Kevin Du
MD, PhD, MSCI
Associate Professor of Therapeutic Radiology; Medical Director, Radiation Oncology Center, Smilow Cancer Hospital Care Center in Trumbull; Network Outreach, Therapeutic Radiology
Research & Publications
Biography
News
Coauthors
Selected Publications
- Medical Student Perspectives on a Multi-institutional Clerkship Curriculum: A Report From the Radiation Oncology Education Collaborative Study Group.Ye JC, Mohindra P, Spektor A, Krishnan MS, Chmura SJ, Howard AR, Viswanathan AN, MacDonald SM, Thaker NG, Das P, Mancini BR, Higgins SA, Braunstein S, Haas-Kogan D, Bradley KA, Hung AY, Thomas CR, Kharofa J, Wheatley M, Currey A, Parashar B, Du K, Jimenez RB, Golden DW. Medical Student Perspectives on a Multi-institutional Clerkship Curriculum: A Report From the Radiation Oncology Education Collaborative Study Group. International Journal Of Radiation Oncology, Biology, Physics 2015, 92: 217-9. PMID: 25968822, PMCID: PMC4768460, DOI: 10.1016/j.ijrobp.2015.01.043.
- Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function.Zhang JC, Kim S, Helmke BP, Yu WW, Du KL, Lu MM, Strobeck M, Yu Q, Parmacek MS. Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Molecular And Cellular Biology 2001, 21: 1336-44. PMID: 11158319, PMCID: PMC99586, DOI: 10.1128/MCB.2001.21.4.1336-1344.2001.
- Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells.Strobeck M, Kim S, Zhang JC, Clendenin C, Du KL, Parmacek MS. Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells. The Journal Of Biological Chemistry 2001, 276: 16418-24. PMID: 11279108, DOI: 10.1074/jbc.M100631200.
- SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression.Zhang JC, Helmke BP, Shum A, Du K, Yu WW, Lu MM, Davies PF, Parmacek MS. SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression. Mechanisms Of Development 2002, 115: 161-6. PMID: 12049783, DOI: 10.1016/s0925-4773(02)00088-6.
- Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK, Parmacek MS. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Molecular And Cellular Biology 2003, 23: 2425-37. PMID: 12640126, PMCID: PMC150745, DOI: 10.1128/MCB.23.7.2425-2437.2003.
- Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. The Journal Of Biological Chemistry 2004, 279: 17578-86. PMID: 14970199, DOI: 10.1074/jbc.M400961200.
- Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development.Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 8916-21. PMID: 15951419, PMCID: PMC1157054, DOI: 10.1073/pnas.0503741102.
- Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer.Du KL, Mick R, Busch TM, Zhu TC, Finlay JC, Yu G, Yodh AG, Malkowicz SB, Smith D, Whittington R, Stripp D, Hahn SM. Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer. Lasers In Surgery And Medicine 2006, 38: 427-34. PMID: 16788929, DOI: 10.1002/lsm.20341.
- Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.Evans SM, Du KL, Chalian AA, Mick R, Zhang PJ, Hahn SM, Quon H, Lustig R, Weinstein GS, Koch CJ. Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome. International Journal Of Radiation Oncology, Biology, Physics 2007, 69: 1024-31. PMID: 17967299, PMCID: PMC2737259, DOI: 10.1016/j.ijrobp.2007.04.067.
- Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma.Du KL, Both S, Friedberg JS, Rengan R, Hahn SM, Cengel KA. Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma. Cancer Biology & Therapy 2010, 10: 425-9. PMID: 20699634, DOI: 10.4161/cbt.10.5.12616.
- Impact of marital status and race on outcomes of patients enrolled in Radiation Therapy Oncology Group prostate cancer trials.Du KL, Bae K, Movsas B, Yan Y, Bryan C, Bruner DW. Impact of marital status and race on outcomes of patients enrolled in Radiation Therapy Oncology Group prostate cancer trials. Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer 2012, 20: 1317-25. PMID: 21720747, DOI: 10.1007/s00520-011-1219-4.
- Inhibition of Hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic acid repair.Guttmann DM, Hart L, Du K, Seletsky A, Koumenis C. Inhibition of Hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic acid repair. International Journal Of Radiation Oncology, Biology, Physics 2013, 87: 168-75. PMID: 23849696, DOI: 10.1016/j.ijrobp.2013.05.028.
- Chemoradiation therapy versus chemotherapy alone for gastric cancer after R0 surgical resection: a meta-analysis of randomized trials.Min C, Bangalore S, Jhawar S, Guo Y, Nicholson J, Formenti SC, Leichman LP, Du KL. Chemoradiation therapy versus chemotherapy alone for gastric cancer after R0 surgical resection: a meta-analysis of randomized trials. Oncology 2014, 86: 79-85. PMID: 24435019, DOI: 10.1159/000354641.
- Outcomes of rectal cancer with liver oligometastases.Resende Salgado L, Hsu H, Du K. Outcomes of rectal cancer with liver oligometastases. Journal Of Gastrointestinal Oncology 2014, 5: 414-20. PMID: 25436119, PMCID: PMC4226821, DOI: 10.3978/j.issn.2078-6891.2014.078.
- Radiation therapy improves survival in rectal small cell cancer - Analysis of Surveillance Epidemiology and End Results (SEER) data.Modrek AS, Hsu HC, Leichman CG, Du KL. Radiation therapy improves survival in rectal small cell cancer - Analysis of Surveillance Epidemiology and End Results (SEER) data. Radiation Oncology (London, England) 2015, 10: 101. PMID: 25902707, PMCID: PMC4464878, DOI: 10.1186/s13014-015-0411-y.
- Comparison of anal cancer outcomes in public and private hospital patients treated at a single radiation oncology center.Bitterman DS, Grew D, Gu P, Cohen RF, Sanfilippo NJ, Leichman CG, Leichman LP, Moore HG, Gold HT, Du KL. Comparison of anal cancer outcomes in public and private hospital patients treated at a single radiation oncology center. Journal Of Gastrointestinal Oncology 2015, 6: 524-33. PMID: 26487947, PMCID: PMC4570920, DOI: 10.3978/j.issn.2078-6891.2015.061.
- HIV Infection Is Associated With Poor Outcomes for Patients With Anal Cancer in the Highly Active Antiretroviral Therapy Era.Grew D, Bitterman D, Leichman CG, Leichman L, Sanfilippo N, Moore HG, Du K. HIV Infection Is Associated With Poor Outcomes for Patients With Anal Cancer in the Highly Active Antiretroviral Therapy Era. Diseases Of The Colon And Rectum 2015, 58: 1130-6. PMID: 26544809, DOI: 10.1097/DCR.0000000000000476.
- Predictors of Complete Response and Disease Recurrence Following Chemoradiation for Rectal Cancer.Bitterman DS, Resende Salgado L, Moore HG, Sanfilippo NJ, Gu P, Hatzaras I, Du KL. Predictors of Complete Response and Disease Recurrence Following Chemoradiation for Rectal Cancer. Frontiers In Oncology 2015, 5: 286. PMID: 26734570, PMCID: PMC4686647, DOI: 10.3389/fonc.2015.00286.
- Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice.Seifert L, Werba G, Tiwari S, Giao Ly NN, Nguy S, Alothman S, Alqunaibit D, Avanzi A, Daley D, Barilla R, Tippens D, Torres-Hernandez A, Hundeyin M, Mani VR, Hajdu C, Pellicciotta I, Oh P, Du K, Miller G. Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice. Gastroenterology 2016, 150: 1659-1672.e5. PMID: 26946344, PMCID: PMC4909514, DOI: 10.1053/j.gastro.2016.02.070.
- Dosimetric evaluation of magnetic resonance-generated synthetic CT for radiation treatment of rectal cancer.Wang H, Du K, Qu J, Chandarana H, Das IJ. Dosimetric evaluation of magnetic resonance-generated synthetic CT for radiation treatment of rectal cancer. PloS One 2018, 13: e0190883. PMID: 29304105, PMCID: PMC5755922, DOI: 10.1371/journal.pone.0190883.
- Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.Chadi SA, Malcomson L, Ensor J, Riley RD, Vaccaro CA, Rossi GL, Daniels IR, Smart NJ, Osborne ME, Beets GL, Maas M, Bitterman DS, Du K, Gollins S, Sun Myint A, Smith FM, Saunders MP, Scott N, O'Dwyer ST, de Castro Araujo RO, Valadao M, Lopes A, Hsiao CW, Lai CL, Smith RK, Paulson EC, Appelt A, Jakobsen A, Wexner SD, Habr-Gama A, Sao Julião G, Perez R, Renehan AG. Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet. Gastroenterology & Hepatology 2018, 3: 825-836. PMID: 30318451, DOI: 10.1016/S2468-1253(18)30301-7.
- Breaking Tradition to Bridge Bench and Bedside: Accelerating the MD-PhD-Residency Pathway.Modrek AS, Tanese N, Placantonakis DG, Sulman EP, Rivera R, Du KL, Gerber NK, David G, Chesler M, Philips MR, Cangiarella J. Breaking Tradition to Bridge Bench and Bedside: Accelerating the MD-PhD-Residency Pathway. Academic Medicine : Journal Of The Association Of American Medical Colleges 2021, 96: 518-521. PMID: 33464738, DOI: 10.1097/ACM.0000000000003920.
- Interprofessional Image Verification Workshop for Physician and Physics Residents: A Multi-Institutional Experience.Padilla L, Burmeister JW, Burnett OL, Covington EL, Den RB, Dominello MM, Du KL, Galavis PE, Junell S, Kahn J, Kishore M, Mooney K, Mukhopadhyay ND, Studenski MT, Yechieli RL, Fields EC. Interprofessional Image Verification Workshop for Physician and Physics Residents: A Multi-Institutional Experience. International Journal Of Radiation Oncology, Biology, Physics 2021, 111: 1058-1065. PMID: 34380009, DOI: 10.1016/j.ijrobp.2021.07.1706.
- Analysis of Radiation Therapy Quality Assurance in NRG Oncology RTOG 0848.Tchelebi L, Winter K, Abrams RA, Safran H, Regine WF, McNulty S, Wu AJ, Du KL, Seaward SA, Bian SX, Aljumaily R, Shivnani AT, Moore T, Crocenzi T, DiPetrillo TA, Kuykendal A, Crane CH, Goodman KA. Analysis of Radiation Therapy Quality Assurance in NRG Oncology RTOG 0848. International Journal Of Radiation Oncology, Biology, Physics 2021, 111: S40. PMID: 34700550, DOI: 10.1016/j.ijrobp.2021.07.114.