Lieping Chen, MD, PhD
United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology); Co-Leader, Cancer Immunology, Yale Cancer Center
Research & Publications
Biography
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Research Summary
T lymphocyte biology and functional modification
Specialized Terms: Lymphocyte activation and tolerance; costimulation and coinhibition; tumor microenvironment; cancer immunotherapy
Extensive Research Description
My laboratory is interested in:
- Molecular regulation of T cell quiescence, activation, tolerance and memory
- Mechanisms of tumor escape from immune attack in the tumor microenvironment
- Developing novel treatments for human diseases based on our laboratory discoveries
Coauthors
Research Interests
Immunotherapy; Inflammation; Medical Oncology; Neoplasms; Autoimmunity
Public Health Interests
Cancer; Immunology
Selected Publications
- Molecular mechanisms of T cell co-stimulation and co-inhibition.Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews. Immunology 2013, 13:227-42.
- Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.Chen L, Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. The Journal Of Clinical Investigation 2015, 125:3384-91.
- A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.Sanmamed MF, Chen L. A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Cell 2018, 175:313-326.