Lei Song, MD, PhD
Research & Publications
Biography
News
Coauthors
Selected Publications
- Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place codingZhang Y, Lin G, Xue N, Wang Y, Du T, Liu H, Xiong W, Shang W, Wu H, Song L. Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding. The FASEB Journal 2023, 37: e23167. PMID: 37651093, DOI: 10.1096/fj.202300457rr.
- Prestin derived OHC surface area reduction underlies age‐related rescaling of frequency place codingZhang Y, Lin G, Wang Y, Xue N, Lin X, Du T, Xiong W, Song L. Prestin derived OHC surface area reduction underlies age‐related rescaling of frequency place coding. Hearing Research 2021, 423: 108406. PMID: 34933788, DOI: 10.1016/j.heares.2021.108406.
- Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoformLiu H, Liu H, Wang L, Song L, Jiang G, Lu Q, Yang T, Peng H, Cai R, Zhao X, Zhao T, Wu H. Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform. Nature Communications 2023, 14: 3085. PMID: 37248244, PMCID: PMC10227054, DOI: 10.1038/s41467-023-38621-3.
- Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing lossTan W, Song L. Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hearing Research 2023, 434: 108783. PMID: 37167889, DOI: 10.1016/j.heares.2023.108783.
- Outer hair cell function is normal in βV spectrin knockout miceStankewich MC, Bai JP, Stabach PR, Khan S, Tan WJT, Surguchev A, Song L, Morrow JS, Santos-Sacchi J, Navaratnam DS. Outer hair cell function is normal in βV spectrin knockout mice. Hearing Research 2022, 423: 108564. PMID: 35864018, DOI: 10.1016/j.heares.2022.108564.
- Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in MiceLi J, Liu S, Song C, Zhu T, Zhao Z, Sun W, Wang Y, Song L, Xiong W. Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice. Neuroscience Bulletin 2022, 38: 769-784. PMID: 35279808, PMCID: PMC9276951, DOI: 10.1007/s12264-022-00839-4.
- In vivo CRISPR‐Cas9‐mediated DNA chop identifies a cochlear outer hair cell‐specific enhancerSun Y, Zhang Y, Zhang D, Wang G, Song L, Liu Z. In vivo CRISPR‐Cas9‐mediated DNA chop identifies a cochlear outer hair cell‐specific enhancer. The FASEB Journal 2022, 36: e22233. PMID: 35225354, DOI: 10.1096/fj.202100421rr.
- Real-time threshold determination of auditory brainstem responses by cross-correlation analysisWang H, Li B, Lu Y, Han K, Sheng H, Zhou J, Qi Y, Wang X, Huang Z, Song L, Hua Y. Real-time threshold determination of auditory brainstem responses by cross-correlation analysis. IScience 2021, 24: 103285. PMID: 34765914, PMCID: PMC8571499, DOI: 10.1016/j.isci.2021.103285.
- Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochleaXue N, Song L, Song Q, Santos-Sacchi J, Wu H, Navaratnam D. Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea. Hearing Research 2021, 410: 108347. PMID: 34536825, DOI: 10.1016/j.heares.2021.108347.
- Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing lossZhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, Li G, Shang W, Wu H, Song L. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging 2020, 12: 5590-5611. PMID: 32240104, PMCID: PMC7185105, DOI: 10.18632/aging.102977.
- Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane InsertionZhai F, Song L, Bai JP, Dai C, Navaratnam D, Santos-Sacchi J. Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion. Neuroscience 2020, 431: 128-133. PMID: 32061780, PMCID: PMC8720582, DOI: 10.1016/j.neuroscience.2020.02.003.
- Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutationLin X, Li G, Zhang Y, Zhao J, Lu J, Gao Y, Liu H, Li G, Yang T, Song L, Wu H. Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation. Aging 2019, 11: 7416-7441. PMID: 31562289, PMCID: PMC6782001, DOI: 10.18632/aging.102246.
- Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing lossLiu H, Lu J, Wang Z, Song L, Wang X, Li G, Wu H. Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss. Neuroscience Letters 2019, 707: 134268. PMID: 31103727, DOI: 10.1016/j.neulet.2019.05.022.
- Modulators of Kv3 potassium channels rescue the auditory function of Fragile X miceEl-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 potassium channels rescue the auditory function of Fragile X mice. Journal Of Neuroscience 2019, 39: 0839-18. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.
- Cellular Differences in the Cochlea of CBA and B6 Mice May Underlie Their Difference in Susceptibility to Hearing LossLiu H, Li G, Lu J, Gao Y, Song L, Li G, Wu H. Cellular Differences in the Cochlea of CBA and B6 Mice May Underlie Their Difference in Susceptibility to Hearing Loss. Frontiers In Cellular Neuroscience 2019, 13: 60. PMID: 30873008, PMCID: PMC6400987, DOI: 10.3389/fncel.2019.00060.
- Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochleaLi C, Shu Y, Wang G, Zhang H, Lu Y, Li X, Li G, Song L, Liu Z. Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea. Hearing Research 2018, 364: 12-24. PMID: 29706463, DOI: 10.1016/j.heares.2018.04.006.
- Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editingZhang H, Pan H, Zhou C, Wei Y, Ying W, Li S, Wang G, Li C, Ren Y, Li G, Ding X, Sun Y, Li G, Song L, Li Y, Yang H, Liu Z. Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing. Development 2018, 145: dev168906. PMID: 30275281, DOI: 10.1242/dev.168906.
- Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner EarTan WJ, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV. Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxidants & Redox Signaling 2017, 27: 489-509. PMID: 28135838, PMCID: PMC5564041, DOI: 10.1089/ars.2016.6851.
- Intracellular calcium affects prestin’s voltage operating point indirectly via turgor-induced membrane tensionSong L, Santos-Sacchi J. Intracellular calcium affects prestin’s voltage operating point indirectly via turgor-induced membrane tension. AIP Conference Proceedings 2015, 1703: 030009. DOI: 10.1063/1.4939324.
- Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial DeafnessMcKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS. Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. American Journal Of Pathology 2015, 185: 3132-3140. PMID: 26552864, PMCID: PMC5801480, DOI: 10.1016/j.ajpath.2015.08.014.
- An Electrical Inspection of the Subsurface Cisternae of the Outer Hair CellSong L, Santos-Sacchi J. An Electrical Inspection of the Subsurface Cisternae of the Outer Hair Cell. Biophysical Journal 2015, 108: 568-577. PMID: 25650924, PMCID: PMC4317539, DOI: 10.1016/j.bpj.2014.12.010.
- Chloride-driven Electromechanical Phase Lags at Acoustic Frequencies Are Generated by SLC26a5, the Outer Hair Cell Motor ProteinSantos-Sacchi J, Song L. Chloride-driven Electromechanical Phase Lags at Acoustic Frequencies Are Generated by SLC26a5, the Outer Hair Cell Motor Protein. Biophysical Journal 2014, 107: 126-133. PMID: 24988347, PMCID: PMC4119270, DOI: 10.1016/j.bpj.2014.05.018.
- Chloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance SUPPORT FOR THE AREA MOTOR MODEL* * This work was supported, in whole or in part, by National Institutes of Health Grant NIDCD DC00273 (to J. S. S.).Santos-Sacchi J, Song L. Chloride and Salicylate Influence Prestin-dependent Specific Membrane Capacitance SUPPORT FOR THE AREA MOTOR MODEL* * This work was supported, in whole or in part, by National Institutes of Health Grant NIDCD DC00273 (to J. S. S.). Journal Of Biological Chemistry 2014, 289: 10823-10830. PMID: 24554714, PMCID: PMC4036195, DOI: 10.1074/jbc.m114.549329.
- Role of Kv1.3 Potassium Channels in Auditory FunctionEl-Hassar L, Song L, Gazula V, Navaratnam D, Santos-Sacchi J, Kaczmarek L. Role of Kv1.3 Potassium Channels in Auditory Function. Biophysical Journal 2014, 106: 740a. DOI: 10.1016/j.bpj.2013.11.4076.
- Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living ZebrafishRicci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J. Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish. Journal Of Neuroscience 2013, 33: 3131-3134. PMID: 23407967, PMCID: PMC3684625, DOI: 10.1523/jneurosci.4265-12.2013.
- Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause DeafnessRaimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness. Cell 2012, 148: 716-726. PMID: 22341444, PMCID: PMC3285425, DOI: 10.1016/j.cell.2011.12.027.
- Coupling Molecular Motions of Prestin to Cellular Motility: Effects of Voltage, Chloride and CytoskeletonSong L, Santos-Sacchi J. Coupling Molecular Motions of Prestin to Cellular Motility: Effects of Voltage, Chloride and Cytoskeleton. Biophysical Journal 2012, 102: 707a-708a. DOI: 10.1016/j.bpj.2011.11.3840.
- Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's OrganSong L, Santos-Sacchi J, Shera C, Olson E. Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ. AIP Conference Proceedings 2011, 1403: 179-184. DOI: 10.1063/1.3658083.
- Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cellWu T, Song L, Shi X, Jiang Z, Santos-Sacchi J, Nuttall A. Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell. Hearing Research 2010, 272: 117-124. PMID: 21044673, PMCID: PMC3387680, DOI: 10.1016/j.heares.2010.10.010.
- Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage SensingBai JP, Surguchev A, Bian S, Song L, Santos-Sacchi J, Navaratnam D. Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage Sensing. Biophysical Journal 2010, 99: 85-94. PMID: 20655836, PMCID: PMC2895379, DOI: 10.1016/j.bpj.2010.03.066.
- Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein*Bai JP, Surguchev A, Ogando Y, Song L, Bian S, Santos-Sacchi J, Navaratnam D. Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein*. Journal Of Biological Chemistry 2010, 285: 20834-20843. PMID: 20418376, PMCID: PMC2898336, DOI: 10.1074/jbc.m110.117853.
- FIRING UP THE AMPLIFIER: TEMPERATURE, PRESSURE AND VOLTAGE JUMP STUDIES ON OHC MOTOR CAPACITANCESANTOS-SACCHI J, SONG L, LI X. FIRING UP THE AMPLIFIER: TEMPERATURE, PRESSURE AND VOLTAGE JUMP STUDIES ON OHC MOTOR CAPACITANCE. 2009, 363-370. DOI: 10.1142/9789812833785_0058.
- Fast Electromechanical Amplification in the Lateral Membrane of the Outer Hair CellSantos-Sacchi J, Navarrete E, Song L. Fast Electromechanical Amplification in the Lateral Membrane of the Outer Hair Cell. Biophysical Journal 2009, 96: 739-747. PMID: 19167318, PMCID: PMC2716482, DOI: 10.1016/j.bpj.2008.10.015.
- CHLORIDE AND THE OHC LATERAL MEMBRANE MOTORSANTOS-SACCHI J, SONG L, BAI J, NAVARATNAM D. CHLORIDE AND THE OHC LATERAL MEMBRANE MOTOR. 2006, 162-168. DOI: 10.1142/9789812773456_0028.
- Control of Mammalian Cochlear Amplification by Chloride AnionsSantos-Sacchi J, Song L, Zheng J, Nuttall AL. Control of Mammalian Cochlear Amplification by Chloride Anions. Journal Of Neuroscience 2006, 26: 3992-3998. PMID: 16611815, PMCID: PMC6673883, DOI: 10.1523/jneurosci.4548-05.2006.
- On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestinSantos-Sacchi J, Rybalchenko V, Bai JP, Song L, Navaratnam D. On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin. Pflügers Archiv - European Journal Of Physiology 2006, 452: 283. PMID: 16521020, DOI: 10.1007/s00424-005-0037-2.
- Glibenclamide Stimulates Fluid Secretion in Rodent Cholangiocytes Through a Cystic Fibrosis Transmembrane Conductance Regulator-Independent MechanismSpirlì C, Fiorotto R, Song L, Santos-Sacchi J, Okolicsanyi L, Masier S, Rocchi L, Vairetti MP, de Bernard M, Melero S, Pozzan T, Strazzabosco M. Glibenclamide Stimulates Fluid Secretion in Rodent Cholangiocytes Through a Cystic Fibrosis Transmembrane Conductance Regulator-Independent Mechanism. Gastroenterology 2005, 129: 220-233. PMID: 16012949, DOI: 10.1053/j.gastro.2005.03.048.