2001
CAK-independent Activation of CDK6 by a Viral Cyclin
Kaldis P, Ojala P, Tong L, Mäkelä T, Solomon M. CAK-independent Activation of CDK6 by a Viral Cyclin. Molecular Biology Of The Cell 2001, 12: 3987-3999. PMID: 11739795, PMCID: PMC60770, DOI: 10.1091/mbc.12.12.3987.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesCyclinsEnzyme ActivationFluorescent Antibody TechniqueHerpesvirus 8, HumanHumansPhosphorylationProtein ConformationProtein Serine-Threonine KinasesTumor Cells, CulturedViral ProteinsConceptsKSHV-cyclinSarcoma-associated herpesvirusKaposi's sarcoma-associated herpesvirusCell cycle progression independentAbsence of phosphorylationCyclin-dependent kinasesD-type cyclinsCAK phosphorylationExpression of CDK6CDK6 activationMitogenic signalsSubstrate specificityCell-based assaysCDK inhibitorsViral cyclinConformational changesCell deathPhosphorylationCAKCDK inhibitionKinaseCyclinCDK6Ternary complexNormal cells
1999
Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity
Nagahara H, Ezhevsky S, Vocero-Akbani A, Kaldis P, Solomon M, Dowdy S. Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 14961-14966. PMID: 10611320, PMCID: PMC24755, DOI: 10.1073/pnas.96.26.14961.Peer-Reviewed Original ResearchMeSH KeywordsCDC2-CDC28 KinasesCyclin ECyclin HCyclin-Dependent Kinase 2Cyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesCyclinsDown-RegulationEnzyme ActivationG1 PhaseHumansModels, BiologicalPhosphorylationProtein Serine-Threonine KinasesThreonineTransforming Growth Factor betaTumor Cells, CulturedConceptsTGF-beta treatmentInhibition of CDK2Cyclin ECyclin DGrowth factor betaGrowth factor βHepG2 hepatocellular carcinoma cellsHepatocellular carcinoma cellsTGF-beta signalingHuman HepG2 hepatocellular carcinoma cellsFactor betaCarcinoma cellsCyclin-dependent kinase 2 complexFactor βKinase activityCDK7 activityCDK4/6 activityHepG2 cellsWhole cell lysatesTumor suppressor proteinCDK2TreatmentCdk2 complexesArrestCells