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Marina Picciotto, PhD

Charles B. G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology; Director Division of Molecular Psychiatry, Psychiatry; Deputy Chair for Basic Science Research, Dept. of Psychiatry; Deputy Director, Kavli Institute for Neuroscience; Co-Director, Neuroscience Research Training Program, Yale Department of Psychiatry

Research & Publications
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Research Summary

The goal of Dr. Picciotto's research team is to understand the role of single molecules in complex behaviors related to addiction, depression, feeding and learning. She and her colleagues use molecular genetic, pharmacological and in vivo imaging approaches to link the biochemical, cellular, circuit and anatomical levels of investigation to behavior. Of primary interest is the role of acetylcholine and acetylcholine receptors in brain function and development, as well as sex differences in molecular and circuit-level signaling relevant for behavior.

Dr. Picciotto’s laboratory also studies signaling molecules downstream of nicotinic receptors which mediate long-term changes in behavior downstream of these receptors.

Specialized Terms: Neuroscience; Molecular basis of behavior; Intracellular signaling; fiber photometry; Mouse genetic models; alcohol; sex differences

Extensive Research Description

Our goal is to understand the role of single molecules in both typical behaviors and those relevant to psychiatric illness. We use molecular genetic, pharmacological and in vivo imaging approaches to link the biochemical, cellular, and anatomical levels of investigation to behavior. A primary focus is the role of acetylcholine signaling in brain development and function.

We also use proteomic approaches to discover signaling molecules downstream of nicotinic receptors that may mediate long-term changes in behavior following receptor activation. Ultimately, integration of studies at the molecular, cellular, and systems levels will be necessary to understand the neurobiological basis for expression and plasticity of complex behaviors.

Current projects include:

Sex differences in molecules and circuits underlying behaviors relevant to alcohol or nicotine addiction
Long-range circuits involved in reward enhancement relevant to addiction
Intracellular signaling pathways involved in the transition to behaviors related to nicotine addiction
Cholinergic compounds as novel anxiolytics or antidepressants
Interactions between acetylcholine and GABA signaling in BLA involved in stress-induced alcohol intake: sex differences and role of microglial signaling
Effects of acetylcholine on brain-body interactions related to contextual tolerance to opiates

Coauthors

Research Interests

Acetylcholine; Alcohol Drinking; Behavior and Behavior Mechanisms; Mental Disorders; Nervous System Diseases; Neurobiology; Neurosciences; Nicotine; Pharmacology; Stress, Psychological; Opiate Alkaloids

Research Images

Acetylcholine (ACh) levels in the basolateral amygdala (BLA) during reward learning

Heatmap of BLA ACh signaling in a mouse across training phases of a reward learning task, aligned to tone onset (Tone), correct nose poke (NP), and receptacle entry (Rec). Each row is the average of rewarded trials across a training session. White dashed horizontal line: first Training day earning 10 rewards. Horizontal white line: acquisition threshold, when a mouse began to earn 20 rewards consistently in Training. Black horizontal lines: divisions between training phases. Black vertical lines: divisions between breaks in time to allow for variable latencies in tone onset, correct nose poke, and receptacle entry (reward retrieval).

Localization of nicotinic acetylcholine receptors (nAChRs) at the level of the striatum and ventral segmental area measured by nicotinic binding in wild type (left), knockout and inducible transgenic mice.

Nicotinic acetylcholine receptors (nAChRs) measured by nicotinic binding in wild type (left), knockout and inducible transgenic mice. Localized expression of high affinity nAChRs in ventral tegmental neurons (right) is important for normal nicotine-induced locomotor activation.

Selected Publications

The role of acetylcholine in negative encoding bias: Too much of a good thing?Mineur YS, Picciotto MR. The role of acetylcholine in negative encoding bias: Too much of a good thing? The European Journal Of Neuroscience 2021, 53: 114-125. PMID: 31821620, PMCID: PMC7282966, DOI: 10.1111/ejn.14641.
Mechanisms of Nicotine Addiction.Picciotto MR, Kenny PJ. Mechanisms of Nicotine Addiction. Cold Spring Harbor Perspectives In Medicine 2021, 11 PMID: 32341069, PMCID: PMC8091956, DOI: 10.1101/cshperspect.a039610.
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses.Fogaça MV, Wu M, Li C, Li XY, Picciotto MR, Duman RS. Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses. Molecular Psychiatry 2021, 26: 3277-3291. PMID: 33070149, PMCID: PMC8052382, DOI: 10.1038/s41380-020-00916-y.
Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.George AA, Vieira JM, Xavier-Jackson C, Gee MT, Cirrito JR, Bimonte-Nelson HA, Picciotto MR, Lukas RJ, Whiteaker P. Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2021, 41: 555-575. PMID: 33239400, PMCID: PMC7821864, DOI: 10.1523/JNEUROSCI.0876-20.2020.
Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders.Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.
Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction.Lee AM, Picciotto MR. Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction. Advances In Pharmacology (San Diego, Calif.) 2021, 90: 89-115. PMID: 33706940, PMCID: PMC8008986, DOI: 10.1016/bs.apha.2020.09.002.
Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure.Lee AM, Mansuri MS, Wilson RS, Lam TT, Nairn AC, Picciotto MR. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers In Molecular Neuroscience 2021, 14: 657064. PMID: 34335180, PMCID: PMC8317211, DOI: 10.3389/fnmol.2021.657064.
Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine's Effects on Food Intake.Calarco CA, Picciotto MR. Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine's Effects on Food Intake. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2020, 22: 152-163. PMID: 30690485, PMCID: PMC7297099, DOI: 10.1093/ntr/ntz010.
Induction of reversible bidirectional social approach bias by olfactory conditioning in male mice.Chan J, Stout D, Pittenger ST, Picciotto MR, Lewis AS. Induction of reversible bidirectional social approach bias by olfactory conditioning in male mice. Social Neuroscience 2020, 15: 25-35. PMID: 31303111, PMCID: PMC6980898, DOI: 10.1080/17470919.2019.1644370.
Variability in nicotine conditioned place preference and stress-induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine.Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress-induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes, Brain, And Behavior 2020, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.
GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.Gerhard DM, Pothula S, Liu RJ, Wu M, Li XY, Girgenti MJ, Taylor SR, Duman CH, Delpire E, Picciotto M, Wohleb ES, Duman RS. GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. The Journal Of Clinical Investigation 2020, 130: 1336-1349. PMID: 31743111, PMCID: PMC7269589, DOI: 10.1172/JCI130808.
Regulation of aggressive behaviors by nicotinic acetylcholine receptors: Animal models, human genetics, and clinical studies.Lewis AS, Picciotto MR. Regulation of aggressive behaviors by nicotinic acetylcholine receptors: Animal models, human genetics, and clinical studies. Neuropharmacology 2020, 167: 107929. PMID: 32058178, PMCID: PMC7080580, DOI: 10.1016/j.neuropharm.2019.107929.
Ronald S. Duman, Ph.D. (1954-2020).Krystal JH, Nestler EJ, Picciotto MR. Ronald S. Duman, Ph.D. (1954-2020). Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2020, 45: 1078. PMID: 32076104, PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity.Barthas F, Hu MY, Siniscalchi MJ, Ali F, Mineur YS, Picciotto MR, Kwan AC. Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity. Biological Psychiatry 2020, 88: 541-553. PMID: 32276717, PMCID: PMC7434704, DOI: 10.1016/j.biopsych.2020.02.008.
Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.Mineur YS, Ernsten C, Islam A, Maibom KL, Picciotto MR. Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning. Genes, Brain, And Behavior 2020, 19: e12677. PMID: 32447811, PMCID: PMC8018799, DOI: 10.1111/gbb.12677.
Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice.Tan Y, Hang F, Liu ZW, Stoiljkovic M, Wu M, Tu Y, Han W, Lee AM, Kelley C, Hajos M, Lu L, de Lecea L, de Araujo I, Picciotto M, Horvath TL, Gao XB. Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. The Journal Of Clinical Investigation 2020, 130: 4985-4998. PMID: 32516139, PMCID: PMC7456212, DOI: 10.1172/JCI130889.
Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus.Cope ZA, Lavadia ML, Joosen AJM, van de Cappelle CJA, Lara JC, Huval A, Kwiatkowski MK, Picciotto MR, Mineur YS, Dulcis D, Young JW. Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus. Cognitive, Affective & Behavioral Neuroscience 2020, 20: 1173-1183. PMID: 32794101, PMCID: PMC7718303, DOI: 10.3758/s13415-020-00824-2.
Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency.Crouse RB, Kim K, Batchelor HM, Girardi EM, Kamaletdinova R, Chan J, Rajebhosale P, Pittenger ST, Role LW, Talmage DA, Jing M, Li Y, Gao XB, Mineur YS, Picciotto MR. Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency. ELife 2020, 9 PMID: 32945260, PMCID: PMC7529459, DOI: 10.7554/eLife.57335.
Origin and Function of Stress-Induced IL-6 in Murine Models.Qing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 1660. PMID: 32946784, DOI: 10.1016/j.cell.2020.08.044.
Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine.Deyama S, Bang E, Wohleb ES, Li XY, Kato T, Gerhard DM, Dutheil S, Dwyer JM, Taylor SR, Picciotto MR, Duman RS. Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine. The American Journal Of Psychiatry 2019, 176: 388-400. PMID: 30606046, PMCID: PMC6494682, DOI: 10.1176/appi.ajp.2018.17121368.
Sex differences in stress-related alcohol use.Peltier MR, Verplaetse TL, Mineur YS, Petrakis IL, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in stress-related alcohol use. Neurobiology Of Stress 2019, 10: 100149. PMID: 30949562, PMCID: PMC6430711, DOI: 10.1016/j.ynstr.2019.100149.
Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice.Lee AM, Picciotto MR. Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice. Behavioural Brain Research 2019, 367: 176-180. PMID: 30959127, PMCID: PMC6481625, DOI: 10.1016/j.bbr.2019.04.007.
Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.
Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia.Lewis AS, Olincy A, Buchanan RW, Kem WR, Picciotto MR, Freedman R. Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia. Schizophrenia Research 2018, 195: 568-569. PMID: 29050790, PMCID: PMC6476180, DOI: 10.1016/j.schres.2017.10.016.
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder.Lewis AS, van Schalkwyk GI, Lopez MO, Volkmar FR, Picciotto MR, Sukhodolsky DG. An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2018, 48: 2748-2757. PMID: 29536216, PMCID: PMC6394231, DOI: 10.1007/s10803-018-3536-7.
Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL/6J mice.Mineur YS, Mose TN, Blakeman S, Picciotto MR. Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL/6J mice. British Journal Of Pharmacology 2018, 175: 1903-1914. PMID: 28264149, PMCID: PMC5979617, DOI: 10.1111/bph.13769.
Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice.Mineur YS, Cahuzac EL, Mose TN, Bentham MP, Plantenga ME, Thompson DC, Picciotto MR. Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43: 2118-2125. PMID: 29472646, PMCID: PMC6098039, DOI: 10.1038/s41386-018-0024-x.
The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study.Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43: 1052-1058. PMID: 28944773, PMCID: PMC5854798, DOI: 10.1038/npp.2017.223.
Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.Lewis AS, Pittenger ST, Mineur YS, Stout D, Smith PH, Picciotto MR. Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43: 1267-1275. PMID: 29114104, PMCID: PMC5916354, DOI: 10.1038/npp.2017.276.
Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo.Miller MB, Wilson RS, Lam TT, Nairn AC, Picciotto MR. Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo. Proteomes 2018, 6 PMID: 30326594, PMCID: PMC6313896, DOI: 10.3390/proteomes6040042.
The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.Tebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE, Sestan-Pesa M, Franjic D, Sousa AMM, Liu ZW, Li M, Bichsel C, Koch M, Szigeti-Buck K, Liu F, Li Z, Kawasawa YI, Paspalas CD, Mineur YS, Prontera P, Merla G, Picciotto MR, Arnsten AFT, Horvath TL, Sestan N. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell 2018, 175: 1088-1104.e23. PMID: 30318146, PMCID: PMC6459420, DOI: 10.1016/j.cell.2018.09.014.
Analytical Transparency and Reproducibility in Human Neuroimaging Studies.Picciotto M. Analytical Transparency and Reproducibility in Human Neuroimaging Studies. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2018, 38: 3375-3376. PMID: 29618543, PMCID: PMC6596046, DOI: 10.1523/JNEUROSCI.0424-18.2018.
Science is a Marathon Not a Sprint: Creating a Positive Culture for Early Career Researchers.Picciotto M, Munafò MR. Science is a Marathon Not a Sprint: Creating a Positive Culture for Early Career Researchers. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2018, 20: 1037. PMID: 29868800, DOI: 10.1093/ntr/nty113.
Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus.Calarco CA, Li Z, Taylor SR, Lee S, Zhou W, Friedman JM, Mineur YS, Gotti C, Picciotto MR. Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus. The European Journal Of Neuroscience 2018 PMID: 29791746, PMCID: PMC6251769, DOI: 10.1111/ejn.13966.
Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons.Li D, Musante V, Zhou WL, Picciotto MR, Nairn AC. Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. The Journal Of Biological Chemistry 2018, 293: 11179-11194. PMID: 29802198, PMCID: PMC6052221, DOI: 10.1074/jbc.RA117.001519.
Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators.Jung Y, Lee AM, McKee SA, Picciotto MR. Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators. Scientific Reports 2017, 7: 4315. PMID: 28659613, PMCID: PMC5489536, DOI: 10.1038/s41598-017-04413-1.
Effect of doxazosin on stress reactivity and the ability to resist smoking.Verplaetse TL, Weinberger AH, Oberleitner LM, Smith KM, Pittman BP, Shi JM, Tetrault JM, Lavery ME, Picciotto MR, McKee SA. Effect of doxazosin on stress reactivity and the ability to resist smoking. Journal Of Psychopharmacology (Oxford, England) 2017, 31: 830-840. PMID: 28440105, PMCID: PMC5823502, DOI: 10.1177/0269881117699603.
Access to nicotine in drinking water reduces weight gain without changing caloric intake on high fat diet in male C57BL/6J mice.Calarco CA, Lee S, Picciotto MR. Access to nicotine in drinking water reduces weight gain without changing caloric intake on high fat diet in male C57BL/6J mice. Neuropharmacology 2017, 123: 210-220. PMID: 28623168, PMCID: PMC5544033, DOI: 10.1016/j.neuropharm.2017.06.012.
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms.Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal Of Psychopharmacology (Oxford, England) 2017, 31: 906-914. PMID: 28351203, PMCID: PMC5823265, DOI: 10.1177/0269881117699618.
Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice.Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behavioural Brain Research 2017, 334: 72-77. PMID: 28743602, PMCID: PMC5580257, DOI: 10.1016/j.bbr.2017.07.027.
Reporting on Experimental Design and Statistical Analysis.Picciotto M. Reporting on Experimental Design and Statistical Analysis. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2017, 37: 3737. PMID: 28381649, PMCID: PMC6596713, DOI: 10.1523/JNEUROSCI.0654-17.2017.
CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O'Malley SS, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2016, 18: 1845-52. PMID: 27611310, PMCID: PMC4978979, DOI: 10.1093/ntr/ntw081.
Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex.McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. ENeuro 2016, 3 PMID: 27559543, PMCID: PMC4985585, DOI: 10.1523/ENEURO.0166-16.2016.
CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory.Park J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S. CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory. Neuron 2016, 92: 75-83. PMID: 27667007, PMCID: PMC5059846, DOI: 10.1016/j.neuron.2016.09.002.
Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.Fan L, Balakrishna S, Jabba SV, Bonner PE, Taylor SR, Picciotto MR, Jordt SE. Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tobacco Control 2016, 25: ii50-ii54. PMID: 27698211, PMCID: PMC5496986, DOI: 10.1136/tobaccocontrol-2016-053209.
SfN Journals: Two Paths, One Goal: Sharing Strong Science.Bernard C, Picciotto M. SfN Journals: Two Paths, One Goal: Sharing Strong Science. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2016, 36: 7075. PMID: 27383584, PMCID: PMC6705532, DOI: 10.1523/JNEUROSCI.1863-16.2016.
Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress.Mineur YS, Fote GM, Blakeman S, Cahuzac EL, Newbold SA, Picciotto MR. Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2016, 41: 1579-87. PMID: 26471256, PMCID: PMC4832019, DOI: 10.1038/npp.2015.316.
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior.Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience 2016, 19: 905-14. PMID: 27239938, PMCID: PMC4925298, DOI: 10.1038/nn.4315.
GABA interneurons mediate the rapid antidepressant-like effects of scopolamine.Wohleb ES, Wu M, Gerhard DM, Taylor SR, Picciotto MR, Alreja M, Duman RS. GABA interneurons mediate the rapid antidepressant-like effects of scopolamine. The Journal Of Clinical Investigation 2016, 126: 2482-94. PMID: 27270172, PMCID: PMC4922686, DOI: 10.1172/JCI85033.
Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample.Lewis AS, Oberleitner LM, Morgan PT, Picciotto MR, McKee SA. Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2016, 18: 1456-62. PMID: 26718905, PMCID: PMC5942535, DOI: 10.1093/ntr/ntv287.
Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine.Mineur YS, Einstein EB, Bentham MP, Wigestrand MB, Blakeman S, Newbold SA, Picciotto MR. Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2015, 40: 938-46. PMID: 25288485, PMCID: PMC4330507, DOI: 10.1038/npp.2014.269.
Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder.Van Schalkwyk GI, Lewis AS, Qayyum Z, Koslosky K, Picciotto MR, Volkmar FR. Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2015, 45: 3061-6. PMID: 25982311, PMCID: PMC4755349, DOI: 10.1007/s10803-015-2471-0.
Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice.Mineur YS, Bentham MP, Zhou WL, Plantenga ME, McKee SA, Picciotto MR. Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice. Psychopharmacology 2015, 232: 3539-49. PMID: 26146014, PMCID: PMC4561580, DOI: 10.1007/s00213-015-4001-3.
A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation.McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten AF, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal Of Psychopharmacology (Oxford, England) 2015, 29: 300-11. PMID: 25516371, PMCID: PMC4376109, DOI: 10.1177/0269881114562091.
Targeting the noradrenergic system for gender-sensitive medication development for tobacco dependence.Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Targeting the noradrenergic system for gender-sensitive medication development for tobacco dependence. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2015, 17: 486-95. PMID: 25762760, PMCID: PMC4432402, DOI: 10.1093/ntr/ntu280.
Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states.Picciotto MR, Lewis AS, van Schalkwyk GI, Mineur YS. Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states. Neuropharmacology 2015, 96: 235-43. PMID: 25582289, PMCID: PMC4486625, DOI: 10.1016/j.neuropharm.2014.12.028.
Modulation of aggressive behavior in mice by nicotinic receptor subtypes.Lewis AS, Mineur YS, Smith PH, Cahuzac EL, Picciotto MR. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochemical Pharmacology 2015, 97: 488-497. PMID: 26212554, PMCID: PMC4600457, DOI: 10.1016/j.bcp.2015.07.019.
Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms.Zhou WL, Gao XB, Picciotto MR. Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms. ENeuro 2015, 2 PMID: 26322330, PMCID: PMC4551500, DOI: 10.1523/ENEURO.0052-14.2015.
DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.Engmann O, Giralt A, Gervasi N, Marion-Poll L, Gasmi L, Filhol O, Picciotto MR, Gilligan D, Greengard P, Nairn AC, Hervé D, Girault JA. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nature Communications 2015, 6: 10099. PMID: 26639316, PMCID: PMC4675091, DOI: 10.1038/ncomms10099.
Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.Ercan-Sencicek AG, Jambi S, Franjic D, Nishimura S, Li M, El-Fishawy P, Morgan TM, Sanders SJ, Bilguvar K, Suri M, Johnson MH, Gupta AR, Yuksel Z, Mane S, Grigorenko E, Picciotto M, Alberts AS, Gunel M, Šestan N, State MW. Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans. European Journal Of Human Genetics : EJHG 2015, 23: 165-72. PMID: 24781755, PMCID: PMC4297910, DOI: 10.1038/ejhg.2014.82.
Neuromodulation by acetylcholine: examples from schizophrenia and depression.Higley MJ, Picciotto MR. Neuromodulation by acetylcholine: examples from schizophrenia and depression. Current Opinion In Neurobiology 2014, 29: 88-95. PMID: 24983212, PMCID: PMC4268065, DOI: 10.1016/j.conb.2014.06.004.
Molecules and circuits involved in nicotine addiction: The many faces of smoking.Picciotto MR, Mineur YS. Molecules and circuits involved in nicotine addiction: The many faces of smoking. Neuropharmacology 2014, 76 Pt B: 545-53. PMID: 23632083, PMCID: PMC3772953, DOI: 10.1016/j.neuropharm.2013.04.028.
Mediating role of stress reactivity in the effects of prenatal tobacco exposure on childhood mental health outcomes.Park A, O'Malley SS, King SL, Picciotto MR. Mediating role of stress reactivity in the effects of prenatal tobacco exposure on childhood mental health outcomes. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2014, 16: 174-85. PMID: 23990474, PMCID: PMC3880234, DOI: 10.1093/ntr/ntt131.
In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia.Esterlis I, Ranganathan M, Bois F, Pittman B, Picciotto MR, Shearer L, Anticevic A, Carlson J, Niciu MJ, Cosgrove KP, D'Souza DC. In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia. Biological Psychiatry 2014, 76: 495-502. PMID: 24360979, PMCID: PMC4019710, DOI: 10.1016/j.biopsych.2013.11.001.
Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.McClure-Begley TD, Papke RL, Stone KL, Stokes C, Levy AD, Gelernter J, Xie P, Lindstrom J, Picciotto MR. Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors. The Journal Of Pharmacology And Experimental Therapeutics 2014, 348: 410-20. PMID: 24385388, PMCID: PMC3935145, DOI: 10.1124/jpet.113.209767.
Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons.Mazei-Robison MS, Appasani R, Edwards S, Wee S, Taylor SR, Picciotto MR, Koob GF, Nestler EJ. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. PloS One 2014, 9: e95962. PMID: 24755634, PMCID: PMC3995955, DOI: 10.1371/journal.pone.0095962.
GABAergic and glutamatergic efferents of the mouse ventral tegmental area.Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR. GABAergic and glutamatergic efferents of the mouse ventral tegmental area. The Journal Of Comparative Neurology 2014, 522: 3308-34. PMID: 24715505, PMCID: PMC4107038, DOI: 10.1002/cne.23603.
Calcineurin downregulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL/6J male mice.Mineur YS, Taylor SR, Picciotto MR. Calcineurin downregulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL/6J male mice. Biological Psychiatry 2014, 75: 991-8. PMID: 24742621, PMCID: PMC4037359, DOI: 10.1016/j.biopsych.2014.03.009.
Imaging changes in synaptic acetylcholine availability in living human subjects.Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. Imaging changes in synaptic acetylcholine availability in living human subjects. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2013, 54: 78-82. PMID: 23160789, PMCID: PMC3703589, DOI: 10.2967/jnumed.112.111922.
Constitutive knockout of the membrane cytoskeleton protein beta adducin decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine.Jung Y, Mulholland PJ, Wiseman SL, Chandler LJ, Picciotto MR. Constitutive knockout of the membrane cytoskeleton protein beta adducin decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine. The European Journal Of Neuroscience 2013, 37: 1-9. PMID: 23106536, PMCID: PMC3538958, DOI: 10.1111/ejn.12037.
Morphine dependence and withdrawal induced changes in cholinergic signaling.Neugebauer NM, Einstein EB, Lopez MB, McClure-Begley TD, Mineur YS, Picciotto MR. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, Biochemistry, And Behavior 2013, 109: 77-83. PMID: 23651795, PMCID: PMC3690589, DOI: 10.1016/j.pbb.2013.04.015.
Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography.Hannestad JO, Cosgrove KP, DellaGioia NF, Perkins E, Bois F, Bhagwagar Z, Seibyl JP, McClure-Begley TD, Picciotto MR, Esterlis I. Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography. Biological Psychiatry 2013, 74: 768-76. PMID: 23773793, PMCID: PMC3805761, DOI: 10.1016/j.biopsych.2013.04.004.
Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice.McClure-Begley TD, Stone KL, Marks MJ, Grady SR, Colangelo CM, Lindstrom JM, Picciotto MR. Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice. Genomics, Proteomics & Bioinformatics 2013, 11: 207-18. PMID: 23891776, PMCID: PMC3806329, DOI: 10.1016/j.gpb.2013.05.005.
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 12078-83. PMID: 23818597, PMCID: PMC3718126, DOI: 10.1073/pnas.1307849110.
Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice.Rao Y, Mineur YS, Gan G, Wang AH, Liu ZW, Wu X, Suyama S, de Lecea L, Horvath TL, Picciotto MR, Gao XB. Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice. The Journal Of Physiology 2013, 591: 1951-66. PMID: 23318871, PMCID: PMC3624862, DOI: 10.1113/jphysiol.2012.246983.
Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule.Peng C, Stokes C, Mineur YS, Picciotto MR, Tian C, Eibl C, Tomassoli I, Guendisch D, Papke RL. Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule. The Journal Of Pharmacology And Experimental Therapeutics 2013, 347: 424-37. PMID: 23959137, PMCID: PMC3807070, DOI: 10.1124/jpet.113.206904.
Nicotine, food intake, and activation of POMC neurons.Picciotto MR, Mineur YS. Nicotine, food intake, and activation of POMC neurons. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2013, 38: 245. PMID: 23147487, PMCID: PMC3521975, DOI: 10.1038/npp.2012.163.
Molecular mechanisms underlying behaviors related to nicotine addiction.Picciotto MR, Kenny PJ. Molecular mechanisms underlying behaviors related to nicotine addiction. Cold Spring Harbor Perspectives In Medicine 2013, 3: a012112. PMID: 23143843, PMCID: PMC3530035, DOI: 10.1101/cshperspect.a012112.
The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior.Giza JI, Jung Y, Jeffrey RA, Neugebauer NM, Picciotto MR, Biederer T. The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2013, 38: 628-38. PMID: 23169347, PMCID: PMC3572459, DOI: 10.1038/npp.2012.226.
Nicotine, striatum, and reward.Addy NA, Picciotto MR. Nicotine, striatum, and reward. Biological Psychiatry 2013, 73: 205-6. PMID: 23337022, DOI: 10.1016/j.biopsych.2012.11.001.
Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2.Einstein EB, Asaka Y, Yeckel MF, Higley MJ, Picciotto MR. Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. The European Journal Of Neuroscience 2013, 37: 1541-9. PMID: 23387435, PMCID: PMC3648588, DOI: 10.1111/ejn.12151.
Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior.Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM, Picciotto MR. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3573-8. PMID: 23401542, PMCID: PMC3587265, DOI: 10.1073/pnas.1219731110.
An indirect resilience to addiction.Picciotto MR. An indirect resilience to addiction. Nature Neuroscience 2013, 16: 521-3. PMID: 23619754, DOI: 10.1038/nn.3375.
High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness.Lewis AS, Picciotto MR. High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. Psychopharmacology 2013, 229: 477-85. PMID: 23624811, PMCID: PMC3766461, DOI: 10.1007/s00213-013-3126-5.
Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion.Horst NK, Heath CJ, Neugebauer NM, Kimchi EY, Laubach M, Picciotto MR. Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion. Behavioural Brain Research 2012, 231: 170-80. PMID: 22433585, PMCID: PMC3334440, DOI: 10.1016/j.bbr.2012.03.002.
Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers.Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O'Malley SS. Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers. Archives Of General Psychiatry 2012, 69: 418-27. PMID: 22474108, PMCID: PMC3508698, DOI: 10.1001/archgenpsychiatry.2011.1465.
FACS purification of immunolabeled cell types from adult rat brain.Guez-Barber D, Fanous S, Harvey BK, Zhang Y, Lehrmann E, Becker KG, Picciotto MR, Hope BT. FACS purification of immunolabeled cell types from adult rat brain. Journal Of Neuroscience Methods 2012, 203: 10-8. PMID: 21911005, PMCID: PMC3221768, DOI: 10.1016/j.jneumeth.2011.08.045.
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors.Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Araújo I, Liu ZW, Horvath TL. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nature Neuroscience 2012, 15: 1108-10. PMID: 22729177, PMCID: PMC3411867, DOI: 10.1038/nn.3147.
Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder.Saricicek A, Esterlis I, Maloney KH, Mineur YS, Ruf BM, Muralidharan A, Chen JI, Cosgrove KP, Kerestes R, Ghose S, Tamminga CA, Pittman B, Bois F, Tamagnan G, Seibyl J, Picciotto MR, Staley JK, Bhagwagar Z. Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder. The American Journal Of Psychiatry 2012, 169: 851-9. PMID: 22772158, PMCID: PMC3494404, DOI: 10.1176/appi.ajp.2012.11101546.
Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior.Picciotto MR, Higley MJ, Mineur YS. Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 2012, 76: 116-29. PMID: 23040810, PMCID: PMC3466476, DOI: 10.1016/j.neuron.2012.08.036.
Nicotinic regulation of energy homeostasis.Zoli M, Picciotto MR. Nicotinic regulation of energy homeostasis. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2012, 14: 1270-90. PMID: 22990212, PMCID: PMC3611985, DOI: 10.1093/ntr/nts159.
The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction.DiLeone RJ, Taylor JR, Picciotto MR. The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction. Nature Neuroscience 2012, 15: 1330-5. PMID: 23007187, PMCID: PMC3570269, DOI: 10.1038/nn.3202.
Galanin negatively modulates opiate withdrawal via galanin receptor 1.Holmes FE, Armenaki A, Iismaa TP, Einstein EB, Shine J, Picciotto MR, Wynick D, Zachariou V. Galanin negatively modulates opiate withdrawal via galanin receptor 1. Psychopharmacology 2012, 220: 619-25. PMID: 21969124, PMCID: PMC3324978, DOI: 10.1007/s00213-011-2515-x.
Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction.Yan Y, Pushparaj A, Gamaleddin I, Steiner RC, Picciotto MR, Roder J, Le Foll B. Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction. Behavioural Brain Research 2012, 230: 34-9. PMID: 22326373, PMCID: PMC3310267, DOI: 10.1016/j.bbr.2012.01.042.
Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler.Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The International Journal Of Neuropsychopharmacology / Official Scientific Journal Of The Collegium Internationale Neuropsychopharmacologicum (CINP) 2011, 14: 389-98. PMID: 21029513, PMCID: PMC3510008, DOI: 10.1017/S1461145710001227.
FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons.Guez-Barber D, Fanous S, Golden SA, Schrama R, Koya E, Stern AL, Bossert JM, Harvey BK, Picciotto MR, Hope BT. FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2011, 31: 4251-9. PMID: 21411666, PMCID: PMC3073079, DOI: 10.1523/JNEUROSCI.6195-10.2011.
The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN, Cubells JF. The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2011, 36: 1412-20. PMID: 21430647, PMCID: PMC3096810, DOI: 10.1038/npp.2011.25.
Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology 2011, 217: 199-210. PMID: 21487659, PMCID: PMC3266849, DOI: 10.1007/s00213-011-2271-y.
Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory.Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ. Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory. The European Journal Of Neuroscience 2011, 33: 2288-98. PMID: 21501258, PMCID: PMC3118976, DOI: 10.1111/j.1460-9568.2011.07687.x.
α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties.Mineur YS, Einstein EB, Seymour PA, Coe JW, O'neill BT, Rollema H, Picciotto MR. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behavioural Pharmacology 2011, 22: 291-9. PMID: 21566524, PMCID: PMC3227135, DOI: 10.1097/FBP.0b013e328347546d.
An instructive role for patterned spontaneous retinal activity in mouse visual map development.Xu HP, Furman M, Mineur YS, Chen H, King SL, Zenisek D, Zhou ZJ, Butts DA, Tian N, Picciotto MR, Crair MC. An instructive role for patterned spontaneous retinal activity in mouse visual map development. Neuron 2011, 70: 1115-27. PMID: 21689598, PMCID: PMC3119851, DOI: 10.1016/j.neuron.2011.04.028.
Nicotine decreases food intake through activation of POMC neurons.Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Nicotine decreases food intake through activation of POMC neurons. Science (New York, N.Y.) 2011, 332: 1330-2. PMID: 21659607, PMCID: PMC3113664, DOI: 10.1126/science.1201889.
Reduced locomotor responses to cocaine in ghrelin-deficient mice.Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL. Reduced locomotor responses to cocaine in ghrelin-deficient mice. Neuroscience 2011, 192: 500-6. PMID: 21699961, DOI: 10.1016/j.neuroscience.2011.06.001.
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biological Psychiatry 2011, 70: 528-36. PMID: 21683344, PMCID: PMC3199609, DOI: 10.1016/j.biopsych.2011.04.017.
Decreased α4β2 nicotinic receptor number in the absence of mRNA changes suggests post-transcriptional regulation in the spontaneously hypertensive rat model of ADHD.Wigestrand MB, Mineur YS, Heath CJ, Fonnum F, Picciotto MR, Walaas SI. Decreased α4β2 nicotinic receptor number in the absence of mRNA changes suggests post-transcriptional regulation in the spontaneously hypertensive rat model of ADHD. Journal Of Neurochemistry 2011, 119: 240-50. PMID: 21824140, PMCID: PMC3171636, DOI: 10.1111/j.1471-4159.2011.07415.x.
Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors.Yalcin I, Charlet A, Cordero-Erausquin M, Tessier LH, Picciotto MR, Schlichter R, Poisbeau P, Freund-Mercier MJ, Barrot M. Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors. Pain 2011, 152: 2131-2137. PMID: 21794985, DOI: 10.1016/j.pain.2011.05.022.
Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.Tian MK, Bailey CD, De Biasi M, Picciotto MR, Lambe EK. Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2011, 31: 16458-63. PMID: 22072695, PMCID: PMC3240894, DOI: 10.1523/JNEUROSCI.3600-11.2011.
Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases.Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto MR, Tokumitsu H, Soderling TR, Sakakibara A, Miyata T, Kamiguchi H, Kaibuchi K. Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases. Science Signaling 2011, 4: ra76. PMID: 22087032, DOI: 10.1126/scisignal.2002011.
Examining antidepressant drug response by smoking status: why is it important and how often is it done?Weinberger AH, McKee SA, Picciotto MR, Mazure CM. Examining antidepressant drug response by smoking status: why is it important and how often is it done? Journal Of Psychopharmacology (Oxford, England) 2011, 25: 1269-76. PMID: 21169392, PMCID: PMC3256572, DOI: 10.1177/0269881110389347.
Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference.Neugebauer NM, Henehan RM, Hales CA, Picciotto MR. Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference. Pharmacology, Biochemistry, And Behavior 2011, 98: 87-93. PMID: 21172385, PMCID: PMC3030658, DOI: 10.1016/j.pbb.2010.12.015.
Neuroscience: MicroRNA knocks down cocaine.Picciotto MR. Neuroscience: MicroRNA knocks down cocaine. Nature 2010, 466: 194-5. PMID: 20613832, DOI: 10.1038/466194a.
Galanin and addiction.Picciotto MR. Galanin and addiction. Experientia Supplementum (2012) 2010, 102: 195-208. PMID: 21299070, DOI: 10.1007/978-3-0346-0228-0_14.
Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice.Kamens HM, Andersen J, Picciotto MR. Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. Psychopharmacology 2010, 208: 613-26. PMID: 20072781, PMCID: PMC2901400, DOI: 10.1007/s00213-009-1759-1.
Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through α4/β2/α5 nicotinic acetylcholine receptors.Heath CJ, King SL, Gotti C, Marks MJ, Picciotto MR. Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through α4/β2/α5 nicotinic acetylcholine receptors. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2010, 35: 2324-38. PMID: 20736992, PMCID: PMC2955839, DOI: 10.1038/npp.2010.130.
Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis.Mineur YS, Picciotto MR. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends In Pharmacological Sciences 2010, 31: 580-6. PMID: 20965579, PMCID: PMC2991594, DOI: 10.1016/j.tips.2010.09.004.
Locomotion and self-administration induced by cocaine in 129/OlaHsd mice lacking galanin.Brabant C, Kuschpel AS, Picciotto MR. Locomotion and self-administration induced by cocaine in 129/OlaHsd mice lacking galanin. Behavioral Neuroscience 2010, 124: 828-38. PMID: 21038934, PMCID: PMC3058554, DOI: 10.1037/a0021221.
The nicotinic acetylcholine receptor partial agonist varenicline increases the ataxic and sedative-hypnotic effects of acute ethanol administration in C57BL/6J mice.Kamens HM, Andersen J, Picciotto MR. The nicotinic acetylcholine receptor partial agonist varenicline increases the ataxic and sedative-hypnotic effects of acute ethanol administration in C57BL/6J mice. Alcoholism, Clinical And Experimental Research 2010, 34: 2053-60. PMID: 20946306, PMCID: PMC2988947, DOI: 10.1111/j.1530-0277.2010.01301.x.
Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors.Picciotto MR, Brabant C, Einstein EB, Kamens HM, Neugebauer NM. Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors. Brain Research 2010, 1314: 206-18. PMID: 19699187, PMCID: PMC2819596, DOI: 10.1016/j.brainres.2009.08.033.
Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence.Heath CJ, Horst NK, Picciotto MR. Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence. Physiology & Behavior 2010, 101: 764-9. PMID: 20826170, PMCID: PMC2975773, DOI: 10.1016/j.physbeh.2010.08.021.
Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning.Mineur YS, Brunzell DH, Grady SR, Lindstrom JM, McIntosh JM, Marks MJ, King SL, Picciotto MR. Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. Genes, Brain, And Behavior 2009, 8: 257-66. PMID: 19077117, PMCID: PMC2672109, DOI: 10.1111/j.1601-183X.2008.00468.x.
The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration.Lavaur J, Mineur YS, Picciotto MR. The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration. Journal Of Neurochemistry 2009, 111: 1129-37. PMID: 19780900, PMCID: PMC2810345, DOI: 10.1111/j.1471-4159.2009.06405.x.
Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation.Venkitaramani DV, Paul S, Zhang Y, Kurup P, Ding L, Tressler L, Allen M, Sacca R, Picciotto MR, Lombroso PJ. Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse (New York, N.Y.) 2009, 63: 69-81. PMID: 18932218, PMCID: PMC2706508, DOI: 10.1002/syn.20608.
Biological basis for the co-morbidity between smoking and mood disorders.Mineur YS, Picciotto MR. Biological basis for the co-morbidity between smoking and mood disorders. Journal Of Dual Diagnosis 2009, 5: 122-130. PMID: 20046987, PMCID: PMC2707026, DOI: 10.1080/15504260902869964.
Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing.Heath CJ, Picciotto MR. Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology 2009, 56 Suppl 1: 254-62. PMID: 18692078, PMCID: PMC2635334, DOI: 10.1016/j.neuropharm.2008.07.020.
Cytisine-based nicotinic partial agonists as novel antidepressant compounds.Mineur YS, Eibl C, Young G, Kochevar C, Papke RL, Gündisch D, Picciotto MR. Cytisine-based nicotinic partial agonists as novel antidepressant compounds. The Journal Of Pharmacology And Experimental Therapeutics 2009, 329: 377-86. PMID: 19164465, PMCID: PMC2670591, DOI: 10.1124/jpet.108.149609.
Molecular mechanisms underlying the motivational effects of nicotine.Brunzell DH, Picciotto MR. Molecular mechanisms underlying the motivational effects of nicotine. Nebraska Symposium On Motivation. Nebraska Symposium On Motivation 2009, 55: 17-30. PMID: 19013937, PMCID: PMC3594851, DOI: 10.1007/978-0-387-78748-0_3.
Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions.Brabant C, Alleva L, Grisar T, Quertemont E, Lakaye B, Ohtsu H, Lin JS, Jatlow P, Picciotto MR, Tirelli E. Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Psychopharmacology 2009, 202: 673-87. PMID: 18843481, DOI: 10.1007/s00213-008-1345-y.
Role of beta2-containing nicotinic acetylcholine receptors in auditory event-related potentials.Rudnick ND, Koehler C, Picciotto MR, Siegel SJ. Role of beta2-containing nicotinic acetylcholine receptors in auditory event-related potentials. Psychopharmacology 2009, 202: 745-51. PMID: 18931833, DOI: 10.1007/s00213-008-1358-6.
Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect.Rollema H, Guanowsky V, Mineur YS, Shrikhande A, Coe JW, Seymour PA, Picciotto MR. Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect. European Journal Of Pharmacology 2009, 605: 114-6. PMID: 19168054, PMCID: PMC2707785, DOI: 10.1016/j.ejphar.2009.01.002.
Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents.Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. Biological Psychiatry 2009, 65: 671-9. PMID: 19058786, PMCID: PMC2864130, DOI: 10.1016/j.biopsych.2008.10.024.
Varenicline reduces alcohol self-administration in heavy-drinking smokers.McKee SA, Harrison EL, O'Malley SS, Krishnan-Sarin S, Shi J, Tetrault JM, Picciotto MR, Petrakis IL, Estevez N, Balchunas E. Varenicline reduces alcohol self-administration in heavy-drinking smokers. Biological Psychiatry 2009, 66: 185-90. PMID: 19249750, PMCID: PMC2863311, DOI: 10.1016/j.biopsych.2009.01.029.
Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference.Brunzell DH, Mineur YS, Neve RL, Picciotto MR. Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2009, 34: 1993-2001. PMID: 19212318, PMCID: PMC2709692, DOI: 10.1038/npp.2009.11.
Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice.Narasimhaiah R, Kamens HM, Picciotto MR. Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice. Psychopharmacology 2009, 204: 95-102. PMID: 19099295, PMCID: PMC2872184, DOI: 10.1007/s00213-008-1438-7.
Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice.Müller Smith K, Fagel DM, Stevens HE, Rabenstein RL, Maragnoli ME, Ohkubo Y, Picciotto MR, Schwartz ML, Vaccarino FM. Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice. Biological Psychiatry 2008, 63: 953-62. PMID: 17988653, DOI: 10.1016/j.biopsych.2007.09.020.
It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood.Picciotto MR, Addy NA, Mineur YS, Brunzell DH. It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress In Neurobiology 2008, 84: 329-42. PMID: 18242816, PMCID: PMC2390914, DOI: 10.1016/j.pneurobio.2007.12.005.
Galanin and addiction.Picciotto MR. Galanin and addiction. Cellular And Molecular Life Sciences : CMLS 2008, 65: 1872-9. PMID: 18500649, DOI: 10.1007/s00018-008-8151-x.
Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors.Vieyra-Reyes P, Picciotto MR, Mineur YS. Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors. Neuroscience Letters 2008, 434: 18-22. PMID: 18261852, PMCID: PMC2757003, DOI: 10.1016/j.neulet.2008.01.021.
Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice.Caldarone BJ, King SL, Picciotto MR. Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice. Neuroscience Letters 2008, 439: 187-91. PMID: 18524488, PMCID: PMC2491450, DOI: 10.1016/j.neulet.2008.05.023.
Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression.Vieyra-Reyes P, Mineur YS, Picciotto MR, Túnez I, Vidaltamayo R, Drucker-Colín R. Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression. Brain Research Bulletin 2008, 77: 13-8. PMID: 18582540, PMCID: PMC2771408, DOI: 10.1016/j.brainresbull.2008.05.007.
Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus.Rao Y, Lu M, Ge F, Marsh DJ, Qian S, Wang AH, Picciotto MR, Gao XB. Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2008, 28: 9101-10. PMID: 18784290, PMCID: PMC2562258, DOI: 10.1523/JNEUROSCI.1766-08.2008.
Galanin protects against behavioral and neurochemical correlates of opiate reward.Hawes JJ, Brunzell DH, Narasimhaiah R, Langel U, Wynick D, Picciotto MR. Galanin protects against behavioral and neurochemical correlates of opiate reward. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2008, 33: 1864-73. PMID: 17957220, PMCID: PMC2504505, DOI: 10.1038/sj.npp.1301579.
Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction.Mineur YS, Picciotto MR. Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochemical Pharmacology 2008, 75: 323-33. PMID: 17632086, PMCID: PMC2212607, DOI: 10.1016/j.bcp.2007.06.010.
Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.Picciotto MR, Zoli M. Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Frontiers In Bioscience : A Journal And Virtual Library 2008, 13: 492-504. PMID: 17981563, DOI: 10.2741/2695.
Administration of the calcineurin inhibitor cyclosporine modulates cocaine-induced locomotor activity in rats.Addy NA, Bahi A, Taylor JR, Picciotto MR. Administration of the calcineurin inhibitor cyclosporine modulates cocaine-induced locomotor activity in rats. Psychopharmacology 2008, 200: 129-39. PMID: 18587562, PMCID: PMC2574760, DOI: 10.1007/s00213-008-1189-5.
Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII.Steiner RC, Heath CJ, Picciotto MR. Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. Journal Of Neurochemistry 2007, 103: 666-78. PMID: 17666046, DOI: 10.1111/j.1471-4159.2007.04799.x.
Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptors.Elsworth JD, Morrow BA, Nguyen VT, Mitra J, Picciotto MR, Roth RH. Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptors. Neuroscience 2007, 147: 419-27. PMID: 17543464, PMCID: PMC2855228, DOI: 10.1016/j.neuroscience.2007.04.036.
Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice.Fornari A, Pedrazzi P, Lippi G, Picciotto MR, Zoli M, Zini I. Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice. Neuroscience Letters 2007, 411: 72-6. PMID: 17052838, DOI: 10.1016/j.neulet.2006.10.014.
Differential effects of nicotinic antagonists perfused into the nucleus accumbens or the ventral tegmental area on cocaine-induced dopamine release in the nucleus accumbens of mice.Zanetti L, Picciotto MR, Zoli M. Differential effects of nicotinic antagonists perfused into the nucleus accumbens or the ventral tegmental area on cocaine-induced dopamine release in the nucleus accumbens of mice. Psychopharmacology 2007, 190: 189-99. PMID: 17061109, DOI: 10.1007/s00213-006-0598-6.
Role of calcineurin in nicotine-mediated locomotor sensitization.Addy NA, Fornasiero EF, Stevens TR, Taylor JR, Picciotto MR. Role of calcineurin in nicotine-mediated locomotor sensitization. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2007, 27: 8571-80. PMID: 17687035, PMCID: PMC6672935, DOI: 10.1523/JNEUROSCI.2601-07.2007.
Antidepressant-like effects of ceftriaxone in male C57BL/6J mice.Mineur YS, Picciotto MR, Sanacora G. Antidepressant-like effects of ceftriaxone in male C57BL/6J mice. Biological Psychiatry 2007, 61: 250-2. PMID: 16860779, DOI: 10.1016/j.biopsych.2006.04.037.
Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats.Lynch WJ, Kiraly DD, Caldarone BJ, Picciotto MR, Taylor JR. Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats. Psychopharmacology 2007, 191: 263-71. PMID: 17180335, DOI: 10.1007/s00213-006-0656-0.
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice.Mineur YS, Somenzi O, Picciotto MR. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology 2007, 52: 1256-62. PMID: 17320916, PMCID: PMC1959230, DOI: 10.1016/j.neuropharm.2007.01.006.
Guidelines on nicotine dose selection for in vivo research.Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology 2007, 190: 269-319. PMID: 16896961, DOI: 10.1007/s00213-006-0441-0.
Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure.Jacobsen LK, Picciotto MR, Heath CJ, Frost SJ, Tsou KA, Dwan RA, Jackowski MP, Constable RT, Mencl WE. Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2007, 27: 13491-8. PMID: 18057207, PMCID: PMC6673092, DOI: 10.1523/JNEUROSCI.2402-07.2007.
A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth.Uboha NV, Flajolet M, Nairn AC, Picciotto MR. A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2007, 27: 4413-23. PMID: 17442826, PMCID: PMC6672303, DOI: 10.1523/JNEUROSCI.0725-07.2007.
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.Rao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. The Journal Of Clinical Investigation 2007, 117: 4022-33. PMID: 18060037, PMCID: PMC2104495, DOI: 10.1172/JCI32829.
Galanin and galanin-like peptide modulate neurite outgrowth via protein kinase C-mediated activation of extracellular signal-related kinase.Hawes JJ, Narasimhaiah R, Picciotto MR. Galanin and galanin-like peptide modulate neurite outgrowth via protein kinase C-mediated activation of extracellular signal-related kinase. The European Journal Of Neuroscience 2006, 23: 2937-46. PMID: 16819983, DOI: 10.1111/j.1460-9568.2006.04828.x.
Expression of ezrin in glial tubes in the adult subventricular zone and rostral migratory stream.Cleary MA, Uboha N, Picciotto MR, Beech RD. Expression of ezrin in glial tubes in the adult subventricular zone and rostral migratory stream. Neuroscience 2006, 143: 851-61. PMID: 16996217, PMCID: PMC1712626, DOI: 10.1016/j.neuroscience.2006.08.028.
Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers.Staley JK, Krishnan-Sarin S, Cosgrove KP, Krantzler E, Frohlich E, Perry E, Dubin JA, Estok K, Brenner E, Baldwin RM, Tamagnan GD, Seibyl JP, Jatlow P, Picciotto MR, London ED, O'Malley S, van Dyck CH. Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2006, 26: 8707-14. PMID: 16928859, PMCID: PMC6674379, DOI: 10.1523/JNEUROSCI.0546-06.2006.
Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum.Zanetti L, de Kerchove D'Exaerde A, Zanardi A, Changeux JP, Picciotto MR, Zoli M. Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum. Psychopharmacology 2006, 187: 181-8. PMID: 16826402, DOI: 10.1007/s00213-006-0419-y.
The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo.Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N. The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron 2006, 51: 587-600. PMID: 16950157, DOI: 10.1016/j.neuron.2006.07.025.
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. The Journal Of Clinical Investigation 2006, 116: 3229-39. PMID: 17060947, PMCID: PMC1618869, DOI: 10.1172/JCI29867.
The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice.Rabenstein RL, Caldarone BJ, Picciotto MR. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology 2006, 189: 395-401. PMID: 17016705, DOI: 10.1007/s00213-006-0568-z.
Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review.Rasmusson AM, Picciotto MR, Krishnan-Sarin S. Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review. Journal Of Psychopharmacology (Oxford, England) 2006, 20: 693-707. PMID: 16401662, DOI: 10.1177/0269881106060193.
Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?Holmes A, Picciotto MR. Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction? CNS & Neurological Disorders Drug Targets 2006, 5: 225-32. PMID: 16611095, DOI: 10.2174/187152706776359600.
beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice.Brunzell DH, Chang JR, Schneider B, Olausson P, Taylor JR, Picciotto MR. beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice. Psychopharmacology 2006, 184: 328-38. PMID: 16133126, DOI: 10.1007/s00213-005-0099-z.
Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures.Hawes JJ, Narasimhaiah R, Picciotto MR. Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. Journal Of Neurochemistry 2006, 96: 1160-8. PMID: 16417577, DOI: 10.1111/j.1471-4159.2005.03613.x.
Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice.Steiner RC, Hsiung HM, Picciotto MR. Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice. Behavioural Brain Research 2006, 171: 56-62. PMID: 16621045, DOI: 10.1016/j.bbr.2006.03.022.
Galanin can attenuate opiate reinforcement and withdrawal.Picciotto MR, Hawes JJ, Brunzell DH, Zachariou V. Galanin can attenuate opiate reinforcement and withdrawal. Neuropeptides 2005, 39: 313-5. PMID: 15944028, DOI: 10.1016/j.npep.2004.12.001.
GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism.Hawes JJ, Brunzell DH, Wynick D, Zachariou V, Picciotto MR. GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism. Journal Of Neurochemistry 2005, 93: 1168-76. PMID: 15934937, PMCID: PMC1352153, DOI: 10.1111/j.1471-4159.2005.03105.x.
Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein.Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR. Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2005, 25: 2138-45. PMID: 15728854, PMCID: PMC1352335, DOI: 10.1523/JNEUROSCI.3530-04.2005.
Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor.Harrist A, Beech RD, King SL, Zanardi A, Cleary MA, Caldarone BJ, Eisch A, Zoli M, Picciotto MR. Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor. Synapse (New York, N.Y.) 2004, 54: 200-6. PMID: 15472930, DOI: 10.1002/syn.20081.
Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain.Stedman DR, Uboha NV, Stedman TT, Nairn AC, Picciotto MR. Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain. FEBS Letters 2004, 566: 275-80. PMID: 15147908, DOI: 10.1016/j.febslet.2004.04.042.
Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain.Hawes JJ, Picciotto MR. Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain. The Journal Of Comparative Neurology 2004, 479: 410-23. PMID: 15514977, DOI: 10.1002/cne.20329.
Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration.King SL, Caldarone BJ, Picciotto MR. Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology 2004, 47 Suppl 1: 132-9. PMID: 15464132, DOI: 10.1016/j.neuropharm.2004.06.024.
Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons.Beech RD, Cleary MA, Treloar HB, Eisch AJ, Harrist AV, Zhong W, Greer CA, Duman RS, Picciotto MR. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons. The Journal Of Comparative Neurology 2004, 475: 128-41. PMID: 15176089, DOI: 10.1002/cne.20179.
High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation.Caldarone BJ, Harrist A, Cleary MA, Beech RD, King SL, Picciotto MR. High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biological Psychiatry 2004, 56: 657-64. PMID: 15522249, DOI: 10.1016/j.biopsych.2004.08.010.
Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning.Wehner JM, Keller JJ, Keller AB, Picciotto MR, Paylor R, Booker TK, Beaudet A, Heinemann SF, Balogh SA. Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience 2004, 129: 11-24. PMID: 15489024, DOI: 10.1016/j.neuroscience.2004.07.016.
Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response.Owens JC, Balogh SA, McClure-Begley TD, Butt CM, Labarca C, Lester HA, Picciotto MR, Wehner JM, Collins AC. Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response. Alcoholism, Clinical And Experimental Research 2003, 27: 1867-75. PMID: 14691373, DOI: 10.1097/01.ALC.0000102700.72447.0F.
Nicotine as a modulator of behavior: beyond the inverted U.Picciotto MR. Nicotine as a modulator of behavior: beyond the inverted U. Trends In Pharmacological Sciences 2003, 24: 493-9. PMID: 12967775, DOI: 10.1016/S0165-6147(03)00230-X.
In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice.Brunzell DH, Russell DS, Picciotto MR. In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice. Journal Of Neurochemistry 2003, 84: 1431-41. PMID: 12614343, DOI: 10.1046/j.1471-4159.2003.01640.x.
Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation.Stevens TR, Krueger SR, Fitzsimonds RM, Picciotto MR. Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 10093-9. PMID: 14602824, PMCID: PMC6740855.
Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex.Lambe EK, Picciotto MR, Aghajanian GK. Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2003, 28: 216-25. PMID: 12589374, DOI: 10.1038/sj.npp.1300032.
The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal.Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, Wynick D, Langel U, Picciotto MR. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 9028-33. PMID: 12853567, PMCID: PMC166432, DOI: 10.1073/pnas.1533224100.
Identification and characterization of Aplysia adducin, an Aplysia cytoskeletal protein homologous to mammalian adducins: increased phosphorylation at a protein kinase C consensus site during long-term synaptic facilitation.Gruenbaum LM, Gilligan DM, Picciotto MR, Marinesco S, Carew TJ. Identification and characterization of Aplysia adducin, an Aplysia cytoskeletal protein homologous to mammalian adducins: increased phosphorylation at a protein kinase C consensus site during long-term synaptic facilitation. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 2675-85. PMID: 12684453, PMCID: PMC6742073.
Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR. Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 3837-43. PMID: 12736354, PMCID: PMC6742204.
Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice.Caldarone BJ, Karthigeyan K, Harrist A, Hunsberger JG, Wittmack E, King SL, Jatlow P, Picciotto MR. Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice. Psychopharmacology 2003, 170: 94-101. PMID: 12879206, DOI: 10.1007/s00213-003-1518-7.
Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice.Marks MJ, Whiteaker P, Grady SR, Picciotto MR, McIntosh JM, Collins AC. Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice. Journal Of Neurochemistry 2002, 81: 1102-15. PMID: 12065623, DOI: 10.1046/j.1471-4159.2002.00910.x.
Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1.Zachariou V, Benoit-Marand M, Allen PB, Ingrassia P, Fienberg AA, Gonon F, Greengard P, Picciotto MR. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Biological Psychiatry 2002, 51: 612-20. PMID: 11955461, DOI: 10.1016/s0006-3223(01)01318-x.
Effect of nicotine and nicotinic receptors on anxiety and depression.Picciotto MR, Brunzell DH, Caldarone BJ. Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport 2002, 13: 1097-106. PMID: 12151749, DOI: 10.1097/00001756-200207020-00006.
Nicotinic receptors in aging and dementia.Picciotto MR, Zoli M. Nicotinic receptors in aging and dementia. Journal Of Neurobiology 2002, 53: 641-55. PMID: 12436427, DOI: 10.1002/neu.10102.
Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.Picciotto MR, Corrigall WA. Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2002, 22: 3338-41. PMID: 11978809, PMCID: PMC6758396, DOI: 20026360.
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E, Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O, De Camilli P. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron 2002, 33: 789-804. PMID: 11879655, DOI: 10.1016/s0896-6273(02)00601-3.
Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections.Ferrari R, Le Novère N, Picciotto MR, Changeux JP, Zoli M. Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections. The European Journal Of Neuroscience 2002, 15: 1810-8. PMID: 12081661, DOI: 10.1046/j.1460-9568.2001.02009.x.
Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism.Zachariou V, Georgescu D, Kansal L, Merriam P, Picciotto MR. Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism. Journal Of Neurochemistry 2001, 76: 191-200. PMID: 11145992, DOI: 10.1046/j.1471-4159.2001.00018.x.
Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum.Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP, McIntosh JM, Marks MJ, Collins AC. Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. Journal Of Neurochemistry 2001, 76: 258-68. PMID: 11145999, DOI: 10.1046/j.1471-4159.2001.00019.x.
Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects.George TP, Picciotto MR, Verrico CD, Roth RH. Effects of nicotine pretreatment on dopaminergic and behavioral responses to conditioned fear stress in rats: dissociation of biochemical and behavioral effects. Biological Psychiatry 2001, 49: 300-6. PMID: 11230881, DOI: 10.1016/s0006-3223(00)00928-8.
Nicotine receptor inactivation decreases sensitivity to cocaine.Zachariou V, Caldarone BJ, Weathers-Lowin A, George TP, Elsworth JD, Roth RH, Changeux JP, Picciotto MR. Nicotine receptor inactivation decreases sensitivity to cocaine. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2001, 24: 576-89. PMID: 11282258, DOI: 10.1016/S0893-133X(00)00224-4.
Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications.Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, King SL. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacology & Therapeutics 2001, 92: 89-108. PMID: 11916531, DOI: 10.1016/s0163-7258(01)00161-9.
Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization.George TP, Verrico CD, Picciotto MR, Roth RH. Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization. The Journal Of Pharmacology And Experimental Therapeutics 2000, 295: 58-66. PMID: 10991961.
Nicotinic-agonist stimulated (86)Rb(+) efflux and [(3)H]epibatidine binding of mice differing in beta2 genotype.Marks MJ, Stitzel JA, Grady SR, Picciotto MR, Changeux JP, Collins AC. Nicotinic-agonist stimulated (86)Rb(+) efflux and [(3)H]epibatidine binding of mice differing in beta2 genotype. Neuropharmacology 2000, 39: 2632-45. PMID: 11044733, DOI: 10.1016/s0028-3908(00)00115-5.
Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain.Caldarone BJ, Duman CH, Picciotto MR. Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain. Neuropharmacology 2000, 39: 2779-84. PMID: 11044747, DOI: 10.1016/s0028-3908(00)00137-4.
Nicotinic receptors in the brain. Links between molecular biology and behavior.Picciotto MR, Caldarone BJ, King SL, Zachariou V. Nicotinic receptors in the brain. Links between molecular biology and behavior. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2000, 22: 451-65. PMID: 10731620, DOI: 10.1016/S0893-133X(99)00146-3.
Pharmacological and null mutation approaches reveal nicotinic receptor diversity.Whiteaker P, Marks MJ, Grady SR, Lu Y, Picciotto MR, Changeux JP, Collins AC. Pharmacological and null mutation approaches reveal nicotinic receptor diversity. European Journal Of Pharmacology 2000, 393: 123-35. PMID: 10771005, DOI: 10.1016/s0014-2999(00)00052-2.
Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal.Zachariou V, Thome J, Parikh K, Picciotto MR. Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2000, 23: 127-37. PMID: 10882839, DOI: 10.1016/S0893-133X(00)00094-4.
Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4.Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2000, 20: 5608-15. PMID: 10908597, PMCID: PMC6772558.
The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway.Paul S, Snyder GL, Yokakura H, Picciotto MR, Nairn AC, Lombroso PJ. The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2000, 20: 5630-8. PMID: 10908600, PMCID: PMC6772528.
Gender differences in learned helplessness behavior are influenced by genetic background.Caldarone BJ, George TP, Zachariou V, Picciotto MR. Gender differences in learned helplessness behavior are influenced by genetic background. Pharmacology, Biochemistry, And Behavior 2000, 66: 811-7. PMID: 10973520, DOI: 10.1016/s0091-3057(00)00271-9.
5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors.Mukhin AG, Gündisch D, Horti AG, Koren AO, Tamagnan G, Kimes AS, Chambers J, Vaupel DB, King SL, Picciotto MR, Innis RB, London ED. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Molecular Pharmacology 2000, 57: 642-9. PMID: 10692507, DOI: 10.1124/mol.57.3.642.
Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors.Zoli M, Picciotto MR, Ferrari R, Cocchi D, Changeux JP. Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. The EMBO Journal 1999, 18: 1235-44. PMID: 10064590, PMCID: PMC1171214, DOI: 10.1093/emboj/18.5.1235.
Modulation of morphine analgesia in alphaCGRP mutant mice.Salmon AM, Damaj I, Sekine S, Picciotto MR, Marubio L, Changeux JP. Modulation of morphine analgesia in alphaCGRP mutant mice. Neuroreport 1999, 10: 849-54. PMID: 10208559, DOI: 10.1097/00001756-199903170-00033.
Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit.Marks MJ, Whiteaker P, Calcaterra J, Stitzel JA, Bullock AE, Grady SR, Picciotto MR, Changeux JP, Collins AC. Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit. The Journal Of Pharmacology And Experimental Therapeutics 1999, 289: 1090-103. PMID: 10215692.
Centrally administered galanin blocks morphine place preference in the mouse.Zachariou V, Parikh K, Picciotto MR. Centrally administered galanin blocks morphine place preference in the mouse. Brain Research 1999, 831: 33-42. PMID: 10411981, DOI: 10.1016/s0006-8993(99)01476-6.
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine.Kelz MB, Chen J, Carlezon WA, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 1999, 401: 272-6. PMID: 10499584, DOI: 10.1038/45790.
Knock-out mouse models used to study neurobiological systems.Picciotto MR. Knock-out mouse models used to study neurobiological systems. Critical Reviews In Neurobiology 1999, 13: 103-49. PMID: 10512487, DOI: 10.1615/critrevneurobiol.v13.i2.10.
Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation.Lawson ND, Zain M, Zibello T, Picciotto MR, Nairn AC, Berliner N. Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation. Experimental Hematology 1999, 27: 1682-90. PMID: 10560916, DOI: 10.1016/s0301-472x(99)00108-3.
Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion.le Novère N, Zoli M, Léna C, Ferrari R, Picciotto MR, Merlo-Pich E, Changeux JP. Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. Neuroreport 1999, 10: 2497-501. PMID: 10574359, DOI: 10.1097/00001756-199908200-00012.
Use of knock-out mice to determine the molecular basis for the actions of nicotine.Picciotto MR, Zoli M, Changeux JP. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 1999, 1 Suppl 2: S121-5; discussion S139-40. PMID: 11768168, DOI: 10.1080/14622299050011931.
Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice.Epping-Jordan MP, Picciotto MR, Changeux JP, Pich EM. Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice. Psychopharmacology 1999, 147: 25-6. PMID: 10591862, DOI: 10.1007/s002130051135.
Testing the genetics of behavior in mice.Picciotto MR, Self DW. Testing the genetics of behavior in mice. Science (New York, N.Y.) 1999, 285: 2067; author reply 2069-70. PMID: 10523199, DOI: 10.1126/science.285.5436.2067d.
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine.Picciotto MR, Zoli M, Rimondini R, Léna C, Marubio LM, Pich EM, Fuxe K, Changeux JP. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 1998, 391: 173-7. PMID: 9428762, DOI: 10.1038/34413.
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.Zoli M, Léna C, Picciotto MR, Changeux JP. Identification of four classes of brain nicotinic receptors using beta2 mutant mice. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 1998, 18: 4461-72. PMID: 9614223, PMCID: PMC6792706.
Common aspects of the action of nicotine and other drugs of abuse.Picciotto MR. Common aspects of the action of nicotine and other drugs of abuse. Drug And Alcohol Dependence 1998, 51: 165-72. PMID: 9716938, DOI: 10.1016/s0376-8716(98)00074-x.
Transgenic animals with inducible, targeted gene expression in brain.Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PE, Picciotto MR, Duman RS, Nestler EJ. Transgenic animals with inducible, targeted gene expression in brain. Molecular Pharmacology 1998, 54: 495-503. PMID: 9730908, DOI: 10.1124/mol.54.3.495.
Using knockout and transgenic mice to study neurophysiology and behavior.Picciotto MR, Wickman K. Using knockout and transgenic mice to study neurophysiology and behavior. Physiological Reviews 1998, 78: 1131-63. PMID: 9790572, DOI: 10.1152/physrev.1998.78.4.1131.
Contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine.Picciotto MR, Zoli M, Zachariou V, Changeux JP. Contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine. Biochemical Society Transactions 1997, 25: 824-9. PMID: 9388554, DOI: 10.1042/bst0250824.
Structure, regulation, and function of calcium/calmodulin-dependent protein kinase I.Picciotto MR, Nastiuk KL, Nairn AC. Structure, regulation, and function of calcium/calmodulin-dependent protein kinase I. Advances In Pharmacology (San Diego, Calif.) 1996, 36: 251-75. PMID: 8783563, DOI: 10.1016/s1054-3589(08)60585-2.
The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains.Yokokura H, Picciotto MR, Nairn AC, Hidaka H. The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains. The Journal Of Biological Chemistry 1995, 270: 23851-9. PMID: 7559563, DOI: 10.1074/jbc.270.40.23851.
Immunochemical localization of calcium/calmodulin-dependent protein kinase I.Picciotto MR, Zoli M, Bertuzzi G, Nairn AC. Immunochemical localization of calcium/calmodulin-dependent protein kinase I. Synapse (New York, N.Y.) 1995, 20: 75-84. PMID: 7624832, DOI: 10.1002/syn.890200111.
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain.Picciotto MR, Zoli M, Léna C, Bessis A, Lallemand Y, Le Novère N, Vincent P, Pich EM, Brûlet P, Changeux JP. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 1995, 374: 65-7. PMID: 7870173, DOI: 10.1038/374065a0.
Calcium/calmodulin-dependent protein kinases.Nairn AC, Picciotto MR. Calcium/calmodulin-dependent protein kinases. Seminars In Cancer Biology 1994, 5: 295-303. PMID: 7803766.
Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells.Cohn JA, Strong TV, Picciotto MR, Nairn AC, Collins FS, Fitz JG. Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells. Gastroenterology 1993, 105: 1857-64. PMID: 7504645, DOI: 10.1016/0016-5085(93)91085-v.
Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site.Picciotto MR, Czernik AJ, Nairn AC. Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site. The Journal Of Biological Chemistry 1993, 268: 26512-21. PMID: 8253780.
Phosphorylation of the cystic fibrosis transmembrane conductance regulator.Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC. Phosphorylation of the cystic fibrosis transmembrane conductance regulator. The Journal Of Biological Chemistry 1992, 267: 12742-52. PMID: 1377674.
Purification and characterization of PCPP-260: a Purkinje cell-enriched cyclic AMP-regulated membrane phosphoprotein of Mr 260,000.Weeks G, Picciotto M, Nairn AC, Walaas SI, Greengard P. Purification and characterization of PCPP-260: a Purkinje cell-enriched cyclic AMP-regulated membrane phosphoprotein of Mr 260,000. Synapse (New York, N.Y.) 1988, 2: 89-96. PMID: 2844000, DOI: 10.1002/syn.890020112.
Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides.Schaefer M, Picciotto MR, Kreiner T, Kaldany RR, Taussig R, Scheller RH. Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides. Cell 1985, 41: 457-67. PMID: 3838698, DOI: 10.1016/s0092-8674(85)80019-2.
Two introns define functional domains of a neuropeptide precursor in Aplysia.Taussig R, Picciotto MR, Scheller RH. Two introns define functional domains of a neuropeptide precursor in Aplysia. Clinical And Experimental Hypertension. Part A, Theory And Practice 1984, 6: 2133-40. PMID: 6532597, DOI: 10.3109/10641968409046142.
Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs.Mineur YS, Mose TN, Vanopdenbosch L, Etherington IM, Ogbejesi C, Islam A, Pineda CM, Crouse RB, Zhou W, Thompson DC, Bentham MP, Picciotto MR. Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs. Molecular Psychiatry 2022, 27: 1829-1838. PMID: 34997190, PMCID: PMC9106825, DOI: 10.1038/s41380-021-01404-7.
Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.Mineur YS, Garcia-Rivas V, Thomas MA, Soares AR, McKee SA, Picciotto MR. Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. Psychopharmacology 2022, 239: 2041-2061. PMID: 35359158, DOI: 10.1007/s00213-022-06120-w.
Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear.Lee B, Pothula S, Wu M, Kang H, Girgenti MJ, Picciotto MR, DiLeone RJ, Taylor JR, Duman RS. Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear. Molecular Psychiatry 2022, 27: 2580-2589. PMID: 35418600, DOI: 10.1038/s41380-022-01498-7.
Animal models to investigate the impact of flavors on nicotine addiction and dependence.Bagdas D, Kebede N, Zepei AM, Harris L, Minanov K, Picciotto MR, Addy NA. Animal models to investigate the impact of flavors on nicotine addiction and dependence. Current Neuropharmacology 2022 PMID: 35611777, DOI: 10.2174/1570159X20666220524120231.

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Marina Picciotto, PhD

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