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Marcus Bosenberg, MD, PhD

Professor of Dermatology, Pathology, and Immunobiology; Co-Leader, Cancer Immunology, Yale Cancer Center; Director, Yale Center for Immuno-Oncology; Director, Yale SPORE in Skin Cancer

Contact Information

Marcus Bosenberg, MD, PhD

Office Location

Mailing Address

  • Dermatology

    PO Box 208059, 333 Cedar Street

    New Haven, CT 06520-8059

    United States

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Yale Medicine

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Research Summary

Directs a National Cancer Institute funded melanoma research laboratory with interests in several aspects of melanoma biology including the cell biology and genetics of metastasis, tumor immunology, prognostic and diagnostic markers and development of new therapeutic agents.

Specialized Terms: Tumor immunology; Melanoma models; Melanocytic neoplasms; Genodermatoses

Extensive Research Description

Directs a National Cancer Institute funded melanoma research laboratory with interests in several aspects of melanoma biology including the cell biology and genetics of metastasis, prognostic and diagnostic markers and development of new therapeutic agents.

Coauthors

Research Interests

Cell Biology; Dermatology; Melanoma; Neoplasm Metastasis; Pathology

Selected Publications

  • KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.
  • IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature 2020, 583: 609-614. PMID: 32581358, PMCID: PMC7381364, DOI: 10.1038/s41586-020-2422-6.
  • DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.Micevic G, Muthusamy V, Damsky W, Theodosakis N, Liu X, Meeth K, Wingrove E, Santhanakrishnan M, Bosenberg M. DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR. Cell Reports 2016, 14: 2180-2192. PMID: 26923591, PMCID: PMC4785087, DOI: 10.1016/j.celrep.2016.02.010.
  • mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell 2015, 27: 41-56. PMID: 25584893, PMCID: PMC4295062, DOI: 10.1016/j.ccell.2014.11.014.
  • β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas.Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell 2011, 20: 741-54. PMID: 22172720, PMCID: PMC3241928, DOI: 10.1016/j.ccr.2011.10.030.
  • Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nature Genetics 2009, 41: 544-52. PMID: 19282848, PMCID: PMC2705918, DOI: 10.1038/ng.356.
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