Kelly Cosgrove, PhD
Professor of Psychiatry and of Neuroscience and of Radiology and Biomedical Imaging
Research & Publications
Biography
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Research Summary
We are using novel, creative PET paradigms to gain insight into the neurochemical mechanisms that drive addiction and psychiatric disorders. PET allows us to measure specific molecules in the living human brain. We are particularly interested in identifying deficits in the cholinergic and dopaminergic neurotransmitter systems in tobacco smokers and how these systems change during acute and prolonged abstinence from smoking. We are uncovering the variables, such as sex, neurocognitive function, psychiatric status and genetic makeup that influence these changes. We are also examining the neuroadaptations that occur during the recovery from alcohol dependence including changes in the GABA-ergic system, the neuroimmune system, and synaptic plasticity.
Specialized Terms: Positron Emission Tomography; Neuroimaging; Alcohol Dependence; Tobacco Smoking; Nicotine Dependence; Brain; nicotinic acetylcholine receptor; GABAA-benzodiazepine receptor; Sex differences, Dopamine
Extensive Research Description
- Understanding the functional basis and behavioral and cognitive correlates of the changes in beta2*-nicotinic acetylcholine receptor availability during acute and prolonged abstinence in tobacco smokers.
- Examining the changes in mglu5 receptor availability that occur during acute and prolonged abstinence from alcohol and nicotine dependence.
- Radiotracer development targeted at the stress and glucocorticoid systems.
- Examination of sex differences in the dopaminergic signature of smoking- and nicotine-induced dopamine release using novel PET brain imaging techniques.
- Examining effects of chronic alcohol consumption on the neuroimmune system and relationships to synaptic plasticity in living humans with alcohol use disorder.
- Examining the stress and neuroimmune system with PET and the application to psychiatric disorders such as PTSD.
- Measuring the neuroimmune state of the brain in individuals with opioid use disorder during early recovery.
Coauthors
Research Interests
Alcohol Drinking; Brain; Opioid-Related Disorders; Neurobiology; Nicotine; Radiology; Positron-Emission Tomography; Neuroimaging; alpha7 Nicotinic Acetylcholine Receptor; Diseases; Chemicals and Drugs; Psychiatry and Psychology
Selected Publications
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Verplaetse TL, Cosgrove KP, Tanabe J, McKee SA. Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. Journal Of Neuroscience Research 2021, 99: 309-323. PMID: 32333417, PMCID: PMC7584757, DOI: 10.1002/jnr.24625.
- Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence.Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley SSO, Cosgrove KP. Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2021, 46: 380-385. PMID: 32919411, PMCID: PMC7852514, DOI: 10.1038/s41386-020-00856-9.
- First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2020, 40: 695-704. PMID: 30895878, PMCID: PMC7168798, DOI: 10.1177/0271678X19838633.
- Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study.Hillmer AT, Matuskey D, Huang Y, Nabulsi NB, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2020, 61: 1200-1204. PMID: 32005773, PMCID: PMC7413239, DOI: 10.2967/jnumed.119.237735.
- PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
- Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.Woodcock EA, Hillmer AT, Sandiego CM, Maruff P, Carson RE, Cosgrove KP, Pietrzak RH. Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study. Brain, Behavior, And Immunity 2021, 91: 784-787. PMID: 33002632, PMCID: PMC7749814, DOI: 10.1016/j.bbi.2020.09.027.
- Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.
- The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study.Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43: 1052-1058. PMID: 28944773, PMCID: PMC5854798, DOI: 10.1038/npp.2017.223.
- In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence. Molecular Psychiatry 2017, 22: 1759-1766. PMID: 28242869, PMCID: PMC5573660, DOI: 10.1038/mp.2017.10.
- Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence.Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Alcoholism, Clinical And Experimental Research 2016, 40: 698-705. PMID: 26971694, PMCID: PMC4983773, DOI: 10.1111/acer.12997.
- Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 12468-73. PMID: 26385967, PMCID: PMC4603509, DOI: 10.1073/pnas.1511003112.
- Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-6. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
- Sex differences in the brain's dopamine signature of cigarette smoking.Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. Sex differences in the brain's dopamine signature of cigarette smoking. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2014, 34: 16851-5. PMID: 25505336, PMCID: PMC4261105, DOI: 10.1523/JNEUROSCI.3661-14.2014.
- Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.Gallezot JD, Kloczynski T, Weinzimmer D, Labaree D, Zheng MQ, Lim K, Rabiner EA, Ridler K, Pittman B, Huang Y, Carson RE, Morris ED, Cosgrove KP. Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2014, 39: 866-74. PMID: 24220025, PMCID: PMC3924521, DOI: 10.1038/npp.2013.286.
- Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers.Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O'Malley SS. Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers. Archives Of General Psychiatry 2012, 69: 418-27. PMID: 22474108, PMCID: PMC3508698, DOI: 10.1001/archgenpsychiatry.2011.1465.
- Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates.Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP. Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. NeuroImage 2012, 63: 232-9. PMID: 22776451, PMCID: PMC3699786, DOI: 10.1016/j.neuroimage.2012.06.055.
- beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.Cosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O'Malley S, Perry E, Tamagnan G, Seibyl JP, Staley JK. beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Archives Of General Psychiatry 2009, 66: 666-76. PMID: 19487632, PMCID: PMC2796827, DOI: 10.1001/archgenpsychiatry.2009.41.
- Evolving knowledge of sex differences in brain structure, function, and chemistry.Cosgrove KP, Mazure CM, Staley JK. Evolving knowledge of sex differences in brain structure, function, and chemistry. Biological Psychiatry 2007, 62: 847-55. PMID: 17544382, PMCID: PMC2711771, DOI: 10.1016/j.biopsych.2007.03.001.
- Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers.Staley JK, Krishnan-Sarin S, Cosgrove KP, Krantzler E, Frohlich E, Perry E, Dubin JA, Estok K, Brenner E, Baldwin RM, Tamagnan GD, Seibyl JP, Jatlow P, Picciotto MR, London ED, O'Malley S, van Dyck CH. Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2006, 26: 8707-14. PMID: 16928859, PMCID: PMC6674379, DOI: 10.1523/JNEUROSCI.0546-06.2006.
- PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain. Cerebral Cortex (New York, N.Y. : 1991) 2021, 31: 2787-2798. PMID: 33442731, PMCID: PMC8355478, DOI: 10.1093/cercor/bhaa387.
- Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders.Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.
- Assessment of transient dopamine responses to smoked cannabis.Calakos KC, Liu H, Lu Y, Anderson JM, Matuskey D, Nabulsi N, Ye Y, Skosnik PD, D'Souza DC, Morris ED, Cosgrove KP, Hillmer AT. Assessment of transient dopamine responses to smoked cannabis. Drug And Alcohol Dependence 2021, 227: 108920. PMID: 34399137, PMCID: PMC8464527, DOI: 10.1016/j.drugalcdep.2021.108920.
- Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study.Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2022, 24: 745-752. PMID: 34628508, PMCID: PMC8962719, DOI: 10.1093/ntr/ntab208.
- Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1. The Journal Of Clinical Investigation 2021, 131 PMID: 34651587, PMCID: PMC8516462, DOI: 10.1172/JCI150452.
- Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.Calakos KC, Rusowicz A, Pittman B, Gallezot JD, Potenza MN, Cosgrove KP, Matuskey D. Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans. Neuroscience Letters 2022, 771: 136463. PMID: 35051435, PMCID: PMC8821418, DOI: 10.1016/j.neulet.2022.136463.
- Nicotine patch alters patterns of cigarette smoking-induced dopamine release: Patterns relate to biomarkers associated with treatment response.Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine patch alters patterns of cigarette smoking-induced dopamine release: Patterns relate to biomarkers associated with treatment response. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2022 PMID: 35100429, DOI: 10.1093/ntr/ntac026.
- Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder.Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder. Alcoholism, Clinical And Experimental Research 2022 PMID: 35342968, DOI: 10.1111/acer.14816.