Mateus Guerra, PhD
Senior Staff Scientist
Research & Publications
Biography
Research Summary
The unifying theme of my research has been the study of Ca2+ signaling mechanisms in the pathophysiology of liver diseases. For that, I employ a combination of biochemical, molecular biology, fluorescence imaging and in vivo studies to investigate the role of Ca2+ signaling in relevant models of cholestatic diseases, liver regeneration and liver tumor growth. My expertise is the use of multiple microscopy techniques from confocal to super resolution to interrogate changes in cellular and subcellular Ca2+ and how these changes related to the function of different cell types within the liver and in other organ systems.
Coauthors
Selected Publications
- Above the legal limit: Alcohol brings ER and mitochondria too close togetherGuerra M, Nathanson M. Above the legal limit: Alcohol brings ER and mitochondria too close together. Cell Calcium 2023, 113: 102763. PMID: 37235972, PMCID: PMC10726477, DOI: 10.1016/j.ceca.2023.102763.
- 219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial OxidationLAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, MOOTHA V, SHULMAN G. 219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation. Diabetes 2022, 71 DOI: 10.2337/db22-219-lb.
- Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tractLemos F, Guerra M, de Fátima Leite M. Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract. Current Opinion In Physiology 2020, 17: 169-174. DOI: 10.1016/j.cophys.2020.08.003.
- AS080 Interaction between neutrophils and cholangiocytes causes cholestasis in alcoholic hepatitisTakeuchi M, Vidigal P, Guerra M, Hundt M, Robert M, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, Banales J, Nathanson M, Weerachayaphorn J. AS080 Interaction between neutrophils and cholangiocytes causes cholestasis in alcoholic hepatitis. Journal Of Hepatology 2020, 73: s58-s59. DOI: 10.1016/s0168-8278(20)30659-0.
- 224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and GluconeogenesisLAMOIA T, LEE J, GUERRA M, GOODMAN R, SHULMAN G. 224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis. Diabetes 2020, 69 DOI: 10.2337/db20-224-lb.
- Ca2+ Signaling in the LiverGuerra M, Leite M, Nathanson M. Ca2+ Signaling in the Liver. 2020, 496-508. DOI: 10.1002/9781119436812.ch40.
- Signaling pathways in biliary epithelial cellsLeite M, Guerra M, Andrade V, Nathanson M. Signaling pathways in biliary epithelial cells. 2015, 15-33. DOI: 10.1002/9781118663387.ch2.
- Signaling pathways in biliary epithelial cellsLeite Mde, F., et al. (2015). Signaling Pathways in Liver Diseases. J. F. Dufour and P. A. Clavien, Wiley-Blackwell: 520.
- Mitochondrial Calcium Regulates Liver Regeneration Through Modulation of ApoptosisMelo F, Guerra M, Andrade V, Fonseca E, Souza-Fagundes E, Menezes G, de Paula A, Nathanson M, Leite M. Mitochondrial Calcium Regulates Liver Regeneration Through Modulation of Apoptosis. Gastroenterology 2011, 140: s-472. DOI: 10.1016/s0016-5085(11)61941-0.
- 538 Regulation of MRP2 by Calcium SignalingGuerra M, Cruz L, Kruglov E, Garcia C, Chen J, Nathanson M. 538 Regulation of MRP2 by Calcium Signaling. Gastroenterology 2010, 138: s-790. DOI: 10.1016/s0016-5085(10)63641-4.
- Ca2+ Signaling in the LiverLeite F, Guerra M, Nathanson M. Ca2+ Signaling in the Liver. 2009, 485-510. DOI: 10.1002/9780470747919.ch32.
- Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]Marius P, Guerra M, Nathanson M, Ehrlich B, Leite M. Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]. Cell Calcium 2006, 39: 551. DOI: 10.1016/j.ceca.2006.02.001.
- Calcium release from ryanodine receptors in the nucleoplasmic reticulumMarius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF. Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium 2005, 39: 65-73. PMID: 16289270, DOI: 10.1016/j.ceca.2005.09.010.
- Ca2+ in the nucleus is independently regulated and has distinct effects on protein kinase C (PKC) in a liver cell lineGuerra M, de Fatima Leite M, Echevarria W, Nathanson M. Ca2+ in the nucleus is independently regulated and has distinct effects on protein kinase C (PKC) in a liver cell line. Gastroenterology 2003, 124: a689. DOI: 10.1016/s0016-5085(03)83484-4.