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Lieping Chen, MD, PhD

United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)

Contact Information

Lieping Chen, MD, PhD

Lab Location

Office Location

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Research Summary

My laboratory is interested in:

  1. T cell biology: Control of T cell response to antigens by cell surface receptors/ligands
  2. Cancer immunology: Mechanisms of tumor escape from immune attack in the tumor microenvironment
  3. Immunotherapy: Development of novel therapeutic approaches for human diseases (cancer, autoimmune diseases, inflammation etc.) based on our laboratory discoveries

Extensive Research Description

In 1992, Dr. Chen showed the first proof-of-concept study that the B7-CD28 family molecules could be the targets for cancer immunotherapy. This study inspires subsequent studies targeting the B7-CD28 family molecules for the treatment of human cancer.

In 1999, Dr. Chen first to discover a molecule he called B7-H1 (also known as PD-L1). He subsequently showed that PD-L1 is expressed by tumors and that its activity can cause T cell dysfunction, thus preventing T cells from eliminating cancer cells in the tumor microenvironment. Bringing these lines of inquiry full circle, he later showed that PD-L1 is highly upregulated in a fraction of human cancer and blocking the interaction between PD-1 and PD-L1 by monoclonal antibodies (mAbs) improved the immune system’s ability to eliminate tumors in a 2002. Chen’s work provided a foundation for the subsequent development of anti-PD-L1/PD-1 mAb-based immunotherapies. Dr. Chen also initiated and help organized the first-in-man clinical trial of anti-PD-1/PD-L1 mAbs for treating human cancer in and developed PD-L1 staining as a biomarker. His discoveries directly led to the development of anti-PD-1/PD-L1 antibody therapy against broad spectrum of human cancers, which become new standard for cancer treatment now.

Other findings made by Dr. Chen's laboratory include the development of an agonist antibody against the 4-1BB (also known as CD137) co-stimulatory pathway to costimulate and to promote survival of effector T cells, leading to elimination of established tumors in mouse models. These findings have since been developed and are now being evaluated in clinical trials for human cancer. Dr. Chen’s laboratory also discovered various molecular pathways with T cell costimulatory and coinhibitory functions and/or their applications in human disease treatment. These pathways include B7-H2 (ICOSL), B7-H3, B7-H4, B7-H5/CD28H, PD-1H (VISTA), TNFRSF19, RELT, LIGHT/HVEM, B7-H2/CD28/CTLA-4 (human), SALM5/HVEM, FGL1/LAG-3, Siglec-15 etc. Many of these findings are now being developed clinically for the treatment of human cancer, autoimmune diseases and inflammation.

Coauthors

Research Interests

Immunotherapy; Inflammation; Medical Oncology; Neoplasms; Autoimmunity

Public Health Interests

Cancer; Immunology

Selected Publications

  • Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas.Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Journal Of Neuropathology And Experimental Neurology 2021, 80: 150-159. PMID: 33393633, DOI: 10.1093/jnen/nlaa152.
  • Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy.Li Y, Cong Y, Jia M, He Q, Zhong H, Zhao Y, Li H, Yan M, You J, Liu J, Chen L, Hang H, Wang S. Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy. Nature Communications 2021, 12: 951. PMID: 33574265, PMCID: PMC7878483, DOI: 10.1038/s41467-021-21241-0.
  • A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy.Sanmamed MF, Nie X, Desai SS, Villaroel-Espindola F, Badri T, Zhao D, Kim AW, Ji L, Zhang T, Quinlan E, Cheng X, Han X, Vesely MD, Nassar AF, Sun J, Zhang Y, Kim TK, Wang J, Melero I, Herbst RS, Schalper KA, Chen L. A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy. Cancer Discovery 2021, 11: 1700-1715. PMID: 33658301, DOI: 10.1158/2159-8290.CD-20-0962.
  • Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas.Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M, Peyre M, Kalamarides M, Rimm DL, Gunel M, Chen L. Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas. Neuro-oncology 2021, 23: 1922-1935. PMID: 33914067, PMCID: PMC8563319, DOI: 10.1093/neuonc/noab075.
  • YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment.Yang X, Lam W, Jiang Z, Guan F, Han X, Hu R, Cai W, Cheng W, Liu SH, Cheng P, Cai Y, Rattray NJW, Johnson CH, Chen L, Cheng YC. YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment. Scientific Reports 2021, 11: 13482. PMID: 34188068, PMCID: PMC8242098, DOI: 10.1038/s41598-021-91623-3.
  • Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy.Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, Goodspeed AE, Dimberg A, Wang XJ, Edil BH, Barnett CC, Schulick RD, Chen L, Zhu Y. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine 2021, 13 PMID: 34321321, PMCID: PMC8749958, DOI: 10.1126/scitranslmed.abc8922.
  • Structural insight into T cell coinhibition by PD-1H (VISTA).Slater BT, Han X, Chen L, Xiong Y. Structural insight into T cell coinhibition by PD-1H (VISTA). Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 1648-1657. PMID: 31919279, PMCID: PMC6983362, DOI: 10.1073/pnas.1908711117.
  • Normalization Cancer Immunotherapy for Melanoma.Vesely MD, Chen L. Normalization Cancer Immunotherapy for Melanoma. The Journal Of Investigative Dermatology 2020, 140: 1134-1142. PMID: 32092349, PMCID: PMC7247948, DOI: 10.1016/j.jid.2020.02.005.
  • Calnexin Impairs the Antitumor Immunity of CD4+ and CD8+ T Cells.Chen Y, Ma D, Wang X, Fang J, Liu X, Song J, Li X, Ren X, Li Q, Li Q, Wen S, Luo L, Xia J, Cui J, Zeng G, Chen L, Cheng B, Wang Z. Calnexin Impairs the Antitumor Immunity of CD4+ and CD8+ T Cells. Cancer Immunology Research 2019, 7: 123-135. PMID: 30401678, DOI: 10.1158/2326-6066.CIR-18-0124.
  • Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3.Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell 2019, 176: 334-347.e12. PMID: 30580966, PMCID: PMC6365968, DOI: 10.1016/j.cell.2018.11.010.
  • CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers.Tian Y, Sun Y, Gao F, Koenig MR, Sunderland A, Fujiwara Y, Torphy RJ, Chen L, Edil BH, Schulick RD, Zhu Y. CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers. Oncoimmunology 2019, 8: e1538440. PMID: 30713797, PMCID: PMC6343811, DOI: 10.1080/2162402X.2018.1538440.
  • Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes.Doroshow DB, Sanmamed MF, Hastings K, Politi K, Rimm DL, Chen L, Melero I, Schalper KA, Herbst RS. Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2019, 25: 4592-4602. PMID: 30824587, PMCID: PMC6679805, DOI: 10.1158/1078-0432.CCR-18-1538.
  • The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection.David P, Megger DA, Kaiser T, Werner T, Liu J, Chen L, Sitek B, Dittmer U, Zelinskyy G. The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection. Frontiers In Immunology 2019, 10: 54. PMID: 30804928, PMCID: PMC6370637, DOI: 10.3389/fimmu.2019.00054.
  • The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer.Lee JW, Zhang Y, Eoh KJ, Sharma R, Sanmamed MF, Wu J, Choi J, Park HS, Iwasaki A, Kaftan E, Chen L, Papadimitrakopoulou V, Herbst RS, Koo JS. The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer. Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2019, 14: 1046-1060. PMID: 30771521, PMCID: PMC6542636, DOI: 10.1016/j.jtho.2019.02.004.
  • A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.Sanmamed MF, Chen L. A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Cell 2019, 176: 677. PMID: 30682374, DOI: 10.1016/j.cell.2019.01.008.
  • Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, Sanmamed MF, Langermann S, Rimm DL, Chen L. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature Medicine 2019, 25: 656-666. PMID: 30833750, PMCID: PMC7175920, DOI: 10.1038/s41591-019-0374-x.
  • Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis.Datar IJ, Sanmamed MF, Wang J, Henick BS, Choi J, Badri T, Dong W, Mani N, Toki MI, Mejías L, Lozano MD, Perez-Gracia JL, Velcheti V, Hellmann MD, Gainor JF, McEachern K, Jenkins D, Syrigos KN, Politi K, Gettinger S, Rimm DL, Herbst RS, Melero I, Chen L, Schalper KA. Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2019, 25: 4663-4673. PMID: 31053602, PMCID: PMC7444693, DOI: 10.1158/1078-0432.CCR-18-4142.
  • Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus.Zheng X, Xiao ZX, Hu L, Fang X, Luo L, Chen L. Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus. Cell Death & Disease 2019, 10: 393. PMID: 31113935, PMCID: PMC6529467, DOI: 10.1038/s41419-019-1623-0.
  • Targeting CD137 enhances the efficacy of cetuximab.Kohrt HE, Colevas AD, Houot R, Weiskopf K, Goldstein MJ, Lund P, Mueller A, Sagiv-Barfi I, Marabelle A, Lira R, Troutner E, Richards L, Rajapaska A, Hebb J, Chester C, Waller E, Ostashko A, Weng WK, Chen L, Czerwinski D, Fu YX, Sunwoo J, Levy R. Targeting CD137 enhances the efficacy of cetuximab. The Journal Of Clinical Investigation 2019, 129: 2595. PMID: 31157621, PMCID: PMC6546445, DOI: 10.1172/JCI129689.
  • Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.Kohrt HE, Houot R, Weiskopf K, Goldstein MJ, Scheeren F, Czerwinski D, Colevas AD, Weng WK, Clarke MF, Carlson RW, Stockdale FE, Mollick JA, Chen L, Levy R. Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. The Journal Of Clinical Investigation 2019, 129: 2595. PMID: 31157620, PMCID: PMC6546446, DOI: 10.1172/JCI129688.
  • Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology 2019, 20: 835-851. PMID: 31160797, PMCID: PMC6619502, DOI: 10.1038/s41590-019-0400-7.
  • Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity.Chen Y, Wang J, Wang X, Li X, Song J, Fang J, Liu X, Liu T, Wang D, Li Q, Wen S, Ma D, Xia J, Luo L, Zheng SG, Cui J, Zeng G, Chen L, Cheng B, Wang Z. Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2019, 25: 6180-6194. PMID: 31350312, DOI: 10.1158/1078-0432.CCR-18-4134.
  • PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L. PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine 2019, 11 PMID: 31826980, DOI: 10.1126/scitranslmed.aax1159.
  • B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction.Chen L, Azuma T, Yu W, Zheng X, Luo L, Chen L. B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 3126-3131. PMID: 29507197, PMCID: PMC5866601, DOI: 10.1073/pnas.1722043115.
  • B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb.Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Cellular & Molecular Immunology 2018, 15: 888-897. PMID: 28479601, PMCID: PMC6207567, DOI: 10.1038/cmi.2017.17.
  • Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non-Small Cell Lung Cancer.Villarroel-Espindola F, Yu X, Datar I, Mani N, Sanmamed MF, Velcheti V, Syrigos KN, Toki MI, Zhao H, Chen L, Herbst RS, Schalper KA. Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non-Small Cell Lung Cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2018, 24: 1562-1573. PMID: 29203588, PMCID: PMC5884702, DOI: 10.1158/1078-0432.CCR-17-2542.
  • A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma.Liu H, Li X, Hu L, Zhu M, He B, Luo L, Chen L. A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma. Cellular & Molecular Immunology 2018, 15: 838-845. PMID: 28479600, PMCID: PMC6203798, DOI: 10.1038/cmi.2017.16.
  • Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4.Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L. Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4. Nature Communications 2018, 9: 742. PMID: 29467366, PMCID: PMC5821868, DOI: 10.1038/s41467-018-03128-9.
  • DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.Xiao Q, Wu J, Wang WJ, Chen S, Zheng Y, Yu X, Meeth K, Sahraei M, Bothwell ALM, Chen L, Bosenberg M, Chen J, Sexl V, Sun L, Li L, Tang W, Wu D. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation. Nature Medicine 2018, 24: 262-270. PMID: 29431745, PMCID: PMC5840007, DOI: 10.1038/nm.4496.
  • Defining and Understanding Adaptive Resistance in Cancer Immunotherapy.Kim TK, Herbst RS, Chen L. Defining and Understanding Adaptive Resistance in Cancer Immunotherapy. Trends In Immunology 2018, 39: 624-631. PMID: 29802087, PMCID: PMC6066429, DOI: 10.1016/j.it.2018.05.001.
  • B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex.Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD. B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. Journal Of Immunology (Baltimore, Md. : 1950) 2018, 201: 897-907. PMID: 29898965, PMCID: PMC6894186, DOI: 10.4049/jimmunol.1700811.
  • S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity.Zhang J, Song K, Wang J, Li Y, Liu S, Dai C, Chen L, Wang S, Qin Z. S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity. Oncoimmunology 2018, 7: e1296996. PMID: 29632708, PMCID: PMC5889198, DOI: 10.1080/2162402X.2017.1296996.
  • A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.Gettinger SN, Choi J, Mani N, Sanmamed MF, Datar I, Sowell R, Du VY, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, Zhao H, Schlessinger J, Lifton R, Rimm DL, Chen L, Herbst RS, Schalper KA. A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. Nature Communications 2018, 9: 3196. PMID: 30097571, PMCID: PMC6086912, DOI: 10.1038/s41467-018-05032-8.
  • A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.Sanmamed MF, Chen L. A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Cell 2018, 175: 313-326. PMID: 30290139, PMCID: PMC6538253, DOI: 10.1016/j.cell.2018.09.035.
  • B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells.Yu W, Chen L, Guo S, Luo L, Chen L. B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells. Oncoimmunology 2018, 7: e1504156. PMID: 30574431, PMCID: PMC6298416, DOI: 10.1080/2162402X.2018.1504156.
  • Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer.Schalper KA, Carvajal-Hausdorf D, McLaughlin J, Altan M, Velcheti V, Gaule P, Sanmamed MF, Chen L, Herbst RS, Rimm DL. Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2017, 23: 370-378. PMID: 27440266, PMCID: PMC6350535, DOI: 10.1158/1078-0432.CCR-16-0150.
  • Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection.Drabczyk-Pluta M, Werner T, Hoffmann D, Leng Q, Chen L, Dittmer U, Zelinskyy G. Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection. Retrovirology 2017, 14: 42. PMID: 28835242, PMCID: PMC5569525, DOI: 10.1186/s12977-017-0364-3.
  • PD-L1 Studies Across Tumor Types, Its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors.Kluger HM, Zito CR, Turcu G, Baine M, Zhang H, Adeniran A, Sznol M, Rimm DL, Kluger Y, Chen L, Cohen JV, Jilaveanu LB. PD-L1 Studies Across Tumor Types, Its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2017, 23: 4270-4279. PMID: 28223273, PMCID: PMC5540774, DOI: 10.1158/1078-0432.CCR-16-3146.
  • Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.Wang Q, He J, Flies DB, Luo L, Chen L. Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports 2017, 7: 6086. PMID: 28729608, PMCID: PMC5519767, DOI: 10.1038/s41598-017-06410-w.
  • Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients.Sanmamed MF, Perez-Gracia JL, Schalper KA, Fusco JP, Gonzalez A, Rodriguez-Ruiz ME, Oñate C, Perez G, Alfaro C, Martín-Algarra S, Andueza MP, Gurpide A, Morgado M, Wang J, Bacchiocchi A, Halaban R, Kluger H, Chen L, Sznol M, Melero I. Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients. Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / ESMO 2017, 28: 1988-1995. PMID: 28595336, PMCID: PMC5834104, DOI: 10.1093/annonc/mdx190.
  • PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Science Translational Medicine 2016, 8: 328rv4. PMID: 26936508, PMCID: PMC4859220, DOI: 10.1126/scitranslmed.aad7118.
  • A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nature Communications 2016, 7: 10339. PMID: 26842342, PMCID: PMC4742836, DOI: 10.1038/ncomms10339.
  • Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy.Zhang Y, Chen L. Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy. JAMA Oncology 2016, 2: 1403-1404. PMID: 27490017, PMCID: PMC5492376, DOI: 10.1001/jamaoncol.2016.2450.
  • Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM.Zhu Y, Yao S, Augustine MM, Xu H, Wang J, Sun J, Broadwater M, Ruff W, Luo L, Zhu G, Tamada K, Chen L. Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM. Science Advances 2016, 2: e1500637. PMID: 27152329, PMCID: PMC4846428, DOI: 10.1126/sciadv.1500637.
  • Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis.Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Semeraro M, Jégou S, Flores C, Chen L, Kwon BS, Borg C, Weide B, Aubin F, Dalle S, Kohrt H, Ayyoub M, Kroemer G, Marabelle A, Cavalcanti A, Eggermont A, Zitvogel L. Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis. The Journal Of Investigative Dermatology 2016, 136: 994-1001. PMID: 26829031, PMCID: PMC6156792, DOI: 10.1016/j.jid.2015.12.042.
  • Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.Chen L, Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. The Journal Of Clinical Investigation 2015, 125: 3384-91. PMID: 26325035, PMCID: PMC4588282, DOI: 10.1172/JCI80011.
  • Correction: PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells.Park HJ, Park JS, Jeong YH, Son J, Ban YH, Lee BH, Chen L, Chang J, Chung DH, Choi I, Ha SJ. Correction: PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 195: 5841-2. PMID: 26637664, DOI: 10.4049/jimmunol.1502256.
  • Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing.Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing. PLoS Pathogens 2015, 11: e1005364. PMID: 26684741, PMCID: PMC4684197, DOI: 10.1371/journal.ppat.1005364.
  • Consensus nomenclature for CD8+ T cell phenotypes in cancer.Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC. Consensus nomenclature for CD8+ T cell phenotypes in cancer. Oncoimmunology 2015, 4: e998538. PMID: 26137416, PMCID: PMC4485711, DOI: 10.1080/2162402X.2014.998538.
  • Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state.Tongu M, Harashima N, Tamada K, Chen L, Harada M. Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state. Cancer Science 2015, 106: 9-17. PMID: 25363339, PMCID: PMC4317772, DOI: 10.1111/cas.12568.
  • Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens.Baine MK, Turcu G, Zito CR, Adeniran AJ, Camp RL, Chen L, Kluger HM, Jilaveanu LB. Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens. Oncotarget 2015, 6: 24990-5002. PMID: 26317902, PMCID: PMC4694809, DOI: 10.18632/oncotarget.4572.
  • B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L. B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. PloS One 2015, 10: e0130126. PMID: 26065426, PMCID: PMC4465912, DOI: 10.1371/journal.pone.0130126.
  • PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism.McKay JT, Egan RP, Yammani RD, Chen L, Shin T, Yagita H, Haas KM. PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 194: 2289-99. PMID: 25624454, PMCID: PMC4339454, DOI: 10.4049/jimmunol.1401673.
  • B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease.Deng R, Cassady K, Li X, Yao S, Zhang M, Racine J, Lin J, Chen L, Zeng D. B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 194: 560-74. PMID: 25488990, PMCID: PMC4282988, DOI: 10.4049/jimmunol.1402157.
  • Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites.Kluger HM, Zito CR, Barr ML, Baine MK, Chiang VL, Sznol M, Rimm DL, Chen L, Jilaveanu LB. Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2015, 21: 3052-60. PMID: 25788491, PMCID: PMC4490112, DOI: 10.1158/1078-0432.CCR-14-3073.
  • PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.Park HJ, Park JS, Jeong YH, Son J, Ban YH, Lee BH, Chen L, Chang J, Chung DH, Choi I, Ha SJ. PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 194: 5801-11. PMID: 25934860, DOI: 10.4049/jimmunol.1401936.
  • PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing.Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing. PLoS Pathogens 2015, 11: e1005224. PMID: 26484769, PMCID: PMC4617866, DOI: 10.1371/journal.ppat.1005224.
  • Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer.Byers JT, Paniccia A, Kaplan J, Koenig M, Kahn N, Wilson L, Chen L, Schulick RD, Edil BH, Zhu Y. Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer. Annals Of Surgical Oncology 2015, 22 Suppl 3: S1574-9. PMID: 25519928, DOI: 10.1245/s10434-014-4293-2.
  • Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.Flies DB, Higuchi T, Chen L. Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 194: 5294-304. PMID: 25917101, PMCID: PMC4433880, DOI: 10.4049/jimmunol.1402648.
  • Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.Weigelin B, Bolaños E, Teijeira A, Martinez-Forero I, Labiano S, Azpilikueta A, Morales-Kastresana A, Quetglas JI, Wagena E, Sánchez-Paulete AR, Chen L, Friedl P, Melero I. Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 7551-6. PMID: 26034288, PMCID: PMC4475992, DOI: 10.1073/pnas.1506357112.
  • Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.Flies DB, Han X, Higuchi T, Zheng L, Sun J, Ye JJ, Chen L. Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity. The Journal Of Clinical Investigation 2014, 124: 1966-75. PMID: 24743150, PMCID: PMC4001557, DOI: 10.1172/JCI74589.
  • Programmed death ligand-1 expression in non-small cell lung cancer.Velcheti V, Schalper KA, Carvajal DE, Anagnostou VK, Syrigos KN, Sznol M, Herbst RS, Gettinger SN, Chen L, Rimm DL. Programmed death ligand-1 expression in non-small cell lung cancer. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2014, 94: 107-16. PMID: 24217091, PMCID: PMC6125250, DOI: 10.1038/labinvest.2013.130.
  • PD-L1 Expression in Clear Cell Renal Cell Carcinoma: An Analysis of Nephrectomy and Sites of Metastases.Jilaveanu LB, Shuch B, Zito CR, Parisi F, Barr M, Kluger Y, Chen L, Kluger HM. PD-L1 Expression in Clear Cell Renal Cell Carcinoma: An Analysis of Nephrectomy and Sites of Metastases. Journal Of Cancer 2014, 5: 166-72. PMID: 24563671, PMCID: PMC3931264, DOI: 10.7150/jca.8167.
  • Tissue-expressed B7-H1 critically controls intestinal inflammation.Scandiuzzi L, Ghosh K, Hofmeyer KA, Abadi YM, Lázár-Molnár E, Lin EY, Liu Q, Jeon H, Almo SC, Chen L, Nathenson SG, Zang X. Tissue-expressed B7-H1 critically controls intestinal inflammation. Cell Reports 2014, 6: 625-32. PMID: 24529703, PMCID: PMC3962725, DOI: 10.1016/j.celrep.2014.01.020.
  • Myeloid cells' evasion of melanoma immunity.Wang J, Chen L. Myeloid cells' evasion of melanoma immunity. The Journal Of Investigative Dermatology 2014, 134: 2675-2677. PMID: 25318429, PMCID: PMC4455019, DOI: 10.1038/jid.2014.251.
  • Targeting CD137 enhances the efficacy of cetuximab.Kohrt HE, Colevas AD, Houot R, Weiskopf K, Goldstein MJ, Lund P, Mueller A, Sagiv-Barfi I, Marabelle A, Lira R, Troutner E, Richards L, Rajapaska A, Hebb J, Chester C, Waller E, Ostashko A, Weng WK, Chen L, Czerwinski D, Fu YX, Sunwoo J, Levy R. Targeting CD137 enhances the efficacy of cetuximab. The Journal Of Clinical Investigation 2014, 124: 2668-82. PMID: 24837434, PMCID: PMC4089447, DOI: 10.1172/JCI73014.
  • CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert.Zhu Y, Chen L. CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2014, 20: 3-5. PMID: 24166912, DOI: 10.1158/1078-0432.CCR-13-2573.
  • Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W, Diao L, Wang J, Roybal J, Patel M, Ungewiss C, Peng D, Antonia S, Mediavilla-Varela M, Robertson G, Suraokar M, Welsh JW, Erez B, Wistuba II, Chen L, Peng D, Wang S, Ullrich SE, Heymach JV, Kurie JM, Qin FX. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nature Communications 2014, 5: 5241. PMID: 25348003, PMCID: PMC4212319, DOI: 10.1038/ncomms6241.
  • PD-1 as an immune modulatory receptor.Yao S, Chen L. PD-1 as an immune modulatory receptor. Cancer Journal (Sudbury, Mass.) 2014, 20: 262-4. PMID: 25098286, PMCID: PMC4455017, DOI: 10.1097/PPO.0000000000000060.
  • Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Chen L, Azuma M, Yagita H, Tanimoto M. Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease. Journal Of Immunology (Baltimore, Md. : 1950) 2014, 193: 2565-73. PMID: 25080485, DOI: 10.4049/jimmunol.1400954.
  • Hair follicle mesenchyme-associated PD-L1 regulates T-cell activation induced apoptosis: a potential mechanism of immune privilege.Wang X, Marr AK, Breitkopf T, Leung G, Hao J, Wang E, Kwong N, Akhoundsadegh N, Chen L, Mui A, Carr N, Warnock GL, Shapiro J, McElwee KJ. Hair follicle mesenchyme-associated PD-L1 regulates T-cell activation induced apoptosis: a potential mechanism of immune privilege. The Journal Of Investigative Dermatology 2014, 134: 736-745. PMID: 24005055, DOI: 10.1038/jid.2013.368.
  • Inducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation.Sanmamed MF, Chen L. Inducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation. Cancer Journal (Sudbury, Mass.) 2014, 20: 256-61. PMID: 25098285, PMCID: PMC4455021, DOI: 10.1097/PPO.0000000000000061.
  • From the guest editor: Tumor site immune modulation therapy.Chen L. From the guest editor: Tumor site immune modulation therapy. Cancer Journal (Sudbury, Mass.) 2014, 20: 254-5. PMID: 25098284, PMCID: PMC4451829, DOI: 10.1097/PPO.0000000000000062.
  • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL, Anders RA. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2014, 20: 5064-74. PMID: 24714771, PMCID: PMC4185001, DOI: 10.1158/1078-0432.CCR-13-3271.
  • Molecular mechanisms of T cell co-stimulation and co-inhibition.Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews. Immunology 2013, 13: 227-42. PMID: 23470321, PMCID: PMC3786574, DOI: 10.1038/nri3405.
  • Advances in targeting cell surface signalling molecules for immune modulation.Yao S, Zhu Y, Chen L. Advances in targeting cell surface signalling molecules for immune modulation. Nature Reviews. Drug Discovery 2013, 12: 130-46. PMID: 23370250, PMCID: PMC3698571, DOI: 10.1038/nrd3877.
  • B7-H5 costimulates human T cells via CD28H.Zhu Y, Yao S, Iliopoulou BP, Han X, Augustine MM, Xu H, Phennicie RT, Flies SJ, Broadwater M, Ruff W, Taube JM, Zheng L, Luo L, Zhu G, Chen J, Chen L. B7-H5 costimulates human T cells via CD28H. Nature Communications 2013, 4: 2043. PMID: 23784006, PMCID: PMC3698612, DOI: 10.1038/ncomms3043.
  • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.Sznol M, Chen L. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2013, 19: 1021-34. PMID: 23460533, PMCID: PMC3702373, DOI: 10.1158/1078-0432.CCR-12-2063.
  • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer--response.Sznol M, Chen L. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer--response. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2013, 19: 5542. PMID: 24048329, PMCID: PMC6101650, DOI: 10.1158/1078-0432.CCR-13-2234.
  • B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.Podojil JR, Liu LN, Marshall SA, Chiang MY, Goings GE, Chen L, Langermann S, Miller SD. B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms. Journal Of Autoimmunity 2013, 44: 71-81. PMID: 23683881, PMCID: PMC3973032, DOI: 10.1016/j.jaut.2013.04.001.
  • Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.Bigelow E, Bever KM, Xu H, Yager A, Wu A, Taube J, Chen L, Jaffee EM, Anders RA, Zheng L. Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue. Journal Of Visualized Experiments : JoVE 2013 PMID: 23328703, PMCID: PMC3582653, DOI: 10.3791/4059.
  • Endogenous expression of B7-H4 improves long-term murine islet allograft survival.Wang X, Hao J, Metzger DL, Mui A, Lee IF, Akhoundsadegh N, Ao Z, Chen L, Ou D, Verchere CB, Warnock GL. Endogenous expression of B7-H4 improves long-term murine islet allograft survival. Transplantation 2013, 95: 94-9. PMID: 23192157, DOI: 10.1097/TP.0b013e318277229d.
  • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody.Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, Xu H, Yao S, Pons A, Chen L, Pardoll DM, Brahmer JR, Topalian SL. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2013, 19: 462-8. PMID: 23169436, PMCID: PMC3548952, DOI: 10.1158/1078-0432.CCR-12-2625.
  • B7-H4.Ig inhibits the development of type 1 diabetes by regulating Th17 cells in NOD mice.Lee IF, Wang X, Hao J, Akhoundsadegh N, Chen L, Liu L, Langermann S, Ou D, Warnock GL. B7-H4.Ig inhibits the development of type 1 diabetes by regulating Th17 cells in NOD mice. Cellular Immunology 2013, 282: 1-8. PMID: 23623902, DOI: 10.1016/j.cellimm.2013.03.005.
  • Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Research 2013, 73: 1733-41. PMID: 23288508, PMCID: PMC3602406, DOI: 10.1158/0008-5472.CAN-12-2384.
  • CD137 ligand signaling enhances myelopoiesis during infections.Tang Q, Jiang D, Alonso S, Pant A, Martínez Gómez JM, Kemeny DM, Chen L, Schwarz H. CD137 ligand signaling enhances myelopoiesis during infections. European Journal Of Immunology 2013, 43: 1555-67. PMID: 23519951, DOI: 10.1002/eji.201243071.
  • Cancer immunotherapy: are we there yet?Li Z, Chen L, Rubinstein MP. Cancer immunotherapy: are we there yet? Experimental Hematology & Oncology 2013, 2: 33. PMID: 24326015, PMCID: PMC4176488, DOI: 10.1186/2162-3619-2-33.
  • CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice.Martínez Gómez JM, Chen L, Schwarz H, Karrasch T. CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice. PloS One 2013, 8: e73277. PMID: 24023849, PMCID: PMC3762711, DOI: 10.1371/journal.pone.0073277.
  • Adaptive resistance: a tumor strategy to evade immune attack.Yao S, Chen L. Adaptive resistance: a tumor strategy to evade immune attack. European Journal Of Immunology 2013, 43: 576-9. PMID: 23381914, PMCID: PMC4135307, DOI: 10.1002/eji.201243275.
  • Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma.Tamura H, Ishibashi M, Yamashita T, Tanosaki S, Okuyama N, Kondo A, Hyodo H, Shinya E, Takahashi H, Dong H, Tamada K, Chen L, Dan K, Ogata K. Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma. Leukemia 2013, 27: 464-72. PMID: 22828443, DOI: 10.1038/leu.2012.213.
  • Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infection And Immunity 2013, 81: 2156-67. PMID: 23545295, PMCID: PMC3676013, DOI: 10.1128/IAI.01185-12.
  • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, Chen L. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Science Translational Medicine 2012, 4: 127ra37. PMID: 22461641, PMCID: PMC3568523, DOI: 10.1126/scitranslmed.3003689.
  • PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model.Tzeng HT, Tsai HF, Liao HJ, Lin YJ, Chen L, Chen PJ, Hsu PN. PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. PloS One 2012, 7: e39179. PMID: 22761734, PMCID: PMC3382233, DOI: 10.1371/journal.pone.0039179.
  • The B7 homologues and their receptors in hematologic malignancies.Wilcox RA, Ansell SM, Lim MS, Zou W, Chen L. The B7 homologues and their receptors in hematologic malignancies. European Journal Of Haematology 2012, 88: 465-75. PMID: 22372959, DOI: 10.1111/j.1600-0609.2012.01766.x.
  • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. The New England Journal Of Medicine 2012, 366: 2443-54. PMID: 22658127, PMCID: PMC3544539, DOI: 10.1056/NEJMoa1200690.
  • Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.Park JJ, Anand S, Zhao Y, Matsumura Y, Sakoda Y, Kuramasu A, Strome SE, Chen L, Tamada K. Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory. Cancer Immunology, Immunotherapy : CII 2012, 61: 203-214. PMID: 21877247, PMCID: PMC3746333, DOI: 10.1007/s00262-011-1101-8.
  • Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.Tewalt EF, Cohen JN, Rouhani SJ, Guidi CJ, Qiao H, Fahl SP, Conaway MR, Bender TP, Tung KS, Vella AT, Adler AJ, Chen L, Engelhard VH. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood 2012, 120: 4772-82. PMID: 22993390, PMCID: PMC3520619, DOI: 10.1182/blood-2012-04-427013.
  • Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.Li X, Deng R, He W, Liu C, Wang M, Young J, Meng Z, Du C, Huang W, Chen L, Chen Y, Martin P, Forman S, Zeng D. Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease. Journal Of Immunology (Baltimore, Md. : 1950) 2012, 188: 724-34. PMID: 22156590, PMCID: PMC3891913, DOI: 10.4049/jimmunol.1102630.
  • B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation.Wang X, Hao J, Metzger DL, Ao Z, Chen L, Ou D, Verchere CB, Mui A, Warnock GL. B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation. PloS One 2012, 7: e28232. PMID: 22238573, PMCID: PMC3251556, DOI: 10.1371/journal.pone.0028232.
  • Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert JD, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mécheri S, Kaplanski G, Prévost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L. Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Research 2012, 72: 2757-67. PMID: 22427351, DOI: 10.1158/0008-5472.CAN-11-3379.
  • Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.Kohrt HE, Houot R, Weiskopf K, Goldstein MJ, Scheeren F, Czerwinski D, Colevas AD, Weng WK, Clarke MF, Carlson RW, Stockdale FE, Mollick JA, Chen L, Levy R. Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. The Journal Of Clinical Investigation 2012, 122: 1066-75. PMID: 22326955, PMCID: PMC3287235, DOI: 10.1172/JCI61226.
  • B7-H4 induces donor-specific tolerance in mouse islet allografts.Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. B7-H4 induces donor-specific tolerance in mouse islet allografts. Cell Transplantation 2012, 21: 99-111. PMID: 21929869, DOI: 10.3727/096368911X582750.
  • Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection.Luan Y, Ju J, Luo L, Zhang Z, Wang J, Zhu DM, Cheng L, Zhang SY, Chen L, Wang FS, Wang S. Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection. Journal Of Viral Hepatitis 2012, 19: 23-31. PMID: 22187944, DOI: 10.1111/j.1365-2893.2010.01421.x.
  • Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.Wang X, Hao J, Metzger DL, Mui A, Lee IF, Akhoundsadegh N, Chen CL, Ou D, Ao Z, Verchere CB, Warnock GL. Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival. Islets 2012, 4: 284-95. PMID: 22878670, PMCID: PMC3496653, DOI: 10.4161/isl.21239.
  • B7-h2 is a costimulatory ligand for CD28 in human.Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. B7-h2 is a costimulatory ligand for CD28 in human. Immunity 2011, 34: 729-40. PMID: 21530327, PMCID: PMC3103603, DOI: 10.1016/j.immuni.2011.03.014.
  • Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.Zheng J, Umikawa M, Zhang S, Huynh H, Silvany R, Chen BP, Chen L, Zhang CC. Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell 2011, 9: 119-30. PMID: 21816363, PMCID: PMC3151486, DOI: 10.1016/j.stem.2011.06.003.
  • Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.Flies DB, Sandler BJ, Sznol M, Chen L. Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. The Yale Journal Of Biology And Medicine 2011, 84: 409-21. PMID: 22180678, PMCID: PMC3238327.
  • CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Müller A, Pachynski R, Czerwinski D, Coutre S, Chao MP, Chen L, Tedder TF, Levy R. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood 2011, 117: 2423-32. PMID: 21193697, PMCID: PMC3062409, DOI: 10.1182/blood-2010-08-301945.
  • The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope.Han X, Ye P, Luo L, Zheng L, Liu Y, Chen L, Wang S. The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope. Cellular & Molecular Immunology 2011, 8: 333-40. PMID: 21643003, PMCID: PMC4002444, DOI: 10.1038/cmi.2011.14.
  • Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L, Fallon PG. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 5648-55. PMID: 21490158, DOI: 10.4049/jimmunol.1003161.
  • Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, van Rooijen N, Chen L, Strome SE, Hancock WW, Chen L, Tamada K. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. The Journal Of Clinical Investigation 2011, 121: 4810-9. PMID: 22080867, PMCID: PMC3225994, DOI: 10.1172/JCI57332.
  • Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.Flies DB, Wang S, Xu H, Chen L. Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 187: 1537-41. PMID: 21768399, PMCID: PMC3150865, DOI: 10.4049/jimmunol.1100660.
  • Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.Wang S, Chen L. Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways. Current Topics In Microbiology And Immunology 2011, 344: 245-67. PMID: 20582531, DOI: 10.1007/82_2010_81.
  • Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients.Yi T, Li X, Yao S, Wang L, Chen Y, Zhao D, Johnston HF, Young JS, Liu H, Todorov I, Forman SJ, Chen L, Zeng D. Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 2739-49. PMID: 21263067, PMCID: PMC3786569, DOI: 10.4049/jimmunol.1002939.
  • Cell surface signaling molecules in the control of immune responses: a tide model.Zhu Y, Yao S, Chen L. Cell surface signaling molecules in the control of immune responses: a tide model. Immunity 2011, 34: 466-78. PMID: 21511182, PMCID: PMC3176719, DOI: 10.1016/j.immuni.2011.04.008.
  • Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, Akiyama T, Matsumoto M. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 5047-57. PMID: 21441458, DOI: 10.4049/jimmunol.1003533.
  • Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.Wang X, Hao J, Metzger DL, Mui A, Ao Z, Akhoundsadegh N, Langermann S, Liu L, Chen L, Ou D, Verchere CB, Warnock GL. Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes 2011, 60: 3246-55. PMID: 21984581, PMCID: PMC3219946, DOI: 10.2337/db11-0375.
  • B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies.Wang X, Hao J, Metzger DL, Ao Z, Meloche M, Verchere CB, Chen L, Ou D, Mui A, Warnock GL. B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies. Journal Of Transplantation 2011, 2011: 418902. PMID: 22028949, PMCID: PMC3196026, DOI: 10.1155/2011/418902.
  • B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.Lin PY, Sun L, Thibodeaux SR, Ludwig SM, Vadlamudi RK, Hurez VJ, Bahar R, Kious MJ, Livi CB, Wall SR, Chen L, Zhang B, Shin T, Curiel TJ. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185: 2747-53. PMID: 20686128, PMCID: PMC3244840, DOI: 10.4049/jimmunol.1000496.
  • B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.Hamel KM, Cao Y, Wang Y, Rodeghero R, Kobezda T, Chen L, Finnegan A. B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis. European Journal Of Immunology 2010, 40: 3117-27. PMID: 21061440, PMCID: PMC3638795, DOI: 10.1002/eji.201040690.
  • CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells.Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood 2010, 115: 1941-8. PMID: 20068221, PMCID: PMC2837330, DOI: 10.1182/blood-2008-12-192591.
  • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nature Immunology 2010, 11: 535-42. PMID: 20453843, PMCID: PMC2874069, DOI: 10.1038/ni.1877.
  • Structural immunology of costimualtory and coinhibitory molecules.Wang S, Chen L. Structural immunology of costimualtory and coinhibitory molecules. Science China. Life Sciences 2010, 53: 183-9. PMID: 20596825, DOI: 10.1007/s11427-010-0043-2.
  • Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M, Shinya E, Takahashi H, Tamada K, Chen L, Dan K, Ogata K. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood 2010, 116: 1124-31. PMID: 20472834, PMCID: PMC3375140, DOI: 10.1182/blood-2009-12-255125.
  • CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.Wang J, Zhao W, Cheng L, Guo M, Li D, Li X, Tan Y, Ma S, Li S, Yang Y, Chen L, Wang S. CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185: 7654-62. PMID: 21059892, PMCID: PMC3601909, DOI: 10.4049/jimmunol.1000927.
  • Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.Nguyen LT, Ciric B, Van Keulen VP, Rodriguez M, Pease LR, Tamada K, Flies DB, Chen L. Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research 2010, 70: 9528. PMID: 21045150, DOI: 10.1158/0008-5472.CAN-10-3461.
  • Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.Ishiwata K, Watanabe N, Guo M, Tomihara K, Brumlik MJ, Yagita H, Pardoll D, Chen L, Shin T. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 184: 2086-94. PMID: 20065112, PMCID: PMC4862405, DOI: 10.4049/jimmunol.0804051.
  • Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Tseng SY, Shin T, Chen L, Dong H, Kyle RA, Rodriguez M, Pease LR. Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 184: 6552. PMID: 20483792, DOI: 10.4049/jimmunol.1090031.
  • Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.Dubrot J, Milheiro F, Alfaro C, Palazón A, Martinez-Forero I, Perez-Gracia JL, Morales-Kastresana A, Romero-Trevejo JL, Ochoa MC, Hervás-Stubbs S, Prieto J, Jure-Kunkel M, Chen L, Melero I. Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ. Cancer Immunology, Immunotherapy : CII 2010, 59: 1223-33. PMID: 20336294, DOI: 10.1007/s00262-010-0846-9.
  • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2010, 28: 3167-75. PMID: 20516446, PMCID: PMC4834717, DOI: 10.1200/JCO.2009.26.7609.
  • Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.Rajasalu T, Brosi H, Schuster C, Spyrantis A, Boehm BO, Chen L, Reimann J, Schirmbeck R. Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells. Diabetes 2010, 59: 1966-73. PMID: 20484136, PMCID: PMC2911076, DOI: 10.2337/db09-1135.
  • Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood 2010, 116: 2266-76. PMID: 20574047, PMCID: PMC3368550, DOI: 10.1182/blood-2009-10-250472.
  • B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.Park JJ, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S, Liu Y, Strome SE, Chen L, Tamada K. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 2010, 116: 1291-8. PMID: 20472828, PMCID: PMC2938239, DOI: 10.1182/blood-2010-01-265975.
  • Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions.Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Research 2009, 69: 8067-75. PMID: 19826049, PMCID: PMC4397483, DOI: 10.1158/0008-5472.CAN-09-0901.
  • PD-1 on dendritic cells impedes innate immunity against bacterial infection.Yao S, Wang S, Zhu Y, Luo L, Zhu G, Flies S, Xu H, Ruff W, Broadwater M, Choi IH, Tamada K, Chen L. PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood 2009, 113: 5811-8. PMID: 19339692, PMCID: PMC2700320, DOI: 10.1182/blood-2009-02-203141.
  • Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.Azuma T, Zhu G, Xu H, Rietz AC, Drake CG, Matteson EL, Chen L. Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data. PLoS Medicine 2009, 6: e1000166. PMID: 19841745, PMCID: PMC2760136, DOI: 10.1371/journal.pmed.1000166.
  • Turning the tide of lymphocyte costimulation.Zhu Y, Chen L. Turning the tide of lymphocyte costimulation. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 182: 2557-8. PMID: 19234146, DOI: 10.4049/jimmunol.0990006.
  • Fine tuning the immune response through B7-H3 and B7-H4.Yi KH, Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunological Reviews 2009, 229: 145-51. PMID: 19426220, PMCID: PMC2696224, DOI: 10.1111/j.1600-065X.2009.00768.x.
  • Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.Houot R, Goldstein MJ, Kohrt HE, Myklebust JH, Alizadeh AA, Lin JT, Irish JM, Torchia JA, Kolstad A, Chen L, Levy R. Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood 2009, 114: 3431-8. PMID: 19641184, PMCID: PMC2765679, DOI: 10.1182/blood-2009-05-223958.
  • Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel F, Forman S, Zeng D. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 2009, 114: 3101-12. PMID: 19602708, PMCID: PMC2756212, DOI: 10.1182/blood-2009-05-219402.
  • Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.Yamashita T, Tamura H, Satoh C, Shinya E, Takahashi H, Chen L, Kondo A, Tsuji T, Dan K, Ogata K. Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 770-7. PMID: 19188146, DOI: 10.1158/1078-0432.CCR-08-0501.
  • B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.Zhu G, Augustine MM, Azuma T, Luo L, Yao S, Anand S, Rietz AC, Huang J, Xu H, Flies AS, Flies SJ, Tamada K, Colonna M, van Deursen JM, Chen L. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood 2009, 113: 1759-67. PMID: 19109567, PMCID: PMC2647680, DOI: 10.1182/blood-2008-01-133223.
  • Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation 2009, 87: 482-90. PMID: 19307783, DOI: 10.1097/TP.0b013e318195e5fa.
  • NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.Castellaneta A, Sumpter TL, Chen L, Tokita D, Thomson AW. NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 6922-32. PMID: 19890047, PMCID: PMC2786082, DOI: 10.4049/jimmunol.0900582.
  • Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma.Karim R, Jordanova ES, Piersma SJ, Kenter GG, Chen L, Boer JM, Melief CJ, van der Burg SH. Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 6341-7. PMID: 19825956, DOI: 10.1158/1078-0432.CCR-09-1652.
  • B and T lymphocyte attenuator tempers early infection immunity.Sun Y, Brown NK, Ruddy MJ, Miller ML, Lee Y, Wang Y, Murphy KM, Pfeffer K, Chen L, Kaye J, Fu YX. B and T lymphocyte attenuator tempers early infection immunity. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 183: 1946-51. PMID: 19587015, PMCID: PMC2895307, DOI: 10.4049/jimmunol.0801866.
  • Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity.Omiya R, Tsushima F, Narazaki H, Sakoda Y, Kuramasu A, Kim Y, Xu H, Tamura H, Zhu G, Chen L, Tamada K. Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity. Immunology 2009, 128: 543-55. PMID: 19930044, PMCID: PMC2792138, DOI: 10.1111/j.1365-2567.2009.03140.x.
  • Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.Melero I, Martinez-Forero I, Dubrot J, Suarez N, Palazón A, Chen L. Palettes of vaccines and immunostimulatory monoclonal antibodies for combination. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2009, 15: 1507-9. PMID: 19240168, PMCID: PMC3653776, DOI: 10.1158/1078-0432.CCR-08-2931.
  • Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.Phares TW, Ramakrishna C, Parra GI, Epstein A, Chen L, Atkinson R, Stohlman SA, Bergmann CC. Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 182: 5430-8. PMID: 19380790, PMCID: PMC2909606, DOI: 10.4049/jimmunol.0803557.
  • B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.Talay O, Shen CH, Chen L, Chen J. B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 2741-6. PMID: 19202065, PMCID: PMC2637274, DOI: 10.1073/pnas.0813367106.
  • PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer.Crane CA, Panner A, Murray JC, Wilson SP, Xu H, Chen L, Simko JP, Waldman FM, Pieper RO, Parsa AT. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene 2009, 28: 306-12. PMID: 18850006, PMCID: PMC3786571, DOI: 10.1038/onc.2008.384.
  • Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.Diehl L, Schurich A, Grochtmann R, Hegenbarth S, Chen L, Knolle PA. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology (Baltimore, Md.) 2008, 47: 296-305. PMID: 17975811, DOI: 10.1002/hep.21965.
  • B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.Wahl C, Bochtler P, Chen L, Schirmbeck R, Reimann J. B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses. Gastroenterology 2008, 135: 980-8. PMID: 18621049, DOI: 10.1053/j.gastro.2008.05.076.
  • B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.Ortler S, Leder C, Mittelbronn M, Zozulya AL, Knolle PA, Chen L, Kroner A, Wiendl H. B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. European Journal Of Immunology 2008, 38: 1734-44. PMID: 18421793, DOI: 10.1002/eji.200738071.
  • Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection.Seo SK, Jeong HY, Park SG, Lee SW, Choi IW, Chen L, Choi I. Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection. Immunology 2008, 123: 90-9. PMID: 17971153, PMCID: PMC2433284, DOI: 10.1111/j.1365-2567.2007.02708.x.
  • Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.Lafon M, Mégret F, Meuth SG, Simon O, Velandia Romero ML, Lafage M, Chen L, Alexopoulou L, Flavell RA, Prehaud C, Wiendl H. Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 180: 7506-15. PMID: 18490751, DOI: 10.4049/jimmunol.180.11.7506.
  • Inhibitory B7-family molecules in the tumour microenvironment.Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nature Reviews. Immunology 2008, 8: 467-77. PMID: 18500231, DOI: 10.1038/nri2326.
  • CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.Olofsson PS, Söderström LA, Wågsäter D, Sheikine Y, Ocaya P, Lang F, Rabu C, Chen L, Rudling M, Aukrust P, Hedin U, Paulsson-Berne G, Sirsjö A, Hansson GK. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 2008, 117: 1292-301. PMID: 18285570, DOI: 10.1161/CIRCULATIONAHA.107.699173.
  • PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.Schreiner B, Bailey SL, Shin T, Chen L, Miller SD. PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE. European Journal Of Immunology 2008, 38: 2706-17. PMID: 18825752, PMCID: PMC2727707, DOI: 10.1002/eji.200838137.
  • Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies.Lin W, Voskens CJ, Zhang X, Schindler DG, Wood A, Burch E, Wei Y, Chen L, Tian G, Tamada K, Wang LX, Schulze DH, Mann D, Strome SE. Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies. Blood 2008, 112: 699-707. PMID: 18519814, PMCID: PMC2481534, DOI: 10.1182/blood-2007-11-122465.
  • Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development.Kryczek I, Wei S, Gong W, Shu X, Szeliga W, Vatan L, Chen L, Wang G, Zou W. Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 181: 5842-6. PMID: 18941172, DOI: 10.4049/jimmunol.181.9.5842.
  • Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.Wei S, Shreiner AB, Takeshita N, Chen L, Zou W, Chang AE. Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta. Cancer Research 2008, 68: 5432-8. PMID: 18593946, PMCID: PMC3094850, DOI: 10.1158/0008-5472.CAN-07-6598.
  • Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection.Jeong HY, Lee YJ, Seo SK, Lee SW, Park SJ, Lee JN, Sohn HS, Yao S, Chen L, Choi I. Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection. Journal Of Leukocyte Biology 2008, 83: 755-64. PMID: 18086898, DOI: 10.1189/jlb.0307168.
  • Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson DJ, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. Journal Of Neuroinflammation 2008, 5: 48. PMID: 18947414, PMCID: PMC2588578, DOI: 10.1186/1742-2094-5-48.
  • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008, 111: 3635-43. PMID: 18223165, PMCID: PMC2275025, DOI: 10.1182/blood-2007-11-123141.
  • Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.McNamara JO, Kolonias D, Pastor F, Mittler RS, Chen L, Giangrande PH, Sullenger B, Gilboa E. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. The Journal Of Clinical Investigation 2008, 118: 376-86. PMID: 18060045, PMCID: PMC2104483, DOI: 10.1172/JCI33365.
  • B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.Chen L, Zhang Z, Chen W, Zhang Z, Li Y, Shi M, Zhang J, Chen L, Wang S, Wang FS. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 6634-41. PMID: 17475895, DOI: 10.4049/jimmunol.178.10.6634.
  • Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, Archer D, Spencer T, Dillehay D, Kwon B, Chen L, Vella AT, Mittler RS. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 4194-213. PMID: 17371976, PMCID: PMC2770095, DOI: 10.4049/jimmunol.178.7.4194.
  • Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.Xu Y, Flies AS, Flies DB, Zhu G, Anand S, Flies SJ, Xu H, Anders RA, Hancock WW, Chen L, Tamada K. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood 2007, 109: 4097-104. PMID: 17179227, PMCID: PMC1874563, DOI: 10.1182/blood-2006-09-047332.
  • CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype.Zhu Y, Zhu G, Luo L, Flies AS, Chen L. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 2007, 109: 4882-9. PMID: 17244673, PMCID: PMC1885532, DOI: 10.1182/blood-2006-10-043463.
  • Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.Kryczek I, Wei S, Zhu G, Myers L, Mottram P, Cheng P, Chen L, Coukos G, Zou W. Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Research 2007, 67: 8900-5. PMID: 17875732, DOI: 10.1158/0008-5472.CAN-07-1866.
  • Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.Tsushima F, Yao S, Shin T, Flies A, Flies S, Xu H, Tamada K, Pardoll DM, Chen L. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood 2007, 110: 180-5. PMID: 17289811, PMCID: PMC1896111, DOI: 10.1182/blood-2006-11-060087.
  • Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation.Piconi S, Trabattoni D, Saresella M, Iemoli E, Schenal M, Fusi A, Borelli M, Chen L, Mascheri A, Clerici M. Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 1931-7. PMID: 17237444, DOI: 10.4049/jimmunol.178.3.1931.
  • The new B7s: playing a pivotal role in tumor immunity.Flies DB, Chen L. The new B7s: playing a pivotal role in tumor immunity. Journal Of Immunotherapy (Hagerstown, Md. : 1997) 2007, 30: 251-60. PMID: 17414316, DOI: 10.1097/CJI.0b013e31802e085a.
  • How Ebola and Marburg viruses battle the immune system.Mohamadzadeh M, Chen L, Schmaljohn AL. How Ebola and Marburg viruses battle the immune system. Nature Reviews. Immunology 2007, 7: 556-67. PMID: 17589545, DOI: 10.1038/nri2098.
  • LIGHT-related molecular network in the regulation of innate and adaptive immunity.Xu Y, Tamada K, Chen L. LIGHT-related molecular network in the regulation of innate and adaptive immunity. Immunologic Research 2007, 37: 17-32. PMID: 17496344, DOI: 10.1007/bf02686093.
  • Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.Goldberg MV, Maris CH, Hipkiss EL, Flies AS, Zhen L, Tuder RM, Grosso JF, Harris TJ, Getnet D, Whartenby KA, Brockstedt DG, Dubensky TW, Chen L, Pardoll DM, Drake CG. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood 2007, 110: 186-92. PMID: 17392506, PMCID: PMC1896112, DOI: 10.1182/blood-2006-12-062422.
  • Immunostimulatory monoclonal antibodies for cancer therapy.Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nature Reviews. Cancer 2007, 7: 95-106. PMID: 17251916, DOI: 10.1038/nrc2051.
  • Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.Pentcheva-Hoang T, Chen L, Pardoll DM, Allison JP. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 17765-70. PMID: 17968013, PMCID: PMC2077030, DOI: 10.1073/pnas.0708767104.
  • Modulation of immune response by B7 family molecules in tumor microenvironments.Flies DB, Chen L. Modulation of immune response by B7 family molecules in tumor microenvironments. Immunological Investigations 2006, 35: 395-418. PMID: 16916759, DOI: 10.1080/08820130600755017.
  • Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RF, Chen L, Warnock GL. Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway. Cell Transplantation 2006, 15: 399-410. PMID: 16970282.
  • Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.Sun Y, Blink SE, Liu W, Lee Y, Chen B, Solway J, Weinstock J, Chen L, Fu YX. Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 814-21. PMID: 16818735, DOI: 10.4049/jimmunol.177.2.814.
  • Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.Tirapu I, Huarte E, Guiducci C, Arina A, Zaratiegui M, Murillo O, Gonzalez A, Berasain C, Berraondo P, Fortes P, Prieto J, Colombo MP, Chen L, Melero I. Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma. Cancer Research 2006, 66: 2442-50. PMID: 16489051, DOI: 10.1158/0008-5472.CAN-05-1681.
  • The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans.Salih HR, Wintterle S, Krusch M, Kroner A, Huang YH, Chen L, Wiendl H. The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Experimental Hematology 2006, 34: 888-94. PMID: 16797416, DOI: 10.1016/j.exphem.2006.03.006.
  • Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function.Zhang X, Dong H, Lin W, Voss S, Hinkley L, Westergren M, Tian G, Berry D, Lewellen D, Vile RG, Chen L, Farber DL, Strome SE. Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 6730-7. PMID: 17082586, DOI: 10.4049/jimmunol.177.10.6730.
  • Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 40-4. PMID: 16785496, DOI: 10.4049/jimmunol.177.1.40.
  • Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.Yao S, Chen L. Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade. Trends In Molecular Medicine 2006, 12: 244-6. PMID: 16650803, DOI: 10.1016/j.molmed.2006.04.007.
  • Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules.Tamada K, Chen L. Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules. Cancer Immunology, Immunotherapy : CII 2006, 55: 355-62. PMID: 16187084, DOI: 10.1007/s00262-005-0081-y.
  • Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. The Journal Of Clinical Investigation 2006, 116: 1045-51. PMID: 16557300, PMCID: PMC1409742, DOI: 10.1172/JCI27083.
  • Filoviruses and the balance of innate, adaptive, and inflammatory responses.Mohamadzadeh M, Chen L, Olinger GG, Pratt WD, Schmaljohn AL. Filoviruses and the balance of innate, adaptive, and inflammatory responses. Viral Immunology 2006, 19: 602-12. PMID: 17201655, DOI: 10.1089/vim.2006.19.602.
  • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. The Journal Of Experimental Medicine 2006, 203: 871-81. PMID: 16606666, PMCID: PMC2118300, DOI: 10.1084/jem.20050930.
  • Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).Lee SJ, Jang BC, Lee SW, Yang YI, Suh SI, Park YM, Oh S, Shin JG, Yao S, Chen L, Choi IH. Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274). FEBS Letters 2006, 580: 755-62. PMID: 16413538, DOI: 10.1016/j.febslet.2005.12.093.
  • Suppression of Human T-Cell Responses to β-Cells by Activation of B7-H4 Pathway.Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RFL, Chen L, Warnock GL. Suppression of Human T-Cell Responses to β-Cells by Activation of B7-H4 Pathway. Cell Transplantation 2006, 15: 399-410. PMID: 28871868, DOI: 10.3727/000000006783981837.
  • In vivo immune modulatory activity of hepatic stellate cells in mice.Chen CH, Kuo LM, Chang Y, Wu W, Goldbach C, Ross MA, Stolz DB, Chen L, Fung JJ, Lu L, Qian S. In vivo immune modulatory activity of hepatic stellate cells in mice. Hepatology (Baltimore, Md.) 2006, 44: 1171-81. PMID: 17058227, DOI: 10.1002/hep.21379.
  • Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response.Seo SK, Seo HM, Jeong HY, Choi IW, Park YM, Yagita H, Chen L, Choi IH. Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response. Immunology Letters 2006, 102: 222-8. PMID: 16236366, DOI: 10.1016/j.imlet.2005.09.007.
  • Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms.Ichikawa M, Chen L. Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms. Frontiers In Bioscience : A Journal And Virtual Library 2005, 10: 2856-60. PMID: 15970540, DOI: 10.2741/1742.
  • B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK).Jun H, Seo SK, Jeong HY, Seo HM, Zhu G, Chen L, Choi IH. B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK). FEBS Letters 2005, 579: 6259-64. PMID: 16253242, DOI: 10.1016/j.febslet.2005.09.098.
  • In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses.Shin T, Yoshimura K, Shin T, Crafton EB, Tsuchiya H, Housseau F, Koseki H, Schulick RD, Chen L, Pardoll DM. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. The Journal Of Experimental Medicine 2005, 201: 1531-41. PMID: 15897272, PMCID: PMC2212923, DOI: 10.1084/jem.20050072.
  • B7-H3 promotes acute and chronic allograft rejection.Wang L, Fraser CC, Kikly K, Wells AD, Han R, Coyle AJ, Chen L, Hancock WW. B7-H3 promotes acute and chronic allograft rejection. European Journal Of Immunology 2005, 35: 428-38. PMID: 15682454, DOI: 10.1002/eji.200425518.
  • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Research 2005, 65: 1089-96. PMID: 15705911.
  • Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H, Wang SD, Dong H, Chen L, Ogata K. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2005, 11: 5708-17. PMID: 16115907, DOI: 10.1158/1078-0432.CCR-04-2672.
  • Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells.Shao H, Fu Y, Liao T, Peng Y, Chen L, Kaplan HJ, Sun D. Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Investigative Ophthalmology & Visual Science 2005, 46: 596-603. PMID: 15671287, DOI: 10.1167/iovs.04-0835.
  • Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus.Arribillaga L, Sarobe P, Arina A, Gorraiz M, Borrás-Cuesta F, Ruiz J, Prieto J, Chen L, Melero I, Lasarte JJ. Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. Vaccine 2005, 23: 3493-9. PMID: 15855007, DOI: 10.1016/j.vaccine.2005.02.003.
  • The many sounds of T lymphocyte silence.Melero I, Arina A, Chen L. The many sounds of T lymphocyte silence. Immunologic Research 2005, 33: 135-47. PMID: 16234580, DOI: 10.1385/IR:33:2:135.
  • Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming.Vassallo R, Tamada K, Lau JS, Kroening PR, Chen L. Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 175: 2684-91. PMID: 16081845, DOI: 10.4049/jimmunol.175.4.2684.
  • Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.Kim J, Myers AC, Chen L, Pardoll DM, Truong-Tran QA, Lane AP, McDyer JF, Fortuno L, Schleimer RP. Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells. American Journal Of Respiratory Cell And Molecular Biology 2005, 33: 280-9. PMID: 15961727, PMCID: PMC2715317, DOI: 10.1165/rcmb.2004-0129OC.
  • Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.de Haij S, Woltman AM, Trouw LA, Bakker AC, Kamerling SW, van der Kooij SW, Chen L, Kroczek RA, Daha MR, van Kooten C. Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1. Kidney International 2005, 68: 2091-102. PMID: 16221208, DOI: 10.1111/j.1523-1755.2005.00665.x.
  • Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma.Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Chen L, Zincke H, Blute ML, Leibovich BC, Kwon ED. Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma. Cancer 2005, 104: 2084-91. PMID: 16208700, DOI: 10.1002/cncr.21470.
  • Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.Magnus T, Schreiner B, Korn T, Jack C, Guo H, Antel J, Ifergan I, Chen L, Bischof F, Bar-Or A, Wiendl H. Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2005, 25: 2537-46. PMID: 15758163, PMCID: PMC6725171, DOI: 10.1523/JNEUROSCI.4794-04.2005.
  • B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 2004, 20: 327-36. PMID: 15030776, DOI: 10.1016/s1074-7613(04)00050-0.
  • Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 173: 7135-9. PMID: 15585834, DOI: 10.4049/jimmunol.173.12.7135.
  • Structural and functional analysis of the costimulatory receptor programmed death-1.Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC. Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity 2004, 20: 337-47. PMID: 15030777, DOI: 10.1016/s1074-7613(04)00051-2.
  • Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.Schreiber K, Cannon RE, Karrison T, Beck-Engeser G, Huo D, Tennant RW, Jensen H, Kast WM, Krausz T, Meredith SC, Chen L, Schreiber H. Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors. Oncogene 2004, 23: 3972-9. PMID: 15077191, DOI: 10.1038/sj.onc.1207507.
  • Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model.Mukherjee P, Tinder TL, Basu GD, Pathangey LB, Chen L, Gendler SJ. Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model. Breast Disease 2004, 20: 53-63. PMID: 15687707, DOI: 10.3233/bd-2004-20107.
  • Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. The Journal Of Clinical Investigation 2004, 113: 694-700. PMID: 14991067, PMCID: PMC351315, DOI: 10.1172/JCI19210.
  • Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.Radhakrishnan S, Nguyen LT, Ciric B, Flies D, Van Keulen VP, Tamada K, Chen L, Rodriguez M, Pease LR. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research 2004, 64: 4965-72. PMID: 15256470, DOI: 10.1158/0008-5472.CAN-03-3025.
  • Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo.Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar BR, Kast WM, Chen L. Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood 2004, 103: 177-84. PMID: 12969968, DOI: 10.1182/blood-2003-06-2184.
  • 53BP1 is required for class switch recombination.Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. The Journal Of Cell Biology 2004, 165: 459-64. PMID: 15159415, PMCID: PMC2172356, DOI: 10.1083/jcb.200403021.
  • Costimulation-based immunotherapy for head and neck cancer.Strome SE, Chen L. Costimulation-based immunotherapy for head and neck cancer. Current Treatment Options In Oncology 2004, 5: 27-33. PMID: 14697154, DOI: 10.1007/s11864-004-0003-9.
  • Selective suppression of dendritic cell functions by cigarette smoke extract.Vassallo R, Chen L. Selective suppression of dendritic cell functions by cigarette smoke extract. Chest 2004, 125: 107S. PMID: 15136445, DOI: 10.1378/chest.125.5_suppl.107s.
  • Control of autoimmune diseases by the B7-CD28 family molecules.Anand S, Chen L. Control of autoimmune diseases by the B7-CD28 family molecules. Current Pharmaceutical Design 2004, 10: 121-8. PMID: 14754392, DOI: 10.2174/1381612043453450.
  • B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.Luo L, Chapoval AI, Flies DB, Zhu G, Hirano F, Wang S, Lau JS, Dong H, Tamada K, Flies AS, Liu Y, Chen L. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 173: 5445-50. PMID: 15494491, DOI: 10.4049/jimmunol.173.9.5445.
  • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nature Reviews. Immunology 2004, 4: 336-47. PMID: 15122199, DOI: 10.1038/nri1349.
  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, Zhu Y, Wei S, Kryczek I, Daniel B, Gordon A, Myers L, Lackner A, Disis ML, Knutson KL, Chen L, Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Medicine 2004, 10: 942-9. PMID: 15322536, DOI: 10.1038/nm1093.
  • Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.Tirapu I, Arina A, Mazzolini G, Duarte M, Alfaro C, Feijoo E, Qian C, Chen L, Prieto J, Melero I. Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens. International Journal Of Cancer. Journal International Du Cancer 2004, 110: 51-60. PMID: 15054868, DOI: 10.1002/ijc.20093.
  • New B7 family members with positive and negative costimulatory function.Rietz C, Chen L. New B7 family members with positive and negative costimulatory function. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2004, 4: 8-14. PMID: 14678029, DOI: 10.1046/j.1600-6143.2003.00303.x.
  • Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis.Schreiner B, Mitsdoerffer M, Kieseier BC, Chen L, Hartung HP, Weller M, Wiendl H. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. Journal Of Neuroimmunology 2004, 155: 172-82. PMID: 15342209, DOI: 10.1016/j.jneuroim.2004.06.013.
  • Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Krejci KG, Lobo JR, Sengupta S, Chen L, Zincke H, Blute ML, Strome SE, Leibovich BC, Kwon ED. Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17174-9. PMID: 15569934, PMCID: PMC534606, DOI: 10.1073/pnas.0406351101.
  • T lymphocyte co-signaling pathways of the B7-CD28 family.Wang S, Chen L. T lymphocyte co-signaling pathways of the B7-CD28 family. Cellular & Molecular Immunology 2004, 1: 37-42. PMID: 16212919.
  • Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses.Wang S, Chen L. Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses. Microbes And Infection / Institut Pasteur 2004, 6: 759-66. PMID: 15207823, DOI: 10.1016/j.micinf.2004.03.007.
  • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003, 18: 849-61. PMID: 12818165, DOI: 10.1016/s1074-7613(03)00152-3.
  • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, David O, Burow M, Gordon A, Dhurandhar N, Myers L, Berggren R, Hemminki A, Alvarez RD, Emilie D, Curiel DT, Chen L, Zou W. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nature Medicine 2003, 9: 562-7. PMID: 12704383, DOI: 10.1038/nm863.
  • Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.Radhakrishnan S, Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Dong H, Tseng SY, Shin T, Pardoll DM, Chen L, Kyle RA, Rodriguez M, Pease LR. Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 170: 1830-8. PMID: 12574348, DOI: 10.4049/jimmunol.170.4.1830.
  • CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis.Morris GP, Chen L, Kong YC. CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. Cellular Immunology 2003, 226: 20-9. PMID: 14746804, DOI: 10.1016/j.cellimm.2003.11.002.
  • B7 family molecules are favorably positioned at the human maternal-fetal interface.Petroff MG, Chen L, Phillips TA, Azzola D, Sedlmayr P, Hunt JS. B7 family molecules are favorably positioned at the human maternal-fetal interface. Biology Of Reproduction 2003, 68: 1496-504. PMID: 12606489, DOI: 10.1095/biolreprod.102.010058.
  • Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.Kurosawa S, Myers AC, Chen L, Wang S, Ni J, Plitt JR, Heller NM, Bochner BS, Schleimer RP. Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. American Journal Of Respiratory Cell And Molecular Biology 2003, 28: 563-73. PMID: 12707012, DOI: 10.1165/rcmb.2002-0199OC.
  • Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma.Weinman EC, Roche PC, Kasperbauer JL, Cha SS, Sargent DJ, Cheville J, Murphy LM, Chen L, Wettstein PJ, Gostout B, Ferrone S, Strome SE. Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma. Cancer 2003, 97: 2203-11. PMID: 12712472, DOI: 10.1002/cncr.11311.
  • Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways.Zhu Y, Chen L. Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways. Current Opinion In Investigational Drugs (London, England : 2000) 2003, 4: 691-5. PMID: 12901227.
  • Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.Rajagopalan G, Kudva YC, Chen L, Wen L, David CS. Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans. International Immunology 2003, 15: 1035-44. PMID: 12917255, DOI: 10.1093/intimm/dxg103.
  • Differential binding properties of B7-H1 and B7-DC to programmed death-1.Youngnak P, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochemical And Biophysical Research Communications 2003, 307: 672-7. PMID: 12893276, DOI: 10.1016/s0006-291x(03)01257-9.
  • A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization.Flies DB, Chen L. A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization. Journal Of Immunological Methods 2003, 276: 239-42. PMID: 12738377, DOI: 10.1016/s0022-1759(03)00081-4.
  • Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. The Journal Of Experimental Medicine 2003, 198: 31-8. PMID: 12847135, PMCID: PMC2196092, DOI: 10.1084/jem.20030242.
  • B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.Trabattoni D, Saresella M, Biasin M, Boasso A, Piacentini L, Ferrante P, Dong H, Maserati R, Shearer GM, Chen L, Clerici M. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood 2003, 101: 2514-20. PMID: 12468426, DOI: 10.1182/blood-2002-10-3065.
  • Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 171: 4650-4. PMID: 14568939, DOI: 10.4049/jimmunol.171.9.4650.
  • B7-H1 pathway and its role in the evasion of tumor immunity.Dong H, Chen L. B7-H1 pathway and its role in the evasion of tumor immunity. Journal Of Molecular Medicine (Berlin, Germany) 2003, 81: 281-7. PMID: 12721664, DOI: 10.1007/s00109-003-0430-2.
  • Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.Wintterle S, Schreiner B, Mitsdoerffer M, Schneider D, Chen L, Meyermann R, Weller M, Wiendl H. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Research 2003, 63: 7462-7. PMID: 14612546.
  • Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism.Lee I, Wang L, Wells AD, Ye Q, Han R, Dorf ME, Kuziel WA, Rollins BJ, Chen L, Hancock WW. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 171: 6929-35. PMID: 14662900, DOI: 10.4049/jimmunol.171.12.6929.
  • B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Research 2003, 63: 6501-5. PMID: 14559843.
  • Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.Wiendl H, Mitsdoerffer M, Schneider D, Chen L, Lochmüller H, Melms A, Weller M. Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2003, 17: 1892-4. PMID: 12923066, DOI: 10.1096/fj.03-0039fje.
  • Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 171: 4156-63. PMID: 14530338, DOI: 10.4049/jimmunol.171.8.4156.
  • Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.Dong H, Strome SE, Matteson EL, Moder KG, Flies DB, Zhu G, Tamura H, Driscoll CL, Chen L. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. The Journal Of Clinical Investigation 2003, 111: 363-70. PMID: 12569162, PMCID: PMC151851, DOI: 10.1172/JCI16015.
  • Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. The Journal Of Experimental Medicine 2003, 197: 1083-91. PMID: 12719480, PMCID: PMC2193977, DOI: 10.1084/jem.20021752.
  • Immunology of B7-H1 and its roles in human diseases.Tamura H, Ogata K, Dong H, Chen L. Immunology of B7-H1 and its roles in human diseases. International Journal Of Hematology 2003, 78: 321-8. PMID: 14686489, DOI: 10.1007/bf02983556.
  • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Medicine 2002, 8: 793-800. PMID: 12091876, DOI: 10.1038/nm730.
  • Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.May KF, Chen L, Zheng P, Liu Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Research 2002, 62: 3459-65. PMID: 12067989.
  • [Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo].Li X, Li X, Huang J, Wei L, Chen L, Wu M, Guo Y. [Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal Of Hepatology 2002, 10: 409-12. PMID: 12502438.
  • Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis.Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 1457-65. PMID: 11801689, DOI: 10.4049/jimmunol.168.3.1457.
  • Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients.Strome SE, Martin E, Flies D, Khurana D, Salomao D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD, Chen L. Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients. Otolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-Head And Neck Surgery 2002, 126: 180-7. PMID: 11870350, DOI: 10.1067/mhn.2002.122263.
  • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. The Journal Of Clinical Investigation 2002, 109: 651-9. PMID: 11877473, PMCID: PMC150893, DOI: 10.1172/JCI14184.
  • Cutting edge: Expression of functional CD137 receptor by dendritic cells.Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L. Cutting edge: Expression of functional CD137 receptor by dendritic cells. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 4262-7. PMID: 11970964, DOI: 10.4049/jimmunol.168.9.4262.
  • Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T, Pardoll DM, Chen L, Rodriguez M, Pease LR. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. The Journal Of Experimental Medicine 2002, 196: 1393-8. PMID: 12438431, PMCID: PMC2193990, DOI: 10.1084/jem.20021466.
  • Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.Tamada K, Ni J, Zhu G, Fiscella M, Teng B, van Deursen JM, Chen L. Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 4832-5. PMID: 11994431, DOI: 10.4049/jimmunol.168.10.4832.
  • Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance.Wilcox RA, Chen L. Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance. Frontiers In Bioscience : A Journal And Virtual Library 2002, 7: d853-71. PMID: 11897572, DOI: 10.2741/wilcox.
  • Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo Y, Chen L. Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Research 2002, 62: 4413-8. PMID: 12154048.
  • Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nature Medicine 2002, 8: 1405-13. PMID: 12426559, DOI: 10.1038/nm1202-796.
  • Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models.Strome SE, Kawakami K, Alejandro D, Voss S, Kasperbauer JL, Salomao D, Chen L, Maki RA, Puri RK. Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2002, 8: 281-6. PMID: 11801570.
  • Strategies for antigen loading of dendritic cells to enhance the antitumor immune response.Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, Vile R, Gastineau D, Wettstein P, Chen L. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Research 2002, 62: 1884-9. PMID: 11912169.
  • Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. The Journal Of Clinical Investigation 2002, 109: 549-57. PMID: 11854328, PMCID: PMC150873, DOI: 10.1172/JCI13604.
  • Antibody gene therapy: old wine in a new bottle.Chen L. Antibody gene therapy: old wine in a new bottle. Nature Medicine 2002, 8: 333-4. PMID: 11927934, DOI: 10.1038/nm0402-333.
  • Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity.Wilcox RA, Tamada K, Strome SE, Chen L. Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 169: 4230-6. PMID: 12370353, DOI: 10.4049/jimmunol.169.8.4230.
  • Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules.Chapoval AI, Zhu G, Chen L. Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules. Molecular Biotechnology 2002, 21: 259-64. PMID: 12102550, DOI: 10.1385/MB:21:3:259.
  • Ligand binding sites of inducible costimulator and high avidity mutants with improved function.Wang S, Zhu G, Tamada K, Chen L, Bajorath J. Ligand binding sites of inducible costimulator and high avidity mutants with improved function. The Journal Of Experimental Medicine 2002, 195: 1033-41. PMID: 11956294, PMCID: PMC2193694, DOI: 10.1084/jem.20011607.
  • Modulation of dendritic cell differentiation and maturation by decoy receptor 3.Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL. Modulation of dendritic cell differentiation and maturation by decoy receptor 3. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 4846-53. PMID: 11994433, DOI: 10.4049/jimmunol.168.10.4846.
  • B7 family molecules: novel immunomodulators at the maternal-fetal interface.Petroff MG, Chen L, Phillips TA, Hunt JS. B7 family molecules: novel immunomodulators at the maternal-fetal interface. Placenta 2002, 23 Suppl A: S95-101. PMID: 11978065, DOI: 10.1053/plac.2002.0813.
  • B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nature Immunology 2001, 2: 269-74. PMID: 11224528, DOI: 10.1038/85339.
  • Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L. Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167: 2671-6. PMID: 11509610, DOI: 10.4049/jimmunol.167.5.2671.
  • RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB.Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Blood 2001, 97: 2702-7. PMID: 11313261, DOI: 10.1182/blood.v97.9.2702.
  • The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. The Journal Of Clinical Investigation 2001, 108: 1771-80. PMID: 11748260, PMCID: PMC209470, DOI: 10.1172/JCI13827.
  • The critical role of LIGHT, a TNF family member, in T cell development.Wang J, Chun T, Lo JC, Wu Q, Wang Y, Foster A, Roca K, Chen M, Tamada K, Chen L, Wang CR, Fu YX. The critical role of LIGHT, a TNF family member, in T cell development. Journal Of Immunology (Baltimore, Md. : 1950) 2001, 167: 5099-105. PMID: 11673520, DOI: 10.4049/jimmunol.167.9.5099.
  • TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells.Pakala SV, Ilic A, Chen L, Sarvetnick N. TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells. Clinical Immunology (Orlando, Fla.) 2001, 100: 198-207. PMID: 11465949, DOI: 10.1006/clim.2001.5059.
  • Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy.Khurana D, Martin EA, Kasperbauer JL, O'Malley BW, Salomao DR, Chen L, Strome SE. Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy. Head & Neck 2001, 23: 899-906. PMID: 11592238, DOI: 10.1002/hed.1130.
  • B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001, 97: 1809-16. PMID: 11238124, DOI: 10.1182/blood.v97.6.1809.
  • Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway.Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu YX, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine 2000, 6: 283-9. PMID: 10700230, DOI: 10.1038/73136.
  • Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma.Strome SE, Martin B, Flies D, Tamada K, Chapoval AI, Sargent DJ, Shu S, Chen L. Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma. Journal Of Immunotherapy (Hagerstown, Md. : 1997) 2000, 23: 430-7. PMID: 10916752, DOI: 10.1097/00002371-200007000-00006.
  • Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.Wang S, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-13. PMID: 11023515.
  • Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation.Chen SH, Pham-Nguyen KB, Martinet O, Huang Y, Yang W, Thung SN, Chen L, Mittler R, Woo SL. Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation. Molecular Therapy : The Journal Of The American Society Of Gene Therapy 2000, 2: 39-46. PMID: 10899826, DOI: 10.1006/mthe.2000.0086.
  • Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long- term remission of liver metastases in a mouse model.Martinet O, Ermekova V, Qiao JQ, Sauter B, Mandeli J, Chen L, Chen SH. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long- term remission of liver metastases in a mouse model. Journal Of The National Cancer Institute 2000, 92: 931-6. PMID: 10841829, DOI: 10.1093/jnci/92.11.931.
  • LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response.Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, Chen SF, Hsieh SL, Nagata S, Ni J, Chen L. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. Journal Of Immunology (Baltimore, Md. : 1950) 2000, 164: 4105-10. PMID: 10754304, DOI: 10.4049/jimmunol.164.8.4105.
  • In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells.Chapoval AI, Tamada K, Chen L. In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells. Blood 2000, 95: 2346-51. PMID: 10733505.
  • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-9. PMID: 10581077, DOI: 10.1038/70932.
  • Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily.Hu S, Tamada K, Ni J, Vincenz C, Chen L. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics 1999, 62: 103-7. PMID: 10585776, DOI: 10.1006/geno.1999.5979.
  • Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.Johnson AJ, Njenga MK, Hansen MJ, Kuhns ST, Chen L, Rodriguez M, Pease LR. Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28. Journal Of Virology 1999, 73: 3702-8. PMID: 10196262, PMCID: PMC104145, DOI: 10.1128/JVI.73.5.3702-3708.1999.
  • Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway.Melero I, Bach N, Hellström KE, Aruffo A, Mittler RS, Chen L. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. European Journal Of Immunology 1998, 28: 1116-21. PMID: 9541607, DOI: 10.1002/(SICI)1521-4141(199803)28:03<1116::AID-IMMU1116>3.0.CO;2-A.
  • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cellular Immunology 1998, 190: 167-72. PMID: 9878117, DOI: 10.1006/cimm.1998.1396.
  • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, Mittler RS, Chen L. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nature Medicine 1997, 3: 682-5. PMID: 9176498.
  • Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. The Journal Of Experimental Medicine 1997, 186: 229-38. PMID: 9221752, PMCID: PMC2198977, DOI: 10.1084/jem.186.2.229.
  • B7-negative versus B7-positive P815 tumor: differential requirements for priming of an antitumor immune response in lymph nodes.Yang G, Mizuno MT, Hellström KE, Chen L. B7-negative versus B7-positive P815 tumor: differential requirements for priming of an antitumor immune response in lymph nodes. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 158: 851-8. PMID: 8993003.
  • Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.Melero I, Singhal MC, McGowan P, Haugen HS, Blake J, Hellstrom KE, Yang G, Clegg CH, Chen L. Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16. Journal Of Virology 1997, 71: 3998-4004. PMID: 9094677, PMCID: PMC191552, DOI: 10.1128/JVI.71.5.3998-4004.1997.
  • A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha.Maric M, Chen L, Sherry B, Liu Y. A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha. Journal Of Immunology (Baltimore, Md. : 1950) 1997, 159: 360-8. PMID: 9200474.
  • Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes.Blake J, Johnston JV, Hellström KE, Marquardt H, Chen L. Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes. The Journal Of Experimental Medicine 1996, 184: 121-30. PMID: 8691125, PMCID: PMC2192679, DOI: 10.1084/jem.184.1.121.
  • Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors.Li Y, Hellstrom KE, Newby SA, Chen L. Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. The Journal Of Experimental Medicine 1996, 183: 639-44. PMID: 8627175, PMCID: PMC2192440, DOI: 10.1084/jem.183.2.639.
  • B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes.Johnston JV, Malacko AR, Mizuno MT, McGowan P, Hellström I, Hellström KE, Marquardt H, Chen L. B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes. The Journal Of Experimental Medicine 1996, 183: 791-800. PMID: 8642283, PMCID: PMC2192349, DOI: 10.1084/jem.183.3.791.
  • Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules.Yang G, Hellström KE, Hellström I, Chen L. Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 154: 2794-800. PMID: 7533183.
  • In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation.Yang G, Hellström KE, Mizuno MT, Chen L. In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 155: 3897-903. PMID: 7561096.
  • Hyaluronan on the surface of tumor cells is correlated with metastatic behavior.Zhang L, Underhill CB, Chen L. Hyaluronan on the surface of tumor cells is correlated with metastatic behavior. Cancer Research 1995, 55: 428-33. PMID: 7529138.
  • Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected.Ramarathinam L, Sarma S, Maric M, Zhao M, Yang G, Chen L, Liu Y. Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 155: 5323-9. PMID: 7594546.
  • Protective immunity induced by B7/CD28-costimulated gamma delta T cells to the EL-4 lymphoma in allogenic athymic mice.Li Y, Newby SA, Johnston JV, Hellström KE, Chen L. Protective immunity induced by B7/CD28-costimulated gamma delta T cells to the EL-4 lymphoma in allogenic athymic mice. Journal Of Immunology (Baltimore, Md. : 1950) 1995, 155: 5705-10. PMID: 7499857.
  • Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma.Li Y, McGowan P, Hellström I, Hellström KE, Chen L. Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma. Journal Of Immunology (Baltimore, Md. : 1950) 1994, 153: 421-8. PMID: 7515929.
  • Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.Chen L, McGowan P, Ashe S, Johnston J, Li Y, Hellström I, Hellström KE. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity. The Journal Of Experimental Medicine 1994, 179: 523-32. PMID: 7507508, PMCID: PMC2191382, DOI: 10.1084/jem.179.2.523.
  • Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo.Zhang L, Hellström KE, Chen L. Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo. Clinical & Experimental Metastasis 1994, 12: 87-92. PMID: 8306531, DOI: 10.1007/BF01753974.
  • B7-1/CD80-transduced tumor cells elicit better systemic immunity than wild-type tumor cells admixed with Corynebacterium parvum.Chen L, McGowan P, Ashe S, Johnston JV, Hellström I, Hellström KE. B7-1/CD80-transduced tumor cells elicit better systemic immunity than wild-type tumor cells admixed with Corynebacterium parvum. Cancer Research 1994, 54: 5420-3. PMID: 7522958.
  • Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes.Chen L, Ashe S, Singhal MC, Galloway DA, Hellström I, Hellström KE. Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 6523-7. PMID: 8341664, PMCID: PMC46964, DOI: 10.1073/pnas.90.14.6523.
  • Costimulation of T cells for tumor immunity.Chen L, Linsley PS, Hellström KE. Costimulation of T cells for tumor immunity. Immunology Today 1993, 14: 483-6. PMID: 7506034, DOI: 10.1016/0167-5699(93)90262-J.
  • Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.Chen L, Ashe S, Brady WA, Hellström I, Hellström KE, Ledbetter JA, McGowan P, Linsley PS. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 1992, 71: 1093-102. PMID: 1335364.
  • Induction of cytotoxic T lymphocytes specific for a syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16.Chen L, Mizuno MT, Singhal MC, Hu SL, Galloway DA, Hellström I, Hellström KE. Induction of cytotoxic T lymphocytes specific for a syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16. Journal Of Immunology (Baltimore, Md. : 1950) 1992, 148: 2617-21. PMID: 1313847.
  • Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.Chen LP, Thomas EK, Hu SL, Hellström I, Hellström KE. Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 110-4. PMID: 1846033, PMCID: PMC50759, DOI: 10.1073/pnas.88.1.110.
  • An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion.Zhen G, Dan Y, Wang R, Dou C, Guo Q, Zarr M, Liu LN, Chen L, Deng R, Li Y, Shao Z, Cao X. An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion. Bone Research 2021, 9: 47. PMID: 34719673, PMCID: PMC8558327, DOI: 10.1038/s41413-021-00161-1.
  • Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy.Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, Cho C, Luo L, Huang G, Chen L. Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. JCI Insight 2022, 7 PMID: 34905507, PMCID: PMC8855794, DOI: 10.1172/jci.insight.148247.
  • Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies.Glez-Vaz J, Azpilikueta A, Olivera I, Cirella A, Teijeira A, Ochoa MC, Alvarez M, Eguren-Santamaria I, Luri-Rey C, Rodriguez-Ruiz ME, Nie X, Chen L, Guedan S, Sanamed MF, Luis Perez Gracia J, Melero I. Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies. Journal For Immunotherapy Of Cancer 2022, 10 PMID: 35236742, PMCID: PMC8896037, DOI: 10.1136/jitc-2021-003532.
  • Resistance Mechanisms to Anti-PD Cancer Immunotherapy.Vesely MD, Zhang T, Chen L. Resistance Mechanisms to Anti-PD Cancer Immunotherapy. Annual Review Of Immunology 2022, 40: 45-74. PMID: 35471840, DOI: 10.1146/annurev-immunol-070621-030155.
  • Could Programmed Death-Ligand 1 Copy Number Alterations be a Predictive Biomarker for Immunotherapy Response?Woodard GA, Cho C, Chen L. Could Programmed Death-Ligand 1 Copy Number Alterations be a Predictive Biomarker for Immunotherapy Response? Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer 2022, 17: 592-595. PMID: 35465963, DOI: 10.1016/j.jtho.2022.03.009.
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