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Maor Sauler, MD

Associate Professor of Medicine (Pulmonary)

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Maor Sauler, MD

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Lee
Yale Medicine

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Research Summary

Our research is focused on understanding how changes in the lung's cellular stress responses, either with age or in disease, contribute to disease susceptibility and disease progression.

Coauthors

Research Interests

Aging; Emphysema; Lung Diseases; Respiratory Distress Syndrome; Frail Elderly; Lung Injury

Selected Publications

  • MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease.Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Skold CM, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6 PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.
  • The DNA repair transcriptome in severe COPD.Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL. The DNA repair transcriptome in severe COPD. The European Respiratory Journal 2018, 52 PMID: 30190272, PMCID: PMC6422831, DOI: 10.1183/13993003.01994-2017.
  • Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease.Sauler M, Leng L, Trentalange M, Haslip M, Shan P, Piecychna M, Zhang Y, Andrews N, Mannam P, Allore H, Fried T, Bucala R, Lee PJ. Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2014, 306: L487-96. PMID: 24441872, PMCID: PMC3949087, DOI: 10.1152/ajplung.00284.2013.
  • Non-coding RNAs as Regulators of Cellular Senescence in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease.Omote N, Sauler M. Non-coding RNAs as Regulators of Cellular Senescence in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease. Frontiers In Medicine 2020, 7: 603047. PMID: 33425948, PMCID: PMC7785852, DOI: 10.3389/fmed.2020.603047.
  • Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.Pellowe AS, Sauler M, Hou Y, Merola J, Liu R, Calderon B, Lauridsen HM, Harris MR, Leng L, Zhang Y, Tilstam PV, Pober JS, Bucala R, Lee PJ, Gonzalez AL. Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2019, 33: 2171-2186. PMID: 30252532, PMCID: PMC6338650, DOI: 10.1096/fj.201800480R.
  • Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury.Sauler M, Zhang Y, Min JN, Leng L, Shan P, Roberts S, Jorgensen WL, Bucala R, Lee PJ. Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2015, 29: 1940-9. PMID: 25609432, PMCID: PMC4415022, DOI: 10.1096/fj.14-260299.
  • A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K, Song YS, Michael H, McCormack M, Allore H, Morris A, Crothers K, Bucala R, Lee PJ, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2019, 316: L400-L405. PMID: 30520689, PMCID: PMC6397351, DOI: 10.1152/ajplung.00439.2018.
  • Form, Function, and Dysfunction: Airway Diseases Are Associated With Increased Risk for Rheumatoid Arthritis.Sauler M. Form, Function, and Dysfunction: Airway Diseases Are Associated With Increased Risk for Rheumatoid Arthritis. Arthritis & Rheumatology (Hoboken, N.J.) 2020, 72: 699-701. PMID: 31876099, PMCID: PMC7188593, DOI: 10.1002/art.41193.
  • Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension.Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6 PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
  • SPLUNC1: a novel marker of cystic fibrosis exacerbations.Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. SPLUNC1: a novel marker of cystic fibrosis exacerbations. The European Respiratory Journal 2021, 58 PMID: 33958427, PMCID: PMC8571118, DOI: 10.1183/13993003.00507-2020.
  • Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/CIRCULATIONAHA.120.052318.
  • Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B. Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 651-666. PMID: 34033525, PMCID: PMC8521702, DOI: 10.1164/rccm.202012-4510OC.
  • Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia.Kim BS, Tilstam PV, Arnke K, Leng L, Ruhl T, Piecychna M, Schulte W, Sauler M, Frueh FS, Storti G, Lindenblatt N, Giovanoli P, Pallua N, Bernhagen J, Bucala R. Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2020, 34: 4219-4233. PMID: 31961019, PMCID: PMC7060131, DOI: 10.1096/fj.201901511R.
  • A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 51-64. PMID: 32255668, PMCID: PMC7328332, DOI: 10.1164/rccm.201912-2360OC.
  • PECAM-1 is Associated WithOutcomes and Response to Treatment in Pulmonary Arterial Hypertension.Clapham KR, Rao Y, Sahay S, Sauler M, Lee PJ, Psotka MA, Fares WH, Ahmad T. PECAM-1 is Associated WithOutcomes and Response to Treatment in Pulmonary Arterial Hypertension. The American Journal Of Cardiology 2020, 127: 198-199. PMID: 32430164, DOI: 10.1016/j.amjcard.2020.04.031.
  • Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991OC.
  • Macrophage Migration Inhibitory Factor is not Associated with Sarcoidosis Susceptibility or Severity in Whites or Blacks.Odio CD, Miller EJ, Sauler M, Leng L, Piecychna M, Drake WP, Bucala R. Macrophage Migration Inhibitory Factor is not Associated with Sarcoidosis Susceptibility or Severity in Whites or Blacks. Sarcoidosis, Vasculitis, And Diffuse Lung Diseases : Official Journal Of WASOG / World Association Of Sarcoidosis And Other Granulomatous Disorders 2020, 37: e2020003. PMID: 33264374, PMCID: PMC7690059, DOI: 10.36141/svdld.v37i3.9273.
  • BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.Britto CJ, Niu N, Khanal S, Huleihel L, Herazo-Maya J, Thompson A, Sauler M, Slade MD, Sharma L, Dela Cruz CS, Kaminski N, Cohn LE. BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2019, 316: L321-L333. PMID: 30461288, PMCID: PMC6397348, DOI: 10.1152/ajplung.00056.2018.
  • Cell Death in the Lung: The Apoptosis-Necroptosis Axis.Sauler M, Bazan IS, Lee PJ. Cell Death in the Lung: The Apoptosis-Necroptosis Axis. Annual Review Of Physiology 2019, 81: 375-402. PMID: 30485762, PMCID: PMC6598441, DOI: 10.1146/annurev-physiol-020518-114320.
  • Role of macrophage migration inhibitory factor in age-related lung disease.Sauler M, Bucala R, Lee PJ. Role of macrophage migration inhibitory factor in age-related lung disease. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2015, 309: L1-10. PMID: 25957294, PMCID: PMC4491511, DOI: 10.1152/ajplung.00339.2014.
  • Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell 2019, 18: e12914. PMID: 30790400, PMCID: PMC6516428, DOI: 10.1111/acel.12914.
  • MIF and Pulmonary DiseaseBaker T, Lee P, Sauler M. MIF and Pulmonary Disease: MIF Family Cytokines in Innate Immunity and Homeostasis, Springer, 2017
  • D-dopachrome tautomerase in adipose tissue inflammation and wound repair.Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D-dopachrome tautomerase in adipose tissue inflammation and wound repair. Journal Of Cellular And Molecular Medicine 2017, 21: 35-45. PMID: 27605340, PMCID: PMC5192814, DOI: 10.1111/jcmm.12936.
  • Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension.Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee PJ, Fares WH. Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension. Pulmonary Circulation 2017, 7: 730-733. PMID: 28714356, PMCID: PMC5841895, DOI: 10.1177/2045893217724141.
  • COPD: Clinical Manifestations and Management (include pulmonary rehabilitation)COPD: Clinical Manifestations and Management (include pulmonary rehabilitation). By Rennard S, Dela Cruz CS, Sauler M. Clinical Advisor Dec 20, 2016.
  • MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, Cho CS, Kim WU, Bucala R. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: E7917-E7926. PMID: 27872288, PMCID: PMC5150393, DOI: 10.1073/pnas.1612717113.
  • The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn.Kim BS, Stoppe C, Grieb G, Leng L, Sauler M, Assis D, Simons D, Boecker AH, Schulte W, Piecychna M, Hager S, Bernhagen J, Pallua N, Bucala R. The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn. Burns : Journal Of The International Society For Burn Injuries 2016, 42: 1265-76. PMID: 27209369, PMCID: PMC5010466, DOI: 10.1016/j.burns.2016.02.005.
  • Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus.Yao J, Leng L, Sauler M, Fu W, Zheng J, Zhang Y, Du X, Yu X, Lee P, Bucala R. Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus. The Journal Of Clinical Investigation 2016, 126: 732-44. PMID: 26752645, PMCID: PMC4731159, DOI: 10.1172/JCI81937.
  • Suppression of NLRX1 in chronic obstructive pulmonary disease.Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Suppression of NLRX1 in chronic obstructive pulmonary disease. The Journal Of Clinical Investigation 2015, 125: 2458-62. PMID: 25938787, PMCID: PMC4497738, DOI: 10.1172/JCI71747.
  • Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma.Gutiérrez A, Sauler M, Mitchell JM, Siegel MD, Trow TK, Bacchetta M, Fares WH. Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma. Heart & Lung : The Journal Of Critical Care 2014, 43: 574-6. PMID: 24928184, DOI: 10.1016/j.hrtlng.2014.05.006.
  • Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury.Zhang Y, Sauler M, Shinn AS, Gong H, Haslip M, Shan P, Mannam P, Lee PJ. Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury. Journal Of Immunology (Baltimore, Md. : 1950) 2014, 192: 5296-304. PMID: 24778451, PMCID: PMC4047670, DOI: 10.4049/jimmunol.1400653.
  • Oxidants in Acute and Chronic Lung Disease.Mannam P, Srivastava A, Sugunaraj JP, Lee PJ, Sauler M. Oxidants in Acute and Chronic Lung Disease. Journal Of Blood & Lymph 2014, 4 PMID: 25705575, PMCID: PMC4335304, DOI: 10.4172/2165-7831.1000128.
  • Standard nonspecific therapies in the management of pulmonary arterial hypertension.Sauler M, Fares WH, Trow TK. Standard nonspecific therapies in the management of pulmonary arterial hypertension. Clinics In Chest Medicine 2013, 34: 799-810. PMID: 24267305, DOI: 10.1016/j.ccm.2013.08.013.
  • Lung endothelial HO-1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury.Zhang Y, Jiang G, Sauler M, Lee PJ. Lung endothelial HO-1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2013, 27: 4041-58. PMID: 23771928, PMCID: PMC4046184, DOI: 10.1096/fj.13-231225.
  • The past, present, and future of advance directives as a guide to end-of-life decision making.Sauler M, Siegel MD. The past, present, and future of advance directives as a guide to end-of-life decision making. Chest 2012, 141: 9-10. PMID: 22215824, DOI: 10.1378/chest.11-2744.
  • Newly recognized occupational and environmental causes of chronic terminal airways and parenchymal lung disease.Sauler M, Gulati M. Newly recognized occupational and environmental causes of chronic terminal airways and parenchymal lung disease. Clinics In Chest Medicine 2012, 33: 667-80. PMID: 23153608, PMCID: PMC3515663, DOI: 10.1016/j.ccm.2012.09.002.
  • Pulmonary Embolism in Older Patients38. Mathur A, Sauler M (co-first author), and Pisani M. Pulmonary Embolism in Older Patients: Aging and Lung Disease, A Clinical Guide. Humana Press, 2011.
  • Reporting of multivariable methods in the medical literature.Tetrault JM, Sauler M, Wells CK, Concato J. Reporting of multivariable methods in the medical literature. Journal Of Investigative Medicine : The Official Publication Of The American Federation For Clinical Research 2008, 56: 954-7. PMID: 18797413, DOI: 10.2310/JIM.0b013e31818914ff.
  • Leveraging ageing models of pulmonary fibrosis: the efficacy of nintedanib in ageing.Kato K, Shin YJ, Palumbo S, Papageorgiou I, Hahn S, Irish JD, Rounseville SP, Krafty RT, Wollin L, Sauler M, Hecker L. Leveraging ageing models of pulmonary fibrosis: the efficacy of nintedanib in ageing. The European Respiratory Journal 2021, 58 PMID: 34531276, PMCID: PMC8613836, DOI: 10.1183/13993003.00759-2021.
  • MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R. MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model. The Journal Of Clinical Investigation 2021, 131 PMID: 34850744, PMCID: PMC8631602, DOI: 10.1172/JCI127171.
  • Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma.Chen A, Diaz-Soto MP, Sanmamed MF, Adams T, Schupp JC, Gupta A, Britto C, Sauler M, Yan X, Liu Q, Nino G, Cruz CSD, Chupp GL, Gomez JL. Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma. Respiratory Research 2021, 22: 122. PMID: 33902571, PMCID: PMC8074196, DOI: 10.1186/s12931-021-01709-9.
  • Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency.Chu JH, Zang W, Vukmirovic M, Yan X, Adams T, DeIuliis G, Hu B, Mihaljinec A, Schupp JC, Becich MJ, Hochheiser H, Gibson KF, Chen ES, Morris A, Leader JK, Wisniewski SR, Zhang Y, Sciurba FC, Collman RG, Sandhaus R, Herzog EL, Patterson KC, Sauler M, Strange C, Kaminski N. Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency. Thorax 2021, 76: 134-143. PMID: 33303696, DOI: 10.1136/thoraxjnl-2019-214301.
  • Characterization of the COPD alveolar niche using single-cell RNA sequencing.Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.
  • Sex differences and altered mitophagy in experimental pulmonary hypertension.Bazan IS, Kim SJ, Ardito TA, Zhang Y, Shan P, Sauler M, Lee P. Sex differences and altered mitophagy in experimental pulmonary hypertension. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2022, 322: L761-L769. PMID: 35137625, PMCID: PMC9076415, DOI: 10.1152/ajplung.00019.2020.
  • Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.
  • Untargeted metabolomics analysis of esophageal squamous cell cancer progression.Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q. Untargeted metabolomics analysis of esophageal squamous cell cancer progression. Journal Of Translational Medicine 2022, 20: 127. PMID: 35287685, PMCID: PMC8919643, DOI: 10.1186/s12967-022-03311-z.
  • Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection.Yang CX, Tomchaney M, Landecho MF, Zamacona BR, Marin Oto M, Zulueta J, Malo J, Knoper S, Contoli M, Papi A, Vasilescu DM, Sauler M, Straub C, Tan C, Martinez FD, Bhattacharya D, Rosas IO, Kheradmand F, Hackett TL, Polverino F. Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection. Cells 2022, 11 PMID: 35740993, PMCID: PMC9220844, DOI: 10.3390/cells11121864.
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