Leying Guan
Assistant Professor of Biostatistics (Biostatistics)
Research & Publications
Biography
News
Extensive Research Description
High-dimensional Statistics; Statistical Inference; Outlier Detection; Machine Learning and Data Science; Statistical Genetics; Computational Neuroscience; Statistical Analysis of Immune Signatures in Human infection.
Research Interests
Genetics; Immune System Diseases; Neurosciences; Computational Biology; Statistics; Gene Regulatory Networks; Metabolic Networks and Pathways; Epigenomics; Machine Learning
Selected Publications
- Exon expression QTL (eeQTL) analysis highlights distant genomic variations associated with splicing regulationLeying Guan, Qian Yang, Mengting Gu, Liang Chen, and Xuegong Zhang. "Exon expression QTL (eeQTL) analysis highlights distant genomic variations associated with splicing regulation." Quantitative Biology 2, no. 2 (2014): 71-79.
- Big data modeling to predict platelet usage and minimize wastage in a tertiary care system.Guan L, Tian X, Gombar S, Zemek AJ, Krishnan G, Scott R, Narasimhan B, Tibshirani RJ, Pham TD. Big data modeling to predict platelet usage and minimize wastage in a tertiary care system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114:11368-11373.
- Scalable multi-sample single-cell data analysis by Partition-Assisted Clustering and Multiple Alignments of Networks.Li YH, Li D, Samusik N, Wang X, Guan L, Nolan GP, Wong WH. Scalable multi-sample single-cell data analysis by Partition-Assisted Clustering and Multiple Alignments of Networks. PLoS Computational Biology 2017, 13:e1005875.
- Approximate l0-penalized estimation of piecewise constant signals on graphsZhou Fan, and Leying Guan. "Approximate $\ell_ {0} $-penalized estimation of piecewise-constant signals on graphs." The Annals of Statistics 46, no. 6B (2018): 3217-3245.
- SUPERVISED LEARNING VIA THE “HUBNET” PROCEDURELeying Guan, Zhou Fan, and Robert Tibshirani. "SUPERVISED LEARNING VIA THE “HUBNET” PROCEDURE." Statistica Sinica 28, no. 3 (2018): 1225-1243.
- Detecting Strong Signals in Gene Perturbation Experiments: An Adaptive Approach With Power Guarantee and FDR ControlLeying Guan, Xi Chen, and Wing Hung Wong. "Detecting strong signals in gene perturbation experiments: An adaptive approach with power guarantee and FDR control." Journal of the American Statistical Association just-accepted (2019): 1-18.