.1053/j.gastro.2012.06.031.
Prophylactic anticoagulation decreases catheter-related thrombosis and occlusion in children with home parenteral nutrition.Vegting IL, Tabbers MM, Benninga MA, Wilde JC, Serlie MJ, Tas TA, Jonkers CF, van Ommen CH. Prophylactic anticoagulation decreases catheter-related thrombosis and occlusion in children with home parenteral nutrition. JPEN. Journal Of Parenteral And Enteral Nutrition 2012, 36: 456-62. PMID: 22245761, DOI: 10.1177/0148607111416482.
Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite.Soeters MR, Serlie MJ, Sauerwein HP, Duran M, Ruiter JP, Kulik W, Ackermans MT, Minkler PE, Hoppel CL, Wanders RJ, Houten SM. Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite. Metabolism: Clinical And Experimental 2012, 61: 966-73. PMID: 22209095, DOI: 10.1016/j.metabol.2011.11.009.
Assessing the optimal time point for the measurement of extrastriatal serotonin transporter binding with 123I-FP-CIT SPECT in healthy, male subjects.Koopman KE, la Fleur SE, Fliers E, Serlie MJ, Booij J. Assessing the optimal time point for the measurement of extrastriatal serotonin transporter binding with 123I-FP-CIT SPECT in healthy, male subjects. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2012, 53: 1087-90. PMID: 22627000, DOI: 10.2967/jnumed.111.102277.
Glucose challenge test for detecting gestational diabetes mellitus: a systematic review.van Leeuwen M, Louwerse MD, Opmeer BC, Limpens J, Serlie MJ, Reitsma JB, Mol BW. Glucose challenge test for detecting gestational diabetes mellitus: a systematic review. BJOG : An International Journal Of Obstetrics And Gynaecology 2012, 119: 393-401. PMID: 22260369, DOI: 10.1111/j.1471-0528.2011.03254.x.
Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity.Yi CX, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur SE, Serlie MJ, Fliers E, Buijs RM, Tschöp MH, Kalsbeek A. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 2012, 61: 339-45. PMID: 22210324, PMCID: PMC3266416, DOI: 10.2337/db11-1239.
Infusion of a lipid emulsion in healthy men decreases the serotonergic response.Sondermeijer BM, Klein Twennaar CF, Kastelein JJ, Franssen EJ, Hutten BA, Dallinga-Thie GM, Stroes ES, Fliers E, Twickler MT, Serlie MJ. Infusion of a lipid emulsion in healthy men decreases the serotonergic response. Neuroendocrinology 2012, 95: 325-31. PMID: 22327404, DOI: 10.1159/000333038.
Role of mitochondrial function in insulin resistance.Brands M, Verhoeven AJ, Serlie MJ. Role of mitochondrial function in insulin resistance. Advances In Experimental Medicine And Biology 2012, 942: 215-34. PMID: 22399424, DOI: 10.1007/978-94-007-2869-1_9.
Regulation of Glucose MetabolismHandbook Diabetes Mellitus. ISBN 9789058981622. Chapter on Regulation of Glucose Metabolism.
Role of Mitochondrial Function in Insulin ResistanceAdvances in Mitochondrial Medicine. Dordrecht; New York: Springer Verlag, 2012 Chapter on Role of Mitochondrial Function in Insulin Resistance.
Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects.de Weijer BA, van de Giessen E, van Amelsvoort TA, Boot E, Braak B, Janssen IM, van de Laar A, Fliers E, Serlie MJ, Booij J. Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects. EJNMMI Research 2011, 1: 37. PMID: 22214469, PMCID: PMC3265412, DOI: 10.1186/2191-219X-1-37.
Short-term increase of plasma free fatty acids does not interfere with intrinsic mitochondrial function in healthy young men.Brands M, Hoeks J, Sauerwein HP, Ackermans MT, Ouwens M, Lammers NM, van der Plas MN, Schrauwen P, Groen AK, Serlie MJ. Short-term increase of plasma free fatty acids does not interfere with intrinsic mitochondrial function in healthy young men. Metabolism: Clinical And Experimental 2011, 60: 1398-405. PMID: 21489571, DOI: 10.1016/j.metabol.2011.02.006.
Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia.Visser ME, Lammers NM, Nederveen AJ, van der Graaf M, Heerschap A, Ackermans MT, Sauerwein HP, Stroes ES, Serlie MJ. Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia. Diabetologia 2011, 54: 2113-21. PMID: 21547498, PMCID: PMC3131507, DOI: 10.1007/s00125-011-2157-x.
Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial.van Raalte DH, Brands M, van der Zijl NJ, Muskiet MH, Pouwels PJ, Ackermans MT, Sauerwein HP, Serlie MJ, Diamant M. Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial. Diabetologia 2011, 54: 2103-12. PMID: 21562755, PMCID: PMC3131514, DOI: 10.1007/s00125-011-2174-9.
Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs.Koopmans SJ, Dekker R, Ackermans MT, Sauerwein HP, Serlie MJ, van Beusekom HM, van den Heuvel M, van der Giessen WJ. Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs. Cardiovascular Diabetology 2011, 10: 64. PMID: 21756316, PMCID: PMC3143922, DOI: 10.1186/1475-2840-10-64.
Obesity: is evolution to blame?Serlie MJ, La Fleur SE, Fliers E. Obesity: is evolution to blame? The Netherlands Journal Of Medicine 2011, 69: 156-8. PMID: 21527801.
Ceramide in lipid emulsions used in parenteral nutrition: an innocent bystander?Groener JE, Serlie MJ, Poppema A, Mirzaian M, Aerts JM. Ceramide in lipid emulsions used in parenteral nutrition: an innocent bystander? JPEN. Journal Of Parenteral And Enteral Nutrition 2011, 35: 270-1. PMID: 21378257, DOI: 10.1177/0148607110381404.
Accuracy of the random glucose test as screening test for gestational diabetes mellitus: a systematic review.van Leeuwen M, Opmeer BC, Yilmaz Y, Limpens J, Serlie MJ, Mol BW. Accuracy of the random glucose test as screening test for gestational diabetes mellitus: a systematic review. European Journal Of Obstetrics, Gynecology, And Reproductive Biology 2011, 154: 130-5. PMID: 21129838, DOI: 10.1016/j.ejogrb.2010.11.002.
Glycosphingolipids and insulin resistance.Aerts JM, Boot RG, van Eijk M, Groener J, Bijl N, Lombardo E, Bietrix FM, Dekker N, Groen AK, Ottenhoff R, van Roomen C, Aten J, Serlie M, Langeveld M, Wennekes T, Overkleeft HS. Glycosphingolipids and insulin resistance. Advances In Experimental Medicine And Biology 2011, 721: 99-119. PMID: 21910085, DOI: 10.1007/978-1-4614-0650-1_7.
The added value of oral glucose tolerance testing in pre-diabetes.Luijf YM, Hermanides J, Serlie MJ, Hoekstra JB, Soeters MR. The added value of oral glucose tolerance testing in pre-diabetes. Current Diabetes Reviews 2011, 7: 56-60. PMID: 21143105, DOI: 10.2174/157339911794273946.
Erythrocyte glutathione concentration and production during hyperinsulinemia, hyperglycemia, and endotoxemia in healthy humans.van der Crabben SN, Stegenga ME, Blümer RM, Ackermans MT, Endert E, Tanck MW, Serlie MJ, van der Poll T, Sauerwein HP. Erythrocyte glutathione concentration and production during hyperinsulinemia, hyperglycemia, and endotoxemia in healthy humans. Metabolism: Clinical And Experimental 2011, 60: 99-106. PMID: 20850847, DOI: 10.1016/j.metabol.2010.08.003.
Extended metabolic evaluation of suspected symptomatic hypoglycemia: the prolonged fast and beyond.Soeters MR, Huidekoper HH, Duran M, Ackermans MT, Endert E, Fliers E, Wijburg FA, Wanders RJ, Sauerwein HP, Serlie MJ. Extended metabolic evaluation of suspected symptomatic hypoglycemia: the prolonged fast and beyond. Metabolism: Clinical And Experimental 2010, 59: 1543-50. PMID: 20189609, DOI: 10.1016/j.metabol.2010.01.024.
Pituitary adenylate cyclase-activating polypeptide stimulates glucose production via the hepatic sympathetic innervation in rats.Yi CX, Sun N, Ackermans MT, Alkemade A, Foppen E, Shi J, Serlie MJ, Buijs RM, Fliers E, Kalsbeek A. Pituitary adenylate cyclase-activating polypeptide stimulates glucose production via the hepatic sympathetic innervation in rats. Diabetes 2010, 59: 1591-600. PMID: 20357362, PMCID: PMC2889757, DOI: 10.2337/db09-1398.
Optimal nutrition and its potential effect on survival in critically ill patients.Sauerwein HP, Serlie MJ. Optimal nutrition and its potential effect on survival in critically ill patients. The Netherlands Journal Of Medicine 2010, 68: 119-22. PMID: 20308706.
Insulin sensitivity in multiple pathways is differently affected during zidovudine/lamivudine-containing compared with NRTI-sparing combination antiretroviral therapy.van Vonderen MG, Blümer RM, Hassink EA, Sutinen J, Ackermans MT, van Agtmael MA, Yki-Jarvinen H, Danner SA, Serlie MJ, Sauerwein HP, Reiss P. Insulin sensitivity in multiple pathways is differently affected during zidovudine/lamivudine-containing compared with NRTI-sparing combination antiretroviral therapy. Journal Of Acquired Immune Deficiency Syndromes (1999) 2010, 53: 186-93. PMID: 19898246, DOI: 10.1097/QAI.0b013e3181c190f4.
A rosiglitazone-induced increase in adiponectin does not improve glucose metabolism in HIV-infected patients with overt lipoatrophy.Blümer RM, van der Valk M, Ackermans M, Endert E, Serlie MJ, Reiss P, Sauerwein HP. A rosiglitazone-induced increase in adiponectin does not improve glucose metabolism in HIV-infected patients with overt lipoatrophy. American Journal Of Physiology. Endocrinology And Metabolism 2009, 297: E1097-104. PMID: 19690066, DOI: 10.1152/ajpendo.90988.2008.
Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism.Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans M, Jonkers-Schuitema CF, Fliers E, Sauerwein HP, Aerts JM, Serlie MJ. Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism. The American Journal Of Clinical Nutrition 2009, 90: 1244-51. PMID: 19776143, DOI: 10.3945/ajcn.2008.27327.
A major role for perifornical orexin neurons in the control of glucose metabolism in rats.Yi CX, Serlie MJ, Ackermans MT, Foppen E, Buijs RM, Sauerwein HP, Fliers E, Kalsbeek A. A major role for perifornical orexin neurons in the control of glucose metabolism in rats. Diabetes 2009, 58: 1998-2005. PMID: 19592616, PMCID: PMC2731521, DOI: 10.2337/db09-0385.
Glucose metabolism in children: influence of age, fasting, and infectious diseases.Zijlmans WC, van Kempen AA, Serlie MJ, Sauerwein HP. Glucose metabolism in children: influence of age, fasting, and infectious diseases. Metabolism: Clinical And Experimental 2009, 58: 1356-65. PMID: 19501855, DOI: 10.1016/j.metabol.2009.04.020.
Effects of insulin on ketogenesis following fasting in lean and obese men.Soeters MR, Sauerwein HP, Faas L, Smeenge M, Duran M, Wanders RJ, Ruiter AF, Ackermans MT, Fliers E, Houten SM, Serlie MJ. Effects of insulin on ketogenesis following fasting in lean and obese men. Obesity (Silver Spring, Md.) 2009, 17: 1326-31. PMID: 19369940, DOI: 10.1038/oby.2008.678.
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting.Heemstra KA, Soeters MR, Fliers E, Serlie MJ, Burggraaf J, van Doorn MB, van der Klaauw AA, Romijn JA, Smit JW, Corssmit EP, Visser TJ. Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. The Journal Of Clinical Endocrinology And Metabolism 2009, 94: 2144-50. PMID: 19293265, DOI: 10.1210/jc.2008-2520.
Central effects of thyronamines on glucose metabolism in rats.Klieverik LP, Foppen E, Ackermans MT, Serlie MJ, Sauerwein HP, Scanlan TS, Grandy DK, Fliers E, Kalsbeek A. Central effects of thyronamines on glucose metabolism in rats. The Journal Of Endocrinology 2009, 201: 377-86. PMID: 19273499, DOI: 10.1677/JOE-09-0043.
[Oral glucose tolerance test. Invaluable in screening of type 2 diabetes].Soeters MR, Serlie MJ. [Oral glucose tolerance test. Invaluable in screening of type 2 diabetes]. Nederlands Tijdschrift Voor Geneeskunde 2009, 153: 742. PMID: 19469142.
Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver.Klieverik LP, Janssen SF, van Riel A, Foppen E, Bisschop PH, Serlie MJ, Boelen A, Ackermans MT, Sauerwein HP, Fliers E, Kalsbeek A. Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 5966-71. PMID: 19321430, PMCID: PMC2660059, DOI: 10.1073/pnas.0805355106.
Muscle acylcarnitines during short-term fasting in lean healthy men.Soeters MR, Sauerwein HP, Duran M, Wanders RJ, Ackermans MT, Fliers E, Houten SM, Serlie MJ. Muscle acylcarnitines during short-term fasting in lean healthy men. Clinical Science (London, England : 1979) 2009, 116: 585-92. PMID: 18945215, DOI: 10.1042/CS20080433.
Evaluation of Endocrine Tests. C: glucagon and clonidine test in phaeochromocytoma.Bisschop PH, Corssmit EP, Baas SJ, Serlie MJ, Endert E, Wiersinga WM, Fliers E. Evaluation of Endocrine Tests. C: glucagon and clonidine test in phaeochromocytoma. The Netherlands Journal Of Medicine 2009, 67: 91-5. PMID: 19307679.
Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans.van der Crabben SN, Blümer RM, Stegenga ME, Ackermans MT, Endert E, Tanck MW, Serlie MJ, van der Poll T, Sauerwein HP. Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans. The Journal Of Clinical Endocrinology And Metabolism 2009, 94: 463-8. PMID: 18984669, DOI: 10.1210/jc.2008-0761.
Muscle adaptation to short-term fasting in healthy lean humans.Soeters MR, Sauerwein HP, Dubbelhuis PF, Groener JE, Ackermans MT, Fliers E, Aerts JM, Serlie MJ. Muscle adaptation to short-term fasting in healthy lean humans. The Journal Of Clinical Endocrinology And Metabolism 2008, 93: 2900-3. PMID: 18397976, DOI: 10.1210/jc.2008-0250.
Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia.Stegenga ME, van der Crabben SN, Blümer RM, Levi M, Meijers JC, Serlie MJ, Tanck MW, Sauerwein HP, van der Poll T. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood 2008, 112: 82-9. PMID: 18316629, PMCID: PMC2435690, DOI: 10.1182/blood-2007-11-121723.
Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance.Langeveld M, Ghauharali KJ, Sauerwein HP, Ackermans MT, Groener JE, Hollak CE, Aerts JM, Serlie MJ. Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance. The Journal Of Clinical Endocrinology And Metabolism 2008, 93: 845-51. PMID: 18089699, DOI: 10.1210/jc.2007-1702.
Hepatic insulin resistance in antipsychotic naive schizophrenic patients: stable isotope studies of glucose metabolism.van Nimwegen LJ, Storosum JG, Blumer RM, Allick G, Venema HW, de Haan L, Becker H, van Amelsvoort T, Ackermans MT, Fliers E, Serlie MJ, Sauerwein HP. Hepatic insulin resistance in antipsychotic naive schizophrenic patients: stable isotope studies of glucose metabolism. The Journal Of Clinical Endocrinology And Metabolism 2008, 93: 572-7. PMID: 18029467, DOI: 10.1210/jc.2007-1167.
Gender-related differences in the metabolic response to fasting.Soeters MR, Sauerwein HP, Groener JE, Aerts JM, Ackermans MT, Glatz JF, Fliers E, Serlie MJ. Gender-related differences in the metabolic response to fasting. The Journal Of Clinical Endocrinology And Metabolism 2007, 92: 3646-52. PMID: 17566089, DOI: 10.1210/jc.2007-0552.
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O'Rahilly S, Overkleeft HS. Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes 2007, 56: 1341-9. PMID: 17287460, PMCID: PMC4298701, DOI: 10.2337/db06-1619.
Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects.Serlie MJ, Meijer AJ, Groener JE, Duran M, Endert E, Fliers E, Aerts JM, Sauerwein HP. Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. The Journal Of Clinical Endocrinology And Metabolism 2007, 92: 1524-9. PMID: 17264178, DOI: 10.1210/jc.2006-2347.
Chronic treatment with pioglitazone does not protect obese patients with diabetes mellitus type II from free fatty acid-induced insulin resistance.Serlie MJ, Allick G, Groener JE, Ackermans MT, Heijligenberg R, Voermans BC, Aerts JM, Meijer AJ, Sauerwein HP. Chronic treatment with pioglitazone does not protect obese patients with diabetes mellitus type II from free fatty acid-induced insulin resistance. The Journal Of Clinical Endocrinology And Metabolism 2007, 92: 166-71. PMID: 17062758, DOI: 10.1210/jc.2006-1518.
Glycogen synthesis in human gastrocnemius muscle is not representative of whole-body muscle glycogen synthesis.Serlie MJ, de Haan JH, Tack CJ, Verberne HJ, Ackermans MT, Heerschap A, Sauerwein HP. Glycogen synthesis in human gastrocnemius muscle is not representative of whole-body muscle glycogen synthesis. Diabetes 2005, 54: 1277-82. PMID: 15855310, DOI: 10.2337/diabetes.54.5.1277.
Differences in fluid and solute transport between diabetic and nondiabetic patients at the onset of CAPD.Serlie MJ, Struijk DG, de Blok K, Krediet RT. Differences in fluid and solute transport between diabetic and nondiabetic patients at the onset of CAPD. Advances In Peritoneal Dialysis. Conference On Peritoneal Dialysis 1997, 13: 29-32. PMID: 9360646.

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Mireille Serlie, MD, PhD

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