Research & Publications
Currently, I am involved in a number of projects with a primary focus on tumor biology and therapeutic approaches towards its treatment.
- In GBMs, identifying novel driver mutations and elucidating their underlying mode of action using molecular and cell biological approaches in vitro and in vivo with Drosophila as the model system.
- In personalized medicine, integral part of the team establishing primary cultures from various brain tumors and assessing efficacy of drugs based on their mutational profiles.
- In meningiomas, working on elucidating the mode of action of TRAF7 (an E3-ubiquitin ligase) mutations in tumor formation using biochemical approaches.
- In neurodevelopmental disorders, used Drosophila to model microcephaly and elucidated the cellular consequences of mutations in the microtubule-severing enzyme Katanin in regulating asymmetric cell division in neural progenitors. Currently, continuing the work on validating and elucidating the role of other candidate genes in cortical malformations using Drosophila and zebrafish as model systems.
- Actively involved in the biochemical characterization, cell-culture and zebrafish modeling of several genes identified in our lab as potential candidates for aneurysms.
- Part of the team that published a biochemical study aimed at understanding the mode of CCM3 interactions with various signaling pathways and identified potential therapeutics.
- Collaborated with Gilead Pharmaceuticals to test novel compounds for IDH1 mutant gliomas.
- Significant member of the team involved in the collaborative effort to submit a Yale Brain Tumor SPORE grant through the Department of Neurosurgery and the Yale Cancer Center.
- Biological Functions of Heparan Sulfates.Mishra-Gorur K, L. M. Delmolino, J. J. Castellot Jr., (1998) Biological Functions of Heparan Sulfates. Trends Glycosci Glycotech 10 (52): 193-210.