Skip to Main Content

Mei-Ling Yang, PhD

Associate Research Scientist in Medicine (Rheumatology)

Contact Information

Mei-Ling Yang, PhD

Mailing Address

  • Rheumatology

    PO Box 208056, 333 Cedar Street

    New Haven, CT, 06520-8056

    United States

Extensive Research Description

Post-translational protein modification influences immunologic responses ranging from intracellular signaling to protein processing and presentation and creates neo-epitopes from self-proteins to break immune tolerance that leads to autoimmune diseases. Systemic erythematosus lupus (SLE) and type 1 diabetes (T1D) are the complex autoimmune diseases involving multiple genetic and environmental factors. My research is to investigate the role of posttranslational protein modifications including isoaspartyl modification, methylation, carbonylation and citrullination on genetic association analysis and biological functions of T cells in the pathogenesis of SLE and T1D. My work provides new insight into the diagnosis of autoimmune diseases where the specific auto-antigen is unknown and provides targets in autoimmune pathways to discover novel therapeutic concepts and biomarkers for inflammatory conditions.

Coauthors

Research Interests

Autoimmune Diseases; Diabetes Mellitus, Type 1; Lupus Erythematosus, Systemic

Selected Publications