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Mark Perazella, MD

Professor of Medicine (Nephrology); Director, Acute Dialysis Unit; Medical Director, Yale Physician Associate Program; Medical Director, Yale PA Online Program

Contact Information

Mark Perazella, MD

Mailing Address

  • Nephrology

    PO Box 208029

    New Haven, CT 06520–8029

    United States

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Research Summary

  1. Onco-nephrology:
  2. Diagnostic utility of urine microscopy in AKI:
    Urine sediment utility in distinguishing ATN from prerenal azotemia; Prognostic value of the urine sediment in predicting AKI severity;
  3. Adverse renal effects of therapeutic agents and other drugs;
  4. Hypotension in ESRD patients during Hemodialysis:
    Role of vasopressin deficiency in intradialytic hypotension (IDH); Utility of midodrine in treatment of IDH; Potential utility of vasopressin in the treatment of IDH
  5. HIV-related kidney disease:
    Diagnosis and management with HAART, Nephrotoxicity of therapeutic agents (HAART); Nephrogenic systemic fibrosis; Treatment with sodium thiosulfate.

Specialized Terms: Diagnostic utility of urine microscopy in AKI; Adverse renal effects of therapeutic agents and other drugs; Hypotension in ESRD patients during hemodialysis; HIV-related kidney disease; Nephrogenic systemic fibrosis

Coauthors

Research Interests

Dialysis; Hemodialysis Units, Hospital; HIV; Hypotension; Kidney Diseases; Kidney Failure, Chronic; Nephrology; Nephrogenic Fibrosing Dermopathy; Drug-Related Side Effects and Adverse Reactions

Selected Publications

  • Improving Cancer Care for Patients With Chronic Kidney Disease.Sprangers B, Jhaveri KD, Perazella MA. Improving Cancer Care for Patients With Chronic Kidney Disease. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2020, 38: 188-192. PMID: 31800342, DOI: 10.1200/JCO.19.02138.
  • Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation.Renaghan AD, Jaimes EA, Malyszko J, Perazella MA, Sprangers B, Rosner MH. Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation. Clinical Journal Of The American Society Of Nephrology : CJASN 2020, 15: 289-297. PMID: 31836598, PMCID: PMC7015091, DOI: 10.2215/CJN.08580719.
  • Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation.Davenport MS, Perazella MA, Yee J, Dillman JR, Fine D, McDonald RJ, Rodby RA, Wang CL, Weinreb JC. Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Radiology 2020, 294: 660-668. PMID: 31961246, DOI: 10.1148/radiol.2019192094.
  • SGLT2 inhibitor therapy in patients with type-2 diabetes mellitus: is acute kidney injury a concern?Baker ML, Perazella MA. SGLT2 inhibitor therapy in patients with type-2 diabetes mellitus: is acute kidney injury a concern? Journal Of Nephrology 2020, 33: 985-994. PMID: 32067179, DOI: 10.1007/s40620-020-00712-5.
  • Is urine microscopy a useful early biomarker for cardiac surgeryrelated AKI?Perazella MA. Is urine microscopy a useful early biomarker for cardiac surgeryrelated AKI? Jornal Brasileiro De Nefrologia : 'orgão Oficial De Sociedades Brasileira E Latino-Americana De Nefrologia 2020, 42: 1-3. PMID: 32129787, PMCID: PMC7213936, DOI: 10.1590/2175-8239-JBN-2019-0208.
  • COVID-19 therapeutic options for patients with kidney disease.Izzedine H, Jhaveri KD, Perazella MA. COVID-19 therapeutic options for patients with kidney disease. Kidney International 2020, 97: 1297-1298. PMID: 32317113, PMCID: PMC7271263, DOI: 10.1016/j.kint.2020.03.015.
  • How to determine kidney function in cancer patients?Sprangers B, Abudayyeh A, Latcha S, Perazella MA, Jhaveri KD. How to determine kidney function in cancer patients? European Journal Of Cancer (Oxford, England : 1990) 2020, 132: 141-149. PMID: 32361629, DOI: 10.1016/j.ejca.2020.03.026.
  • Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Hoorn EJ, Ingelfinger JR, Inker LA, Levin A, Mehrotra R, Palevsky PM, Perazella MA, Tong A, Allison SJ, Bockenhauer D, Briggs JP, Bromberg JS, Davenport A, Feldman HI, Fouque D, Gansevoort RT, Gill JS, Greene EL, Hemmelgarn BR, Kretzler M, Lambie M, Lane PH, Laycock J, Leventhal SE, Mittelman M, Morrissey P, Ostermann M, Rees L, Ronco P, Schaefer F, St Clair Russell J, Vinck C, Walsh SB, Weiner DE, Cheung M, Jadoul M, Winkelmayer WC. Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney International 2020, 97: 1117-1129. PMID: 32409237, DOI: 10.1016/j.kint.2020.02.010.
  • Vascular injury and COVID-19-related mortality: What lies below the tip of the iceberg?Izzedine H, Jhaveri KD, Perazella MA. Vascular injury and COVID-19-related mortality: What lies below the tip of the iceberg? Clinical Nephrology 2020, 94: 11-13. PMID: 32452757, DOI: 10.5414/CN110217.
  • NSAIDs in CKD: Are They Safe?Baker M, Perazella MA. NSAIDs in CKD: Are They Safe? American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2020, 76: 546-557. PMID: 32479922, DOI: 10.1053/j.ajkd.2020.03.023.
  • Adverse Drug Effects in Patients with CKD: Primum Non Nocere.Perazella MA, Nolin TD. Adverse Drug Effects in Patients with CKD: Primum Non Nocere. Clinical Journal Of The American Society Of Nephrology : CJASN 2020, 15: 1075-1077. PMID: 32611663, PMCID: PMC7409750, DOI: 10.2215/CJN.08890620.
  • Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events.Herrmann SM, Perazella MA. Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events. Kidney International Reports 2020, 5: 1139-1148. PMID: 32775813, PMCID: PMC7403510, DOI: 10.1016/j.ekir.2020.04.018.
  • In Reply to 'Contrast-Enhanced CT in Patients With Kidney Disease: Some Considerations in Response to the ACR/NKF Consensus'.Perazella MA, Weinreb JC, Davenport MS. In Reply to 'Contrast-Enhanced CT in Patients With Kidney Disease: Some Considerations in Response to the ACR/NKF Consensus'. Kidney Medicine 2020, 2: 501. PMID: 32775994, PMCID: PMC7406849, DOI: 10.1016/j.xkme.2020.06.002.
  • Assessment of Interobserver Reliability of Nephrologist Examination of Urine Sediment.Palsson R, Colona MR, Hoenig MP, Lundquist AL, Novak JE, Perazella MA, Waikar SS. Assessment of Interobserver Reliability of Nephrologist Examination of Urine Sediment. JAMA Network Open 2020, 3: e2013959. PMID: 32821922, PMCID: PMC7442930, DOI: 10.1001/jamanetworkopen.2020.13959.
  • Onconephrology: The intersections between the kidney and cancer.Rosner MH, Jhaveri KD, McMahon BA, Perazella MA. Onconephrology: The intersections between the kidney and cancer. CA: A Cancer Journal For Clinicians 2021, 71: 47-77. PMID: 32853404, DOI: 10.3322/caac.21636.
  • In Case of a Pandemic, Pivot: Moving the National Kidney Foundation Spring Clinical Meeting Online.Kramer H, Joseph J, Rosner MH, Perazella MA. In Case of a Pandemic, Pivot: Moving the National Kidney Foundation Spring Clinical Meeting Online. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2021, 77: 1-3. PMID: 32976856, PMCID: PMC7511158, DOI: 10.1053/j.ajkd.2020.09.004.
  • A Hospital-Based Program to Reduce Central Line-Associated Bloodstream Infections among Hospitalized Patients Receiving Hemodialysis Using a Central Venous Catheter for Vascular Access.Conwell P, Aniskiewicz M, Ghidini J, DeVaux L, Perazella M, Giullian J. A Hospital-Based Program to Reduce Central Line-Associated Bloodstream Infections among Hospitalized Patients Receiving Hemodialysis Using a Central Venous Catheter for Vascular Access. Nephrology Nursing Journal : Journal Of The American Nephrology Nurses' Association 2019, 46: 587-590. PMID: 31872988.
  • Drug-induced glomerular disease: direct cellular injury.Markowitz GS, Bomback AS, Perazella MA. Drug-induced glomerular disease: direct cellular injury. Clinical Journal Of The American Society Of Nephrology : CJASN 2015, 10: 1291-9. PMID: 25862776, PMCID: PMC4491280, DOI: 10.2215/CJN.00860115.
  • Crystalline-induced kidney disease: a case for urine microscopy.Luciano RL, Perazella MA. Crystalline-induced kidney disease: a case for urine microscopy. Clinical Kidney Journal 2015, 8: 131-6. PMID: 25815167, PMCID: PMC4370296, DOI: 10.1093/ckj/sfu105.
  • Thrombotic microangiopathy, cancer, and cancer drugs.Izzedine H, Perazella MA. Thrombotic microangiopathy, cancer, and cancer drugs. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2015, 66: 857-68. PMID: 25943718, DOI: 10.1053/j.ajkd.2015.02.340.
  • New drug toxicities in the onco-nephrology world.Perazella MA, Izzedine H. New drug toxicities in the onco-nephrology world. Kidney International 2015, 87: 909-17. PMID: 25671763, DOI: 10.1038/ki.2015.30.
  • The urine sediment as a biomarker of kidney disease.Perazella MA. The urine sediment as a biomarker of kidney disease. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2015, 66: 748-55. PMID: 25943719, DOI: 10.1053/j.ajkd.2015.02.342.
  • Renal vulnerability to drug toxicity.Perazella MA. Renal vulnerability to drug toxicity. Clinical Journal Of The American Society Of Nephrology : CJASN 2009, 4: 1275-83. PMID: 19520747, DOI: 10.2215/CJN.02050309.
  • Acute phosphate nephropathy.Markowitz GS, Perazella MA. Acute phosphate nephropathy. Kidney International 2009, 76: 1027-34. PMID: 19675530, DOI: 10.1038/ki.2009.308.
  • Extreme hyperphosphatemia and acute renal failure after a phosphorus-containing bowel regimen.Orias M, Mahnensmith RL, Perazella MA. Extreme hyperphosphatemia and acute renal failure after a phosphorus-containing bowel regimen. American Journal Of Nephrology 1999, 19: 60-3. PMID: 10085452, DOI: 10.1159/000013427.
  • Use of Intravenous Iodinated Contrast Media in Patients With Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation.Davenport MS, Perazella MA, Yee J, Dillman JR, Fine D, McDonald RJ, Rodby RA, Wang CL, Weinreb JC. Use of Intravenous Iodinated Contrast Media in Patients With Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Kidney Medicine 2020, 2: 85-93. PMID: 33015613, PMCID: PMC7525144, DOI: 10.1016/j.xkme.2020.01.001.
  • Enalapril treatment of posttransplant erythrocytosis: efficacy independent of circulating erythropoietin levels.Perazella M, McPhedran P, Kliger A, Lorber M, Levy E, Bia MJ. Enalapril treatment of posttransplant erythrocytosis: efficacy independent of circulating erythropoietin levels. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 1995, 26: 495-500. PMID: 7645558, DOI: 10.1016/0272-6386(95)90496-4.
  • Posttransplant erythrocytosis: case report and review of newer treatment modalities.Perazella MA, Bia MJ. Posttransplant erythrocytosis: case report and review of newer treatment modalities. Journal Of The American Society Of Nephrology : JASN 1993, 3: 1653-9. PMID: 8318681.
  • ACE inhibitors do not induce recombinant human erythropoietin resistance in hemodialysis patients.Abu-Alfa AK, Cruz D, Perazella MA, Mahnensmith RL, Simon D, Bia MJ. ACE inhibitors do not induce recombinant human erythropoietin resistance in hemodialysis patients. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2000, 35: 1076-82. PMID: 10845820, DOI: 10.1016/s0272-6386(00)70043-6.
  • Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis.Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology, Dialysis, Transplantation : Official Publication Of The European Dialysis And Transplant Association - European Renal Association 2021, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.
  • Use of Intravenous Gadolinium-based Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation.Weinreb JC, Rodby RA, Yee J, Wang CL, Fine D, McDonald RJ, Perazella MA, Dillman JR, Davenport MS. Use of Intravenous Gadolinium-based Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Radiology 2021, 298: 28-35. PMID: 33170103, DOI: 10.1148/radiol.2020202903.
  • Peritonitis associated with disseminated Mycobacterium avium complex in an acquired immunodeficiency syndrome patient on chronic ambulatory peritoneal dialysis.Perazella M, Eisen T, Brown E. Peritonitis associated with disseminated Mycobacterium avium complex in an acquired immunodeficiency syndrome patient on chronic ambulatory peritoneal dialysis. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 1993, 21: 319-21. PMID: 8447310, DOI: 10.1016/s0272-6386(12)80753-0.
  • Use of Intravenous Gadolinium-Based Contrast Media in Patients With Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation.Weinreb JC, Rodby RA, Yee J, Wang CL, Fine D, McDonald RJ, Perazella MA, Dillman JR, Davenport MS. Use of Intravenous Gadolinium-Based Contrast Media in Patients With Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Kidney Medicine 2021, 3: 142-150. PMID: 33604544, PMCID: PMC7873723, DOI: 10.1016/j.xkme.2020.10.001.
  • Checkpoint inhibitor therapy-associated acute kidney injury: time to move on to evidence-based recommendations.Perazella MA, Sprangers B. Checkpoint inhibitor therapy-associated acute kidney injury: time to move on to evidence-based recommendations. Clinical Kidney Journal 2021, 14: 1301-1306. PMID: 33970161, PMCID: PMC8087122, DOI: 10.1093/ckj/sfab052.
  • Genes, COVID-19 and phenotype.Izzedine H, Jhaveri KD, Perazella MA. Genes, COVID-19 and phenotype. Clinical Kidney Journal 2021, 14: 1485-1487. PMID: 34221375, PMCID: PMC7928999, DOI: 10.1093/ckj/sfab044.
  • Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data.Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology, Dialysis, Transplantation : Official Publication Of The European Dialysis And Transplant Association - European Renal Association 2021 PMID: 34865148, DOI: 10.1093/ndt/gfab346.
  • The Crystalline Nephropathies.Perazella MA, Herlitz LC. The Crystalline Nephropathies. Kidney International Reports 2021, 6: 2942-2957. PMID: 34901567, PMCID: PMC8640557, DOI: 10.1016/j.ekir.2021.09.003.
  • Drug-Induced Acute Kidney Injury.Perazella MA, Rosner MH. Drug-Induced Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology : CJASN 2022 PMID: 35273009, DOI: 10.2215/CJN.11290821.
  • Angiotensin-converting enzyme inhibitor therapy in chronic hemodialysis patients: any evidence of erythropoietin resistance?Cruz DN, Perazella MA, Abu-Alfa AK, Mahnensmith RL. Angiotensin-converting enzyme inhibitor therapy in chronic hemodialysis patients: any evidence of erythropoietin resistance? American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 1996, 28: 535-40. PMID: 8840943, DOI: 10.1016/s0272-6386(96)90464-3.
  • Reduction in arteriovenous graft impairment: results of a vascular access surveillance protocol.Cayco AV, Abu-Alfa AK, Mahnensmith RL, Perazella MA. Reduction in arteriovenous graft impairment: results of a vascular access surveillance protocol. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 1998, 32: 302-8. PMID: 9708617, DOI: 10.1053/ajkd.1998.v32.pm9708617.
  • Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate.Alappan R, Cruz D, Abu-Alfa AK, Mahnensmith R, Perazella MA. Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 2001, 37: 294-9. PMID: 11157369, DOI: 10.1053/ajkd.2001.21292.
  • Experience with outpatient computed tomographic-guided renal biopsy.Margaryan A, Perazella MA, Mahnensmith RL, Abu-Alfa AK. Experience with outpatient computed tomographic-guided renal biopsy. Clinical Nephrology 2010, 74: 440-5. PMID: 21084047, DOI: 10.5414/cnp74440.
  • Immunotherapy-Related Acute Kidney Injury.Manohar S, Jhaveri KD, Perazella MA. Immunotherapy-Related Acute Kidney Injury. Advances In Chronic Kidney Disease 2021, 28: 429-437.e1. PMID: 35190109, DOI: 10.1053/j.ackd.2021.07.006.
  • Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy.Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For Immunotherapy Of Cancer 2022, 10 PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.
  • Can NSAIDs Be Used Safely for Analgesia in Patients with CKD?: COMMENTARY.Baker ML, Perazella MA. Can NSAIDs Be Used Safely for Analgesia in Patients with CKD?: COMMENTARY. Kidney360 2020, 1: 1192-1194. PMID: 35372870, PMCID: PMC8815502, DOI: 10.34067/KID.0004652020.
  • A Patient with Nephrotic Syndrome and Acute Flank Pain.Perazella MA. A Patient with Nephrotic Syndrome and Acute Flank Pain. Kidney360 2020, 1: 74-75. PMID: 35372858, PMCID: PMC8808488, DOI: 10.34067/KID.0000482019.
  • Clinical Images in Nephrology and Dialysis: Welcome to an Educational Feature.Perazella MA, Juncos LA, Allon M. Clinical Images in Nephrology and Dialysis: Welcome to an Educational Feature. Kidney360 2020, 1: 5. PMID: 35372859, PMCID: PMC8808492, DOI: 10.34067/KID.0000472019.
  • Introduction to Kidney 360.Allon M, Juncos LA, Perazella MA. Introduction to Kidney 360. Kidney360 2020, 1: 3-4. PMID: 35372862, PMCID: PMC8808487, DOI: 10.34067/KID.0000492019.
  • The Challenges of Acute Interstitial Nephritis: Time to Standardize.Moledina DG, Perazella MA. The Challenges of Acute Interstitial Nephritis: Time to Standardize. Kidney360 2021, 2: 1051-1055. PMID: 35373086, PMCID: PMC8791367, DOI: 10.34067/KID.0001742021.
  • Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection.Rehan A, Moeckel GW, Perazella MA. Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection. Kidney360 2022, 3: 405-406. PMID: 35373119, PMCID: PMC8967631, DOI: 10.34067/KID.0006102021.
  • Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: Commentary.Perazella MA. Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: Commentary. Kidney360 2020, 1: 166-168. PMID: 35378019, PMCID: PMC8809261, DOI: 10.34067/KID.0001072019.
  • Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy.Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.
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