Mariam Aboian, MD/PhD

• Ajay Malhotra
• Amit Mahajan
• Anita Huttner
• Antonio Omuro
• Armine Darbinyan
• Asher Marks
• Benjamin L. Judson
• Bernadette Marquez-Nostra
• Declan McGuone
• E. Zeynep Erson Omay
• Harriet Kluger
• Ichiro Ikuta
• Jennifer Moliterno
• Kanat Yalcin
• Ketu Mishra-Gorur
• Kristopher Kahle
• Lawrence Staib
• Mani Ratnesh Sandhu
• Michael Alperovich
• Michele Johnson
• Murat Gunel
• Nicholas Blondin
• Raffaella Morotti
• Renelle Lim
• Richard Bronen
• Robert Fulbright
• Sam Payabvash
• Sarah Goldberg
• Sarah Kandil
• Sarah Weiss
• Shaurey Vetsa
• Tanyeri Barak
• Thuy Tran
• Veronica Chiang
• Xi Wang

Brain Neoplasms; Glioblastoma; Nuclear Medicine; Radiotherapy; Informatics; Molecular Imaging; Cognitive Neuroscience; Machine Learning; Mentoring

• 124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma.Aboian M, Huang SY, Pampaloni MH, Hawkins RA, Huh Y, Vo K, Gustafson C, Matthay K, Seo Y. 124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2021, 62: 43-47. PMID: 32414950, DOI: 10.2967/jnumed.120.243139.
• Maximizing the use of batch production of 18F-FDOPA for imaging of brain tumors to increase availability of hybrid PET/MR imaging in clinical setting.Aboian M, Barajas R, Shatalov J, Ravanfar V, Bahroos E, Tong E, Taylor JW, Bush NO, Sneed P, Seo Y, Cha S, Hernandez-Pampaloni M. Maximizing the use of batch production of 18F-FDOPA for imaging of brain tumors to increase availability of hybrid PET/MR imaging in clinical setting. Neuro-oncology Practice 2021, 8: 91-97. PMID: 33664973, PMCID: PMC7906261, DOI: 10.1093/nop/npaa065.
• Theranostics in Brain Tumors.Shooli H, Nemati R, Ahmadzadehfar H, Aboian M, Jafari E, Jokar N, Nabipour I, Dadgar H, Gholamrezanezhad A, Larvie M, Assadi M. Theranostics in Brain Tumors. PET Clinics 2021, 16: 397-418. PMID: 34053584, DOI: 10.1016/j.cpet.2021.03.005.
• Letter regarding "Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients-a report of the PET/RANO group": 18F-fluciclovine and target volume delineation.Kotecha R, Aboian M, Nabavizadeh SA, Parent EE, Trifiletti DM, Chao ST. Letter regarding "Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients-a report of the PET/RANO group": 18F-fluciclovine and target volume delineation. Neuro-oncology 2021, 23: 1408-1409. PMID: 34081125, PMCID: PMC8328036, DOI: 10.1093/neuonc/noab097.
• Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.Kazarian E, Marks A, Cui J, Darbinyan A, Tong E, Mueller S, Cha S, Aboian MS. Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas. Scientific Reports 2021, 11: 14377. PMID: 34257334, PMCID: PMC8277861, DOI: 10.1038/s41598-021-92943-0.
• Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings.Payabvash S, Aboian M, Tihan T, Cha S. Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings. Frontiers In Oncology 2020, 10: 71. PMID: 32117728, PMCID: PMC7018938, DOI: 10.3389/fonc.2020.00071.
• High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathology (Zurich, Switzerland) 2020, 30: 46-62. PMID: 31104347, PMCID: PMC6859193, DOI: 10.1111/bpa.12747.
• Phase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002).Nicolaides T, Nazemi KJ, Crawford J, Kilburn L, Minturn J, Gajjar A, Gauvain K, Leary S, Dhall G, Aboian M, Robinson G, Long-Boyle J, Wang H, Molinaro AM, Mueller S, Prados M. Phase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002). Oncotarget 2020, 11: 1942-1952. PMID: 32523649, PMCID: PMC7260122, DOI: 10.18632/oncotarget.27600.
• A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain.Ding Y, Sohn JH, Kawczynski MG, Trivedi H, Harnish R, Jenkins NW, Lituiev D, Copeland TP, Aboian MS, Mari Aparici C, Behr SC, Flavell RR, Huang SY, Zalocusky KA, Nardo L, Seo Y, Hawkins RA, Hernandez Pampaloni M, Hadley D, Franc BL. A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain. Radiology 2019, 290: 456-464. PMID: 30398430, PMCID: PMC6358051, DOI: 10.1148/radiol.2018180958.
• 3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body.Oh HJ, Aboian MS, Yi MYJ, Maslyn JA, Loo WS, Jiang X, Parkinson DY, Wilson MW, Moore T, Yee CR, Robbins GR, Barth FM, DeSimone JM, Hetts SW, Balsara NP. 3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body. ACS Central Science 2019, 5: 419-427. PMID: 30937369, PMCID: PMC6439445, DOI: 10.1021/acscentsci.8b00700.
• Brainstem Injury in Pediatric Patients Receiving Posterior Fossa Photon Radiation.Devine CA, Liu KX, Ioakeim-Ioannidou M, Susko M, Poussaint TY, Huisman TAGM, Aboian M, Brown D, Zaslowe-Dude C, Rao AD, Orlina LT, Rawal B, Mueller S, Marcus KJ, Terezakis SA, Braunstein SE, Haas-Kogan DA. Brainstem Injury in Pediatric Patients Receiving Posterior Fossa Photon Radiation. International Journal Of Radiation Oncology, Biology, Physics 2019, 105: 1034-1042. PMID: 31472183, DOI: 10.1016/j.ijrobp.2019.08.039.
• Diffusion Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3-K27M Mutation Using Apparent Diffusion Coefficient Histogram Analysis.Aboian MS, Tong E, Solomon DA, Kline C, Gautam A, Vardapetyan A, Tamrazi B, Li Y, Jordan CD, Felton E, Weinberg B, Braunstein S, Mueller S, Cha S. Diffusion Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3-K27M Mutation Using Apparent Diffusion Coefficient Histogram Analysis. AJNR. American Journal Of Neuroradiology 2019, 40: 1804-1810. PMID: 31694820, PMCID: PMC6907069, DOI: 10.3174/ajnr.A6302.
• Delayed Fluorodeoxyglucose Positron Emission Tomography Imaging in the Differentiation of Tumor Recurrence and Radiation Necrosis in Pediatric Central Nervous System Tumors: Case Report and Review of the Literature.Wadhwa EL, Franc BL, Aboian M, Kim JY, Pampaloni M, Nicolaides T. Delayed Fluorodeoxyglucose Positron Emission Tomography Imaging in the Differentiation of Tumor Recurrence and Radiation Necrosis in Pediatric Central Nervous System Tumors: Case Report and Review of the Literature. Cure¯us 2018, 10: e3364. PMID: 30510874, PMCID: PMC6257469, DOI: 10.7759/cureus.3364.
• Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles.Blumenfeld CM, Schulz MD, Aboian MS, Wilson MW, Moore T, Hetts SW, Grubbs RH. Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles. Nature Communications 2018, 9: 2870. PMID: 30030447, PMCID: PMC6054622, DOI: 10.1038/s41467-018-05305-2.
• Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy.Panditharatna E, Kilburn LB, Aboian MS, Kambhampati M, Gordish-Dressman H, Magge SN, Gupta N, Myseros JS, Hwang EI, Kline C, Crawford JR, Warren KE, Cha S, Liang WS, Berens ME, Packer RJ, Resnick AC, Prados M, Mueller S, Nazarian J. Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2018, 24: 5850-5859. PMID: 30322880, PMCID: PMC6279526, DOI: 10.1158/1078-0432.CCR-18-1345.
• Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging.Aboian MS, Kline CN, Li Y, Solomon DA, Felton E, Banerjee A, Braunstein SE, Mueller S, Dillon WP, Cha S. Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging. Neuro-oncology Practice 2018, 5: 234-240. PMID: 30402262, PMCID: PMC6213943, DOI: 10.1093/nop/npx036.
• Apparent diffusion coefficient and pituitary macroadenomas: pre-operative assessment of tumor atypia.Tamrazi B, Pekmezci M, Aboian M, Tihan T, Glastonbury CM. Apparent diffusion coefficient and pituitary macroadenomas: pre-operative assessment of tumor atypia. Pituitary 2017, 20: 195-200. PMID: 27734275, DOI: 10.1007/s11102-016-0759-5.
• Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation.Aboian MS, Solomon DA, Felton E, Mabray MC, Villanueva-Meyer JE, Mueller S, Cha S. Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation. AJNR. American Journal Of Neuroradiology 2017, 38: 795-800. PMID: 28183840, PMCID: PMC5394943, DOI: 10.3174/ajnr.A5076.
• Case 245.Mamlouk MD, Aboian MS, Glastonbury CM. Case 245. Radiology 2017, 283: 609-612. PMID: 28418827, DOI: 10.1148/radiol.2017141150.
• Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-oncology 2017, 19: 699-709. PMID: 28453743, PMCID: PMC5464451, DOI: 10.1093/neuonc/now254.
• Case 245: Erdheim-Chester Disease.Mamlouk MD, Aboian MS, Glastonbury CM. Case 245: Erdheim-Chester Disease. Radiology 2017, 284: 910-917. PMID: 28825890, DOI: 10.1148/radiol.2017141151.
• Case-based review: pediatric medulloblastoma.Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S. Case-based review: pediatric medulloblastoma. Neuro-oncology Practice 2017, 4: 138-150. PMID: 29692919, PMCID: PMC5909805, DOI: 10.1093/nop/npx011.
• In vitro clearance of doxorubicin with a DNA-based filtration device designed for intravascular use with intra-arterial chemotherapy.Aboian MS, Yu JF, Gautam A, Sze CH, Yang JK, Chan J, Lillaney PV, Jordan CD, Oh HJ, Wilson DM, Patel AS, Wilson MW, Hetts SW. In vitro clearance of doxorubicin with a DNA-based filtration device designed for intravascular use with intra-arterial chemotherapy. Biomedical Microdevices 2016, 18: 98. PMID: 27778226, PMCID: PMC5441460, DOI: 10.1007/s10544-016-0124-5.
• A family of tetraspans organizes cargo for sorting into multivesicular bodies.MacDonald C, Payne JA, Aboian M, Smith W, Katzmann DJ, Piper RC. A family of tetraspans organizes cargo for sorting into multivesicular bodies. Developmental Cell 2015, 33: 328-42. PMID: 25942624, PMCID: PMC4421094, DOI: 10.1016/j.devcel.2015.03.007.
• SISCOM in children with tuberous sclerosis complex-related epilepsy.Aboian MS, Wong-Kisiel LC, Rank M, Wetjen NM, Wirrell EC, Witte RJ. SISCOM in children with tuberous sclerosis complex-related epilepsy. Pediatric Neurology 2011, 45: 83-8. PMID: 21763947, DOI: 10.1016/j.pediatrneurol.2011.05.001.
• Mesial temporal sclerosis after posterior reversible encephalopathy syndrome.Aboian MS, Junna MR, Krecke KN, Wirrell EC. Mesial temporal sclerosis after posterior reversible encephalopathy syndrome. Pediatric Neurology 2009, 41: 226-8. PMID: 19664544, DOI: 10.1016/j.pediatrneurol.2009.03.007.
• The putative role of the venous system in the genesis of vascular malformations.Aboian MS, Daniels DJ, Rammos SK, Pozzati E, Lanzino G. The putative role of the venous system in the genesis of vascular malformations. Neurosurgical Focus 2009, 27: E9. PMID: 19877799, DOI: 10.3171/2009.8.FOCUS09161.
• Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.Oestreich AJ, Aboian M, Lee J, Azmi I, Payne J, Issaka R, Davies BA, Katzmann DJ. Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5. Molecular Biology Of The Cell 2007, 18: 707-20. PMID: 17182849, PMCID: PMC1783786, DOI: 10.1091/mbc.e06-08-0680.
• Loss of cap structure causes mitotic defect in Tetrahymena thermophila telomerase mutants.Petcherskaia M, McGuire JM, Pherson JM, Kirk KE. Loss of cap structure causes mitotic defect in Tetrahymena thermophila telomerase mutants. Chromosoma 2003, 111: 429-37. PMID: 12707780, DOI: 10.1007/s00412-003-0233-9.
• Protein binding to expanded telomere repeats in Tetrahymena thermophila.McGuire JM, Gana JA, Petcherskaia M, Kirk KE. Protein binding to expanded telomere repeats in Tetrahymena thermophila. The Journal Of Eukaryotic Microbiology 2003, 50: 341-8. PMID: 14563172, DOI: 10.1111/j.1550-7408.2003.tb00146.x.
• Incidence and characteristics of metastatic intracranial lesions in stage III and IV melanoma: a single institute retrospective analysis.Sandhu MRS, Chiang VL, Tran T, Yu JB, Weiss S, Goldberg S, Aboian M, Kluger HM, Mahajan A. Incidence and characteristics of metastatic intracranial lesions in stage III and IV melanoma: a single institute retrospective analysis. Journal Of Neuro-oncology 2021, 154: 197-203. PMID: 34351544, DOI: 10.1007/s11060-021-03813-8.
• Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas.Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA, Gorelick E, Omay SB, Pointdujour-Lim R, Judson BL, Alperovich M, Aboian MS, McGuone D, Gunel M, Erson-Omay Z, Fulbright RK, Moliterno J. Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas. Journal Of Neuro-oncology 2021, 154: 237-246. PMID: 34350560, DOI: 10.1007/s11060-021-03819-2.
• Trends in Development of Novel Machine Learning Methods for the Identification of Gliomas in Datasets That Include Non-Glioma Images: A Systematic Review.Subramanian H, Dey R, Brim WR, Tillmanns N, Cassinelli Petersen G, Brackett A, Mahajan A, Johnson M, Malhotra A, Aboian M. Trends in Development of Novel Machine Learning Methods for the Identification of Gliomas in Datasets That Include Non-Glioma Images: A Systematic Review. Frontiers In Oncology 2021, 11: 788819. PMID: 35004312, PMCID: PMC8733688, DOI: 10.3389/fonc.2021.788819.
• Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma.Puthenpura V, DeNunzio NJ, Zeng X, Giantsoudi D, Aboian M, Ebb D, Kahle KT, Yock TI, Marks AM. Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma. International Journal Of Particle Therapy 2022, 8: 58-65. PMID: 35127977, PMCID: PMC8768897, DOI: 10.14338/IJPT-21-00013.1.
• Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature.Wang X, Habet V, Aboian M, Leelatian N, McGuone D, Morotti R, Kandil S, Darbinyan A. Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature. Journal Of Neuropathology And Experimental Neurology 2022, 81: 296-298. PMID: 35139536, DOI: 10.1093/jnen/nlab137.
• Machine Learning Applications for Differentiation of Glioma from Brain Metastasis-A Systematic Review.Jekel L, Brim WR, von Reppert M, Staib L, Cassinelli Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Machine Learning Applications for Differentiation of Glioma from Brain Metastasis-A Systematic Review. Cancers 2022, 14 PMID: 35326526, PMCID: PMC8946855, DOI: 10.3390/cancers14061369.
• Machine Learning in Differentiating Gliomas from Primary CNS Lymphomas: A Systematic Review, Reporting Quality, and Risk of Bias Assessment.Cassinelli Petersen GI, Shatalov J, Verma T, Brim WR, Subramanian H, Brackett A, Bahar RC, Merkaj S, Zeevi T, Staib LH, Cui J, Omuro A, Bronen RA, Malhotra A, Aboian MS. Machine Learning in Differentiating Gliomas from Primary CNS Lymphomas: A Systematic Review, Reporting Quality, and Risk of Bias Assessment. AJNR. American Journal Of Neuroradiology 2022, 43: 526-533. PMID: 35361577, PMCID: PMC8993193, DOI: 10.3174/ajnr.A7473.
• Radiomics: A Primer on Processing Workflow and Analysis.Avery E, Sanelli PC, Aboian M, Payabvash S. Radiomics: A Primer on Processing Workflow and Analysis. Seminars In Ultrasound, CT, And MR 2022, 43: 142-146. PMID: 35339254, PMCID: PMC8961004, DOI: 10.1053/j.sult.2022.02.003.
• Brain Tumor Imaging: Applications of Artificial Intelligence.Afridi M, Jain A, Aboian M, Payabvash S. Brain Tumor Imaging: Applications of Artificial Intelligence. Seminars In Ultrasound, CT, And MR 2022, 43: 153-169. PMID: 35339256, PMCID: PMC8961005, DOI: 10.1053/j.sult.2022.02.005.
• Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis.Bahar RC, Merkaj S, Cassinelli Petersen GI, Tillmanns N, Subramanian H, Brim WR, Zeevi T, Staib L, Kazarian E, Lin M, Bousabarah K, Huttner AJ, Pala A, Payabvash S, Ivanidze J, Cui J, Malhotra A, Aboian MS. Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis. Frontiers In Oncology 2022, 12: 856231. PMID: 35530302, PMCID: PMC9076130, DOI: 10.3389/fonc.2022.856231.
• Clinical Evaluation of Nuclear Imaging Agents in Breast Cancer.Li Z, Aboian MS, Zhu X, Marquez-Nostra B. Clinical Evaluation of Nuclear Imaging Agents in Breast Cancer. Cancers 2022, 14 PMID: 35565232, PMCID: PMC9101155, DOI: 10.3390/cancers14092103.
• Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities.Merkaj S, Bahar RC, Zeevi T, Lin M, Ikuta I, Bousabarah K, Cassinelli Petersen GI, Staib L, Payabvash S, Mongan JT, Cha S, Aboian MS. Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities. Cancers 2022, 14 PMID: 35681603, DOI: 10.3390/cancers14112623.