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Lesley Devine, PhD

Research Scientist; Scientific Director, Cancer Center Immune Monitoring Laboratory

Contact Information

Lesley Devine, PhD

Mailing Address

  • Laboratory Medicine

    PO Box 208035, 333 Cedar Street

    New Haven, CT, 06520-8035

    United States

Research Summary

The main goal of the lab is in monitoring the cellular immune response to determine the effects on the immune system of treatments with novel immune therapies.Current trials that the core is involved with include anti-CD3 treatment for diabetes and angiogenesis inhibitors and immunomodulatory reagents such as anti-CTLA-4, anti-PD-1 and IL-2 in the treatment of melanoma. 6-color flow cytometry is used for phenotypic analysis of the different immune cell populations, including the use of MHC class I tetramers to measure the antigen-specific response.Functional assays include the use of Luminex, a bead-based technology for multiplex cytokine analysis and flow-based cytotoxicity assays.

Specialized Terms: Effects of novel immune therapies on the immune system

Coauthors

Research Interests

Diabetes Mellitus; Immune System; Melanoma; Medical Laboratory Science; Angiogenesis Inhibitors

Selected Publications