Lydia Aoun-Barakat, MD
Associate Professor Term; Project Director, Connecticut AIDS Education & Training Center; Director, Yale Infectious Disease Ambulatory Services, Infectious Diseases; Medical Director Nathan Smith Clinic, Infectious Diseases; Program Director, HIV Primary Care Training Track, Internal Medicine
Research & Publications
Biography
News
Coauthors
Research Interests
HIV Infections; Patient Outcome Assessment
Selected Publications
- The Changing Face of HIV Care: Expanding HIV Training in an Internal Medicine Residency Program.Barakat LA, Dunne DW, Tetrault JM, Soares S, Chia D, Ogbuagu OE, Moriarty JP, Huot SJ, Green ML. The Changing Face of HIV Care: Expanding HIV Training in an Internal Medicine Residency Program. Academic Medicine : Journal Of The Association Of American Medical Colleges 2018, 93: 1673-1678. PMID: 29901657, DOI: 10.1097/ACM.0000000000002317.
- Training the next generation of HIV providers: impact of trainees on patient satisfaction in an urban HIV clinic.Sherbuk JE, Barakat LA. Training the next generation of HIV providers: impact of trainees on patient satisfaction in an urban HIV clinic. AIDS Care 2019, 31: 41-44. PMID: 29779395, DOI: 10.1080/09540121.2018.1476663.
- Comparing clinical outcomes in HIV-infected and uninfected older men hospitalized with community-acquired pneumonia.Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes in HIV-infected and uninfected older men hospitalized with community-acquired pneumonia. HIV Medicine 2015, 16: 421-30. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.
- Trends in hospital deaths among human immunodeficiency virus-infected patients during the antiretroviral therapy era, 1995 to 2011.Cowell A, Shenoi SV, Kyriakides TC, Friedland G, Barakat LA. Trends in hospital deaths among human immunodeficiency virus-infected patients during the antiretroviral therapy era, 1995 to 2011. Journal Of Hospital Medicine 2015, 10: 608-14. PMID: 26130520, PMCID: PMC4560992, DOI: 10.1002/jhm.2409.
- Fatal inhalational anthrax in a 94-year-old Connecticut woman.Barakat LA, Quentzel HL, Jernigan JA, Kirschke DL, Griffith K, Spear SM, Kelley K, Barden D, Mayo D, Stephens DS, Popovic T, Marston C, Zaki SR, Guarner J, Shieh WJ, Carver HW, Meyer RF, Swerdlow DL, Mast EE, Hadler JL. Fatal inhalational anthrax in a 94-year-old Connecticut woman. JAMA 2002, 287: 863-8. PMID: 11851578, DOI: 10.1001/jama.287.7.863.
- Complicated left-sided native valve endocarditis in adults: risk classification for mortality.Hasbun R, Vikram HR, Barakat LA, Buenconsejo J, Quagliarello VJ. Complicated left-sided native valve endocarditis in adults: risk classification for mortality. JAMA 2003, 289: 1933-40. PMID: 12697795, DOI: 10.1001/jama.289.15.1933.
- Infectious mimicry complicates diagnosis in hemophagocytic syndrome caused by anaplastic large-cell lymphoma.Peluso MJ, Chia D, Sheen W, Hutchinson C, Barakat L. Infectious mimicry complicates diagnosis in hemophagocytic syndrome caused by anaplastic large-cell lymphoma. Case Reports In Medicine 2012, 2012: 968706. PMID: 22761627, PMCID: PMC3385285, DOI: 10.1155/2012/968706.
- Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition.Selvaraj S, Ghebremichael M, Li M, Foli Y, Langs-Barlow A, Ogbuagu A, Barakat L, Tubridy E, Edifor R, Lam W, Cheng YC, Paintsil E. Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition. Clinical Pharmacology And Therapeutics 2014, 96: 110-20. PMID: 24637942, PMCID: PMC4065195, DOI: 10.1038/clpt.2014.64.
- Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E. Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. Journal Of Virology 2015, 89: 5502-14. PMID: 25740989, PMCID: PMC4442529, DOI: 10.1128/JVI.00118-15.
- Steroid-exacerbated HIV-associated cutaneous Kaposi's sarcoma immune reconstitution inflammatory syndrome: 'Where a good intention turns bad'.Chabria S, Barakat L, Ogbuagu O. Steroid-exacerbated HIV-associated cutaneous Kaposi's sarcoma immune reconstitution inflammatory syndrome: 'Where a good intention turns bad'. International Journal Of STD & AIDS 2016, 27: 1026-9. PMID: 26769754, DOI: 10.1177/0956462415627735.
- Unusual presentation of disseminated Nocardia abscessus infection in a patient with AIDS.Sherbuk J, Saly D, Barakat L, Ogbuagu O. Unusual presentation of disseminated Nocardia abscessus infection in a patient with AIDS. BMJ Case Reports 2016, 2016 PMID: 27440848, PMCID: PMC4964189, DOI: 10.1136/bcr-2016-215649.
- Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study.Helou E, Shenoi S, Kyriakides T, Landry ML, Kozal M, Barakat LA. Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study. Journal Of The International Association Of Providers Of AIDS Care 2017, 16: 261-266. PMID: 27903948, PMCID: PMC5423832, DOI: 10.1177/2325957416680028.
- Dolutegravir/rilpivirine for the treatment of HIV-1 infection.Dowers E, Zamora F, Barakat LA, Ogbuagu O. Dolutegravir/rilpivirine for the treatment of HIV-1 infection. HIV/AIDS (Auckland, N.Z.) 2018, 10: 215-224. PMID: 30464642, PMCID: PMC6220428, DOI: 10.2147/HIV.S157855.
- Prevalence and Correlates of Unhealthy Alcohol and Drug Use Among Men Who Have Sex with Men Prescribed HIV Pre-exposure Prophylaxis in Real-World Clinical Settings.Ogbuagu O, Marshall BDL, Tiberio P, Ogunbajo A, Barakat L, Montgomery M, Almonte A, Wray T, Williams EC, Edelman EJ, Chan PA. Prevalence and Correlates of Unhealthy Alcohol and Drug Use Among Men Who Have Sex with Men Prescribed HIV Pre-exposure Prophylaxis in Real-World Clinical Settings. AIDS And Behavior 2019, 23: 190-200. PMID: 30145707, PMCID: PMC7020905, DOI: 10.1007/s10461-018-2260-9.
- Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes.Zapata HJ, Van Ness PH, Avey S, Siconolfi B, Allore HG, Tsang S, Wilson J, Barakat L, Mohanty S, Shaw AC. Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences 2019, 74: 794-801. PMID: 30239628, PMCID: PMC6521921, DOI: 10.1093/gerona/gly209.
- Implementing a Comprehensive HCV Clinic within an HIV Clinic: A Model of Care for HCV Micro-elimination.Rizk C, Miceli J, Shiferaw B, Malinis M, Barakat L, Ogbuagu O, Villanueva M. Implementing a Comprehensive HCV Clinic within an HIV Clinic: A Model of Care for HCV Micro-elimination. Open Forum Infectious Diseases 2019 PMID: 31412130, PMCID: PMC6785669, DOI: 10.1093/ofid/ofz361.
- Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals.Sopeyin A, Zhou L, Li M, Barakat L, Paintsil E. Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals. PloS One 2019, 14: e0226573. PMID: 31846498, PMCID: PMC6917281, DOI: 10.1371/journal.pone.0226573.
- Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes.Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, Britto CJ, Azmy V, Kaman K, Gaston DC, Davis M, Burrello T, Harris Z, Villanueva MS, Aoun-Barakat L, Kang I, Seropian S, Chupp G, Bucala R, Kaminski N, Lee AI, LoRusso PM, Topal JE, Dela Cruz C, Malinis M. Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes. Chest 2020, 158: 1397-1408. PMID: 32553536, PMCID: PMC7831876, DOI: 10.1016/j.chest.2020.06.006.
- Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.
- Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Cruz CD, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Aoun Barakat L. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Research Square 2020 PMID: 32702723, PMCID: PMC7336693, DOI: 10.21203/rs.3.rs-28583/v1.
- Unilateral laterothoracic exanthem in association with coronavirus disease 2019.Glick LR, Fogel AL, Ramachandran S, Barakat LA. Unilateral laterothoracic exanthem in association with coronavirus disease 2019. JAAD Case Reports 2020, 6: 900-901. PMID: 32835047, PMCID: PMC7372280, DOI: 10.1016/j.jdcr.2020.07.020.
- Decreased Overall Survival in HIV-associated Non-small-cell Lung Cancer.Hysell K, Yusuf R, Barakat L, Virata M, Gan G, Deng Y, Perez-Irizarry J, Vega T, Goldberg SB, Emu B. Decreased Overall Survival in HIV-associated Non-small-cell Lung Cancer. Clinical Lung Cancer 2021, 22: e498-e505. PMID: 33468393, PMCID: PMC8169710, DOI: 10.1016/j.cllc.2020.11.006.
- Confronting Another Pandemic: Lessons from HIV can Inform Our COVID-19 Response.Edelman EJ, Aoun-Barakat L, Villanueva M, Friedland G. Confronting Another Pandemic: Lessons from HIV can Inform Our COVID-19 Response. AIDS And Behavior 2020, 24: 1977-1979. PMID: 32399798, PMCID: PMC7215127, DOI: 10.1007/s10461-020-02908-z.
- Development of a Novel Competency-Based Evaluation System for HIV Primary Care Training: the HIV Entrustable Professional Activities.Dunne D, Green M, Tetrault J, Barakat LA. Development of a Novel Competency-Based Evaluation System for HIV Primary Care Training: the HIV Entrustable Professional Activities. Journal Of General Internal Medicine 2020, 35: 331-335. PMID: 31667752, PMCID: PMC6957645, DOI: 10.1007/s11606-019-04956-1.
- Substantial gap in primary care: older adults with HIV presenting late to care.Yasin F, Rizk C, Taylor B, Barakat LA. Substantial gap in primary care: older adults with HIV presenting late to care. BMC Geriatrics 2020, 20: 438. PMID: 33129258, PMCID: PMC7603686, DOI: 10.1186/s12877-020-01842-y.
- Race and ethnicity do not impact eligibility for remdesivir: A single-center experience.Pischel L, Walelo M, Benson J, Osborn R, Schrier R, Tuan J, Barakat L, Ogbuagu O. Race and ethnicity do not impact eligibility for remdesivir: A single-center experience. PloS One 2021, 16: e0250735. PMID: 33956849, PMCID: PMC8101938, DOI: 10.1371/journal.pone.0250735.
- VZV myelitis with secondary HIV CSF escape.Weiss JJ, Spudich S, Barakat L. VZV myelitis with secondary HIV CSF escape. BMJ Case Reports 2021, 14 PMID: 34187795, PMCID: PMC8245447, DOI: 10.1136/bcr-2021-241738.
- Qualitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV.Tuan JJ, Zapata H, Critch-Gilfillan T, Ryall L, Turcotte B, Mutic S, Andrews L, Roh ME, Friedland G, Barakat L, Ogbuagu O. Qualitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV. HIV Medicine 2022, 23: 178-185. PMID: 34632695, PMCID: PMC8652674, DOI: 10.1111/hiv.13188.
- Lower Gastrointestinal Syphilis: Case Series and Literature Review.Ferzacca E, Barbieri A, Barakat L, Olave MC, Dunne D. Lower Gastrointestinal Syphilis: Case Series and Literature Review. Open Forum Infectious Diseases 2021, 8: ofab157. PMID: 34631920, PMCID: PMC8494075, DOI: 10.1093/ofid/ofab157.
- Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study.Virata MD, Shenoi SV, Ladines-Lim J, Villanueva MS, Barakat LA. Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study. PloS One 2021, 16: e0260251. PMID: 34851963, PMCID: PMC8635326, DOI: 10.1371/journal.pone.0260251.
- High HIV Detection in a Tertiary Facility in Liberia: Implications and Opportunities.Ogbuagu O, Wachekwa I, Yasin F, Nuta C, Donato S, Toomey J, Adeiza M, Barakat LA. High HIV Detection in a Tertiary Facility in Liberia: Implications and Opportunities. Annals Of Global Health 2021, 87: 117. PMID: 34900617, PMCID: PMC8622250, DOI: 10.5334/aogh.3243.
- Experiences with Telemedicine for HIV Care During the COVID-19 Pandemic: A Mixed-Methods Study.Harsono D, Deng Y, Chung S, Barakat LA, Friedland G, Meyer JP, Porter E, Villanueva M, Wolf MS, Yager JE, Edelman EJ. Experiences with Telemedicine for HIV Care During the COVID-19 Pandemic: A Mixed-Methods Study. AIDS And Behavior 2022, 26: 2099-2111. PMID: 35064390, PMCID: PMC8782707, DOI: 10.1007/s10461-021-03556-7.
- COVID-19 Vaccine Hesitancy and Associated Factors among People with HIV in the United States: Findings from a National Survey.Shrestha R, Meyer JP, Shenoi S, Khati A, Altice FL, Mistler C, Aoun-Barakat L, Virata M, Olivares M, Wickersham JA. COVID-19 Vaccine Hesitancy and Associated Factors among People with HIV in the United States: Findings from a National Survey. Vaccines 2022, 10 PMID: 35335054, PMCID: PMC8949562, DOI: 10.3390/vaccines10030424.
Clinical Trials
Conditions | Study Title |
---|---|
HIV/AIDS | A Study to Evaluate Efficacy and Safety of Cabotegravir (CAB) Long Acting (LA) Plus (+) Rilpivirine (RPV) LA Versus BIKTARVY® (BIK) in Participants With Human Immunodeficiency Virus (HIV)-1 Who Are Virologically Suppressed (SOLAR) |
Diseases of the Digestive System - Liver; HIV/AIDS; Infectious Diseases | HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients |
HIV/AIDS | Mechanisms of HIV latency |