Mike Matthias, PhD, BSc
Senior Research Scientist; Affiliate Faculty, Yale Institute for Global Health
Research & Publications
Biography
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Coauthors
Selected Publications
- Culture-Independent Detection and Identification of Leptospira SerovarsMatthias M, Lubar A, Acharige S, Chaiboonma K, Pilau N, Marroquin A, Jayasundara D, Agampodi S, Vinetz J. Culture-Independent Detection and Identification of Leptospira Serovars Microbiology Spectrum 2022, 10: e02475-22. PMID: 36445143, PMCID: PMC9769591, DOI: 10.1128/spectrum.02475-22.
- Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri LankaAgampodi S, Warnasekara J, Siribaddana S, Kularatna S, Gamage C, Jayasundara D, Senevirathna I, Srimantha S, Kappagoda C, Weerawansa P, Pilapitiya S, Lokunarangoda N, Sarathchandra C, Senanayake H, Matthias M, Vinetz J. Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka Data In Brief 2022, 43: 108378. PMID: 35770027, PMCID: PMC9234077, DOI: 10.1016/j.dib.2022.108378.
- Serological and molecular epidemiology of leptospirosis and the role of dogs as sentinel for human infection in NigeriaPilau NN, Lubar AA, Daneji AI, Mera UM, Magaji AA, Abiayi EA, Chaiboonma KL, Busayo EI, Vinetz JM, Matthias MA. Serological and molecular epidemiology of leptospirosis and the role of dogs as sentinel for human infection in Nigeria Heliyon 2022, 8: e09484. PMID: 35647333, PMCID: PMC9136256, DOI: 10.1016/j.heliyon.2022.e09484.
- Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic settingWarnasekara J, Srimantha S, Kappagoda C, Jayasundara D, Senevirathna I, Matthias M, Agampodi S, Vinetz J. Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting PLOS Neglected Tropical Diseases 2022, 16: e0010331. PMID: 35377883, PMCID: PMC9009773, DOI: 10.1371/journal.pntd.0010331.
- Pathogenic Leptospira Evolved a Unique Gene Family Comprised of Ricin B-Like Lectin Domain-Containing CytotoxinsChaurasia R, Marroquin AS, Vinetz JM, Matthias MA. Pathogenic Leptospira Evolved a Unique Gene Family Comprised of Ricin B-Like Lectin Domain-Containing Cytotoxins Frontiers In Microbiology 2022, 13: 859680. PMID: 35422779, PMCID: PMC9002632, DOI: 10.3389/fmicb.2022.859680.
- Clinical spectrum of endemic leptospirosis in relation to cytokine responseDahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.
- Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivityJayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.
- Correction: 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri LankaJayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz JM. Correction: 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka PLOS Neglected Tropical Diseases 2021, 15: e0009471. PMID: 34038414, PMCID: PMC8153494, DOI: 10.1371/journal.pntd.0009471.
- 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri LankaJayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.
- Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri LankaSenevirathna I, Jayasundara D, Lefler JP, Chaiboonm KL, Warnasekara J, Agampodi S, Matthias MA, Vinetz JM. Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka Journal Of Genomics 2020, 8: 49-52. PMID: 32494307, PMCID: PMC7256012, DOI: 10.7150/jgen.43953.
- Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae.Fernandez C, Lubar AA, Vinetz JM, Matthias MA. Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae. American Journal Of Tropical Medicine And Hygiene 2018, 99: 275-280. PMID: 29943708, PMCID: PMC6090328, DOI: 10.4269/ajtmh.17-0844.
- Clinical Case Report of Suspected Fulminating Leptospirosis In A 4‐Months Old Caucasian Dog And Molecular Detection of Pathogenic Leptospira In Canine In Northwestern Nigeria: Public Health Significance And RamificationsPilau N, Matthias M, Sani Y, DanMaigoro A. Clinical Case Report of Suspected Fulminating Leptospirosis In A 4‐Months Old Caucasian Dog And Molecular Detection of Pathogenic Leptospira In Canine In Northwestern Nigeria: Public Health Significance And Ramifications The FASEB Journal 2018, 32: 669.1-669.1. DOI: 10.1096/fasebj.2018.32.1_supplement.669.1.
- Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancerLozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer BMC Cancer 2017, 17: 133. PMID: 28201999, PMCID: PMC5310019, DOI: 10.1186/s12885-017-3114-y.
- Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of HamstersWunder EA, Figueira CP, Santos GR, Lourdault K, Matthias MA, Vinetz JM, Ramos E, Haake DA, Picardeau M, dos Reis MG, Ko AI. Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters Infection And Immunity 2016, 84: 2105-2115. PMID: 27141082, PMCID: PMC4936353, DOI: 10.1128/iai.00094-16.
- What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus LeptospiraFouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira PLOS Neglected Tropical Diseases 2016, 10: e0004403. PMID: 26890609, PMCID: PMC4758666, DOI: 10.1371/journal.pntd.0004403.
- Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture AttenuationLehmann JS, Corey VC, Ricaldi JN, Vinetz JM, Winzeler EA, Matthias MA. Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation American Journal Of Tropical Medicine And Hygiene 2015, 94: 302-313. PMID: 26711524, PMCID: PMC4751964, DOI: 10.4269/ajtmh.15-0401.
- Comparative analysis of lipopolysaccharides of pathogenic and intermediately pathogenic Leptospira speciesPatra KP, Choudhury B, Matthias MM, Baga S, Bandyopadhya K, Vinetz JM. Comparative analysis of lipopolysaccharides of pathogenic and intermediately pathogenic Leptospira species BMC Microbiology 2015, 15: 244. PMID: 26518696, PMCID: PMC4628369, DOI: 10.1186/s12866-015-0581-7.
- Correction: Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected RatsRamachandraRao SP, Matthias MA, Kokoy-Mondrogon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. Correction: Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected Rats PLOS Neglected Tropical Diseases 2015, 9: e0003718. PMID: 25860882, PMCID: PMC4393270, DOI: 10.1371/journal.pntd.0003718.
- Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected RatsRamachandraRao SP, Matthias MA, Mondrogon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected Rats PLOS Neglected Tropical Diseases 2015, 9: e0003640. PMID: 25793258, PMCID: PMC4368819, DOI: 10.1371/journal.pntd.0003640.
- Leptospiral PathogenomicsLehmann JS, Matthias MA, Vinetz JM, Fouts DE. Leptospiral Pathogenomics Pathogens 2014, 3: 280-308. PMID: 25437801, PMCID: PMC4243447, DOI: 10.3390/pathogens3020280.
- Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, Perera M, Priyankara S, Weerawansa P, Matthias MA, Vinetz JM. Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011 PLOS Neglected Tropical Diseases 2014, 8: e2626. PMID: 24454971, PMCID: PMC3894175, DOI: 10.1371/journal.pntd.0002626.
- Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogansLehmann JS, Fouts DE, Haft DH, Cannella AP, Ricaldi JN, Brinkac L, Harkins D, Durkin S, Sanka R, Sutton G, Moreno A, Vinetz JM, Matthias MA. Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans PLOS Neglected Tropical Diseases 2013, 7: e2468. PMID: 24098822, PMCID: PMC3789758, DOI: 10.1371/journal.pntd.0002468.
- Current trends in translational research in leptospirosisRicaldi JN, Swancutt MA, Matthias MA. Current trends in translational research in leptospirosis Current Opinion In Infectious Diseases 2013, 26: 399-403. PMID: 23982231, DOI: 10.1097/qco.0000000000000001.
- A Foodborne Outbreak of Brucellosis at a Police Station Cafeteria, Lima, PeruRomán K, Castillo R, Gilman RH, Calderón M, Vivar A, Céspedes M, Smits HL, Meléndez P, Gotuzzo E, Guerra H, Maves RC, Matthias MA, Vinetz JM, Saito M. A Foodborne Outbreak of Brucellosis at a Police Station Cafeteria, Lima, Peru American Journal Of Tropical Medicine And Hygiene 2013, 88: 552-558. PMID: 23382164, PMCID: PMC3592540, DOI: 10.4269/ajtmh.12-0606.
- Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira StrainAgampodi SB, Moreno AC, Vinetz JM, Matthias MA. Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain American Journal Of Tropical Medicine And Hygiene 2012, 88: 184-185. PMID: 23208890, PMCID: PMC3541733, DOI: 10.4269/ajtmh.2012.12-0526.
- Whole Genome Analysis of Leptospira licerasiae Provides Insight into Leptospiral Evolution and PathogenicityRicaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA. Whole Genome Analysis of Leptospira licerasiae Provides Insight into Leptospiral Evolution and Pathogenicity PLOS Neglected Tropical Diseases 2012, 6: e1853. PMID: 23145189, PMCID: PMC3493377, DOI: 10.1371/journal.pntd.0001853.
- Expression of sialic acids and other nonulosonic acids in LeptospiraRicaldi N J, Matthias MA, Vinetz JM, Lewis AL. Expression of sialic acids and other nonulosonic acids in Leptospira BMC Microbiology 2012, 12: 161. PMID: 22853805, PMCID: PMC3438082, DOI: 10.1186/1471-2180-12-161.
- High Degree of Plasmodium vivax Diversity in the Peruvian Amazon Demonstrated by Tandem Repeat Polymorphism AnalysisKosek M, Yori PP, Gilman RH, Calderon M, Zimic M, Chuquiyauri R, Jeri C, Pinedo-Cancino V, Matthias MA, Llanos-Cuentas A, Vinetz JM. High Degree of Plasmodium vivax Diversity in the Peruvian Amazon Demonstrated by Tandem Repeat Polymorphism Analysis American Journal Of Tropical Medicine And Hygiene 2012, 86: 580-586. PMID: 22492139, PMCID: PMC3403772, DOI: 10.4269/ajtmh.2012.11-0627.
- Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri LankaAgampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.
- Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by LeptospiraGanoza CA, Matthias MA, Saito M, Cespedes M, Gotuzzo E, Vinetz JM. Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira PLOS Neglected Tropical Diseases 2010, 4: e612. PMID: 20186328, PMCID: PMC2826405, DOI: 10.1371/journal.pntd.0000612.
- Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian AmazonMatthias MA, Ricaldi JN, Cespedes M, Diaz MM, Galloway RL, Saito M, Steigerwalt AG, Patra KP, Ore CV, Gotuzzo E, Gilman RH, Levett PN, Vinetz JM. Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon PLOS Neglected Tropical Diseases 2008, 2: e213. PMID: 18382606, PMCID: PMC2271056, DOI: 10.1371/journal.pntd.0000213.
- Suburban Leptospirosis: Atypical Lymphocytosis and γ-δ T Cell ResponseBarry M, Wisnewski AV, Matthias MA, Inouye SK, Vinetz JM. Suburban Leptospirosis: Atypical Lymphocytosis and γ-δ T Cell Response Clinical Infectious Diseases 2006, 43: 1304-1307. PMID: 17051497, DOI: 10.1086/508537.
- Determining Risk for Severe Leptospirosis by Molecular Analysis of Environmental Surface Waters for Pathogenic LeptospiraGanoza CA, Matthias MA, Collins-Richards D, Brouwer KC, Cunningham CB, Segura ER, Gilman RH, Gotuzzo E, Vinetz JM. Determining Risk for Severe Leptospirosis by Molecular Analysis of Environmental Surface Waters for Pathogenic Leptospira PLOS Medicine 2006, 3: e308. PMID: 16933963, PMCID: PMC1551915, DOI: 10.1371/journal.pmed.0030308.
- Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral BurdenViriyakosol S, Matthias MA, Swancutt MA, Kirkland TN, Vinetz JM. Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden Infection And Immunity 2006, 74: 887-895. PMID: 16428731, PMCID: PMC1360355, DOI: 10.1128/iai.74.2.887-895.2006.
- Diversity of bat-associated Leptospira in the Peruvian Amazon inferred by bayesian phylogenetic analysis of 16S ribosomal DNA sequences.Matthias MA, Díaz MM, Campos KJ, Calderon M, Willig MR, Pacheco V, Gotuzzo E, Gilman RH, Vinetz JM. Diversity of bat-associated Leptospira in the Peruvian Amazon inferred by bayesian phylogenetic analysis of 16S ribosomal DNA sequences. American Journal Of Tropical Medicine And Hygiene 2005, 73: 964-74. PMID: 16282313, PMCID: PMC2270400, DOI: 10.4269/ajtmh.2005.73.964.
- Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral BurdenSegura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, Céspedes MJ, Matthias MA, Swancutt MA, Liñán R, Gotuzzo E, Guerra H, Gilman RH, Vinetz JM. Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden Clinical Infectious Diseases 2005, 40: 343-351. PMID: 15668855, PMCID: PMC2366057, DOI: 10.1086/427110.
- Leptospirosis: a zoonotic disease of global importanceBharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM, Consortium O. Leptospirosis: a zoonotic disease of global importance The Lancet Infectious Diseases 2003, 3: 757-771. PMID: 14652202, DOI: 10.1016/s1473-3099(03)00830-2.
- Leptospira interrogans Activation of Human Peripheral Blood Mononuclear Cells: Preferential Expansion of TCRγδ+ T Cells vs TCRαβ+ T CellsKlimpel GR, Matthias MA, Vinetz JM. Leptospira interrogans Activation of Human Peripheral Blood Mononuclear Cells: Preferential Expansion of TCRγδ+ T Cells vs TCRαβ+ T Cells The Journal Of Immunology 2003, 171: 1447-1455. PMID: 12874237, DOI: 10.4049/jimmunol.171.3.1447.
- Leptospiral carriage by mice and mongooses on the island of Barbados.Matthias M, Levett P. Leptospiral carriage by mice and mongooses on the island of Barbados. West Indian Medical Journal 2002, 51: 10-3. PMID: 12089866.