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Mehran M Sadeghi, MD

Professor

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Mehran M Sadeghi, MD

Lab Locations

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Mailing Addresses

  • Cardiovascular Medicine

    950 Campbell Avenue, #111B

    West Haven, CT 06516

    United States

  • Yale Cardiovascular Research Center

    300 George Street

    New Haven, CT 06511

    United States

Sadeghi Lab
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Research Summary

Molecular imaging provides a unique opportunity to link vascular and molecular biology and imaging, ultimately leading to the development of novel imaging approaches, both for research and clinical diagnostics. The ultimate goal of research in my laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo. Our comprehensive approach includes several components. Through basic vascular biology research we identify relevant molecular processes and potential targets for imaging (and therapeutics). Next, we use the state of the art technology to develop novel tracers targeted at relevant molecular markers, and establish molecular vascular imaging protocols in animal models of human disease. Finally, we exploit these techniques to further advance vascular biology and clinical research. We have made significant progress towards achieving these goals in the past few years. Specifically, we have focused on vascular remodeling, as the prototypic pathological vascular process shared by many vascular diseases, including atherosclerosis, graft arteriosclerosis, post-angioplasty restenosis, and aneurysm formation.

Extensive Research Description

Despite remarkable recent progress in molecular and vascular biology research, little has been achieved in adapting traditional imaging modalities to detect molecular pathobiology in vivo. Molecular imaging provides a unique opportunity to link vascular and molecular biology and imaging, ultimately leading to the development of novel imaging approaches, both for research and clinical diagnostics. The ultimate goal of research in my laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo. Our comprehensive approach includes several components. Through basic vascular biology research we identify relevant molecular processes and potential targets for imaging (and therapeutics). Next, we use the state of the art technology to develop novel tracers targeted at relevant molecular markers, and establish molecular vascular imaging protocols in animal models of human disease. Finally, we exploit these techniques to further advance vascular biology and clinical research. We have made significant progress towards achieving these goals in the past few years. Specifically, we have focused on vascular remodeling, as the prototypic pathological vascular process shared by many vascular diseases, including atherosclerosis, graft arteriosclerosis, post-angioplasty restenosis, and aneurysm formation. Our federally funded studies of the pathophysiology of vascular remodeling in graft arteriosclerosis, performed under the umbrella of the Interdepartmental Program in Vascular Biology and Transplantation at Yale have led to the identification novel molecular markers, including a neuropilin-like protein, ESDN, as a potential target for diagnosis and therapy of vascular remodeling. We have demonstrated that ESDN is upregulated in vascular remodeling, and have defined its function as regulator of vascular cell proliferation in vivo. We are currently in the process of defining other aspects of ESDN function, including its role in growth factor and integrin signaling pathways, and identification of ESDN ligands. In molecular imaging arena, we have identified and validated avß3 integrin activation as a target for imaging the proliferative process in vascular remodeling, and have demonstrated the suitability of avß3-targeted tracers for imaging graft arteriosclerosis. Matrix metalloproteinase (MMP) activation, as a key regulator of vascular remodeling, was targeted for in vivo imaging of injury-induced vascular remodeling and aneurysm formation using high resolution microSPECT imaging in conjunction with CT angiography for anatomical localization. We are currently in the process of optimizing the technical aspects of in vivo microSPECT/CT imaging to improve visualization and quantitation of molecular targets. In parallel, we have developed a novel “tracer design” concept for in vivo applications and have been involved in the development of a novel intravascular detection system which combines scintigraphy with high resolution optical coherence tomography imaging.

  • Molecular Imaging of Vascular and Valvular Remodeling
  • Molecular Imaging of Plaque Vulnerability and Aneurysm
  • Neuropilin-like Proteins in Vascular Remodeling

Coauthors

Research Interests

Aneurysm; Aortic Aneurysm; Aortic Diseases; Aortic Valve; Aortic Valve Stenosis; Cardiovascular Diseases; Heart Diseases; Industry; Molecular Biology; Cardiomyopathies; Radioactive Tracers; Technology; Tomography, X-Ray Computed; Vascular Diseases; Molecular Probes; Peripheral Vascular Diseases; Diagnostic Techniques and Procedures; Biomedical Technology; Early Diagnosis; Positron-Emission Tomography; Molecular Imaging; Optical Imaging; Diseases; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Health Care; Single Photon Emission Computed Tomography Computed Tomography

Selected Publications

  • 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 8301-5 PubMed ID: 12048257, PMCID: PMC123062, DOI: 10.1073/pnas.122228799.
  • Lake Tahoe Invitation Meeting 2002; Vascular ImagingTatum JL, Narula J, Bender JR, Heller G, Sadeghi MM, Strauss HW: doi:10.1067.mnc.2003.391, Journal of Nuclear Cardiology, 2003; 10(2): 234-237
  • Simultaneous optical coherence tomography imaging and beta particle detection.Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Optics Letters 2003, 28: 1704-6 PubMed ID: 13677543, DOI: 10.1364/ol.28.001704.
  • Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo.Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo. Circulation 2004, 110: 84-90 PubMed ID: 15210600, DOI: 10.1161/01.CIR.0000133319.84326.70.
  • Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction.Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. The Journal Of Clinical Investigation 2004, 113: 1684-91 PubMed ID: 15199403, PMCID: PMC420502, DOI: 10.1172/JCI20352.
  • Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27.Zeng L, Xu H, Chew TL, Chisholm R, Sadeghi MM, Kanwar YS, Danesh FR. Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. Journal Of The American Society Of Nephrology : JASN 2004, 15: 1711-20 PubMed ID: 15213258, DOI: 10.1097/01.asn.0000129839.91567.68.
  • Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature.Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36: 1585-91 PubMed ID: 15251390, DOI: 10.1016/j.transproceed.2004.05.060.
  • Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models.Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Journal Of Biomedical Optics 2005, 10: 44010 PubMed ID: 16178644, DOI: 10.1117/1.1954773.
  • Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study.Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM. Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2005, 19: 1857-9 PubMed ID: 16150802, DOI: 10.1096/fj.05-4130fje.
  • Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia.Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation 2005, 111: 3255-60 PubMed ID: 15956134, DOI: 10.1161/CIRCULATIONAHA.104.485029.
  • HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation.Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2005, 19: 1845-7 PubMed ID: 16160062, DOI: 10.1096/fj.05-4240fje.
  • HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation.Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. American Journal Of Physiology. Renal Physiology 2006, 291: F995-1004 PubMed ID: 16774905, DOI: 10.1152/ajprenal.00092.2006.
  • The pathobiology of the vessel wall: implications for imaging.Sadeghi MM. The pathobiology of the vessel wall: implications for imaging. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2006, 13: 402-14 PubMed ID: 16750785, DOI: 10.1016/j.nuclcard.2006.03.012.
  • Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling.Sadeghi MM, Bender JR. Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling. Trends In Cardiovascular Medicine 2007, 17: 5-10 PubMed ID: 17210471, DOI: 10.1016/j.tcm.2006.07.003.
  • ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis.Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER. ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2007, 7: 2098-105 PubMed ID: 17697260, DOI: 10.1111/j.1600-6143.2007.01919.x.
  • Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction.Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology (Bethesda, Md. : 1985) 2008, 104: 1504-12 PubMed ID: 18356482, DOI: 10.1152/japplphysiol.00861.2007.
  • Molecular imaging of activated matrix metalloproteinases in vascular remodeling.Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation 2008, 118: 1953-60 PubMed ID: 18936327, PMCID: PMC2637824, DOI: 10.1161/CIRCULATIONAHA.108.789743.
  • Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging ReportsTavakoli S, Sadeghi MM, Imaging of Vascular Biology in the Heart Current Cardiovascular Imaging Reports, 2009, 2:40-49.
  • Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination.Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. The Journal Of Biological Chemistry 2009, 284: 29376-82 PubMed ID: 19696027, PMCID: PMC2785569, DOI: 10.1074/jbc.M109.049684.
  • Multimodality cardiovascular molecular imaging, Part II.Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality cardiovascular molecular imaging, Part II. Circulation. Cardiovascular Imaging 2009, 2: 56-70 PubMed ID: 19808565, PMCID: PMC2760054, DOI: 10.1161/CIRCIMAGING.108.839092.
  • Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury.Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology : An Official Journal Of The Polish Physiological Society 2009, 60 Suppl 4: 117-23 PubMed ID: 20083860.
  • Imaging atherosclerosis and vulnerable plaque.Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging atherosclerosis and vulnerable plaque. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2010, 51 Suppl 1: 51S-65S PubMed ID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.
  • Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo.Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2010, 51: 1107-15 PubMed ID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.
  • VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling.Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM. VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circulation Research 2010, 107: 408-17 PubMed ID: 20538685, PMCID: PMC2929975, DOI: 10.1161/CIRCRESAHA.109.210963.
  • Cardiovascular nuclear imaging: balancing proven clinical value and potential radiation risk.Cardiovascular Council Board of Directors.. Cardiovascular nuclear imaging: balancing proven clinical value and potential radiation risk. J Nucl Med 2011, 52:1162-4.
  • Integrin-targeted imaging of inflammation in vascular remodeling.Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-targeted imaging of inflammation in vascular remodeling. Arteriosclerosis, Thrombosis, And Vascular Biology 2011, 31: 2820-6 PubMed ID: 21940943, PMCID: PMC3228522, DOI: 10.1161/ATVBAHA.111.231654.
  • Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation.Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2011, 52: 1795-802 PubMed ID: 21969358, PMCID: PMC3235922, DOI: 10.2967/jnumed.111.092379.
  • Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries.Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arteriosclerosis, Thrombosis, And Vascular Biology 2011, 31: 102-9 PubMed ID: 20947820, PMCID: PMC3005135, DOI: 10.1161/ATVBAHA.110.216036.
  • Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis.Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2012, 32: 1849-55 PubMed ID: 22723442, PMCID: PMC3401339, DOI: 10.1161/ATVBAHA.112.252510.
  • Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis.Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology 2012, 119: 765-70 PubMed ID: 22197438, PMCID: PMC3314126, DOI: 10.1016/j.ophtha.2011.09.044.
  • Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. The Journal Of Clinical Investigation 2013, 123: 5082-97 PubMed ID: 24177422, PMCID: PMC3859420, DOI: 10.1172/JCI67752.
  • Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis, Thrombosis, And Vascular Biology 2014, 34: 2387-93 PubMed ID: 25189570, PMCID: PMC4199903, DOI: 10.1161/ATVBAHA.114.302523.
  • Lipid lowering and imaging protease activation in atherosclerosis.Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21: 319-328 PubMed ID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.
  • Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management.Golestani R, Sadeghi MM. Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21: 251-67; quiz 268-70 PubMed ID: 24381115, PMCID: PMC3991015, DOI: 10.1007/s12350-013-9845-5.
  • Molecular imaging of plaque vulnerability.Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2014, 21: 1112-28; quiz 1129 PubMed ID: 25124827, PMCID: PMC4229449, DOI: 10.1007/s12350-014-9959-4.
  • Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease.Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2015, 56: 933-8 PubMed ID: 25908827, PMCID: PMC4454445, DOI: 10.2967/jnumed.114.152355.
  • Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients. Circulation Research 2015, 117: 943-55 PubMed ID: 26399469, PMCID: PMC4636943, DOI: 10.1161/CIRCRESAHA.115.306932.
  • (18)F-FDG PET and vascular inflammation: time to refine the paradigm?Sadeghi MM. (18)F-FDG PET and vascular inflammation: time to refine the paradigm? Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22: 319-24 PubMed ID: 24925623, PMCID: PMC4265310, DOI: 10.1007/s12350-014-9917-1.
  • Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm.Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circulation. Cardiovascular Imaging 2015, 8 PubMed ID: 25550400, PMCID: PMC4284949, DOI: 10.1161/CIRCIMAGING.114.002471.
  • Cardiovascular molecular imaging: Expanding the paradigms and parameters.Sadeghi MM, Wu JC. Cardiovascular molecular imaging: Expanding the paradigms and parameters. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2015, 22: 401-2 PubMed ID: 25809082, PMCID: PMC4807129, DOI: 10.1007/s12350-015-0110-y.
  • A New Tracer for Imaging Atherosclerosis.Toczek J, Sadeghi MM. A New Tracer for Imaging Atherosclerosis. Circulation. Cardiovascular Imaging 2016, 9 PubMed ID: 27162132, DOI: 10.1161/CIRCIMAGING.116.004889.
  • Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification.Toczek J, Meadows JL, Sadeghi MM. Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification. Circulation. Cardiovascular Imaging 2016, 9: e003023 PubMed ID: 26763279, PMCID: PMC4714781, DOI: 10.1161/CIRCIMAGING.115.003023.
  • Optical imaging of MMP-12 active form in inflammation and aneurysm.Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM. Optical imaging of MMP-12 active form in inflammation and aneurysm. Scientific Reports 2016, 6: 38345 PubMed ID: 27917892, PMCID: PMC5137160, DOI: 10.1038/srep38345.
  • Molecular imaging concepts.Toczek J, Sadeghi MM. Molecular imaging concepts. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2016, 23: 271-3 PubMed ID: 26809440, PMCID: PMC4807131, DOI: 10.1007/s12350-016-0403-9.
  • Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjugate Chemistry 2016, 27: 2407-2417 PubMed ID: 27564088, PMCID: PMC5100701, DOI: 10.1021/acs.bioconjchem.6b00377.
  • Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice.Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659 PubMed ID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.
  • The neuropilin-like protein ESDN regulates insulin signaling and sensitivity.Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. American Journal Of Physiology. Heart And Circulatory Physiology 2016, 310: H1184-93 PubMed ID: 26921437, PMCID: PMC4867389, DOI: 10.1152/ajpheart.00782.2015.
  • Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology.Golestani R, Jung JJ, Sadeghi MM. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology. Journal Of Clinical Medicine 2016, 5 PubMed ID: 27275836, PMCID: PMC4929412, DOI: 10.3390/jcm5060057.
  • Molecular cardiovascular imaging is ready for prime time: almost there.Sadeghi MM. Molecular cardiovascular imaging is ready for prime time: almost there. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2016, 23: 67-70 PubMed ID: 26542993, DOI: 10.1007/s12350-015-0237-x.
  • Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production.Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37: 328-340 PubMed ID: 27834690, PMCID: PMC5269510, DOI: 10.1161/ATVBAHA.116.308507.
  • Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling.Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58: 138-143 PubMed ID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.
  • Joint SNMMI-ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring.Chareonthaitawee P, Beanlands RS, Chen W, Dorbala S, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, Di Carli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. Joint SNMMI-ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58: 1341-1353 PubMed ID: 28765228, PMCID: PMC6944184, DOI: 10.2967/jnumed.117.196287.
  • Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation.Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology 2017, 283: 87-97 PubMed ID: 27849433, PMCID: PMC5375627, DOI: 10.1148/radiol.2016160839.
  • Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2017, 58: 1318-1323 PubMed ID: 28360209, PMCID: PMC5537616, DOI: 10.2967/jnumed.116.188656.
  • Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis.Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2017, 37: 1840-1848 PubMed ID: 28798141, PMCID: PMC8036006, DOI: 10.1161/ATVBAHA.117.308848.
  • Multi-modality molecular imaging of aortic aneurysms.Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2017, 24: 1239-1245 PubMed ID: 28447279, PMCID: PMC7720418, DOI: 10.1007/s12350-017-0883-2.
  • Myocardial perfusion imaging: Lessons learned and work to be done-update.Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done-update. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25: 39-52 PubMed ID: 29110288, DOI: 10.1007/s12350-017-1093-7.
  • Molecular imaging of calcific aortic valve disease.Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2018, 25: 1148-1155 PubMed ID: 29359271, PMCID: PMC6054901, DOI: 10.1007/s12350-017-1158-7.
  • Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation.Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8: 11647 PubMed ID: 30076321, PMCID: PMC6076275, DOI: 10.1038/s41598-018-29941-2.
  • 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging.Sadeghi MM. 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2018, 59: 9N-15N PubMed ID: 30181235.
  • Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population.He BJ, Malm BJ, Carino M, Sadeghi MM. Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2019, 26: 1688-1693 PubMed ID: 29492838, DOI: 10.1007/s12350-018-1232-9.
  • 18F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification.Tavakoli S, Sadeghi MM. 18F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification. Circulation. Cardiovascular Imaging 2019, 12: e008712 PubMed ID: 30642218, PMCID: PMC6338233, DOI: 10.1161/CIRCIMAGING.118.008712.
  • PET-Based Imaging of Ischemic Heart Disease.Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14: 211-221 PubMed ID: 30826019, PMCID: PMC6426655, DOI: 10.1016/j.cpet.2018.12.003.
  • Reply to letter to the editor regarding "prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population".Malm BJ, He BJ, Carino M, Sadeghi MM. Reply to letter to the editor regarding "prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population". Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27: 1054 PubMed ID: 30825113, DOI: 10.1007/s12350-019-01667-2.
  • FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study.Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28: 688-694 PubMed ID: 31073848, PMCID: PMC6842076, DOI: 10.1007/s12350-019-01724-w.
  • Hype or Hope18F-NaF Positron Emission Tomography for Vulnerable Coronary Plaque Imaging.Salarian M, Sadeghi MM. Hype or Hope18F-NaF Positron Emission Tomography for Vulnerable Coronary Plaque Imaging. Circulation. Cardiovascular Imaging 2019, 12: e009591 PubMed ID: 31382767, PMCID: PMC6788767, DOI: 10.1161/CIRCIMAGING.119.009591.
  • Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging.Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Yunpeng Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62: 9743-9752 PubMed ID: 31603669, PMCID: PMC7054845, DOI: 10.1021/acs.jmedchem.9b01186.
  • Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis.Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight 2019, 4 PubMed ID: 31613798, PMCID: PMC6948871, DOI: 10.1172/jci.insight.131102.
  • Imaging Targets in Atherosclerosis.Smith, D., Sadeghi, MM, Bender, JR: Textbook of Cardiovascular Molecular Imaging. Informa Healthcare Publishing. Ed. Sinusas A, Gropler R, Glover D, Taegtmeyer H. 2007: Ch. 18, p. 189-202.
  • Molecular Imaging of Vascular Inflammation, Atherosclerosis, and ThrombosisJane-Wit D and Sadeghi MM: Molecular and Translational Vascular Medicine. Springer Science+Business Media New York. Ed. Homeister JW and Willis MS 2012: Ch. 5, 129-168.
  • Applications of Molecular Small-Animal Imaging in CardiologyMarfatia R, Tavakoli S, Sadeghi MM: Multimodality Molecular Imaging of Small Animals. Springer Science+Business Media New York. Ed. Zaidi H. 2014: Ch. 20, 525-560.
  • Chapter 9: Cardiovascular Molecular ImagingMorrison A, Wu JC, Sadeghi MM: Nuclear Cardiac Imaging: Principles and Applications, 5th Edition. Oxford University Press. New York, NY. Ed. Iskandrian A and Garcia E. 2015: Ch. 29, 601-36.
  • Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses.Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3994-8 PubMed ID: 7513430, PMCID: PMC43709, DOI: 10.1073/pnas.91.9.3994.
  • Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein.Sadeghi MM, Collinge M, Pardi R, Bender JR. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 165: 2712-8 PubMed ID: 10946302, DOI: 10.4049/jimmunol.165.5.2712.
  • Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors.Sadeghi MM, Tiglio A, Sadigh K, O'Donnell L, Collinge M, Pardi R, Bender JR. Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation 2001, 71: 1262-8 PubMed ID: 11397960, DOI: 10.1097/00007890-200105150-00014.
  • 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging.Sadeghi MM. 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2019, 60: 7N-13N PubMed ID: 31792135.
  • Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2020, 27: 1578-1581 PubMed ID: 32043239, PMCID: PMC7415600, DOI: 10.1007/s12350-020-02055-x.
  • 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers.Pucar D, Sadeghi MM. 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021, 28: 1017-1020 PubMed ID: 32607838, PMCID: PMC7772274, DOI: 10.1007/s12350-020-02248-4.
  • 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging.Sadeghi MM. 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2020, 61: 15N-22N PubMed ID: 33139397.
  • Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging.Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049 PubMed ID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.
  • Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database.Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74: 729-737 PubMed ID: 33617982, DOI: 10.1016/j.jvs.2021.01.063.
  • Advancing the mission of cardiovascular molecular imaging.Dorbala S, Zhou W, Sadeghi M. Advancing the mission of cardiovascular molecular imaging. Journal Of Nuclear Cardiology : Official Publication Of The American Society Of Nuclear Cardiology 2021 PubMed ID: 33655449, PMCID: PMC7924910, DOI: 10.1007/s12350-021-02534-9.
  • ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3.Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Cancer Letters 2021, 510: 13-23 PubMed ID: 33862151, PMCID: PMC8581997, DOI: 10.1016/j.canlet.2021.04.005.
  • Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm.Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11: 5876-5888 PubMed ID: 33897887, PMCID: PMC8058712, DOI: 10.7150/thno.55106.

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Mental Health & Behavioral ResearchImaging Microglial Activation in PTSD wITH PET
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