Kyung-Heup Ahn, MD
Research & Publications
Biography
News
Research Summary
The main area of research interest has been investigating neurochemical underpinning of schizophrenia. More specifically, investigating effects and interactions of various psychoactive chemicals inducing clinical characteristics of schizophrenia or inducing vulnerability to psychosis in human subjects. In this context, I have involved in several challenge studies using ketamine, iomezanil, and amphetamine during my residency training at Seoul National University and postdoctoral fellowship at the VA-Yale schizophrenia research program. I also have some expertise in neuro-imaging studies from experience as a research fellow at Brain Imaging Center at McLean Hospital, Harvard Medical School. Currently, I am conducting study, as a PI, investigating interactive effects of GABA and Dopamine system in schizophrenia.
Coauthors
Research Interests
Affective Disorders, Psychotic; Schizophrenia Spectrum and Other Psychotic Disorders
Selected Publications
- Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of AmphetamineAhn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC. Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine. Neuropsychopharmacology 2015, 40: 2822-2831. PMID: 25953357, PMCID: PMC4864658, DOI: 10.1038/npp.2015.132.
- Nicotine Fails to Attenuate Ketamine-Induced Cognitive Deficits and Negative and Positive Symptoms in Humans: Implications for SchizophreniaD'Souza DC, Ahn K, Bhakta S, Elander J, Singh N, Nadim H, Jatlow P, Suckow RF, Pittman B, Ranganathan M. Nicotine Fails to Attenuate Ketamine-Induced Cognitive Deficits and Negative and Positive Symptoms in Humans: Implications for Schizophrenia. Biological Psychiatry 2012, 72: 785-794. PMID: 22717030, DOI: 10.1016/j.biopsych.2012.05.009.
- Probing GABA Receptor Function in Schizophrenia with IomazenilAhn K, Gil R, Seibyl J, Sewell RA, D'Souza DC. Probing GABA Receptor Function in Schizophrenia with Iomazenil. Neuropsychopharmacology 2010, 36: 677-683. PMID: 21068719, PMCID: PMC3055690, DOI: 10.1038/npp.2010.198.
- White matter hyperintensities in subjects with bipolar disorderAHN KH, LYOO IK, LEE HK, SONG IC, OH JS, HWANG J, KWON J, KIM MJ, KIM M, RENSHAW PF. White matter hyperintensities in subjects with bipolar disorder. Psychiatry And Clinical Neurosciences 2004, 58: 516-521. PMID: 15482583, DOI: 10.1111/j.1440-1819.2004.01294.x.
- N-Methyl-d-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory processAhn KH, Youn T, Cho SS, Ha TH, Ha KS, Kim MS, Kwon JS. N-Methyl-d-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory process. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2003, 27: 993-999. PMID: 14499316, DOI: 10.1016/s0278-5846(03)00159-3.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Mental Health & Behavioral Research | M1 Schizophrenia PET Study |
| Mental Health & Behavioral Research | The Monarch Study for PTSD |