Liang Liang
Research & Publications
Biography
Research Summary
Our laboratory seeks to illuminate functional organization and information processing in the visual thalamic circuits, and to understand how distinct streams of inputs are integrated and transformed to impact visual behavior. We are also interested to identify and understand biophysical and circuit motifs that are utilized for neural computation. Our study will provide insight into how subcortical visual areas selectively transmit and regulate visual information and contribute to visual perception.
We use interdisciplinary approaches, including in vivo and in vitro optical imaging methods, in vivo and in vitro electrophysiology, along with genetic-based, circuit-specific tracing/manipulation methods to examine neural computation in visual circuit.
Research Interests
Behavior; Neurobiology; Neuronal Plasticity; Neurophysiology; Neurosciences; Visual Pathways; Visual Perception; Computational Biology; Optogenetics
Selected Publications
- Organization, Function, and Development of the Mouse Retinogeniculate Synapse.Liang L, Chen C. Organization, Function, and Development of the Mouse Retinogeniculate Synapse. Annual Review Of Vision Science 2020, 6:261-285.
- Retinal Inputs to the Thalamus Are Selectively Gated by Arousal.Liang L, Fratzl A, Reggiani JDS, El Mansour O, Chen C, Andermann ML. Retinal Inputs to the Thalamus Are Selectively Gated by Arousal. Current Biology : CB 2020, 30:3923-3934.e9.
- A Fine-Scale Functional Logic to Convergence from Retina to Thalamus.Liang L, Fratzl A, Goldey G, Ramesh RN, Sugden AU, Morgan JL, Chen C, Andermann ML. A Fine-Scale Functional Logic to Convergence from Retina to Thalamus. Cell 2018, 173:1343-1355.e24.
- In Vivo Imaging of CNS Injury and Disease.Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B. In Vivo Imaging of CNS Injury and Disease. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2017, 37:10808-10816.
- Linking cell fate, trajectory choice, and target selection: genetic analysis of Sema-2b in olfactory axon targeting.Joo WJ, Sweeney LB, Liang L, Luo L. Linking cell fate, trajectory choice, and target selection: genetic analysis of Sema-2b in olfactory axon targeting. Neuron 2013, 78:673-86.
- GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons.Liang L, Li Y, Potter CJ, Yizhar O, Deisseroth K, Tsien RW, Luo L. GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons. Neuron 2013, 79:917-31.
- High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity.Sinha S, Liang L, Ho ET, Urbanek KE, Luo L, Baer TM, Schnitzer MJ. High-speed laser microsurgery of alert fruit flies for fluorescence imaging of neural activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110:18374-9.
- The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis.Potter CJ, Tasic B, Russler EV, Liang L, Luo L. The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis. Cell 2010, 141:536-48.
- The olfactory circuit of the fruit fly Drosophila melanogaster.Liang L, Luo L. The olfactory circuit of the fruit fly Drosophila melanogaster. Science China. Life Sciences 2010, 53:472-84.