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Lin Shao, PhD

Research Scientist in Neuroscience

Contact Information

Lin Shao, PhD

Mailing Address

  • Neuroscience

    333 Cedar St

    New Haven, CT 06520

    United States

Coauthors

Selected Publications

  • Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella.Chen M, Sun H, Boot M, Shao L, Chang SJ, Wang W, Lam TT, Lara-Tejero M, Rego EH, Galán JE. Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science (New York, N.Y.) 2020, 369: 450-455. PMID: 32703879, PMCID: PMC8020367, DOI: 10.1126/science.aaz1333.
  • Nonlinear structured-illumination microscopy with a photoswitchable protein reveals cellular structures at 50-nm resolution.Rego EH, Shao L, Macklin JJ, Winoto L, Johansson GA, Kamps-Hughes N, Davidson MW, Gustafsson MG. Nonlinear structured-illumination microscopy with a photoswitchable protein reveals cellular structures at 50-nm resolution. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: E135-43. PMID: 22160683, PMCID: PMC3271870, DOI: 10.1073/pnas.1107547108.
  • Time-lapse two-color 3D imaging of live cells with doubled resolution using structured illumination.Fiolka R, Shao L, Rego EH, Davidson MW, Gustafsson MG. Time-lapse two-color 3D imaging of live cells with doubled resolution using structured illumination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5311-5. PMID: 22431626, PMCID: PMC3325651, DOI: 10.1073/pnas.1119262109.
  • Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann AC, Böhme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E. Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. Science (New York, N.Y.) 2014, 346: 1257998. PMID: 25342811, PMCID: PMC4336192, DOI: 10.1126/science.1257998.
  • Practical structured illumination microscopy.Rego EH, Shao L. Practical structured illumination microscopy. Methods In Molecular Biology (Clifton, N.J.) 2015, 1251: 175-92. PMID: 25391800, DOI: 10.1007/978-1-4939-2080-8_10.
  • ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics.Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E. ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. Science (New York, N.Y.) 2015, 349: aab3500. PMID: 26315442, PMCID: PMC4659358, DOI: 10.1126/science.aab3500.
  • High-density three-dimensional localization microscopy across large volumes.Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E. High-density three-dimensional localization microscopy across large volumes. Nature Methods 2016, 13: 359-65. PMID: 26950745, PMCID: PMC4889433, DOI: 10.1038/nmeth.3797.
  • Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.Murugesan S, Hong J, Yi J, Li D, Beach JR, Shao L, Meinhardt J, Madison G, Wu X, Betzig E, Hammer JA. Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse. The Journal Of Cell Biology 2016, 215: 383-399. PMID: 27799367, PMCID: PMC5100289, DOI: 10.1083/jcb.201603080.
  • Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.Hayer A, Shao L, Chung M, Joubert LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T. Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells. Nature Cell Biology 2016, 18: 1311-1323. PMID: 27842057, PMCID: PMC6159904, DOI: 10.1038/ncb3438.
  • Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments.Beach JR, Bruun KS, Shao L, Li D, Swider Z, Remmert K, Zhang Y, Conti MA, Adelstein RS, Rusan NM, Betzig E, Hammer JA. Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments. Nature Cell Biology 2017, 19: 85-93. PMID: 28114272, PMCID: PMC5308804, DOI: 10.1038/ncb3463.
  • Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse.Ashdown GW, Burn GL, Williamson DJ, Pandžić E, Peters R, Holden M, Ewers H, Shao L, Wiseman PW, Owen DM. Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse. Biophysical Journal 2017, 112: 1703-1713. PMID: 28445761, PMCID: PMC5406376, DOI: 10.1016/j.bpj.2017.01.038.
  • I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions.Shao L, Isaac B, Uzawa S, Agard DA, Sedat JW, Gustafsson MG. I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions. Biophysical Journal 2008, 94: 4971-83. PMID: 18326649, PMCID: PMC2397336, DOI: 10.1529/biophysj.107.120352.
  • Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination.Gustafsson MG, Shao L, Carlton PM, Wang CJ, Golubovskaya IN, Cande WZ, Agard DA, Sedat JW. Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophysical Journal 2008, 94: 4957-70. PMID: 18326650, PMCID: PMC2397368, DOI: 10.1529/biophysj.107.120345.
  • Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy.Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW. Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science (New York, N.Y.) 2008, 320: 1332-6. PMID: 18535242, PMCID: PMC2916659, DOI: 10.1126/science.1156947.
  • Fast live simultaneous multiwavelength four-dimensional optical microscopy.Carlton PM, Boulanger J, Kervrann C, Sibarita JB, Salamero J, Gordon-Messer S, Bressan D, Haber JE, Haase S, Shao L, Winoto L, Matsuda A, Kner P, Uzawa S, Gustafsson M, Kam Z, Agard DA, Sedat JW. Fast live simultaneous multiwavelength four-dimensional optical microscopy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 16016-22. PMID: 20705899, PMCID: PMC2941331, DOI: 10.1073/pnas.1004037107.
  • Condensed mitotic chromosome structure at nanometer resolution using PALM and EGFP- histones.Matsuda A, Shao L, Boulanger J, Kervrann C, Carlton PM, Kner P, Agard D, Sedat JW. Condensed mitotic chromosome structure at nanometer resolution using PALM and EGFP- histones. PloS One 2010, 5: e12768. PMID: 20856676, PMCID: PMC2939896, DOI: 10.1371/journal.pone.0012768.
  • Interferometer-based structured-illumination microscopy utilizing complementary phase relationship through constructive and destructive image detection by two cameras.Shao L, Winoto L, Agard DA, Gustafsson MG, Sedat JW. Interferometer-based structured-illumination microscopy utilizing complementary phase relationship through constructive and destructive image detection by two cameras. Journal Of Microscopy 2012, 246: 229-36. PMID: 22472010, PMCID: PMC3447539, DOI: 10.1111/j.1365-2818.2012.03604.x.
  • Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens.Gao L, Shao L, Higgins CD, Poulton JS, Peifer M, Davidson MW, Wu X, Goldstein B, Betzig E. Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens. Cell 2012, 151: 1370-85. PMID: 23217717, PMCID: PMC3615549, DOI: 10.1016/j.cell.2012.10.008.
  • Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions.Legant WR, Choi CK, Miller JS, Shao L, Gao L, Betzig E, Chen CS. Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 881-6. PMID: 23277584, PMCID: PMC3549134, DOI: 10.1073/pnas.1207997110.
  • A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells.Burnette DT, Shao L, Ott C, Pasapera AM, Fischer RS, Baird MA, Der Loughian C, Delanoe-Ayari H, Paszek MJ, Davidson MW, Betzig E, Lippincott-Schwartz J. A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells. The Journal Of Cell Biology 2014, 205: 83-96. PMID: 24711500, PMCID: PMC3987145, DOI: 10.1083/jcb.201311104.
  • 3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy.Gao L, Shao L, Chen BC, Betzig E. 3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy. Nature Protocols 2014, 9: 1083-101. PMID: 24722406, DOI: 10.1038/nprot.2014.087.
  • Nonmuscle myosin II isoforms coassemble in living cells.Beach JR, Shao L, Remmert K, Li D, Betzig E, Hammer JA. Nonmuscle myosin II isoforms coassemble in living cells. Current Biology : CB 2014, 24: 1160-6. PMID: 24814144, PMCID: PMC4108432, DOI: 10.1016/j.cub.2014.03.071.
  • Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments.Billington N, Beach JR, Heissler SM, Remmert K, Guzik-Lendrum S, Nagy A, Takagi Y, Shao L, Li D, Yang Y, Zhang Y, Barzik M, Betzig E, Hammer JA, Sellers JR. Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments. Current Biology : CB 2015, 25: 942-8. PMID: 25754640, DOI: 10.1016/j.cub.2015.02.012.
  • Nonmuscle Myosin II Isoforms Coassemble in Living Cells.Beach JR, Shao L, Remmert K, Li D, Betzig E, Hammer JA. Nonmuscle Myosin II Isoforms Coassemble in Living Cells. Current Biology : CB 2015, 25: 402. PMID: 29665398, DOI: 10.1016/j.cub.2015.01.028.
  • Structural and developmental principles of neuropil assembly in C. elegans.Moyle MW, Barnes KM, Kuchroo M, Gonopolskiy A, Duncan LH, Sengupta T, Shao L, Guo M, Santella A, Christensen R, Kumar A, Wu Y, Moon KR, Wolf G, Krishnaswamy S, Bao Z, Shroff H, Mohler WA, Colón-Ramos DA. Structural and developmental principles of neuropil assembly in C. elegans. Nature 2021, 591: 99-104. PMID: 33627875, PMCID: PMC8385650, DOI: 10.1038/s41586-020-03169-5.
  • Differential adhesion regulates neurite placement via a retrograde zippering mechanism.Sengupta T, Koonce NL, Vázquez-Martínez N, Moyle MW, Duncan LH, Emerson SE, Han X, Shao L, Wu Y, Santella A, Fan L, Bao Z, Mohler WA, Shroff H, Colón-Ramos DA. Differential adhesion regulates neurite placement via a retrograde zippering mechanism. ELife 2021, 10 PMID: 34783657, PMCID: PMC8843091, DOI: 10.7554/eLife.71171.
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