Maricar Malinis
MD, FACP, FIDSA, FAST
Associate Professor of Medicine; Medical Director, Transplant and Oncology Infectious Diseases, Section of Infectious Diseases
Research & Publications
Biography
News
Research Summary
My research is focused on infections in solid organ transplant (SOT) and hematopoietic stem cell transplants. I have a particular interest in clinical outcomes of specific populations including older adults and people living with HIV. I also participate in several multi-center clinical trials on novel anti-virals and diagnostic tests. Also, I am the Yale site primary investigator of the NIH U01- funded HIV to HIV deceased donor kidney transplant and deceased liver transplant clinical trial study led by Johns Hopkins University.
Coauthors
Research Interests
Aging; Herpesviridae; HIV; Transplantation; Immunocompromised Host; Frailty
Selected Publications
- Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients.Malinis MF, Mawhorter SD, Jain A, Shrestha NK, Avery RK, van Duin D. Staphylococcus aureus bacteremia in solid organ transplant recipients: evidence for improved survival when compared with nontransplant patients. Transplantation 2012, 93:1045-50.
- Outcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era.Malinis MF, Chen S, Allore HG, Quagliarello VJ. Outcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era. Annals Of Transplantation 2014, 19:478-87.
- Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature.Bernardo RM, Gurung A, Jain D, Malinis MF. Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature. The American Journal Of Case Reports 2016, 17:484-9.
- Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction.Baghban A, Azar MM, Bernardo RM, Malinis M. Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction. BMJ Case Reports 2016, 2016.
- Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature.Azar MM, Assi R, Patel N, Malinis MF. Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. Mycopathologia 2016, 181:425-33.
- Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines.Azar MM, Malinis MF. Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines. The American Journal Of Tropical Medicine And Hygiene 2016, 95:70-4.
- Fatal case of cutaneous-sparing orolaryngeal zoster in a renal transplant recipient.Helou E, Grant M, Landry M, Wu X, Morrow JS, Malinis MF. Fatal case of cutaneous-sparing orolaryngeal zoster in a renal transplant recipient. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2017, 19.
- Integrase strand transferase inhibitors: the preferred antiretroviral regimen in HIV-positive renal transplantation.Azar MM, Malinis MF, Moss J, Formica RN, Villanueva MS. Integrase strand transferase inhibitors: the preferred antiretroviral regimen in HIV-positive renal transplantation. International Journal Of STD & AIDS 2017, 28:447-458.
- Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia.Azar MM, Assi R, Valika AK, Banach DB, Hall IE, Landry ML, Malinis MF. Graft loss among renal-transplant recipients with early reduction of immunosuppression for BK viremia. World Journal Of Transplantation 2017, 7:269-275.
- Efficacy of an 8-week course of sofosbuvir and ledipasvir for the treatment of HCV infection in selected HIV-infected patients.Ogbuagu O, Hao R, Virata M, Villanueva MS, Malinis M. Efficacy of an 8-week course of sofosbuvir and ledipasvir for the treatment of HCV infection in selected HIV-infected patients. F1000Research 2017, 6:620.
- Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States.Azar MM, Zhang X, Assi R, Hage C, Wheat LJ, Malinis MF. Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States. Medical Mycology 2018, 56:896-899.
- Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient.Fu W, Merola J, Malinis M, Lacy J, Barbieri A, Liapakis AH, Mulligan DC, Yoo PS. Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2018, 20:e12966.
- Ganciclovir and foscarnet dual-therapy for cytomegalovirus encephalitis: A case report and review of the literature.Baghban A, Malinis M. Ganciclovir and foscarnet dual-therapy for cytomegalovirus encephalitis: A case report and review of the literature. Journal Of The Neurological Sciences 2018, 388:28-36.
- Management of Mycobacterium Other than Tuberculosis in Solid Organ Transplantation.Malinis MF. Management of Mycobacterium Other than Tuberculosis in Solid Organ Transplantation. Infectious Disease Clinics Of North America 2018, 32:719-732.
- The impact of a multimodal approach to vancomycin discontinuation in hematopoietic stem cell transplant recipients (HSCT) with febrile neutropenia (FN).Perreault S, McManus D, Bar N, Foss F, Gowda L, Isufi I, Seropian S, Malinis M, Topal JE. The impact of a multimodal approach to vancomycin discontinuation in hematopoietic stem cell transplant recipients (HSCT) with febrile neutropenia (FN). Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2019, 21:e13059.
- Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations.Shallis RM, Gleeson S, Azar M, Malinis M, Xu ML, Seropian SE, Gowda L, Zeidan AM. Allogeneic stem cell transplantation and combination antiretroviral therapy: cautions, complications, and considerations. Leukemia & Lymphoma 2019, 60:2584-2587.
- Screening of donor and candidate prior to solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.Malinis M, Boucher HW. Screening of donor and candidate prior to solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation 2019, 33:e13548.
- Improved mortality in Staphylococcus aureus bacteremia with the involvement of antimicrobial stewardship team and infectious disease consultation.Sherbuk JE, McManus D, Topal JE, Malinis M. Improved mortality in Staphylococcus aureus bacteremia with the involvement of antimicrobial stewardship team and infectious disease consultation. Infection Control And Hospital Epidemiology 2019, 40:932-935.
- An interdisciplinary approach to the older transplant patient: strategies for improving clinical outcomes.Schaenman J, Goldwater D, Malinis M. An interdisciplinary approach to the older transplant patient: strategies for improving clinical outcomes. Current Opinion In Organ Transplantation 2019, 24:504-510.
- Heart or lung transplant outcomes in HIV-infected recipients.Koval CE, Farr M, Krisl J, Haidar G, R Pereira M, Shrestha N, Malinis MF, Mueller NJ, M Hannan M, Grossi P, Huprikar S. Heart or lung transplant outcomes in HIV-infected recipients. The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation 2019, 38:1296-1305.
- Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results.Durand CM, Werbel W, Doby B, Brown D, Desai NM, Malinis M, Price J, Chin-Hong P, Mehta S, Friedman-Moraco R, Turgeon NA, Gilbert A, Morris MI, Stosor V, Elias N, Aslam S, Santos CAQ, Hand JM, Husson J, Pruett TL, Agarwal A, Adebiyi O, Pereira M, Small CB, Apewokin S, Heun Lee D, Haidar G, Blumberg E, Mehta SA, Huprikar S, Florman SS, Redd AD, Tobian AAR, Segev DL. Clarifying the HOPE Act landscape: The challenge of donors with false-positive HIV results. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2020, 20:617-619.
- Gomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses.Azar MM, Slotkin R, Abi-Raad R, Liu Y, Grant MH, Malinis MF. Gomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses. Archives Of Pathology & Laboratory Medicine 2020.
- Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift.Azar MM, Gaston DC, Kotton CN, Malinis MF. Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift. Transplantation 2020, 104:1358-1384.
- Orally Administered Human Immunoglobulin Therapy for Norovirus Enteritis in Solid Organ Transplant Recipients: A Case Series at a Single Academic Transplant Center.Nussbaum EZ, Azar MM, Cohen E, McManus D, Topal JE, Malinis M. Orally Administered Human Immunoglobulin Therapy for Norovirus Enteritis in Solid Organ Transplant Recipients: A Case Series at a Single Academic Transplant Center. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2020, 71:e206-e209.
- Under Our Very Eyes.Koff A, Malinis M, Delgado S, Grant M, Ahmad T. Under Our Very Eyes. The New England Journal Of Medicine 2020, 382:952-957.
- Daptomycin perioperative prophylaxis for the prevention of vancomycin-resistant Enterococcus infection in colonized liver transplant recipients.Sarwar S, Koff A, Malinis M, Azar MM. Daptomycin perioperative prophylaxis for the prevention of vancomycin-resistant Enterococcus infection in colonized liver transplant recipients. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, 22:e13280.
- Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV.Seaman SM, Van Pilsum Rasmussen SE, Nguyen AQ, Halpern SE, You S, Waldram MM, Anjum SK, Bowring MG, Muzaale AD, Ostrander DB, Brown D, Massie AB, Tobian AAR, Henderson ML, Fletcher FE, Smith B, Chao A, Gorupati N, Prakash K, Aslam S, Lee DH, Kirchner V, Pruett TL, Haidar G, Hughes K, Malinis M, Trinh S, Segev DL, Sugarman J, Durand CM. Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV. Journal Of Acquired Immune Deficiency Syndromes (1999) 2020, 85:88-92.
- Chest Pain and a Cavitary Lung Mass in a Woman With Diabetes.Koff A, Malinis M. Chest Pain and a Cavitary Lung Mass in a Woman With Diabetes. JAMA 2020, 323:2421-2422.
- Repurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients.Davis MW, McManus D, Koff A, Jaszczur GR, Malinis M, Dela Cruz C, Britto CJ, Price C, Azmy V, Kaman K, Gaston D, Early K, DeWitt M, Song JS, Ortiz C, Juthani-Mehta M, Topal JE. Repurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients. Infection Control And Hospital Epidemiology 2020, 41:1335-1337.
- Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes.Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes. Chest 2020, 158:1397-1408.
- COVID-19 in solid organ transplant: A multi-center cohort study.Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP. COVID-19 in solid organ transplant: A multi-center cohort study. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2020.
- Donor derived hepatitis B virus infection: Analysis of the Organ Procurement & Transplantation Network/United Network for Organ Sharing Ad Hoc Disease Transmission Advisory Committee.Theodoropoulos NM, La Hoz RM, Wolfe C, Vece G, Bag R, Berry GJ, Bucio J, Danziger-Isakov L, Florescu DF, Goldberg D, Ho CS, Lilly K, Malinis M, Mehta AK, Nalesnik MA, Sawyer R, Strasfeld L, Wood RP, Michaels MG. Donor derived hepatitis B virus infection: Analysis of the Organ Procurement & Transplantation Network/United Network for Organ Sharing Ad Hoc Disease Transmission Advisory Committee. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2021, 23:e13458.
- COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system.Caraballo C, McCullough M, Fuery MA, Chouairi F, Keating C, Ravindra NG, Miller PE, Malinis M, Kashyap N, Hsiao A, Wilson FP, Curtis JP, Grant M, Velazquez EJ, Desai NR, Ahmad T. COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system. PloS One 2020, 15:e0238829.
- Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and ManagementEmerging Transplant Infections, Springer
- Prolonged incubation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a patient on rituximab therapy.Koff A, Laurent-Rolle M, Hsu JC, Malinis M. Prolonged incubation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a patient on rituximab therapy. Infection Control And Hospital Epidemiology 2020, 1-2.
- Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient.Lier AJ, Virmani S, Ilagan-Ying Y, Leelatian N, Darbinyan A, Malinis M. Unilateral leg pain caused by cryptococcal myositis: An unusual presentation of disseminated cryptococcosis in a kidney transplant recipient. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, e13491.
- Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients.Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2021, 21:1304-1311.
- Expecting the unexpected: COVID-19 in Kidney Transplant Recipients within United Network for Organ Sharing Region 1.Zimmerman A, Rogers R, Tan CS, Pavlakis M, Bodziak K, Cardarelli F, Francis J, Gabardi S, Germain M, Ghai S, Gilligan H, Goyal N, Malinis M, Patel H, Rodig N, Theodoropoulos NM, Walshe E, Wood E, Chobanian M. Expecting the unexpected: COVID-19 in Kidney Transplant Recipients within United Network for Organ Sharing Region 1. Transplant International : Official Journal Of The European Society For Organ Transplantation 2020, 33:1843-1844.
- Adverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults.Brzozowski K, Datta R, Canterino J, Malinis M, Juthani-Mehta M. Adverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults. Open Forum Infectious Diseases 2020, 7:ofaa358.
- Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies.Trubin PA, Azar MM, Malinis M. Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies. Current Transplantation Reports 2020, 1-9.
- An overview on the use of antivirals for the treatment of patients with COVID19 disease.Malinis M, McManus D, Davis M, Topal J. An overview on the use of antivirals for the treatment of patients with COVID19 disease. Expert Opinion On Investigational Drugs 2021, 30:45-59.
- Added Diagnostic Utility Of Clinical Metagenomics For The Diagnosis Of Pneumonia In Immunocompromised Adults.Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility Of Clinical Metagenomics For The Diagnosis Of Pneumonia In Immunocompromised Adults. Chest 2020.
- Clinicopathologic Features of Tissue Granulomas in Transplant Recipients: A Single Center Study in a Nontuberculosis Endemic Region.Nussbaum EZ, Patel KK, Assi R, Raad RA, Malinis M, Azar MM. Clinicopathologic Features of Tissue Granulomas in Transplant Recipients: A Single Center Study in a Nontuberculosis Endemic Region. Archives Of Pathology & Laboratory Medicine 2020.
- Cryptococcus transmission through solid organ transplantation in the United States: A Report from the Ad Hoc Disease Transmission Advisory Committee.Penumarthi LR, La Hoz RM, Wolfe CR, Jackson BR, Mehta AK, Malinis M, Danziger-Isakov L, Strasfeld L, Florescu DF, Vece G, Basavaraju SV, Michaels MG. Cryptococcus transmission through solid organ transplantation in the United States: A Report from the Ad Hoc Disease Transmission Advisory Committee. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2020.
- Healthcare resource use among solid organ transplant recipients hospitalized with COVID-19.Heldman MR, Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Jeng A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Limaye AP, Fisher CE. Healthcare resource use among solid organ transplant recipients hospitalized with COVID-19. Clinical Transplantation 2021, 35:e14174.
- A retrospective matched cohort single-center study evaluating outcomes of COVID-19 and the impact of immunomodulation on COVID-19-related cytokine release syndrome in solid organ transplant recipients.Ringer M, Azmy V, Kaman K, Tang D, Cheung H, Azar MM, Price C, Malinis M. A retrospective matched cohort single-center study evaluating outcomes of COVID-19 and the impact of immunomodulation on COVID-19-related cytokine release syndrome in solid organ transplant recipients. Transplant Infectious Disease : An Official Journal Of The Transplantation Society 2020, e13556.
- Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19.Azmy V, Kaman K, Tang D, Zhao H, Dela Cruz C, Topal JE, Malinis M, Price CC. Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19. Journal Of Clinical Immunology 2021.
- How the Field of Infectious Diseases Can Leverage Digital Strategy and Social Media Use During a Pandemic.Marcelin JR, Cortés-Penfield N, Del Rio C, Desai A, Echenique I, Granwehr B, Lawal F, Kuriakose K, Lee DH, Malinis M, Ruidera D, Siddiqui J, Spec A, Swartz TH. How the Field of Infectious Diseases Can Leverage Digital Strategy and Social Media Use During a Pandemic. Open Forum Infectious Diseases 2021, 8:ofab027.
Clinical Trials
Conditions | Study Title |
---|---|
Infectious Diseases | Study for the Treatment of Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant Recipients |
Diseases of the Kidney & Urinary Tract; HIV/AIDS | HOPE in Action Prospective Multicenter, Clinical Trial of Deceased HIVD+ Kidney Transplants for HIV+ Recipients |
Infectious Diseases; Men's Health; Women's Health | Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Adults (PRIOH-1) |