Laura Manuelidis, MD
Professor of Surgery (Neuropathology); Section Chief Neuropathology (Surgery)
Research & Publications
Biography
News
Coauthors
Selected Publications
- Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegenerationSzigeti‐Buck K, Manuelidis L. Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegeneration. Journal Of Cellular Biochemistry 2019, 120: 17687-17698. PMID: 31231867, DOI: 10.1002/jcb.29035.
- Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cellsManuelidis L. Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells. Journal Of Cellular Biochemistry 2018, 120: 6198-6208. PMID: 30317668, DOI: 10.1002/jcb.27907.
- A prokaryotic viral sequence is expressed and conserved in mammalian brainYeh YH, Gunasekharan V, Manuelidis L. A prokaryotic viral sequence is expressed and conserved in mammalian brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 7118-7123. PMID: 28630311, PMCID: PMC5502646, DOI: 10.1073/pnas.1706110114.
- Proteomic links to CJD viral particles highlight common pathways for neurodegenerative diseasesManuelidis L. Proteomic links to CJD viral particles highlight common pathways for neurodegenerative diseases. Neurobiology Of Aging 2016, 39: s6-s7. DOI: 10.1016/j.neurobiolaging.2016.01.039.
- CJD and Scrapie Require Agent‐Associated Nucleic Acids for InfectionBotsios S, Manuelidis L. CJD and Scrapie Require Agent‐Associated Nucleic Acids for Infection. Journal Of Cellular Biochemistry 2016, 117: 1947-1958. PMID: 26773845, DOI: 10.1002/jcb.25495.
- Virulence profile: Laura ManuelidisManuelidis L. Virulence profile: Laura Manuelidis. Virulence 2016, 7: 477-480. PMID: 26854619, PMCID: PMC4871683, DOI: 10.1080/21505594.2016.1151210.
- Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilmsBotsios S, Tittman S, Manuelidis L. Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms. Virulence 2015, 6: 787-801. PMID: 26556670, PMCID: PMC4826107, DOI: 10.1080/21505594.2015.1098804.
- Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt‐Jakob diseaseKipkorir T, Colangelo CM, Manuelidis L. Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt‐Jakob disease. Proteomics 2015, 15: 2983-2998. PMID: 25930988, PMCID: PMC4601564, DOI: 10.1002/pmic.201500059.
- Highly Infectious CJD Particles Lack Prion Protein but Contain Many Viral‐Linked Peptides by LC‐MS/MSKipkorir T, Tittman S, Botsios S, Manuelidis L. Highly Infectious CJD Particles Lack Prion Protein but Contain Many Viral‐Linked Peptides by LC‐MS/MS. Journal Of Cellular Biochemistry 2014, 115: 2012-2021. PMID: 24933657, PMCID: PMC7166504, DOI: 10.1002/jcb.24873.
- Infectious particles, stress, and induced prion amyloidsManuelidis L. Infectious particles, stress, and induced prion amyloids. Virulence 2013, 4: 373-383. PMID: 23633671, PMCID: PMC3714129, DOI: 10.4161/viru.24838.
- Continuous Production of Prions after Infectious Particles Are Eliminated: Implications for Alzheimer’s DiseaseMiyazawa K, Kipkorir T, Tittman S, Manuelidis L. Continuous Production of Prions after Infectious Particles Are Eliminated: Implications for Alzheimer’s Disease. PLOS ONE 2012, 7: e35471. PMID: 22509412, PMCID: PMC3324552, DOI: 10.1371/journal.pone.0035471.
- High CJD infectivity remains after prion protein is destroyedMiyazawa K, Emmerling K, Manuelidis L. High CJD infectivity remains after prion protein is destroyed. Journal Of Cellular Biochemistry 2011, 112: 3630-3637. PMID: 21793041, PMCID: PMC3202053, DOI: 10.1002/jcb.23286.
- Replication and spread of CJD, kuru and scrapie agents in vivo and in cell cultureMiyazawa K, Emmerling K, Manuelidis L. Replication and spread of CJD, kuru and scrapie agents in vivo and in cell culture. Virulence 2011, 2: 188-199. PMID: 21527829, PMCID: PMC3149681, DOI: 10.4161/viru.2.3.15880.
- Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJDManuelidis L. Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD. Journal Of NeuroVirology 2010, 17: 131-145. PMID: 21165784, DOI: 10.1007/s13365-010-0007-0.
- Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell‐to‐cell contactsMiyazawa K, Emmerling K, Manuelidis L. Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell‐to‐cell contacts. Journal Of Cellular Biochemistry 2010, 111: 239-247. PMID: 20518071, PMCID: PMC2930104, DOI: 10.1002/jcb.22723.
- Transmissible encephalopathy agentsManuelidis L. Transmissible encephalopathy agents. Virulence 2010, 1: 101-104. PMID: 21178425, PMCID: PMC3073180, DOI: 10.4161/viru.1.2.10822.
- Agent-specific Shadoo Responses in Transmissible EncephalopathiesMiyazawa K, Manuelidis L. Agent-specific Shadoo Responses in Transmissible Encephalopathies. Journal Of Neuroimmune Pharmacology 2010, 5: 155-163. PMID: 20112073, PMCID: PMC2875883, DOI: 10.1007/s11481-010-9191-1.
- The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt–Jakob disease and scrapie agentsManuelidis L, Chakrabarty T, Miyazawa K, Nduom NA, Emmerling K. The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt–Jakob disease and scrapie agents. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 13529-13534. PMID: 19633190, PMCID: PMC2715327, DOI: 10.1073/pnas.0905825106.
- Strain‐specific viral properties of variant Creutzfeldt–Jakob disease (vCJD) are encoded by the agent and not by host prion proteinManuelidis L, Liu Y, Mullins B. Strain‐specific viral properties of variant Creutzfeldt–Jakob disease (vCJD) are encoded by the agent and not by host prion protein. Journal Of Cellular Biochemistry 2008, 106: 220-231. PMID: 19097123, PMCID: PMC2762821, DOI: 10.1002/jcb.21988.
- Blood borne transit of CJD from brain to gut at early stages of infectionRadebold K, Chernyak M, Martin D, Manuelidis L. Blood borne transit of CJD from brain to gut at early stages of infection. BMC Infectious Diseases 2001, 1: 20. PMID: 11716790, PMCID: PMC59894, DOI: 10.1186/1471-2334-1-20.
- The Stomach Divalent Ion-sensing Receptor SCAR Is a Modulator of Gastric Acid Secretion*Geibel J, Wagner C, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. The Stomach Divalent Ion-sensing Receptor SCAR Is a Modulator of Gastric Acid Secretion*. Journal Of Biological Chemistry 2001, 276: 39549-39552. PMID: 11507103, DOI: 10.1074/jbc.m107315200.
- The force of prions Stanley BPrusinerPrion biology and diseasesed.1999Laboratory PressCold Spring Harbor0879695471Pp 794. US$125·00 ISBN 0879695471.Manuelidis L. The force of prions Stanley BPrusinerPrion biology and diseasesed.1999Laboratory PressCold Spring Harbor0879695471Pp 794. US$125·00 ISBN 0879695471. The Lancet 2000, 355: 2083. DOI: 10.1016/s0140-6736(05)73543-1.
- Gap junctional protins play an important regulatory role in mouse gastric acid secretionRadebold K, Wojdermann M, Zaitsev I, Gloeckner J, Spicer Z, Shull G, Manuelidis L, Geibel J. Gap junctional protins play an important regulatory role in mouse gastric acid secretion. Gastroenterology 2000, 118: a32. DOI: 10.1016/s0016-5085(00)82198-8.
- Cleaning CJD-contaminated instruments.Manuelidis L. Cleaning CJD-contaminated instruments. Science 1998, 281: 1961. PMID: 9767039, DOI: 10.1126/science.281.5385.1961c.
- Beneath the emperor's clothes: The body of data in scrapie and CJDManuelidis L. Beneath the emperor's clothes: The body of data in scrapie and CJD. Annales De L Institut Pasteur / Actualités 1997, 8: 311-326. DOI: 10.1016/s0924-4204(97)86597-3.
- VISUALIZATION OF CANDIDATE VIRAL SEQUENCES IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASEDron M, Manuelidis L, Manuelidis L. VISUALIZATION OF CANDIDATE VIRAL SEQUENCES IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE. Journal Of Neuropathology & Experimental Neurology 1996, 55: 661. DOI: 10.1097/00005072-199605000-00231.
- Po Glycoprotein mRNA distribution in myelin-forming Schwann cells of the developing rat trigeminal ganglionLamperth L, Manuelidis L, deF Webster H. Po Glycoprotein mRNA distribution in myelin-forming Schwann cells of the developing rat trigeminal ganglion. Brain Cell Biology 1990, 19: 756-764. PMID: 1706417, DOI: 10.1007/bf01188043.
- PROTECTED NUCLEIC ACIDS IN INFECTIOUS CREUTZFELDT-JAKOB DISEASE (CJD) BRAIN FRACTIONS CAN BE OF SUBSTANTIAL SIZEAkowitz A, Sklavladis T, Manuelidis E, Manuelidis L. PROTECTED NUCLEIC ACIDS IN INFECTIOUS CREUTZFELDT-JAKOB DISEASE (CJD) BRAIN FRACTIONS CAN BE OF SUBSTANTIAL SIZE. Journal Of Neuropathology & Experimental Neurology 1990, 49: 312. DOI: 10.1097/00005072-199005000-00160.
- MORPHOLOGICAL STUDIES ON NEOPLASMS DERIVED FROM TRANSPLANTATION OF LONG TERM CJD CELL LINESKim J, Manuelidis L, Manuelidis E. MORPHOLOGICAL STUDIES ON NEOPLASMS DERIVED FROM TRANSPLANTATION OF LONG TERM CJD CELL LINES. Journal Of Neuropathology & Experimental Neurology 1990, 49: 312. DOI: 10.1097/00005072-199005000-00159.
- Movement of the X Chromosome in EpilepsyBorden J, Manuelidis L. Movement of the X Chromosome in Epilepsy. Science 1988, 242: 1687-1691. PMID: 3201257, DOI: 10.1126/science.3201257.
- Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA librariesLichter P, Cremer T, Borden J, Manuelidis L, Ward D. Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries. Human Genetics 1988, 80: 224-234. PMID: 3192212, DOI: 10.1007/bf01790090.
- β-Amyloid gene dosage in Alzheimer's diseaseMurdoch G, Manuelidis L, Kim J, Manuelidis E. β-Amyloid gene dosage in Alzheimer's disease. Nucleic Acids Research 1988, 16: 357-357. PMID: 3277160, PMCID: PMC334641, DOI: 10.1093/nar/16.1.357.
- SEQUENTIAL CHANGES IN THE ACTIVITY OF CEREBRAL GLYCOSIDASES IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE OF HAMSTERS.Kim J, Manuelidis L, Manuelidis E. SEQUENTIAL CHANGES IN THE ACTIVITY OF CEREBRAL GLYCOSIDASES IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE OF HAMSTERS. Journal Of Neuropathology & Experimental Neurology 1987, 46: 343. DOI: 10.1097/00005072-198705000-00040.
- DOUBLE LABELLING IN SITU HYBRIDIZATION USING NON-ISOTOPIC AND ISOTOPIC DETECTIONSINGER R, LAWRENCE J, LANGEVIN G, RASHTCHIAN R, VILLNAVE C, CREMER T, TESIN D, MANUELIDIS L, WARD D. DOUBLE LABELLING IN SITU HYBRIDIZATION USING NON-ISOTOPIC AND ISOTOPIC DETECTION. Acta Histochemica Et Cytochemica 1987, 20: 589. DOI: 10.1267/ahc.20.589.
- IMMORTALITY AND TUMORGENICITY OF TISSUE CULTURE LINES DERIVED FROM CREUTZFELDT-JAKOB BRAINS OF HAMSTERS AND MICEManuelidis E, Kim J, Manuelidis L. IMMORTALITY AND TUMORGENICITY OF TISSUE CULTURE LINES DERIVED FROM CREUTZFELDT-JAKOB BRAINS OF HAMSTERS AND MICE. Journal Of Neuropathology & Experimental Neurology 1986, 45: 325. DOI: 10.1097/00005072-198605000-00038.
- LYSOSOMAL GLYCOSIDASE ACTIVITIES IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASEKim J, Manuelidis L, Manuelidis E. LYSOSOMAL GLYCOSIDASE ACTIVITIES IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE. Journal Of Neuropathology & Experimental Neurology 1986, 45: 336. DOI: 10.1097/00005072-198605000-00069.
- EXPERIMENTAL CREUTZFELDT-JAKOB (CJD) WITH DESTRUCTIVE LESIONS IN THE WHITE MATTERManuelidis L, Kim J, Manuelidis E. EXPERIMENTAL CREUTZFELDT-JAKOB (CJD) WITH DESTRUCTIVE LESIONS IN THE WHITE MATTER. Journal Of Neuropathology & Experimental Neurology 1986, 45: 330. DOI: 10.1097/00005072-198605000-00052.
- Individual interphase chromosome domains revealed by in situ hybridizationManuelidis L. Individual interphase chromosome domains revealed by in situ hybridization. Human Genetics 1985, 71: 288-293. PMID: 3908288, DOI: 10.1007/bf00388453.
- Due to a printer's error, page 330 of the May 1984 Issue was incorrectly printed. The abstracts below should have appeared as p. 330. We regret any inconveniences to the authors of these abstractsdel Cerro C, Herndon R, Gregorios J, Mozes L, Norenberg L, Norenberg M, Manuelidis L, Fritch W, Valley S, Herndon M, Norenderg L, Valley S. Due to a printer's error, page 330 of the May 1984 Issue was incorrectly printed. The abstracts below should have appeared as p. 330. We regret any inconveniences to the authors of these abstracts. Journal Of Neuropathology & Experimental Neurology 1984, 43: 458-458. DOI: 10.1097/00005072-198407000-00018.
- 61 NEURONAL ALTERATIONS IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASEKim J, Manuelidis L, Manuelidis E. 61 NEURONAL ALTERATIONS IN EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE. Journal Of Neuropathology & Experimental Neurology 1984, 43: 313. DOI: 10.1097/00005072-198405000-00070.
- 126 IN VITRO TRANSFORMATION OF BALB/C-3T3 FIBROBLASTS BY SYNAPTOSOMAL-MITOCHONDRIAL FRACTION ISOLATED FROM BRAIN OF CREUTZFELDT-JAKOB INFECTED HAMSTERSOleszak E, Manuelidis L, Manuelidis E. 126 IN VITRO TRANSFORMATION OF BALB/C-3T3 FIBROBLASTS BY SYNAPTOSOMAL-MITOCHONDRIAL FRACTION ISOLATED FROM BRAIN OF CREUTZFELDT-JAKOB INFECTED HAMSTERS. Journal Of Neuropathology & Experimental Neurology 1984, 43: 335. DOI: 10.1097/00005072-198405000-00132.
- Scrapie-associated fibrils in Creutzfeldt–Jakob diseaseMerz P, Somerville R, Wisniewski H, Manuelidis L, Manuelidis E. Scrapie-associated fibrils in Creutzfeldt–Jakob disease. Nature 1983, 306: 474-476. PMID: 6358899, DOI: 10.1038/306474a0.
- SEQUENTIAL MORPHOLOGIC CHANGES IN THE BRAIN OF GUINEA PIGS WITH EXPERIMENTAL CREUTZFELDT-JAKOB DISEASEKim J, Manuelidis L, Manuelidis E. SEQUENTIAL MORPHOLOGIC CHANGES IN THE BRAIN OF GUINEA PIGS WITH EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE. Journal Of Neuropathology & Experimental Neurology 1982, 41: 364. DOI: 10.1097/00005072-198205000-00081.
- 110 “NICK TRANSLATED” DNA IN INFECTIVE CREUTZFELDT-JAKOB BRAIN FRACTIONSManuelidis L, Manuelidis E. 110 “NICK TRANSLATED” DNA IN INFECTIVE CREUTZFELDT-JAKOB BRAIN FRACTIONS. Journal Of Neuropathology & Experimental Neurology 1980, 39: 373. DOI: 10.1097/00005072-198005000-00118.
- MORPHOLOGICAL SIGNS OF AGING IN HAMSTERS WITH CREUTZFELDT-JAKOB DISEASEManuelidis E, Manuelidis L. MORPHOLOGICAL SIGNS OF AGING IN HAMSTERS WITH CREUTZFELDT-JAKOB DISEASE. Journal Of Neuropathology & Experimental Neurology 1978, 37: 654. DOI: 10.1097/00005072-197809000-00260.
- TRANSMISSION, FROM MAN TO HAMSTER, OF CREUTZFELDT-JAKOB DISEASE WITH CLINICAL RECOVERYManuelidis E, Manuelidis L, Pincus J, Collins W. TRANSMISSION, FROM MAN TO HAMSTER, OF CREUTZFELDT-JAKOB DISEASE WITH CLINICAL RECOVERY. The Lancet 1978, 312: 40-42. PMID: 78232, DOI: 10.1016/s0140-6736(78)91345-4.
- SCANNING ELECTRON MICROSCOPY OF NORMAL AND NEOPLASTIC NEUROECTODERMAL CELLS IN CULTUREManuelidis L, Manuelidis E. SCANNING ELECTRON MICROSCOPY OF NORMAL AND NEOPLASTIC NEUROECTODERMAL CELLS IN CULTURE. Journal Of Neuropathology & Experimental Neurology 1977, 36: 614. DOI: 10.1097/00005072-197705000-00088.
- Serial propagation of Creutzfeldt-Jakob disease in guinea pigs.Manuelidis E, Kim J, Angelo J, Manuelidis L. Serial propagation of Creutzfeldt-Jakob disease in guinea pigs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1976, 73: 223-227. PMID: 1108016, PMCID: PMC335873, DOI: 10.1073/pnas.73.1.223.
- Bevelled Dual-Channel MicroelectrodesAnderson J, Kleinhaus A, Manuelidis L, Prichard J. Bevelled Dual-Channel Microelectrodes. IEEE Transactions On Biomedical Engineering 1974, BME-21: 482-485. DOI: 10.1109/tbme.1974.324337.