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Leonard Kaczmarek, PhD

Professor of Pharmacology and of Cellular And Molecular Physiology

Contact Information

Leonard Kaczmarek, PhD

Mailing Address

  • PO Box 208066

    333 Cedar Street

    New Haven, CT 06520-8066

    United States

Kaczmarek Lab

Research Summary

Research in our laboratory is aimed at understanding the nature of the biochemical changes that occur in neurons and that result in prolonged changes in the behavior of an animal or in its ability to detect specific patterns of sensory inputs. It is known that alterations of the intrinsic electrical excitability of specific neurons are the key feature of such events, and that these are caused by the short-term and long-term regulation of proteins termed ion channels. Our laboratory has isolated the genes for multiple ion channels, and is studying both how these channels function to in the normal nervous system, and how human mutations in these channels give rise to several neurological conditions that produce severe intellectual disability.

Specialized Terms: Neuroscience; Learning and memory; Ion channels

Extensive Research Description

Our laboratory has investigates the role of potassium channels, as well as other classes of ion channels, in the short-term and long-term regulation of neuronal excitability. Our group was the first to demonstrate directly, using purified enzymes, that excitability of neurons is regulated by cyclic AMP-dependent protein kinase, protein kinase C and tyrosine phosphatases. As part of this work we isolated the genes for over fourteen novel ion channels and were the first to identify the “two-pore” family of potassium channels. Among the channels that our group cloned and characterized are Kv3.1b channel, which is required for high-frequency firing in many neurons and the Slack and Slick genes that underlie Na+-activated K+ channels. Our work was the first to show directly that rapid changes in the phosphorylation state of ion channels and in the synthesis of new channels occur in vivo in response to changes in an animal’s environment. Most recently, we have found that the Slack protein interacts with the Fragile X Mental Retardation Protein FMRP and that human mutations in Slack produce very severe epilepsy and developmental delay. This is now a major focus of our laboratory.

Coauthors

Research Interests

Ion Channels; Learning; Memory; Neurosciences; Pharmacology; Physiology

Selected Publications

  • De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy.Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nature Genetics 2012, 44: 1255-9. PMID: 23086397, PMCID: PMC3687547, DOI: 10.1038/ng.2441.
  • Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK. Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nature Neuroscience 2010, 13: 819-21. PMID: 20512134, PMCID: PMC2893252, DOI: 10.1038/nn.2563.
  • Non-conducting functions of voltage-gated ion channels.Kaczmarek LK. Non-conducting functions of voltage-gated ion channels. Nature Reviews. Neuroscience 2006, 7: 761-71. PMID: 16988652, DOI: 10.1038/nrn1988.
  • Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons.Song P, Yang Y, Barnes-Davies M, Bhattacharjee A, Hamann M, Forsythe ID, Oliver DL, Kaczmarek LK. Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons. Nature Neuroscience 2005, 8: 1335-42. PMID: 16136041, DOI: 10.1038/nn1533.
  • Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors.Fleming MR, Kaczmarek LK. Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors. Journal Of Receptor And Signal Transduction Research 2009, 29: 173-81. PMID: 19640220, PMCID: PMC3727623, DOI: 10.1080/10799890903056883.
  • The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2009, 29: 5654-65. PMID: 19403831, PMCID: PMC3688047, DOI: 10.1523/JNEUROSCI.5978-08.2009.
  • Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission.Nanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, El Manira A. Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 20941-6. PMID: 19095801, PMCID: PMC2634910, DOI: 10.1073/pnas.0806403106.
  • Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C.DeRiemer SA, Strong JA, Albert KA, Greengard P, Kaczmarek LK. Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature 1985, 313: 313-6. PMID: 2578617.
  • Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents.Jonas EA, Knox RJ, Kaczmarek LK, Schwartz JH, Solomon DH. Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 1996, 16: 1645-58. PMID: 8774433.
  • Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica.Knox RJ, Jonas EA, Kao LS, Smith PJ, Connor JA, Kaczmarek LK. Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica. The Journal Of Physiology 1996, 494 ( Pt 3): 627-39. PMID: 8865062, PMCID: PMC1160665.
  • Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion.Jonas EA, Knox RJ, Smith TC, Wayne NL, Connor JA, Kaczmarek LK. Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion. Nature 1997, 385: 343-6. PMID: 9002519, DOI: 10.1038/385343a0.
  • Giga-ohm seals on intracellular membranes: a technique for studying intracellular ion channels in intact cells.Jonas EA, Knox RJ, Kaczmarek LK. Giga-ohm seals on intracellular membranes: a technique for studying intracellular ion channels in intact cells. Neuron 1997, 19: 7-13. PMID: 9247259.
  • Prolonged activation of mitochondrial conductances during synaptic transmission.Jonas EA, Buchanan J, Kaczmarek LK. Prolonged activation of mitochondrial conductances during synaptic transmission. Science (New York, N.Y.) 1999, 286: 1347-50. PMID: 10558987.
  • Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory neurons and transfected cells.Macica CM, Kaczmarek LK. Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory neurons and transfected cells. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2001, 21: 1160-8. PMID: 11160386.
  • Endogenous parathyroid hormone-related protein functions as a neuroprotective agent.Chatterjee O, Nakchbandi IA, Philbrick WM, Dreyer BE, Zhang JP, Kaczmarek LK, Brines ML, Broadus AE. Endogenous parathyroid hormone-related protein functions as a neuroprotective agent. Brain Research 2002, 930: 58-66. PMID: 11879796, DOI: 10.1016/s0006-8993(01)03407-2.
  • Localization of the Slack potassium channel in the rat central nervous system.Bhattacharjee A, Gan L, Kaczmarek LK. Localization of the Slack potassium channel in the rat central nervous system. The Journal Of Comparative Neurology 2002, 454: 241-54. PMID: 12442315, DOI: 10.1002/cne.10439.
  • Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons.Zhang Y, Magoski NS, Kaczmarek LK. Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2002, 22: 10134-41. PMID: 12451114, PMCID: PMC6758731.
  • Act locally: new ways of regulating voltage-gated ion channels.McKay SE, Kaczmarek LK. Act locally: new ways of regulating voltage-gated ion channels. Molecular Interventions 2002, 2: 215-8. PMID: 14993392, DOI: 10.1124/mi.2.4.215.
  • Protein kinase modulation of a neuronal cation channel requires protein-protein interactions mediated by an Src homology 3 domain.Magoski NS, Wilson GF, Kaczmarek LK. Protein kinase modulation of a neuronal cation channel requires protein-protein interactions mediated by an Src homology 3 domain. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2002, 22: 1-9. PMID: 11756482, PMCID: PMC6757624.
  • HSV-1 helper virus 5dl1.2 suppresses sodium currents in amplicon-transduced neurons.White BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 helper virus 5dl1.2 suppresses sodium currents in amplicon-transduced neurons. Journal Of Neurophysiology 2002, 87: 2149-57. PMID: 11929932, DOI: 10.1152/jn.00498.2001.
  • The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight.Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics 2003, 12: 551-9. PMID: 12588802, DOI: 10.1093/hmg/ddg049.
  • Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons.Macica CM, von Hehn CA, Wang LY, Ho CS, Yokoyama S, Joho RH, Kaczmarek LK. Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 1133-41. PMID: 12598601, PMCID: PMC6742259.
  • Modulation of synaptic transmission by the BCL-2 family protein BCL-xL.Jonas EA, Hoit D, Hickman JA, Brandt TA, Polster BM, Fannjiang Y, McCarthy E, Montanez MK, Hardwick JM, Kaczmarek LK. Modulation of synaptic transmission by the BCL-2 family protein BCL-xL. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 8423-31. PMID: 12968005, PMCID: PMC6740692.
  • The sodium-activated potassium channel is encoded by a member of the Slo gene family.Yuan A, Santi CM, Wei A, Wang ZW, Pollak K, Nonet M, Kaczmarek L, Crowder CM, Salkoff L. The sodium-activated potassium channel is encoded by a member of the Slo gene family. Neuron 2003, 37: 765-73. PMID: 12628167, DOI: 10.1016/s0896-6273(03)00096-5.
  • BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development.Fannjiang Y, Kim CH, Huganir RL, Zou S, Lindsten T, Thompson CB, Mito T, Traystman RJ, Larsen T, Griffin DE, Mandir AS, Dawson TM, Dike S, Sappington AL, Kerr DA, Jonas EA, Kaczmarek LK, Hardwick JM. BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development. Developmental Cell 2003, 4: 575-85. PMID: 12689595, DOI: 10.1016/s1534-5807(03)00091-1.
  • How to make a relationship last: release sites with different levels of commitment.Kaczmarek LK. How to make a relationship last: release sites with different levels of commitment. Neuron 2003, 40: 7-9. PMID: 14527428, DOI: 10.1016/s0896-6273(03)00599-3.
  • Modulation of mitochondrial function by endogenous Zn2+ pools.Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH. Modulation of mitochondrial function by endogenous Zn2+ pools. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 6157-62. PMID: 12724524, PMCID: PMC156342, DOI: 10.1073/pnas.1031598100.
  • Functional specialization of male and female vocal motoneurons.Yamaguchi A, Kaczmarek LK, Kelley DB. Functional specialization of male and female vocal motoneurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 11568-76. PMID: 14684859, PMCID: PMC6740944.
  • Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2003, 23: 11681-91. PMID: 14684870, PMCID: PMC6740956.
  • Compensatory anion currents in Kv1.3 channel-deficient thymocytes.Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavella RA. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. The Journal Of Biological Chemistry 2003, 278: 39443-51. PMID: 12878608, DOI: 10.1074/jbc.M304879200.
  • Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals.Jonas EA, Hickman JA, Chachar M, Polster BM, Brandt TA, Fannjiang Y, Ivanovska I, Basañez G, Kinnally KW, Zimmerberg J, Hardwick JM, Kaczmarek LK. Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13590-5. PMID: 15342906, PMCID: PMC518799, DOI: 10.1073/pnas.0401372101.
  • The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 3112-7. PMID: 14981264, PMCID: PMC365752, DOI: 10.1073/pnas.0308450100.
  • Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia.Knox RJ, Magoski NS, Wing D, Barbee SJ, Kaczmarek LK. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Journal Of Neurobiology 2004, 60: 411-23. PMID: 15307146, DOI: 10.1002/neu.20029.
  • The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior.Zhang Y, Joiner WJ, Bhattacharjee A, Rassendren F, Magoski NS, Kaczmarek LK. The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior. The Journal Of Biological Chemistry 2004, 279: 52324-30. PMID: 15375169, DOI: 10.1074/jbc.M408543200.
  • Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice.von Hehn CA, Bhattacharjee A, Kaczmarek LK. Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2004, 24: 1936-40. PMID: 14985434, PMCID: PMC6730406, DOI: 10.1523/JNEUROSCI.4554-03.2004.
  • Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse.Jonas EA, Hickman JA, Hardwick JM, Kaczmarek LK. Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse. The Journal Of Biological Chemistry 2005, 280: 4491-7. PMID: 15561723, DOI: 10.1074/jbc.M410661200.
  • Actions of BAX on mitochondrial channel activity and on synaptic transmission.Jonas EA, Hardwick JM, Kaczmarek LK. Actions of BAX on mitochondrial channel activity and on synaptic transmission. Antioxidants & Redox Signaling 2005, 7: 1092-100. PMID: 16115013, DOI: 10.1089/ars.2005.7.1092.
  • Retraction.Flavell RA, Kaczmarek LK, Badou A, Boulpaep EL, Desai R, Basavappa S, Matza D, Peng YQ, Mehal WZ. Retraction. Science (New York, N.Y.) 2005, 310: 1903. PMID: 16373558, DOI: 10.1126/science.310.5756.1903b.
  • Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science (New York, N.Y.) 2005, 307: 117-21. PMID: 15637280, DOI: 10.1126/science.1100582.
  • Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Research 2005, 206: 133-45. PMID: 16081004, DOI: 10.1016/j.heares.2004.11.023.
  • Association/dissociation of a channel-kinase complex underlies state-dependent modulation.Magoski NS, Kaczmarek LK. Association/dissociation of a channel-kinase complex underlies state-dependent modulation. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2005, 25: 8037-47. PMID: 16135761, PMCID: PMC2873328, DOI: 10.1523/JNEUROSCI.1903-05.2005.
  • Localization of the Na+-activated K+ channel Slick in the rat central nervous system.Bhattacharjee A, von Hehn CA, Mei X, Kaczmarek LK. Localization of the Na+-activated K+ channel Slick in the rat central nervous system. The Journal Of Comparative Neurology 2005, 484: 80-92. PMID: 15717307, DOI: 10.1002/cne.20462.
  • For K+ channels, Na+ is the new Ca2+.Bhattacharjee A, Kaczmarek LK. For K+ channels, Na+ is the new Ca2+. Trends In Neurosciences 2005, 28: 422-8. PMID: 15979166, DOI: 10.1016/j.tins.2005.06.003.
  • Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies.Liu SQ, Kaczmarek LK. Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies. Journal Of Neurobiology 2005, 62: 439-52. PMID: 15547932, DOI: 10.1002/neu.20112.
  • Mitochondrial factors with dual roles in death and survival.Cheng WC, Berman SB, Ivanovska I, Jonas EA, Lee SJ, Chen Y, Kaczmarek LK, Pineda F, Hardwick JM. Mitochondrial factors with dual roles in death and survival. Oncogene 2006, 25: 4697-705. PMID: 16892083, DOI: 10.1038/sj.onc.1209596.
  • Opposite regulation of Slick and Slack K+ channels by neuromodulators.Santi CM, Ferreira G, Yang B, Gazula VR, Butler A, Wei A, Kaczmarek LK, Salkoff L. Opposite regulation of Slick and Slack K+ channels by neuromodulators. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2006, 26: 5059-68. PMID: 16687497, PMCID: PMC6674240, DOI: 10.1523/JNEUROSCI.3372-05.2006.
  • Pharmacological activation and inhibition of Slack (Slo2.2) channels.Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK. Pharmacological activation and inhibition of Slack (Slo2.2) channels. Neuropharmacology 2006, 51: 896-906. PMID: 16876206, DOI: 10.1016/j.neuropharm.2006.06.003.
  • A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia.Kachoei BA, Knox RJ, Uthuza D, Levy S, Kaczmarek LK, Magoski NS. A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia. Journal Of Neurophysiology 2006, 96: 2688-98. PMID: 16885525, PMCID: PMC2894935, DOI: 10.1152/jn.00118.2006.
  • Policing the ball: a new potassium channel subunit determines inactivation rate.Kaczmarek LK. Policing the ball: a new potassium channel subunit determines inactivation rate. Neuron 2006, 49: 642-4. PMID: 16504937, DOI: 10.1016/j.neuron.2006.02.011.
  • Modulation of Kv3.1b potassium channel phosphorylation in auditory neurons by conventional and novel protein kinase C isozymes.Song P, Kaczmarek LK. Modulation of Kv3.1b potassium channel phosphorylation in auditory neurons by conventional and novel protein kinase C isozymes. The Journal Of Biological Chemistry 2006, 281: 15582-91. PMID: 16595659, DOI: 10.1074/jbc.M512866200.
  • Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia.Chen H, von Hehn C, Kaczmarek LK, Ment LR, Pober BR, Hisama FM. Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia. Neurogenetics 2007, 8: 131-5. PMID: 17136396, PMCID: PMC1820748, DOI: 10.1007/s10048-006-0071-z.
  • Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons.Wallén P, Robertson B, Cangiano L, Löw P, Bhattacharjee A, Kaczmarek LK, Grillner S. Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons. The Journal Of Physiology 2007, 585: 75-90. PMID: 17884929, PMCID: PMC2375474, DOI: 10.1113/jphysiol.2007.138156.
  • Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.Yang B, Desai R, Kaczmarek LK. Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2007, 27: 2617-27. PMID: 17344399, PMCID: PMC6672517, DOI: 10.1523/JNEUROSCI.5308-06.2007.
  • Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.Hickman JA, Hardwick JM, Kaczmarek LK, Jonas EA. Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. Journal Of Neurophysiology 2008, 99: 1515-22. PMID: 18160428, PMCID: PMC2836590, DOI: 10.1152/jn.00598.2007.
  • Repetitive firing triggers clustering of Kv2.1 potassium channels in Aplysia neurons.Zhang Y, McKay SE, Bewley B, Kaczmarek LK. Repetitive firing triggers clustering of Kv2.1 potassium channels in Aplysia neurons. The Journal Of Biological Chemistry 2008, 283: 10632-41. PMID: 18276591, DOI: 10.1074/jbc.M800253200.
  • Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons.Knox RJ, Keen KL, Luchansky L, Terasawa E, Freyer H, Barbee SJ, Kaczmarek LK. Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons. Biochemical And Biophysical Research Communications 2008, 366: 48-53. PMID: 18053804, DOI: 10.1016/j.bbrc.2007.11.083.
  • PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.Zhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA. PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2008, 28: 2601-12. PMID: 18322103, PMCID: PMC2830008, DOI: 10.1523/JNEUROSCI.4314-07.
  • Protein kinase C modulates inactivation of Kv3.3 channels.Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LK. Protein kinase C modulates inactivation of Kv3.3 channels. The Journal Of Biological Chemistry 2008, 283: 22283-94. PMID: 18539595, PMCID: PMC2494927, DOI: 10.1074/jbc.M801663200.
  • Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.Brown MR, Kronengold J, Gazula VR, Spilianakis CG, Flavell RA, von Hehn CA, Bhattacharjee A, Kaczmarek LK. Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation. The Journal Of Physiology 2008, 586: 5161-79. PMID: 18787033, PMCID: PMC2652154, DOI: 10.1113/jphysiol.2008.160861.
  • A less flexible BK channel opens more easily.Kronengold J, Kaczmarek LK. A less flexible BK channel opens more easily. Neuron 2010, 66: 817-8. PMID: 20620867, PMCID: PMC3703916, DOI: 10.1016/j.neuron.2010.06.013.
  • Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.Gazula VR, Strumbos JG, Mei X, Chen H, Rahner C, Kaczmarek LK. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. The Journal Of Comparative Neurology 2010, 518: 3205-20. PMID: 20575068, PMCID: PMC2894291, DOI: 10.1002/cne.22393.
  • Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.Strumbos JG, Brown MR, Kronengold J, Polley DB, Kaczmarek LK. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2010, 30: 10263-71. PMID: 20685971, PMCID: PMC3485078, DOI: 10.1523/JNEUROSCI.1125-10.2010.
  • Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut-Smith MP. Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count. The Journal Of Physiology 2010, 588: 1399-406. PMID: 20308249, PMCID: PMC2876798, DOI: 10.1113/jphysiol.2010.188136.
  • The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice.Lu S, Das P, Fadool DA, Kaczmarek LK. The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice. Journal Of Neurophysiology 2010, 103: 3311-9. PMID: 20393063, PMCID: PMC2888249, DOI: 10.1152/jn.00607.2009.
  • Controlling auditory excitability: the benefits of a cultured environment.Kaczmarek LK. Controlling auditory excitability: the benefits of a cultured environment. The Journal Of Physiology 2010, 588: 1387-8. PMID: 20436041, PMCID: PMC2876793, DOI: 10.1113/jphysiol.2010.189712.
  • Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. The Journal Of Cell Biology 2011, 195: 263-76. PMID: 21987637, PMCID: PMC3198165, DOI: 10.1083/jcb.201108059.
  • Potassium channel modulation and auditory processing.Brown MR, Kaczmarek LK. Potassium channel modulation and auditory processing. Hearing Research 2011, 279: 32-42. PMID: 21414395, PMCID: PMC3137660, DOI: 10.1016/j.heares.2011.03.004.
  • Gradients and modulation of K(+) channels optimize temporal accuracy in networks of auditory neurons.Kaczmarek LK. Gradients and modulation of K(+) channels optimize temporal accuracy in networks of auditory neurons. PLoS Computational Biology 2012, 8: e1002424. PMID: 22438799, PMCID: PMC3305353, DOI: 10.1371/journal.pcbi.1002424.
  • Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.Zhang Y, Brown MR, Hyland C, Chen Y, Kronengold J, Fleming MR, Kohn AB, Moroz LL, Kaczmarek LK. Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2012, 32: 15318-27. PMID: 23115170, PMCID: PMC3518385, DOI: 10.1523/JNEUROSCI.2162-12.2012.
  • The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments.Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M. The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments. Frontiers In Cellular Neuroscience 2013, 7: 246. PMID: 24368895, PMCID: PMC3856854, DOI: 10.3389/fncel.2013.00246.
  • Slack, Slick and Sodium-Activated Potassium Channels.Kaczmarek LK. Slack, Slick and Sodium-Activated Potassium Channels. ISRN Neuroscience 2013, 2013 PMID: 24319675, PMCID: PMC3850776, DOI: 10.1155/2013/354262.
  • An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels.Cotella D, Hernandez-Enriquez B, Duan Z, Wu X, Gazula VR, Brown MR, Kaczmarek LK, Sesti F. An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2013, 27: 1381-93. PMID: 23233530, PMCID: PMC3606535, DOI: 10.1096/fj.12-222778.
  • Expression of Kv1.3 potassium channels regulates density of cortical interneurons.Duque A, Gazula VR, Kaczmarek LK. Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Developmental Neurobiology 2013, 73: 841-55. PMID: 23821603, PMCID: PMC3829632, DOI: 10.1002/dneu.22105.
  • A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude.Markham MR, Kaczmarek LK, Zakon HH. A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude. Journal Of Neurophysiology 2013, 109: 1713-23. PMID: 23324315, PMCID: PMC3628015, DOI: 10.1152/jn.00875.2012.
  • More than a pore: ion channel signaling complexes.Lee A, Fakler B, Kaczmarek LK, Isom LL. More than a pore: ion channel signaling complexes. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2014, 34: 15159-69. PMID: 25392484, PMCID: PMC4228125, DOI: 10.1523/JNEUROSCI.3275-14.2014.
  • Human slack potassium channel mutations increase positive cooperativity between individual channels.Kim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK. Human slack potassium channel mutations increase positive cooperativity between individual channels. Cell Reports 2014, 9: 1661-1672. PMID: 25482562, PMCID: PMC4294418, DOI: 10.1016/j.celrep.2014.11.015.
  • Emerging role of the KCNT1 Slack channel in intellectual disability.Kim GE, Kaczmarek LK. Emerging role of the KCNT1 Slack channel in intellectual disability. Frontiers In Cellular Neuroscience 2014, 8: 209. PMID: 25120433, PMCID: PMC4112808, DOI: 10.3389/fncel.2014.00209.
  • Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. Biological Psychiatry 2014, 76: 476-85. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.
  • Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors.Fleming MR, Shamah SM, Kaczmarek LK. Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors. Journal Of Visualized Experiments : JoVE 2014, e51307. PMID: 24562095, PMCID: PMC4122194, DOI: 10.3791/51307.
  • Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis.Martin HC, Kim GE, Pagnamenta AT, Murakami Y, Carvill GL, Meyer E, Copley RR, Rimmer A, Barcia G, Fleming MR, Kronengold J, Brown MR, Hudspith KA, Broxholme J, Kanapin A, Cazier JB, Kinoshita T, Nabbout R, Bentley D, McVean G, Heavin S, Zaiwalla Z, McShane T, Mefford HC, Shears D, Stewart H, Kurian MA, Scheffer IE, Blair E, Donnelly P, Kaczmarek LK, Taylor JC. Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Human Molecular Genetics 2014, 23: 3200-11. PMID: 24463883, PMCID: PMC4030775, DOI: 10.1093/hmg/ddu030.
  • The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice.Bausch AE, Dieter R, Nann Y, Hausmann M, Meyerdierks N, Kaczmarek LK, Ruth P, Lukowski R. The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice. Learning & Memory (Cold Spring Harbor, N.Y.) 2015, 22: 323-35. PMID: 26077685, PMCID: PMC4478330, DOI: 10.1101/lm.037820.114.
  • Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK. Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell 2016, 165: 434-448. PMID: 26997484, PMCID: PMC4826296, DOI: 10.1016/j.cell.2016.02.009.
  • Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.Brown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK. Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons. Journal Of Neurophysiology 2016, 116: 106-21. PMID: 27052580, PMCID: PMC4961756, DOI: 10.1152/jn.00174.2016.
  • Kv3.3 potassium channels and spinocerebellar ataxia.Zhang Y, Kaczmarek LK. Kv3.3 potassium channels and spinocerebellar ataxia. The Journal Of Physiology 2016, 594: 4677-84. PMID: 26442672, PMCID: PMC4983625, DOI: 10.1113/JP271343.
  • T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels.Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA. T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. PloS One 2016, 11: e0147379. PMID: 26815481, PMCID: PMC4729531, DOI: 10.1371/journal.pone.0147379.
  • Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK. Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell Reports 2016, 16: 2281-8. PMID: 27545877, PMCID: PMC5123741, DOI: 10.1016/j.celrep.2016.07.024.
  • Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 2016, 16: 2576-2592. PMID: 27568284, PMCID: PMC5135012, DOI: 10.1016/j.celrep.2016.08.038.
  • Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage.Chambers AR, Pilati N, Balaram P, Large CH, Kaczmarek LK, Polley DB. Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage. Scientific Reports 2017, 7: 17496. PMID: 29235497, PMCID: PMC5727503, DOI: 10.1038/s41598-017-17406-x.
  • International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacological Reviews 2017, 69: 1-11. PMID: 28267675, DOI: 10.1124/pr.116.012864.
  • A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF. A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. PloS One 2017, 12: e0173565. PMID: 28467418, PMCID: PMC5414954, DOI: 10.1371/journal.pone.0173565.
  • The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.Gribkoff VK, Kaczmarek LK. The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes. Neuropharmacology 2017, 120: 11-19. PMID: 26979921, PMCID: PMC5820030, DOI: 10.1016/j.neuropharm.2016.03.021.
  • Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.Kaczmarek LK, Zhang Y. Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance. Physiological Reviews 2017, 97: 1431-1468. PMID: 28904001, PMCID: PMC6151494, DOI: 10.1152/physrev.00002.2017.
  • An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons.Zhang Y, Ni W, Horwich AL, Kaczmarek LK. An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2017, 37: 2258-2265. PMID: 28119399, PMCID: PMC5338764, DOI: 10.1523/JNEUROSCI.3102-16.2017.
  • C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity.Khare S, Galeano K, Zhang Y, Nick JA, Nick HS, Subramony SH, Sampson J, Kaczmarek LK, Waters MF. C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity. Cerebellum (London, England) 2018, 17: 692-697. PMID: 29949095, PMCID: PMC8299775, DOI: 10.1007/s12311-018-0950-5.
  • Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2019, 39: 4797-4813. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/JNEUROSCI.0839-18.2019.
  • An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents.Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2019, 39: 7438-7449. PMID: 31350261, PMCID: PMC6759030, DOI: 10.1523/JNEUROSCI.1628-18.2019.
  • Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability.Kaczmarek LK. Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability. Neuron 2019, 103: 551-553. PMID: 31437449, DOI: 10.1016/j.neuron.2019.07.032.
  • Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons.Forscher P, Kaczmarek LK, Buchanan JA, Smith SJ. Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 1987, 7: 3600-11. PMID: 2824715, PMCID: PMC6569040.
  • Cyclic AMP modulates fast axonal transport in Aplysia bag cell neurons by increasing the probability of single organelle movement.Azhderian EM, Hefner D, Lin CH, Kaczmarek LK, Forscher P. Cyclic AMP modulates fast axonal transport in Aplysia bag cell neurons by increasing the probability of single organelle movement. Neuron 1994, 12: 1223-33. PMID: 7516686, DOI: 10.1016/0896-6273(94)90439-1.
  • Role of KCNQ potassium channels in stress-induced deficit of working memory.Arnsten AFT, Jin LE, Gamo NJ, Ramos B, Paspalas CD, Morozov YM, Kata A, Bamford NS, Yeckel MF, Kaczmarek LK, El-Hassar L. Role of KCNQ potassium channels in stress-induced deficit of working memory. Neurobiology Of Stress 2019, 11: 100187. PMID: 31832507, PMCID: PMC6889760, DOI: 10.1016/j.ynstr.2019.100187.
  • Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1).Ali SR, Malone TJ, Zhang Y, Prechova M, Kaczmarek LK. Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1). FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2020, 34: 1591-1601. PMID: 31914597, PMCID: PMC6956700, DOI: 10.1096/fj.201902366R.
  • Mechanisms underlying auditory processing deficits in Fragile X syndrome.McCullagh EA, Rotschafer SE, Auerbach BD, Klug A, Kaczmarek LK, Cramer KS, Kulesza RJ, Razak KA, Lovelace JW, Lu Y, Koch U, Wang Y. Mechanisms underlying auditory processing deficits in Fragile X syndrome. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2020, 34: 3501-3518. PMID: 32039504, PMCID: PMC7347277, DOI: 10.1096/fj.201902435R.
  • Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels.Quraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK. Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels. Scientific Reports 2020, 10: 3213. PMID: 32081855, PMCID: PMC7035262, DOI: 10.1038/s41598-020-60028-z.
  • Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics.Fadool DA, Tucker K, Perkins R, Fasciani G, Thompson RN, Parsons AD, Overton JM, Koni PA, Flavell RA, Kaczmarek LK. Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics. Neuron 2004, 41: 389-404. PMID: 14766178, PMCID: PMC2737549, DOI: 10.1016/s0896-6273(03)00844-4.
  • Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides.Roy ML, Saal D, Perney T, Sontheimer H, Waxman SG, Kaczmarek LK. Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides. Glia 1996, 18: 177-84. PMID: 8915650, DOI: 10.1002/(SICI)1098-1136(199611)18:3<177::AID-GLIA2>3.0.CO;2-X.
  • Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Neuron 2021, 109: 938-946.e5. PMID: 33508244, PMCID: PMC7979485, DOI: 10.1016/j.neuron.2021.01.006.
  • Modulation of Neuronal Potassium Channels During Auditory Processing.Wu J, Kaczmarek LK. Modulation of Neuronal Potassium Channels During Auditory Processing. Frontiers In Neuroscience 2021, 15: 596478. PMID: 33613177, PMCID: PMC7887315, DOI: 10.3389/fnins.2021.596478.
  • Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK. Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Nature Communications 2021, 12: 1731. PMID: 33741962, PMCID: PMC7979925, DOI: 10.1038/s41467-021-22003-8.
  • A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylation.Zhang Y, Ali SR, Nabbout R, Barcia G, Kaczmarek LK. A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylation. Journal Of Neurophysiology 2021, 126: 532-539. PMID: 34232791, PMCID: PMC8409950, DOI: 10.1152/jn.00257.2021.
  • The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen.Wright JR, Jones S, Parvathy S, Kaczmarek LK, Forsythe I, Farndale RW, Gibbins JM, Mahaut-Smith MP. The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen. Platelets 2022, 33: 451-461. PMID: 34348571, PMCID: PMC8935947, DOI: 10.1080/09537104.2021.1942818.
  • The NaVy paradox: reducing sodium currents increases excitability.Kaczmarek LK. The NaVy paradox: reducing sodium currents increases excitability. Trends In Neurosciences 2021, 44: 767-768. PMID: 34373125, PMCID: PMC8813127, DOI: 10.1016/j.tins.2021.07.008.
  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels.Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. British Journal Of Pharmacology 2021, 178 Suppl 1: S157-S245. PMID: 34529831, DOI: 10.1111/bph.15539.
  • Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.Zhang Y, Quraishi IH, McClure H, Williams LA, Cheng Y, Kale S, Dempsey GT, Agrawal S, Gerber DJ, McManus OB, Kaczmarek LK. Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2021, 35: e22053. PMID: 34820911, PMCID: PMC8630780, DOI: 10.1096/fj.202101356R.
  • The role of altered translation in intellectual disability and epilepsy.Malone TJ, Kaczmarek LK. The role of altered translation in intellectual disability and epilepsy. Progress In Neurobiology 2022, 213: 102267. PMID: 35364140, DOI: 10.1016/j.pneurobio.2022.102267.
  • Editorial: Alterations in the Sound Localization Pathway Related to Impaired Cocktail-Party Performance.McCullagh EA, Kaczmarek LK, Tollin DJ, Klug A. Editorial: Alterations in the Sound Localization Pathway Related to Impaired Cocktail-Party Performance. Frontiers In Neuroscience 2022, 16: 902197. PMID: 35546884, PMCID: PMC9082812, DOI: 10.3389/fnins.2022.902197.
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