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Leying Guan

Assistant Professor of Biostatistics (Biostatistics)

Contact Information

Leying Guan

Mailing Address

  • School of Public Health

    60 College St, rm 208

    NEW HAVEN, CT 06520

    United States

Extensive Research Description

High-dimensional Statistics; Statistical Inference; Outlier Detection; Machine Learning and Data Science; Statistical Genetics; Computational Neuroscience; Statistical Analysis of Immune Signatures in Human infection.

Research Interests

Genetics; Immune System Diseases; Neurosciences; Computational Biology; Statistics; Gene Regulatory Networks; Metabolic Networks and Pathways; Epigenomics; Machine Learning

Selected Publications

  • Exon expression QTL (eeQTL) analysis highlights distant genomic variations associated with splicing regulationLeying Guan, Qian Yang, Mengting Gu, Liang Chen, and Xuegong Zhang. "Exon expression QTL (eeQTL) analysis highlights distant genomic variations associated with splicing regulation." Quantitative Biology 2, no. 2 (2014): 71-79.
  • Approximate l0-penalized estimation of piecewise constant signals on graphsZhou Fan, and Leying Guan. "Approximate $\ell_ {0} $-penalized estimation of piecewise-constant signals on graphs." The Annals of Statistics 46, no. 6B (2018): 3217-3245.
  • SUPERVISED LEARNING VIA THE “HUBNET” PROCEDURELeying Guan, Zhou Fan, and Robert Tibshirani. "SUPERVISED LEARNING VIA THE “HUBNET” PROCEDURE." Statistica Sinica 28, no. 3 (2018): 1225-1243.
  • Detecting Strong Signals in Gene Perturbation Experiments: An Adaptive Approach With Power Guarantee and FDR ControlLeying Guan, Xi Chen, and Wing Hung Wong. "Detecting strong signals in gene perturbation experiments: An adaptive approach with power guarantee and FDR control." Journal of the American Statistical Association just-accepted (2019): 1-18.