Mert Ozan Bahtiyar, MD
Professor, Obstetrics, Gynecology & Reproductive Sciences; Director, Yale Fetal Care Center
Research & Publications
Biography
News
Extensive Research Description
- Effect of intraamniotic infection/inflammation on fetal cardiac function.
- Placental architecture in complicated monochorionic gestations.
- Predictors of survival in fetuses with cystic congenital adenoid malformations.
- Doppler assessment of the uterine blood circulation in abnormal placentation: placenta previa with or without accreta.
Coauthors
Selected Publications
- Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: single-institution experience.Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: single-institution experience. Journal Of Ultrasound In Medicine : Official Journal Of The American Institute Of Ultrasound In Medicine 2008, 27:715-20.
- Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis.Dulay AT, Buhimschi IA, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg VA, Pettker CM, Thung SF, Bahtiyar MO, Bhandari V, Buhimschi CS. Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. American Journal Of Obstetrics And Gynecology 2008, 198:426.e1-9.
- Stillbirth at term in women of advanced maternal age in the United States: when could the antenatal testing be initiated?Bahtiyar MO, Funai EF, Rosenberg V, Norwitz E, Lipkind H, Buhimschi C, Copel JA. Stillbirth at term in women of advanced maternal age in the United States: when could the antenatal testing be initiated? American Journal Of Perinatology 2008, 25:301-4.
- Fetal adrenal gland volume and cortisol/dehydroepiandrosterone sulfate ratio in inflammation-associated preterm birth.Buhimschi CS, Turan OM, Funai EF, Azpurua H, Bahtiyar MO, Turan S, Zhao G, Dulay A, Bhandari V, Copel JA, Buhimschi IA. Fetal adrenal gland volume and cortisol/dehydroepiandrosterone sulfate ratio in inflammation-associated preterm birth. Obstetrics And Gynecology 2008, 111:715-22.
- Defining standards of care in maternal-fetal medicine.Norwitz ER, Bahtiyar MO, Sibai BM. Defining standards of care in maternal-fetal medicine. American Journal Of Obstetrics And Gynecology 2004, 191:1491-6.
- A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes.Buhimschi CS, Sfakianaki AK, Hamar BG, Pettker CM, Bahtiyar MO, Funai E, Norwitz ER, Copel JA, Lockwood CJ, Buhimschi IA. A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 194:309-16.
- Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: analysis of U.S. perinatal mortality data, 1995-1997.Bahtiyar MO, Julien S, Robinson JN, Lumey L, Zybert P, Copel JA, Lockwood CJ, Norwitz ER. Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: analysis of U.S. perinatal mortality data, 1995-1997. American Journal Of Obstetrics And Gynecology 2006, 195:1373-8.
- Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature review.Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature review. Journal Of Ultrasound In Medicine : Official Journal Of The American Institute Of Ultrasound In Medicine 2007, 26:1491-8.
- Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis.Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ, Buhimschi IA. Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. PLoS Medicine 2007, 4:e18.
- The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation.Buhimschi IA, Zhao G, Pettker CM, Bahtiyar MO, Magloire LK, Thung S, Fairchild T, Buhimschi CS. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation. American Journal Of Obstetrics And Gynecology 2007, 196:181.e1-13.
- Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction.Bahtiyar MO, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. American Journal Of Obstetrics And Gynecology 2007, 196:72.e1-6.
- Proteomics: a novel methodology to complement prenatal diagnosis of chromosomal abnormalities and inherited human diseases.Bahtiyar MO, Copel JA, Mahoney MJ, Buhimschi IA, Buhimschi CS. Proteomics: a novel methodology to complement prenatal diagnosis of chromosomal abnormalities and inherited human diseases. American Journal Of Perinatology 2007, 24:167-81.
- Relationships of maternal serum levels of vascular endothelial growth factor and tensile strength properties of the cervix in a rat model of chronic hypoxia.Sfakianaki AK, Buhimschi IA, Ravishankar V, Bahtiyar MO, Dulay AT, Buhimschi CS. Relationships of maternal serum levels of vascular endothelial growth factor and tensile strength properties of the cervix in a rat model of chronic hypoxia. American Journal Of Obstetrics And Gynecology 2008, 198:223.e1-7.
- Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis.Buhimschi IA, Zambrano E, Pettker CM, Bahtiyar MO, Paidas M, Rosenberg VA, Thung S, Salafia CM, Buhimschi CS. Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis. Obstetrics And Gynecology 2008, 111:403-12.
- Fetal heart rate monitoring patterns in women with amniotic fluid proteomic profiles indicative of inflammation.Buhimschi CS, Abdel-Razeq S, Cackovic M, Pettker CM, Dulay AT, Bahtiyar MO, Zambrano E, Martin R, Norwitz ER, Bhandari V, Buhimschi IA. Fetal heart rate monitoring patterns in women with amniotic fluid proteomic profiles indicative of inflammation. American Journal Of Perinatology 2008, 25:359-72.
- Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth.Buhimschi CS, Rosenberg VA, Dulay AT, Thung S, Sfakianaki AK, Bahtiyar MO, Buhimschi IA. Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth. American Journal Of Perinatology 2008, 25:175-87.
- Acute chest syndrome during pregnancy as initial presentation of sickle cell disease: a case report.Campbell K, Ali U, Bahtiyar M. Acute chest syndrome during pregnancy as initial presentation of sickle cell disease: a case report. American Journal Of Perinatology 2008, 25:547-9.
- Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth.Guoyang Luo, Morgan T, Bahtiyar MO, Snegovskikh VV, Schatz F, Kuczynski E, Funai EF, Dulay AT, Huang ST, Buhimschi CS, Buhimschi IA, Fortunato SJ, Menon R, Lockwood CJ, Norwitz ER. Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth. Reproductive Sciences (Thousand Oaks, Calif.) 2008, 15:147-55.
- Cardiac changes in the intrauterine growth-restricted fetus.Bahtiyar MO, Copel JA. Cardiac changes in the intrauterine growth-restricted fetus. Seminars In Perinatology 2008, 32:190-3.
- Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth.Azpurua H, Dulay AT, Buhimschi IA, Bahtiyar MO, Funai E, Abdel-Razeq SS, Luo G, Bhandari V, Copel JA, Buhimschi CS. Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth. American Journal Of Obstetrics And Gynecology 2009, 200:203.e1-11.
- Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity.Azpurua H, Norwitz ER, Campbell KH, Funai EF, Pettker CM, Kleine M, Bahtiyar MO, Malkus H, Copel JA, Thung SF. Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity. American Journal Of Obstetrics And Gynecology 2010, 203:40.e1-8.
- Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome.Abdel-Razeq SS, Campbell K, Funai EF, Kaplan LJ, Bahtiyar MO. Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. American Journal Of Obstetrics And Gynecology 2010, 203:149.e1-4.
- Interpretation of amniotic fluid white blood cell count in "bloody tap" amniocenteses in women with symptoms of preterm labor.Abdel-Razeq SS, Buhimschi IA, Bahtiyar MO, Rosenberg VA, Dulay AT, Han CS, Werner EF, Thung S, Buhimschi CS. Interpretation of amniotic fluid white blood cell count in "bloody tap" amniocenteses in women with symptoms of preterm labor. Obstetrics And Gynecology 2010, 116:344-354.
- Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study.Bahtiyar MO, Campbell K, Dulay AT, Kontic-Vucinic O, Weeks BP, Friedman AH, Copel JA. Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study. Journal Of Ultrasound In Medicine : Official Journal Of The American Institute Of Ultrasound In Medicine 2010, 29:917-22.
- Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast.Wehrum MJ, Buhimschi IA, Salafia C, Thung S, Bahtiyar MO, Werner EF, Campbell KH, Laky C, Sfakianaki AK, Zhao G, Funai EF, Buhimschi CS. Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast. American Journal Of Obstetrics And Gynecology 2011, 204:411.e1-411.e11.
- Ultrasonographic evaluation of myometrial thickness and prediction of a successful external cephalic version.Buhimschi CS, Buhimschi IA, Wehrum MJ, Molaskey-Jones S, Sfakianaki AK, Pettker CM, Thung S, Campbell KH, Dulay AT, Funai EF, Bahtiyar MO. Ultrasonographic evaluation of myometrial thickness and prediction of a successful external cephalic version. Obstetrics And Gynecology 2011, 118:913-20.
- Neoadjuvant and adjuvant chemotherapy of cervical cancer: mature results of the phase 2 PBM-PFU protocol.McCaffrey R, Bahtiyar M, Kohorn EI, Chambers JT, Schwartz PE, Chambers SK. Neoadjuvant and adjuvant chemotherapy of cervical cancer: mature results of the phase 2 PBM-PFU protocol. International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society 2011, 21:535-44.
- IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes.Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186:3226-36.
- Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis.Dulay AT, Buhimschi IA, Zhao G, Bahtiyar MO, Thung SF, Cackovic M, Buhimschi CS. Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis. Cytokine 2015, 76:236-243.
- The North American Fetal Therapy Network Consensus Statement: Management of Complicated Monochorionic Gestations.Emery SP, Bahtiyar MO, Moise KJ. The North American Fetal Therapy Network Consensus Statement: Management of Complicated Monochorionic Gestations. Obstetrics And Gynecology 2015, 126:575-584.
- The North American Fetal Therapy Network consensus statement: prenatal surveillance of uncomplicated monochorionic gestations.Bahtiyar MO, Emery SP, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network consensus statement: prenatal surveillance of uncomplicated monochorionic gestations. Obstetrics And Gynecology 2015, 125:118-123.
- Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA. Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2015, 73:507-21.
- Screening for congenital heart disease during anatomical survey ultrasonography.Bahtiyar MO, Copel JA. Screening for congenital heart disease during anatomical survey ultrasonography. Obstetrics And Gynecology Clinics Of North America 2015, 42:209-23.
- The North American Fetal Therapy Network Consensus Statement: prenatal management of uncomplicated monochorionic gestations.Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement: prenatal management of uncomplicated monochorionic gestations. Obstetrics And Gynecology 2015, 125:1236-1243.
- Evidence for participation of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 (NGAL•MMP-9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth.Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 (NGAL•MMP-9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology (New York, N.Y. : 1989) 2016, 76:108-17.
- Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery.Wilpers AB, Kennedy HP, Wall D, Funk M, Bahtiyar MO. Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery. Journal Of Obstetric, Gynecologic, And Neonatal Nursing : JOGNN / NAACOG 2017, 46:456-464.
- Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes.Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2017, 42:99-110.
- Minimally invasive abdominal cerclage compared to laparotomy: a comparison of surgical and obstetric outcomes.Kim S, Hill A, Menderes G, Cross S, Azodi M, Bahtiyar MO. Minimally invasive abdominal cerclage compared to laparotomy: a comparison of surgical and obstetric outcomes. Journal Of Robotic Surgery 2018, 12:295-301.
- A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability.Kohari K, Mehlhaff K, Merriam A, Abdel-Razeq S, Grechukhina O, Leon-Martinez D, Bahtiyar MO. A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability. AJP Reports 2018, 8:e180-e183.
- Cesarean Scar Pregnancy, Incidence, and Recurrence: Five-Year Experience at a Single Tertiary Care Referral Center.Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar MO, Sfakianaki AK. Cesarean Scar Pregnancy, Incidence, and Recurrence: Five-Year Experience at a Single Tertiary Care Referral Center. Obstetrics And Gynecology 2018, 132:1285-1295.
- Real-time computerized video enhancement for minimally invasive fetoscopic surgery.Sadda P, Onofrey J, Imamoglu M, Papademetris X, Qarni B, Bahtiyar MO. Real-time computerized video enhancement for minimally invasive fetoscopic surgery. Laparoscopic, Endoscopic, And Robotic Surgery 2018, 1:27-32.
- Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†.Rood KM, Buhimschi CS, Zhao G, Oliver EA, Summerfield T, Bahtiyar MO, Buhimschi IA. Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†. Biology Of Reproduction 2019, 100:773-782.
- Deep-learned placental vessel segmentation for intraoperative video enhancement in fetoscopic surgery.Sadda P, Imamoglu M, Dombrowski M, Papademetris X, Bahtiyar MO, Onofrey J. Deep-learned placental vessel segmentation for intraoperative video enhancement in fetoscopic surgery. International Journal Of Computer Assisted Radiology And Surgery 2019, 14:227-235.
- In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence.Bahtiyar MO, Ekmekci E, Demirel E, Irani RA, Copel JA. In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence. Fetal Diagnosis And Therapy 2019, 45:28-35.
- Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions.Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine : Official Journal Of The American Institute Of Ultrasound In Medicine 2019, 38:2361-2372.
- Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation.Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2020, 37:745-753.
- Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis.Kucukgoncu S, Guloksuz S, Celik K, Bahtiyar MO, Luykx JJ, Rutten BPF, Tek C. Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis. Schizophrenia Bulletin 2020, 46:311-318.
- Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction (Oxford, England) 1998, 13:3492-5.
- Fetal interventions in the setting of the coronavirus disease 2019 pandemic: statement from the North American Fetal Therapy Network.Bahtiyar MO, Baschat A, Deprest J, Emery S, Goodnight W, Johnson A, McCullough L, Moldenhauer J, Ryan G, Tsao K, Van Mieghem T, Wagner A, Zaretsky M. Fetal interventions in the setting of the coronavirus disease 2019 pandemic: statement from the North American Fetal Therapy Network. American Journal Of Obstetrics And Gynecology 2020, 223:281-284.
- Post-Laser Twin Anemia Polycythemia Sequence: Diagnosis, Management, and Outcome in an International Cohort of 164 Cases.Tollenaar LSA, Lopriore E, Faiola S, Lanna M, Stirnemann J, Ville Y, Lewi L, Devlieger R, Weingertner AS, Favre R, Hobson SR, Ryan G, Rodo C, Arévalo S, Klaritsch P, Greimel P, Hecher K, de Sousa MT, Khalil A, Thilaganathan B, Bergh EP, Papanna R, Gardener GJ, Carlin A, Bevilacqua E, Sakalo VA, Kostyukov KV, Bahtiyar MO, Wilpers A, Kilby MD, Tiblad E, Oepkes D, Middeldorp JM, Haak MC, Klumper FJCM, Akkermans J, Slaghekke F. Post-Laser Twin Anemia Polycythemia Sequence: Diagnosis, Management, and Outcome in an International Cohort of 164 Cases. Journal Of Clinical Medicine 2020, 9.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Pregnancy, Childbirth and the Puerperium | A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix (PROSPECT) |
| Pregnancy, Childbirth and the Puerperium | A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix (TOPS) |
| Pregnancy, Childbirth and the Puerperium; Hypertension | Chronic Hypertension and Pregnancy (CHAP) Project (CHAP) |
| Child Development & Autism | Understanding Neurodevelopment in Autism |
| Children's Health; Genetics - Pediatric | Pediatric Genomics Discovery Program (PGDP) |