Michael Schilsky, MD
Professor of Medicine; Medical Director, Adult Liver Transplant at Yale-New Haven Transplantation Center
Research & Publications
Biography
News
Research Summary
I participate as an investigator in the NIH sponsored Acute Liver Failure Study Group. I am an investigator in clinical trials for patients with Wilson disease and advanced liver disease.
Extensive Research Description
I participate as an investigator in the NIH sponsored Acute Liver Failure Study Group where we have been focusing on patients with acute liver failure to advance our understanding of this uncommon disorder.
I am an investigator in clinical trials for patients with Wilson disease, including the testing of once daily use of trientine for maintenance therapy, and the novel agent WTX 101 (choline-tetrathiomolybdate).
Coauthors
Research Interests
Copper; Liver Transplantation; Liver Failure, Acute
Selected Publications
- ICU management of acute liver failure.Schilsky ML, Honiden S, Arnott L, Emre S. ICU management of acute liver failure. Clinics In Chest Medicine 2009, 30: 71-87, viii. PMID: 19186281, DOI: 10.1016/j.ccm.2008.10.001.
- Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests.Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML. Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests. Hepatology (Baltimore, Md.) 2008, 48: 1167-74. PMID: 18798336, PMCID: PMC4881751, DOI: 10.1002/hep.22446.
- Diagnosis and treatment of Wilson disease: an update.Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology (Baltimore, Md.) 2008, 47: 2089-111. PMID: 18506894, DOI: 10.1002/hep.22261.
- Prospective pilot study of a single daily dosage of trientine for the treatment of Wilson disease.Ala A, Aliu E, Schilsky ML. Prospective pilot study of a single daily dosage of trientine for the treatment of Wilson disease. Digestive Diseases And Sciences 2015, 60: 1433-9. PMID: 25605552, PMCID: PMC4427615, DOI: 10.1007/s10620-014-3495-6.
- Ferenci P, Czlonkowska A, Stremmel W, Houwen R, Rosenberg W, Schilsky M, Jansen P, Moradpour D, Gitlin J. EASL Clinical Practice Guidelines: Wilson's disease.European Association for Study of Liver. J Hepatol. 56:671-685
- Therapeutic hypothermia in acute liver failure: a multicenter retrospective cohort analysis.Karvellas CJ, Todd Stravitz R, Battenhouse H, Lee WM, Schilsky ML. Therapeutic hypothermia in acute liver failure: a multicenter retrospective cohort analysis. Liver Transplantation : Official Publication Of The American Association For The Study Of Liver Diseases And The International Liver Transplantation Society 2015, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Endocrine System; Genetics - Adult; Genetics - Pediatric | A Phase 2, Open-label Study to Assess Copper and Molybdenum Balance in Participants with Wilson Disease Treated with ALXN1840 |
| Diseases of the Endocrine System; Genetics - Adult | A Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease (GATEWAY) |
| Genetics - Adult | Efficacy and Safety of WTX101 Administered for 48 Weeks Versus Standard of Care in Wilson Disease Subjects |
| Diseases of the Digestive System - Liver; Diseases of the Eye; Diseases of the Nervous System | Wilson Disease Registry |
| Hepatitis; HIV/AIDS; Immune System; Infectious Diseases | Screening In Anticipation of Future Research |