Marc Potenza, PhD, MD
Research & Publications
Biography
News
Research Summary
My research focuses on how non-substance ("behavioral") addictions are similar to and different from substance addictions. We use brain imaging, genetic, clinical, pharmacological, behavioral and epidemiological approaches to study this topic. We are also interested how individual differences related to impulsivity and gender, for example, influence non-substance and substance addictions.
Specialized Terms: Pathological gambling; Impulse control disorders; Substance abuse; Addiction; Gender differences
Extensive Research Description
Dr. Potenza's research has focused on the neurobiology and treatment of substance and non-substance addictions and other disorders characterized by impaired impulse control, particularly the disorders characterized in DSM-IV as “Impulse Control Disorders Not Elsewhere Classified” and in DSM-5 and ICD-11 as behavioral addictions. He has focused on internet use behaviors and disorders such as gaming disorder and problematic pornography use, as well as compulsive sexual behavior disorder, binge eating disorder and food addiction. He has investigated mechanisms underlying the treatment of cocaine and opioid use disorders, as well as the neural correlates of prenatal cocaine use. Much of this work has focused on understanding clinical and neurobiological underpinnings of these disorders and experiences, and their co-occurrences with other mental health disorders, in order to advance prevention and treatment strategies. Dr. Potenza's research has applied brain imaging, genetic, epidemiological and clinical trials methodologies to gain knowledge and improve prevention and treatment strategies for addictive disorders. This work has also involved a specific focus on gender and identifying potential intermediary phenotypes, like facets of impulsivity, that may in part explain the high rates of co-occurrence between addictive disorders and other mental health conditions, and might represent novel targets for prevention and treatment strategies.
Coauthors
Research Interests
Child Psychiatry; Gambling; Disruptive, Impulse Control, and Conduct Disorders; Neurobiology; Psychiatry; Psychotherapy; Substance-Related Disorders; Psychiatry and Psychology
Selected Publications
- Gender-related functional connectivity and craving during gaming and immediate abstinence during a mandatory break: Implications for development and progression of internet gaming disorder.Dong G, Wang Z, Wang Y, Du X, Potenza MN. Gender-related functional connectivity and craving during gaming and immediate abstinence during a mandatory break: Implications for development and progression of internet gaming disorder. Progress In Neuro-psychopharmacology & Biological Psychiatry 2019, 88:1-10.
- Neural Correlates of Personalized Spiritual Experiences.Miller L, Balodis IM, McClintock CH, Xu J, Lacadie CM, Sinha R, Potenza MN. Neural Correlates of Personalized Spiritual Experiences. Cerebral Cortex (New York, N.Y. : 1991) 2019, 29:2331-2338.
- Searching for Replicable Dopamine-Related Findings in Gambling Disorder.Potenza MN. Searching for Replicable Dopamine-Related Findings in Gambling Disorder. Biological Psychiatry 2018, 83:984-986.
- Correlates of frequent gambling and gambling-related chasing behaviors in individuals with schizophrenia-spectrum disorders.Yakovenko I, Fortgang R, Prentice J, Hoff RA, Potenza MN. Correlates of frequent gambling and gambling-related chasing behaviors in individuals with schizophrenia-spectrum disorders. Journal Of Behavioral Addictions 2018, 7:375-383.
- The validation of Implicit Association Test measures for smartphone and Internet addiction in at-risk children and adolescents.Roh D, Bhang SY, Choi JS, Kweon YS, Lee SK, Potenza MN. The validation of Implicit Association Test measures for smartphone and Internet addiction in at-risk children and adolescents. Journal Of Behavioral Addictions 2018, 7:79-87.
- fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals.DeVito EE, Kober H, Carroll KM, Potenza MN. fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals. Addictive Behaviors 2019, 89:10-14.
- White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.Morie KP, Yip SW, Zhai ZW, Xu J, Hamilton KR, Sinha R, Mayes LC, Potenza MN. White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine. Drug And Alcohol Dependence 2017, 174:23-29.
- Validation of a Brief Pornography Screen across multiple samples.Kraus SW, Gola M, Grubbs JB, Kowalewska E, Hoff RA, Lew-Starowicz M, Martino S, Shirk SD, Potenza MN. Validation of a Brief Pornography Screen across multiple samples. Journal Of Behavioral Addictions 2020, 9:259-271.
- Which conditions should be considered as disorders in the International Classification of Diseases (ICD-11) designation of "other specified disorders due to addictive behaviors"?Brand M, Rumpf HJ, Demetrovics Z, MÜller A, Stark R, King DL, Goudriaan AE, Mann K, Trotzke P, Fineberg NA, Chamberlain SR, Kraus SW, Wegmann E, Billieux J, Potenza MN. Which conditions should be considered as disorders in the International Classification of Diseases (ICD-11) designation of "other specified disorders due to addictive behaviors"? Journal Of Behavioral Addictions 2020.
- Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors.Antons S, Brand M, Potenza MN. Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors. Journal Of The Neurological Sciences 2020, 415:116952.
- Self-injurious behavior and gambling-related attitudes, perceptions and behaviors in adolescents.Farhat LC, Roberto AJ, Wampler J, Steinberg MA, Krishnan-Sarin S, Hoff RA, Potenza MN. Self-injurious behavior and gambling-related attitudes, perceptions and behaviors in adolescents. Journal Of Psychiatric Research 2020, 124:77-84.
- Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task.Dong GH, Wang M, Zheng H, Wang Z, Du X, Potenza MN. Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task. Psychological Medicine 2020, 1-13.
- Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence.Chen S, Huang S, Yang C, Cai W, Chen H, Hao W, Liu T, Wang X, Worhunsky PD, Potenza MN. Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence. The International Journal Of Neuropsychopharmacology / Official Scientific Journal Of The Collegium Internationale Neuropsychopharmacologicum (CINP) 2020, 23:135-145.
- Addiction severity modulates the precuneus involvement in internet gaming disorder: Functionality, morphology and effective connectivity.Dong GH, Wang M, Wang Z, Zheng H, Du X, Potenza MN. Addiction severity modulates the precuneus involvement in internet gaming disorder: Functionality, morphology and effective connectivity. Progress In Neuro-psychopharmacology & Biological Psychiatry 2020, 98:109829.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Mental Health & Behavioral Research | Vitamin D OP remote study |
| Addictive Behaviors; Mental Health & Behavioral Research | Previous Study | Return to List | Next Study Influence of Medication on Functional Connectivity |
| Children's Health; Diseases in Infants & Newborns | Oxytocin and Brain Responses in Maternal Addiction |
| Mental Health & Behavioral Research | Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD |
| Diseases of the Nervous System; Mental Health & Behavioral Research | Neurofeedback for Obsessive-Compulsive Disorder |
| Addictive Behaviors; Mental Health & Behavioral Research; Tobacco Addiction | Effects of Brief Training on Craving Regulation |