Karl Insogna, MD, FACP
Research & Publications
Biography
News
Research Summary
Dr. Insogna maintains active programs in both clinical and bench research.
In the clinical arena, Dr. Insogna is interested in the role of dietary protein in skeletal metabolism. Over the past decade, he and Dr. Jane Kerstetter from the University of Connecticut have established a new paradigm for the effect of dietary protein on calcium homeostasis. They have found that, contrary to the widely held view, increases in dietary protein within the physiologic range do not result in negative bone balance. Using dual stable calcium isotopes, they determined that the long-recognized hypercalciuria, which attends an increase in dietary protein, is quantitatively explained by improved intestinal calcium absorption, rather than increased bone resorption. In fact, the rate of resorption tends to slow as dietary protein is increased from low to high-normal. These data have led Drs. Insogna, Kerstetter, and Anne Kenney (from the University of Connecticut) to launch an NIH-funded, multi-center trial examining the impact of a dietary protein supplement on bone metabolism in postmenopausal women. Ongoing studies also seek to better define the cellular and molecular mechanisms by which dietary protein augments intestinal calcium absorption. Some of this work suggests a potential role for the calcium-sensing receptor, but alternative theories are currently being explored in the laboratory.
Dr. Insogna's most recent NIH grant is for a study to explore the role of sphingosine kinase in bone anabolism.
Specialized Terms: Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts.
Extensive Research Description
Dr. Insogna maintains active programs in both clinical and bench research.
In the clinical arena, Dr. Insogna is interested in the role of dietary protein in skeletal metabolism. Over the past decade, he and Dr. Jane Kerstetter from the University of Connecticut have established a new paradigm for the effect of dietary protein on calcium homeostasis. They have found that, contrary to the widely held view, increases in dietary protein within the physiologic range do not result in negative bone balance. Using dual stable calcium isotopes, they determined that the long-recognized hypercalciuria, which attends an increase in dietary protein, is quantitatively explained by improved intestinal calcium absorption, rather than increased bone resorption. In fact, the rate of resorption tends to slow as dietary protein is increased from low to high-normal. These data have led Drs. Insogna, Kerstetter, and Anne Kenney (from the University of Connecticut) to launch an NIH-funded, multi-center trial examining the impact of a dietary protein supplement on bone metabolism in postmenopausal women. Ongoing studies also seek to better define the cellular and molecular mechanisms by which dietary protein augments intestinal calcium absorption. Some of this work suggests a potential role for the calcium-sensing receptor, but alternative theories are currently being explored in the laboratory.
Another area of active clinical investigation involves understanding the factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets. Research over the last decade has improved our understanding of the pathogenesis of hypophosphatemic disorders, and this new information is being applied in two clinical trials currently being conducted by Dr. Insogna and Dr. Thomas Carpenter from the Department of Pediatrics. These studies seek to determine the clinical and biochemical factors that lead to skeletal complications, such as enthesopathy and spinal ligament calcification, in this disease. Finally, Dr. Insogna and Dr. M. Tish Knobf from the School of Nursing are beginning an NIH-funded study to examine the impact of exercise on bone health in postmenopausal breast cancer survivors.
In the laboratory, Dr. Insogna’s interest focuses on cellular mechanisms of PTH-induced bone resorption and bone anabolism. He has had a long-standing interest in the role of interleukin-6 in mediating PTH-induced bone resorption. Current efforts in that area focus on the role of IL-6 in PTH-induced RANK ligand expression. Another major research effort in the laboratory is to define the role of the two Colony Stimulating Factor-1 (CSF1) isoforms in bone. Work from the Insogna laboratory has established that CSF1 is the major colony-stimulating factor released by osteoblasts in response to PTH. Further work supports the hypothesis that the soluble and membrane CSF1 isoforms serve non-redundant roles in bone. Selective deletion of each isoform in vivo is being pursued to better define their separate roles. As an example, we are currently examining the possibility that sCSF-1 has a unique role in estrogen-deficiency bone loss.
The laboratory is also interested in the effects of CSF1 in mature osteoclasts. CSF-1 is an important chemoattractant in vivo for osteoclasts, and the laboratory is exploring the molecular mechanisms by which CSF-1 induces cytoskeletal remodeling and osteoclast motility. The downstream targets for CSF1 in osteoclasts include PI 3-kinase, Rac1, LIM kinase 1, and cofilin. In the course of this work, the laboratory has identified unique interacting proteins that partner with Rac1, including BCA3, (Breast Cancer Associated Protein 3). The role of BCA3 is incompletely understood but one function appears to be a nuclear/cytoplasmic shuttle. This finding, in conjunction with an emerging nuclear role Rac1 suggests novel, hitherto unappreciated nuclear functions for Rac1 in osteoclasts. There is an ongoing interest in the laboratory in identifying environmental and genetic modifiers of PTH’s anabolic actions, which has lead to studies exploring the modulating effects of aging, diet and genes that regulate osteoclast function. Finally, the laboratory is interested in Wnt signaling and its role in lineage allocation in bone. Our current interest is in identifying Wnt-dependent metabolic pathways that regulate mesenchymal stem cell differentiation towards the osteoblast lineage and away from an adipocyte fate. For more information on Dr. Insogna's bench and clinical research, please visit https://medicine.yale.edu/lab/insogna.
Coauthors
Research Interests
Bone and Bones; Bone Resorption; Endocrinology; Hypophosphatemia, Familial; Musculoskeletal Diseases; Osteoblasts; Osteoclasts; Osteogenesis; Skeleton; Sphingosine; Wnt Signaling Pathway; Rickets, Hypophosphatemic
Selected Publications
- New Therapies for Hypophosphatemia-Related to FGF23 Excess.Athonvarangkul D, Insogna KL. New Therapies for Hypophosphatemia-Related to FGF23 Excess. Calcified Tissue International 2021, 108: 143-157. PMID: 32504139, DOI: 10.1007/s00223-020-00705-3.
- Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen.Zhu M, Sun BH, Nevius E, Kaplan J, Pereira J, Insogna K. Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen. PloS One 2021, 16: e0247199. PMID: 33607650, PMCID: PMC7895546, DOI: 10.1371/journal.pone.0247199.
- Corrigendum to "Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation" [Bone Rep. 9 (2018) 154-158].Timme K, Rangel ES, Yuan Q, Wu D, Carpenter TO, Insogna K. Corrigendum to "Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation" [Bone Rep. 9 (2018) 154-158]. Bone Reports 2020, 12: 100252. PMID: 32195293, PMCID: PMC7078292, DOI: 10.1016/j.bonr.2020.100252.
- Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene.Yao GQ, Zhu M, Walker J, Insogna K. Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene. Calcified Tissue International 2020, 107: 52-59. PMID: 32246175, PMCID: PMC7274855, DOI: 10.1007/s00223-020-00685-4.
- Burosumab for the Treatment of Tumor-Induced Osteomalacia.Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, San Martin J, Carpenter TO. Burosumab for the Treatment of Tumor-Induced Osteomalacia. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2021, 36: 627-635. PMID: 33338281, PMCID: PMC8247961, DOI: 10.1002/jbmr.4233.
- Clinical and genetic analysis in a large Chinese cohort of patients with X-linked hypophosphatemia.Zhang C, Zhao Z, Sun Y, Xu L, JiaJue R, Cui L, Pang Q, Jiang Y, Li M, Wang O, He X, He S, Nie M, Xing X, Meng X, Zhou X, Yan L, Kaplan JM, Insogna KL, Xia W. Clinical and genetic analysis in a large Chinese cohort of patients with X-linked hypophosphatemia. Bone 2019, 121: 212-220. PMID: 30682568, DOI: 10.1016/j.bone.2019.01.021.
- Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period.Portale AA, Carpenter TO, Brandi ML, Briot K, Cheong HI, Cohen-Solal M, Crowley R, Jan De Beur S, Eastell R, Imanishi Y, Imel EA, Ing S, Ito N, Javaid M, Kamenicky P, Keen R, Kubota T, Lachmann R, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Zhang L, Theodore-Oklota C, Mealiffe M, San Martin J, Insogna K. Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period. Calcified Tissue International 2019, 105: 271-284. PMID: 31165191, DOI: 10.1007/s00223-019-00568-3.
- Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial.Insogna KL, Rauch F, Kamenický P, Ito N, Kubota T, Nakamura A, Zhang L, Mealiffe M, San Martin J, Portale AA. Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2019, 34: 2183-2191. PMID: 31369697, PMCID: PMC6916280, DOI: 10.1002/jbmr.3843.
- Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps.Hsieh E, Wang Q, Zhang R, Niu X, Xia W, Fraenkel L, Insogna KL, Li J, Smith JS, Zhou C, Qiao YL, Zhang P. Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps. BMC Cancer 2018, 18: 104. PMID: 29378534, PMCID: PMC5789645, DOI: 10.1186/s12885-018-4014-5.
- Three-Month Randomized Clinical Trial of Nasal Calcitonin in Adults with X-linked Hypophosphatemia.Sullivan R, Abraham A, Simpson C, Olear E, Carpenter T, Deng Y, Chen C, Insogna KL. Three-Month Randomized Clinical Trial of Nasal Calcitonin in Adults with X-linked Hypophosphatemia. Calcified Tissue International 2018, 102: 666-670. PMID: 29383408, PMCID: PMC5957766, DOI: 10.1007/s00223-017-0382-0.
- Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation.Shams-White MM, Chung M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Shi J, Wallace TC, Weaver CM. Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation. PloS One 2018, 13: e0192459. PMID: 29474360, PMCID: PMC5825010, DOI: 10.1371/journal.pone.0192459.
- Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women: results from a randomized placebo-controlled trial.Haas AV, Cong E, Simpson CA, Sukumar N, Deng Y, Insogna KL. Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women: results from a randomized placebo-controlled trial. Menopause (New York, N.Y.) 2018, 25: 197-201. PMID: 28816930, DOI: 10.1097/GME.0000000000000974.
- A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis.Insogna KL, Briot K, Imel EA, Kamenický P, Ruppe MD, Portale AA, Weber T, Pitukcheewanont P, Cheong HI, Jan de Beur S, Imanishi Y, Ito N, Lachmann RH, Tanaka H, Perwad F, Zhang L, Chen CY, Theodore-Oklota C, Mealiffe M, San Martin J, Carpenter TO. A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2018, 33: 1383-1393. PMID: 29947083, DOI: 10.1002/jbmr.3475.
- The contribution of cross-talk between the cell-surface proteins CD36 and CD47-TSP-1 in osteoclast formation and function.Koduru SV, Sun BH, Walker JM, Zhu M, Simpson C, Dhodapkar M, Insogna KL. The contribution of cross-talk between the cell-surface proteins CD36 and CD47-TSP-1 in osteoclast formation and function. The Journal Of Biological Chemistry 2018, 293: 15055-15069. PMID: 30082316, PMCID: PMC6166722, DOI: 10.1074/jbc.RA117.000633.
- Primary Hyperparathyroidism.Insogna KL. Primary Hyperparathyroidism. The New England Journal Of Medicine 2018, 379: 1050-1059. PMID: 30207907, DOI: 10.1056/NEJMcp1714213.
- Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation.Ang K, Sanchez Rangel E, Yuan Q, Wu D, Carpenter TO, Insogna K. Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation. Bone Reports 2018, 9: 154-158. PMID: 30364642, PMCID: PMC6197702, DOI: 10.1016/j.bonr.2018.09.001.
- Primary Hyperparathyroidism.Insogna KL. Primary Hyperparathyroidism. The New England Journal Of Medicine 2018, 379: e43. PMID: 30575486, DOI: 10.1056/NEJMc1813648.
- The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial.Stojkovic V, Simpson CA, Sullivan RR, Cusano AM, Kerstetter JE, Kenny AM, Insogna KL, Bihuniak JD. The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial. Nutrients 2017, 9 PMID: 28492492, PMCID: PMC5452214, DOI: 10.3390/nu9050484.
- Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo.Yao C, Yu KP, Philbrick W, Sun BH, Simpson C, Zhang C, Insogna K. Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo. International Journal Of Molecular Medicine 2017, 40: 1067-1077. PMID: 28791343, PMCID: PMC5593463, DOI: 10.3892/ijmm.2017.3091.
- Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group.Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE. Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group. The Journal Of Clinical Endocrinology And Metabolism 2017, 102: 3111-3123. PMID: 28655174, DOI: 10.1210/jc.2017-01127.
- Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis.Foer D, Zhu M, Cardone RL, Simpson C, Sullivan R, Nemiroff S, Lee G, Kibbey RG, Petersen KF, Insogna KL. Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis. Osteoporosis International : A Journal Established As Result Of Cooperation Between The European Foundation For Osteoporosis And The National Osteoporosis Foundation Of The USA 2017, 28: 2011-2017. PMID: 28283687, PMCID: PMC6693506, DOI: 10.1007/s00198-017-3977-4.
- Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation.Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Wallace TC, Weaver CM. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. The American Journal Of Clinical Nutrition 2017, 105: 1528-1543. PMID: 28404575, DOI: 10.3945/ajcn.116.145110.
- The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes.Knobf MT, Jeon S, Smith B, Harris L, Thompson S, Stacy MR, Insogna K, Sinusas AJ. The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes. Heart & Lung : The Journal Of Critical Care 2017, 46: 375-381. PMID: 28803675, PMCID: PMC6129386, DOI: 10.1016/j.hrtlng.2017.06.001.
- Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial.Viscoli CM, Inzucchi SE, Young LH, Insogna KL, Conwit R, Furie KL, Gorman M, Kelly MA, Lovejoy AM, Kernan WN. Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial. The Journal Of Clinical Endocrinology And Metabolism 2017, 102: 914-922. PMID: 27935736, PMCID: PMC5460686, DOI: 10.1210/jc.2016-3237.
- Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice.Yao GQ, Troiano N, Simpson CA, Insogna KL. Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice. Bone Research 2017, 5: 17022. PMID: 29152381, PMCID: PMC5684603, DOI: 10.1038/boneres.2017.22.
- Hypophosphatemia promotes lower rates of muscle ATP synthesis.Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. Hypophosphatemia promotes lower rates of muscle ATP synthesis. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2016, 30: 3378-3387. PMID: 27338702, PMCID: PMC5024687, DOI: 10.1096/fj.201600473R.
- Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy.Knobf MT, Jeon S, Smith B, Harris L, Kerstetter J, Thompson AS, Insogna K. Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy. Breast Cancer Research And Treatment 2016, 155: 491-500. PMID: 26850265, DOI: 10.1007/s10549-016-3693-3.
- Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia.Ruppe MD, Zhang X, Imel EA, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO. Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia. Bone Reports 2016, 5: 158-162. PMID: 28326356, PMCID: PMC4926842, DOI: 10.1016/j.bonr.2016.05.004.
- The liver throws the skeleton a bone (resorption factor).Chung C, Insogna KL. The liver throws the skeleton a bone (resorption factor). Hepatology (Baltimore, Md.) 2016, 64: 977-9. PMID: 27312397, PMCID: PMC4992574, DOI: 10.1002/hep.28688.
- Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV.Hsieh E, Fraenkel L, Han Y, Xia W, Insogna KL, Yin MT, Zhu T, Cheng X, Li T. Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV. AIDS (London, England) 2016, 30: 1935-42. PMID: 27124896, PMCID: PMC4949136, DOI: 10.1097/QAD.0000000000001131.
- Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo.Zhu M, Sun BH, Saar K, Simpson C, Troiano N, Dallas SL, Tiede-Lewis LM, Nevius E, Pereira JP, Weinstein RS, Tommasini SM, Insogna KL. Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2016, 31: 864-73. PMID: 26496249, PMCID: PMC4826801, DOI: 10.1002/jbmr.2733.
- Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia.Zhang X, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey J, Glorieux FH, Portale AA, Insogna K, Carpenter TO, Peacock M. Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia. Journal Of Clinical Pharmacology 2016, 56: 176-85. PMID: 26073451, PMCID: PMC5042055, DOI: 10.1002/jcph.570.
- Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV.Hsieh E, Fraenkel L, Xia W, Hu YY, Han Y, Insogna K, Yin MT, Xie J, Zhu T, Li T. Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV. Osteoporosis International : A Journal Established As Result Of Cooperation Between The European Foundation For Osteoporosis And The National Osteoporosis Foundation Of The USA 2015, 26: 1035-44. PMID: 25224293, PMCID: PMC4334679, DOI: 10.1007/s00198-014-2874-3.
- Effect of 25(OH) vitamin D reference method procedure (RMP) alignment on clinical measurements obtained with the IDS-iSYS chemiluminescent-based automated analyzer.Simpson CA, Cusano AM, Bihuniak J, Walker J, Insogna KL. Effect of 25(OH) vitamin D reference method procedure (RMP) alignment on clinical measurements obtained with the IDS-iSYS chemiluminescent-based automated analyzer. The Journal Of Steroid Biochemistry And Molecular Biology 2015, 148: 41-6. PMID: 25239596, DOI: 10.1016/j.jsbmb.2014.09.013.
- AgRP Neurons Regulate Bone Mass.Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL. AgRP Neurons Regulate Bone Mass. Cell Reports 2015, 13: 8-14. PMID: 26411686, PMCID: PMC5868421, DOI: 10.1016/j.celrep.2015.08.070.
- Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease.Connor J, Olear EA, Insogna KL, Katz L, Baker S, Kaur R, Simpson CA, Sterpka J, Dubrow R, Zhang JH, Carpenter TO. Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease. The Journal Of Clinical Endocrinology And Metabolism 2015, 100: 3625-32. PMID: 26176801, PMCID: PMC4596038, DOI: 10.1210/JC.2015-2199.
- The effects of dietary protein and amino acids on skeletal metabolism.Bihuniak JD, Insogna KL. The effects of dietary protein and amino acids on skeletal metabolism. Molecular And Cellular Endocrinology 2015, 410: 78-86. PMID: 25843057, PMCID: PMC5852680, DOI: 10.1016/j.mce.2015.03.024.
- The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults.Kerstetter JE, Bihuniak JD, Brindisi J, Sullivan RR, Mangano KM, Larocque S, Kotler BM, Simpson CA, Maria Cusano A, Gaffney-Stomberg E, Kleppinger A, Reynolds J, Dziura J, Kenny AM, Insogna KL. The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults. The Journal Of Clinical Endocrinology And Metabolism 2015, 100: 2214-22. PMID: 25844619, PMCID: PMC4454800, DOI: 10.1210/jc.2014-3792.
- Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures.Larocque SC, Kerstetter JE, Cauley JA, Insogna KL, Ensrud K, Lui LY, Allore HG. Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures. Journal Of Nutrition In Gerontology And Geriatrics 2015, 34: 305-18. PMID: 26267443, PMCID: PMC4547350, DOI: 10.1080/21551197.2015.1054574.
- Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.Imel EA, Zhang X, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO. Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23. The Journal Of Clinical Endocrinology And Metabolism 2015, 100: 2565-73. PMID: 25919461, PMCID: PMC4495171, DOI: 10.1210/jc.2015-1551.
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell 2015, 162: 1217-28. PMID: 26321681, PMCID: PMC4567953, DOI: 10.1016/j.cell.2015.08.012.
- Bone Health and Osteoporosis.Lupsa BC, Insogna K. Bone Health and Osteoporosis. Endocrinology And Metabolism Clinics Of North America 2015, 44: 517-30. PMID: 26316240, DOI: 10.1016/j.ecl.2015.05.002.
- An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008.Mangano KM, Kerstetter JE, Kenny AM, Insogna KL, Walsh SJ. An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008. Osteoporosis International : A Journal Established As Result Of Cooperation Between The European Foundation For Osteoporosis And The National Osteoporosis Foundation Of The USA 2014, 25: 1033-41. PMID: 24121998, PMCID: PMC3969769, DOI: 10.1007/s00198-013-2501-8.
- Effect of paricalcitol on circulating parathyroid hormone in X-linked hypophosphatemia: a randomized, double-blind, placebo-controlled study.Carpenter TO, Olear EA, Zhang JH, Ellis BK, Simpson CA, Cheng D, Gundberg CM, Insogna KL. Effect of paricalcitol on circulating parathyroid hormone in X-linked hypophosphatemia: a randomized, double-blind, placebo-controlled study. The Journal Of Clinical Endocrinology And Metabolism 2014, 99: 3103-11. PMID: 25029424, PMCID: PMC4154090, DOI: 10.1210/jc.2014-2017.
- Denosumab for treatment of hypercalcemia of malignancy.Hu MI, Glezerman IG, Leboulleux S, Insogna K, Gucalp R, Misiorowski W, Yu B, Zorsky P, Tosi D, Bessudo A, Jaccard A, Tonini G, Ying W, Braun A, Jain RK. Denosumab for treatment of hypercalcemia of malignancy. The Journal Of Clinical Endocrinology And Metabolism 2014, 99: 3144-52. PMID: 24915117, PMCID: PMC4154084, DOI: 10.1210/jc.2014-1001.
- Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats.Cao C, Thomas CE, Insogna KL, O'Brien KO. Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats. The Journal Of Nutrition 2014, 144: 1710-7. PMID: 25332470, PMCID: PMC4195416, DOI: 10.3945/jn.114.197939.
- Dietary acid load is associated with lower bone mineral density in men with low intake of dietary calcium.Mangano KM, Walsh SJ, Kenny AM, Insogna KL, Kerstetter JE. Dietary acid load is associated with lower bone mineral density in men with low intake of dietary calcium. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2014, 29: 500-6. PMID: 23873776, PMCID: PMC3946957, DOI: 10.1002/jbmr.2053.
- Osteoporosis knowledge, self-efficacy, and health beliefs among Chinese individuals with HIV.Hsieh E, Fraenkel L, Bradley EH, Xia W, Insogna KL, Cui Q, Li K, Li T. Osteoporosis knowledge, self-efficacy, and health beliefs among Chinese individuals with HIV. Archives Of Osteoporosis 2014, 9: 201. PMID: 25487753, PMCID: PMC4269230, DOI: 10.1007/s11657-014-0201-4.
- Measurement of plasma, serum, and platelet serotonin in individuals with high bone mass and mutations in LRP5.Lee GS, Simpson C, Sun BH, Yao C, Foer D, Sullivan B, Matthes S, Alenina N, Belsky J, Bader M, Insogna KL. Measurement of plasma, serum, and platelet serotonin in individuals with high bone mass and mutations in LRP5. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2014, 29: 976-81. PMID: 24038240, PMCID: PMC3935983, DOI: 10.1002/jbmr.2086.
- The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.Yao C, Yao GQ, Sun BH, Zhang C, Tommasini SM, Insogna K. The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis. The Journal Of Biological Chemistry 2014, 289: 6775-6790. PMID: 24394418, PMCID: PMC3945339, DOI: 10.1074/jbc.M113.499210.
- Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women.Bihuniak JD, Sullivan RR, Simpson CA, Caseria DM, Huedo-Medina TB, O'Brien KO, Kerstetter JE, Insogna KL. Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women. The Journal Of Nutrition 2014, 144: 282-8. PMID: 24431325, PMCID: PMC3927545, DOI: 10.3945/jn.113.185009.
- Adequate dietary protein is associated with better physical performance among post-menopausal women 60-90 years.Gregorio L, Brindisi J, Kleppinger A, Sullivan R, Mangano KM, Bihuniak JD, Kenny AM, Kerstetter JE, Insogna KL. Adequate dietary protein is associated with better physical performance among post-menopausal women 60-90 years. The Journal Of Nutrition, Health & Aging 2014, 18: 155-60. PMID: 24522467, PMCID: PMC4433492, DOI: 10.1007/s12603-013-0391-2.
- Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia.Carpenter TO, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Wooddell MM, Kawakami T, Ito T, Zhang X, Humphrey J, Insogna KL, Peacock M. Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia. The Journal Of Clinical Investigation 2014, 124: 1587-97. PMID: 24569459, PMCID: PMC3973088, DOI: 10.1172/JCI72829.
- Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis.Dasgupta D, Wee MJ, Reyes M, Li Y, Simm PJ, Sharma A, Schlingmann KP, Janner M, Biggin A, Lazier J, Gessner M, Chrysis D, Tuchman S, Baluarte HJ, Levine MA, Tiosano D, Insogna K, Hanley DA, Carpenter TO, Ichikawa S, Hoppe B, Konrad M, Sävendahl L, Munns CF, Lee H, Jüppner H, Bergwitz C. Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis. Journal Of The American Society Of Nephrology : JASN 2014, 25: 2366-75. PMID: 24700880, PMCID: PMC4178443, DOI: 10.1681/ASN.2013101085.
- Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5.Simpson CA, Foer D, Lee GS, Bihuniak J, Sun B, Sullivan R, Belsky J, Insogna KL. Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5. Osteoporosis International : A Journal Established As Result Of Cooperation Between The European Foundation For Osteoporosis And The National Osteoporosis Foundation Of The USA 2014, 25: 2383-8. PMID: 24927689, PMCID: PMC4659359, DOI: 10.1007/s00198-014-2767-5.
- Denosumab for patients with persistent or relapsed hypercalcemia of malignancy despite recent bisphosphonate treatment.Hu MI, Glezerman I, Leboulleux S, Insogna K, Gucalp R, Misiorowski W, Yu B, Ying W, Jain RK. Denosumab for patients with persistent or relapsed hypercalcemia of malignancy despite recent bisphosphonate treatment. Journal Of The National Cancer Institute 2013, 105: 1417-20. PMID: 23990665, PMCID: PMC3776443, DOI: 10.1093/jnci/djt225.
- LIM kinase 1 deficient mice have reduced bone mass.Kawano T, Zhu M, Troiano N, Horowitz M, Bian J, Gundberg C, Kolodziejczak K, Insogna K. LIM kinase 1 deficient mice have reduced bone mass. Bone 2013, 52: 70-82. PMID: 23017662, PMCID: PMC3688839, DOI: 10.1016/j.bone.2012.09.024.
- Claudins, dietary milk proteins, and intestinal barrier regulation.Kotler BM, Kerstetter JE, Insogna KL. Claudins, dietary milk proteins, and intestinal barrier regulation. Nutrition Reviews 2013, 71: 60-5. PMID: 23282252, DOI: 10.1111/j.1753-4887.2012.00549.x.
- Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.Thomas CE, Gaffney-Stomberg E, Sun BH, O'Brien KO, Kerstetter JE, Insogna KL. Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2013, 27: 2476-83. PMID: 23447582, DOI: 10.1096/fj.12-221945.
- Dietary protein-induced increases in urinary calcium are accompanied by similar increases in urinary nitrogen and urinary urea: a controlled clinical trial.Bihuniak JD, Simpson CA, Sullivan RR, Caseria DM, Kerstetter JE, Insogna KL. Dietary protein-induced increases in urinary calcium are accompanied by similar increases in urinary nitrogen and urinary urea: a controlled clinical trial. Journal Of The Academy Of Nutrition And Dietetics 2013, 113: 447-451. PMID: 23438496, PMCID: PMC5868414, DOI: 10.1016/j.jand.2012.11.002.
- Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing.Frey MA, Michaud M, VanHouten JN, Insogna KL, Madri JA, Barrett SE. Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5190-5. PMID: 22431609, PMCID: PMC3325667, DOI: 10.1073/pnas.1117293109.
- Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss.Yao GQ, Wu JJ, Troiano N, Zhu ML, Xiao XY, Insogna K. Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss. Journal Of Bone And Mineral Metabolism 2012, 30: 408-18. PMID: 22105655, PMCID: PMC4378684, DOI: 10.1007/s00774-011-0336-y.
- Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.Yao GQ, Wu JJ, Troiano N, Insogna K. Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice. Journal Of Bone And Mineral Metabolism 2011, 29: 141-8. PMID: 20602130, PMCID: PMC3457021, DOI: 10.1007/s00774-010-0202-3.
- Control of bone formation by the serpentine receptor Frizzled-9.Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M, Schilling AF, Rueger JM, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna KL, Pober B, Knobeloch KP, Francke U, Amling M, Schinke T. Control of bone formation by the serpentine receptor Frizzled-9. The Journal Of Cell Biology 2011, 192: 1057-72. PMID: 21402791, PMCID: PMC3063134, DOI: 10.1083/jcb.201008012.
- Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity.Itokowa T, Zhu ML, Troiano N, Bian J, Kawano T, Insogna K. Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity. Calcified Tissue International 2011, 88: 75-86. PMID: 21110188, PMCID: PMC3155765, DOI: 10.1007/s00223-010-9435-3.
- A clinician's guide to X-linked hypophosphatemia.Carpenter TO, Imel EA, Holm IA, Jan de Beur SM, Insogna KL. A clinician's guide to X-linked hypophosphatemia. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2011, 26: 1381-8. PMID: 21538511, PMCID: PMC3157040, DOI: 10.1002/jbmr.340.
- Calcitonin administration in X-linked hypophosphatemia.Liu ES, Carpenter TO, Gundberg CM, Simpson CA, Insogna KL. Calcitonin administration in X-linked hypophosphatemia. The New England Journal Of Medicine 2011, 364: 1678-80. PMID: 21524226, PMCID: PMC3162370, DOI: 10.1056/NEJMc1010928.
- Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003-2006.Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE. Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003-2006. Journal Of The American Dietetic Association 2011, 111: 687-95. PMID: 21515114, PMCID: PMC3896234, DOI: 10.1016/j.jada.2011.02.014.
- Dietary protein and skeletal health: a review of recent human research.Kerstetter JE, Kenny AM, Insogna KL. Dietary protein and skeletal health: a review of recent human research. Current Opinion In Lipidology 2011, 22: 16-20. PMID: 21102327, PMCID: PMC4659357, DOI: 10.1097/MOL.0b013e3283419441.
- Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status.Carpenter TO, Insogna KL, Zhang JH, Ellis B, Nieman S, Simpson C, Olear E, Gundberg CM. Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status. The Journal Of Clinical Endocrinology And Metabolism 2010, 95: E352-7. PMID: 20685863, PMCID: PMC2968736, DOI: 10.1210/jc.2010-0589.
- The effect of dietary protein on intestinal calcium absorption in rats.Gaffney-Stomberg E, Sun BH, Cucchi CE, Simpson CA, Gundberg C, Kerstetter JE, Insogna KL. The effect of dietary protein on intestinal calcium absorption in rats. Endocrinology 2010, 151: 1071-8. PMID: 20147526, PMCID: PMC2840679, DOI: 10.1210/en.2009-0744.
- Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial.Wright MJ, Sullivan RR, Gaffney-Stomberg E, Caseria DM, O'Brien KO, Proctor DD, Simpson CA, Kerstetter JE, Insogna KL. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2010, 25: 2205-11. PMID: 20499372, PMCID: PMC3312746, DOI: 10.1002/jbmr.108.
- Optimizing bone health in older adults: the importance of dietary protein.Surdykowski AK, Kenny AM, Insogna KL, Kerstetter JE. Optimizing bone health in older adults: the importance of dietary protein. Aging Health 2010, 6: 345-357. PMID: 20657805, PMCID: PMC2907525, DOI: 10.2217/ahe.10.16.
- Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.Kukreja A, Radfar S, Sun BH, Insogna K, Dhodapkar MV. Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease. Blood 2009, 114: 3413-21. PMID: 19661269, PMCID: PMC2765677, DOI: 10.1182/blood-2009-03-211920.
- Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice.Liang G, Katz LD, Insogna KL, Carpenter TO, Macica CM. Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice. Calcified Tissue International 2009, 85: 235-46. PMID: 19609735, PMCID: PMC2988401, DOI: 10.1007/s00223-009-9270-6.
- Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice.Yao GQ, Wu JJ, Ovadia S, Troiano N, Sun BH, Insogna K. Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice. American Journal Of Physiology. Endocrinology And Metabolism 2009, 296: E714-20. PMID: 19141689, PMCID: PMC2670621, DOI: 10.1152/ajpendo.90631.2008.
- Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone.Williams BO, Insogna KL. Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2009, 24: 171-8. PMID: 19072724, PMCID: PMC3276354, DOI: 10.1359/jbmr.081235.
- The effect of proton pump-inhibiting drugs on mineral metabolism.Insogna KL. The effect of proton pump-inhibiting drugs on mineral metabolism. The American Journal Of Gastroenterology 2009, 104 Suppl 2: S2-4. PMID: 19262542, DOI: 10.1038/ajg.2009.44.
- Increasing dietary protein requirements in elderly people for optimal muscle and bone health.Gaffney-Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE. Increasing dietary protein requirements in elderly people for optimal muscle and bone health. Journal Of The American Geriatrics Society 2009, 57: 1073-9. PMID: 19460090, DOI: 10.1111/j.1532-5415.2009.02285.x.
- Impact of glucose-dependent insulinotropic peptide on age-induced bone loss.Ding KH, Shi XM, Zhong Q, Kang B, Xie D, Bollag WB, Bollag RJ, Hill W, Washington W, Mi QS, Insogna K, Chutkan N, Hamrick M, Isales CM. Impact of glucose-dependent insulinotropic peptide on age-induced bone loss. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2008, 23: 536-43. PMID: 18072880, PMCID: PMC2669161, DOI: 10.1359/jbmr.071202.
- Proton pump-inhibiting drugs, calcium homeostasis, and bone health.Wright MJ, Proctor DD, Insogna KL, Kerstetter JE. Proton pump-inhibiting drugs, calcium homeostasis, and bone health. Nutrition Reviews 2008, 66: 103-8. PMID: 18254877, DOI: 10.1111/j.1753-4887.2008.00015.x.
- An aerobic weight-loaded pilot exercise intervention for breast cancer survivors: bone remodeling and body composition outcomes.Knobf MT, Insogna K, DiPietro L, Fennie C, Thompson AS. An aerobic weight-loaded pilot exercise intervention for breast cancer survivors: bone remodeling and body composition outcomes. Biological Research For Nursing 2008, 10: 34-43. PMID: 18705153, PMCID: PMC3540790, DOI: 10.1177/1099800408320579.
- The anabolic response to parathyroid hormone is augmented in Rac2 knockout mice.Kawano T, Troiano N, Adams DJ, Wu JJ, Sun BH, Insogna K. The anabolic response to parathyroid hormone is augmented in Rac2 knockout mice. Endocrinology 2008, 149: 4009-15. PMID: 18467443, PMCID: PMC2488220, DOI: 10.1210/en.2008-0034.
- Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus?Insogna K. Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus? Nature Clinical Practice. Endocrinology & Metabolism 2008, 4: 366-7. PMID: 18461065, DOI: 10.1038/ncpendmet0835.
- Orthopaedic management improves the rate of early osteoporosis treatment after hip fracture. A randomized clinical trial.Miki RA, Oetgen ME, Kirk J, Insogna KL, Lindskog DM. Orthopaedic management improves the rate of early osteoporosis treatment after hip fracture. A randomized clinical trial. The Journal Of Bone And Joint Surgery. American Volume 2008, 90: 2346-53. PMID: 18978403, DOI: 10.2106/JBJS.G.01246.
- The role of the receptor activator of nuclear factor-kappaB ligand/osteoprotegerin cytokine system in primary hyperparathyroidism.Nakchbandi IA, Lang R, Kinder B, Insogna KL. The role of the receptor activator of nuclear factor-kappaB ligand/osteoprotegerin cytokine system in primary hyperparathyroidism. The Journal Of Clinical Endocrinology And Metabolism 2008, 93: 967-73. PMID: 18073309, PMCID: PMC2266956, DOI: 10.1210/jc.2007-1645.
- Expression and synthesis of bone morphogenetic proteins by osteoclasts: a possible path to anabolic bone remodeling.Garimella R, Tague SE, Zhang J, Belibi F, Nahar N, Sun BH, Insogna K, Wang J, Anderson HC. Expression and synthesis of bone morphogenetic proteins by osteoclasts: a possible path to anabolic bone remodeling. The Journal Of Histochemistry And Cytochemistry : Official Journal Of The Histochemistry Society 2008, 56: 569-77. PMID: 18319273, PMCID: PMC2386763, DOI: 10.1369/jhc.2008.950394.
- Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 2008, 135: 825-37. PMID: 19041748, PMCID: PMC2614332, DOI: 10.1016/j.cell.2008.09.059.
- A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3.Page K, Bergwitz C, Jaureguiberry G, Harinarayan CV, Insogna K. A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3. Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists 2008, 14: 869-74. PMID: 18996815, PMCID: PMC2773288, DOI: 10.4158/EP.14.7.869.
- Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.Bouyer P, Sakai H, Itokawa T, Kawano T, Fulton CM, Boron WF, Insogna KL. Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1. Endocrinology 2007, 148: 831-40. PMID: 17068143, DOI: 10.1210/en.2006-0547.
- Effects of glucose-dependent insulinotropic peptide on osteoclast function.Zhong Q, Itokawa T, Sridhar S, Ding KH, Xie D, Kang B, Bollag WB, Bollag RJ, Hamrick M, Insogna K, Isales CM. Effects of glucose-dependent insulinotropic peptide on osteoclast function. American Journal Of Physiology. Endocrinology And Metabolism 2007, 292: E543-8. PMID: 17003233, DOI: 10.1152/ajpendo.00364.2006.
- Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting protein.Yu KP, Itokawa T, Zhu ML, Syam S, Seth A, Insogna K. Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting protein. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2007, 22: 628-37. PMID: 17227220, DOI: 10.1359/jbmr.070105.
- Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass.Xie D, Zhong Q, Ding KH, Cheng H, Williams S, Correa D, Bollag WB, Bollag RJ, Insogna K, Troiano N, Coady C, Hamrick M, Isales CM. Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass. Bone 2007, 40: 1352-60. PMID: 17321229, DOI: 10.1016/j.bone.2007.01.007.
- Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.Sakai H, Chen Y, Itokawa T, Yu KP, Zhu ML, Insogna K. Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts. Bone 2006, 39: 1290-301. PMID: 16950670, DOI: 10.1016/j.bone.2006.06.012.
- The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice.Ovadia S, Insogna K, Yao GQ. The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice. Biology Of Reproduction 2006, 74: 331-6. PMID: 16237150, DOI: 10.1095/biolreprod.105.045047.
- Meat and soy protein affect calcium homeostasis in healthy women.Kerstetter JE, Wall DE, O'Brien KO, Caseria DM, Insogna KL. Meat and soy protein affect calcium homeostasis in healthy women. The Journal Of Nutrition 2006, 136: 1890-5. PMID: 16772455, DOI: 10.1093/jn/136.7.1890.
- CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts.Yao GQ, Itokawa T, Paliwal I, Insogna K. CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts. Calcified Tissue International 2005, 76: 371-8. PMID: 15812575, DOI: 10.1007/s00223-004-0099-8.
- L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells.Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2005, 289: G664-9. PMID: 15961860, DOI: 10.1152/ajpgi.00096.2005.
- The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women.Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KL. The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. The Journal Of Clinical Endocrinology And Metabolism 2005, 90: 26-31. PMID: 15546911, DOI: 10.1210/jc.2004-0179.
- Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors.Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R. Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. The Journal Of Clinical Endocrinology And Metabolism 2005, 90: 1012-20. PMID: 15562028, DOI: 10.1210/jc.2004-0357.
- Isotretinoin does have an adverse effect on bone mineral density.Milstone LM, Insogna KL, Leachman SA. Isotretinoin does have an adverse effect on bone mineral density. Journal Of The American Academy Of Dermatology 2005, 53: 181; author reply 182-3. PMID: 15965453, DOI: 10.1016/j.jaad.2005.03.025.
- Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover.Xie D, Cheng H, Hamrick M, Zhong Q, Ding KH, Correa D, Williams S, Mulloy A, Bollag W, Bollag RJ, Runner RR, McPherson JC, Insogna K, Isales CM. Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover. Bone 2005, 37: 759-69. PMID: 16219496, DOI: 10.1016/j.bone.2005.06.021.
- The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone.Knopp E, Troiano N, Bouxsein M, Sun BH, Lostritto K, Gundberg C, Dziura J, Insogna K. The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone. Endocrinology 2005, 146: 1983-90. PMID: 15618351, DOI: 10.1210/en.2004-0770.
- Multiple melanocortin receptors are expressed in bone cells.Zhong Q, Sridhar S, Ruan L, Ding KH, Xie D, Insogna K, Kang B, Xu J, Bollag RJ, Isales CM. Multiple melanocortin receptors are expressed in bone cells. Bone 2005, 36: 820-31. PMID: 15804492, DOI: 10.1016/j.bone.2005.01.020.
- LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.Yang X, Yu K, Hao Y, Li DM, Stewart R, Insogna KL, Xu T. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nature Cell Biology 2004, 6: 609-17. PMID: 15220930, DOI: 10.1038/ncb1140.
- The expanding role of PI3-kinase in bone.Golden LH, Insogna KL. The expanding role of PI3-kinase in bone. Bone 2004, 34: 3-12. PMID: 14751558, DOI: 10.1016/j.bone.2003.09.005.
- Multisystem study of 20 older adults with Williams syndrome.Cherniske EM, Carpenter TO, Klaiman C, Young E, Bregman J, Insogna K, Schultz RT, Pober BR. Multisystem study of 20 older adults with Williams syndrome. American Journal Of Medical Genetics. Part A 2004, 131: 255-64. PMID: 15534874, DOI: 10.1002/ajmg.a.30400.
- The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo.Yao GQ, Wu JJ, Sun BH, Troiano N, Mitnick MA, Insogna K. The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo. Endocrinology 2003, 144: 3677-82. PMID: 12865350, DOI: 10.1210/en.2002-221071.
- Torus palatinus: a new anatomical correlation with bone density in postmenopausal women.Belsky JL, Hamer JS, Hubert JE, Insogna K, Johns W. Torus palatinus: a new anatomical correlation with bone density in postmenopausal women. The Journal Of Clinical Endocrinology And Metabolism 2003, 88: 2081-6. PMID: 12727958, DOI: 10.1210/jc.2002-021726.
- Dietary protein, calcium metabolism, and skeletal homeostasis revisited.Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. The American Journal Of Clinical Nutrition 2003, 78: 584S-592S. PMID: 12936953, DOI: 10.1093/ajcn/78.3.584S.
- Low protein intake: the impact on calcium and bone homeostasis in humans.Kerstetter JE, O'Brien KO, Insogna KL. Low protein intake: the impact on calcium and bone homeostasis in humans. The Journal Of Nutrition 2003, 133: 855S-861S. PMID: 12612169, DOI: 10.1093/jn/133.3.855S.
- High bone density due to a mutation in LDL-receptor-related protein 5.Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP. High bone density due to a mutation in LDL-receptor-related protein 5. The New England Journal Of Medicine 2002, 346: 1513-21. PMID: 12015390, DOI: 10.1056/NEJMoa013444.
- A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis.Yao GQ, Sun BH, Weir EC, Insogna KL. A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis. Calcified Tissue International 2002, 70: 339-46. PMID: 12004339, DOI: 10.1007/s00223-001-1079-x.
- Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis.Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2002, 17: 1164-70. PMID: 12096830, DOI: 10.1359/jbmr.2002.17.7.1164.
- Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate.Cruz DN, Brickel HM, Wysolmerski JJ, Gundberg CG, Simpson CA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2002, 2: 62-7. PMID: 12095058, DOI: 10.1034/j.1600-6143.2002.020111.x.
- Role of the interleukin-6/interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid hormone in perimenopausal women.Insogna K, Mitnick M, Pascarella J, Nakchbandi I, Grey A, Masiukiewicz U. Role of the interleukin-6/interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid hormone in perimenopausal women. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2002, 17 Suppl 2: N108-16. PMID: 12412787.
- Evidence that the IL-6/IL-6 soluble receptor cytokine system plays a role in the increased skeletal sensitivity to PTH in estrogen-deficient women.Masiukiewicz US, Mitnick M, Gulanski BI, Insogna KL. Evidence that the IL-6/IL-6 soluble receptor cytokine system plays a role in the increased skeletal sensitivity to PTH in estrogen-deficient women. The Journal Of Clinical Endocrinology And Metabolism 2002, 87: 2892-8. PMID: 12050269, DOI: 10.1210/jcem.87.6.8577.
- Circulating levels of interleukin-6 soluble receptor predict rates of bone loss in patients with primary hyperparathyroidism.Nakchbandi IA, Mitnick MA, Lang R, Gundberg C, Kinder B, Insogna K. Circulating levels of interleukin-6 soluble receptor predict rates of bone loss in patients with primary hyperparathyroidism. The Journal Of Clinical Endocrinology And Metabolism 2002, 87: 4946-51. PMID: 12414855, DOI: 10.1210/jc.2001-011814.
- IL-6 negatively regulates IL-11 production in vitro and in vivo.Nakchbandi IA, Mitnick MA, Masiukiewicz US, Sun BH, Insogna KL. IL-6 negatively regulates IL-11 production in vitro and in vivo. Endocrinology 2001, 142: 3850-6. PMID: 11517162, DOI: 10.1210/endo.142.9.8368.
- Dietary protein and intestinal calcium absorption.Kerstetter JE, O'Brien K, Insogna K. Dietary protein and intestinal calcium absorption. The American Journal Of Clinical Nutrition 2001, 73: 990-2. PMID: 11333855, DOI: 10.1093/ajcn/73.5.990.
- Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor.Mitnick MA, Grey A, Masiukiewicz U, Bartkiewicz M, Rios-Velez L, Friedman S, Xu L, Horowitz MC, Insogna K. Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor. American Journal Of Physiology. Endocrinology And Metabolism 2001, 280: E405-12. PMID: 11171594, DOI: 10.1152/ajpendo.2001.280.3.E405.
- Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study.Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study. Transplantation 2001, 72: 83-8. PMID: 11468539, DOI: 10.1097/00007890-200107150-00017.
- Nuclear factor-kappaB p50 is required for tumor necrosis factor-alpha-induced colony-stimulating factor-1 gene expression in osteoblasts.Yao GQ, Sun BH, Insogna KL, Weir EC. Nuclear factor-kappaB p50 is required for tumor necrosis factor-alpha-induced colony-stimulating factor-1 gene expression in osteoblasts. Endocrinology 2000, 141: 2914-22. PMID: 10919279, DOI: 10.1210/endo.141.8.7592.
- Low dietary protein and low bone density.Kerstetter JE, Looker AC, Insogna KL. Low dietary protein and low bone density. Calcified Tissue International 2000, 66: 313. PMID: 10742451.
- Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade.Nakchbandi IA, Weir EE, Insogna KL, Philbrick WM, Broadus AE. Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7296-300. PMID: 10829073, PMCID: PMC16539, DOI: 10.1073/pnas.110553397.
- Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1.Grey A, Chen Y, Paliwal I, Carlberg K, Insogna K. Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1. Endocrinology 2000, 141: 2129-38. PMID: 10830300, DOI: 10.1210/endo.141.6.7480.
- Estrogen modulates parathyroid hormone-induced interleukin-6 production in vivo and in vitro.Masiukiewicz US, Mitnick M, Grey AB, Insogna KL. Estrogen modulates parathyroid hormone-induced interleukin-6 production in vivo and in vitro. Endocrinology 2000, 141: 2526-31. PMID: 10875254, DOI: 10.1210/endo.141.7.7537.
- A threshold for low-protein-diet-induced elevations in parathyroid hormone.Kerstetter JE, Svastisalee CM, Caseria DM, Mitnick ME, Insogna KL. A threshold for low-protein-diet-induced elevations in parathyroid hormone. The American Journal Of Clinical Nutrition 2000, 72: 168-73. PMID: 10871576, DOI: 10.1093/ajcn/72.1.168.
- Posttransplant bone disease: evidence for a high bone resorption state.Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M. Posttransplant bone disease: evidence for a high bone resorption state. Transplantation 2000, 70: 1722-8. PMID: 11152104.
- Bone densities in patients receiving isotretinoin for cystic acne.Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone densities in patients receiving isotretinoin for cystic acne. Archives Of Dermatology 1999, 135: 961-5. PMID: 10456346.
- A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo.Grey A, Mitnick MA, Masiukiewicz U, Sun BH, Rudikoff S, Jilka RL, Manolagas SC, Insogna K. A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo. Endocrinology 1999, 140: 4683-90. PMID: 10499526, DOI: 10.1210/endo.140.10.7036.
- Changes in bone turnover in young women consuming different levels of dietary protein.Kerstetter JE, Mitnick ME, Gundberg CM, Caseria DM, Ellison AF, Carpenter TO, Insogna KL. Changes in bone turnover in young women consuming different levels of dietary protein. The Journal Of Clinical Endocrinology And Metabolism 1999, 84: 1052-5. PMID: 10084594, DOI: 10.1210/jcem.84.3.5552.
- The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells.Yao GQ, Sun Bh, Hammond EE, Spencer EN, Horowitz MC, Insogna KL, Weir EC. The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells. The Journal Of Biological Chemistry 1998, 273: 4119-28. PMID: 9461606.
- The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal osteoporosis.Masiukiewicz US, Insogna KL. The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal osteoporosis. Aging (Milan, Italy) 1998, 10: 232-9. PMID: 9801733, DOI: 10.1007/BF03339657.
- Dietary protein affects intestinal calcium absorption.Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein affects intestinal calcium absorption. The American Journal Of Clinical Nutrition 1998, 68: 859-65. PMID: 9771863, DOI: 10.1093/ajcn/68.4.859.
- Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts.Insogna KL, Sahni M, Grey AB, Tanaka S, Horne WC, Neff L, Mitnick M, Levy JB, Baron R. Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts. The Journal Of Clinical Investigation 1997, 100: 2476-85. PMID: 9366562, PMCID: PMC508448, DOI: 10.1172/JCI119790.
- Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet.Kerstetter JE, Caseria DM, Mitnick ME, Ellison AF, Gay LF, Liskov TA, Carpenter TO, Insogna KL. Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet. The American Journal Of Clinical Nutrition 1997, 66: 1188-96. PMID: 9356538, DOI: 10.1093/ajcn/66.5.1188.
- Role of c-Src in cellular events associated with colony-stimulating factor-1-induced spreading in osteoclasts.Insogna K, Tanaka S, Neff L, Horne W, Levy J, Baron R. Role of c-Src in cellular events associated with colony-stimulating factor-1-induced spreading in osteoclasts. Molecular Reproduction And Development 1997, 46: 104-8. PMID: 8981371, DOI: 10.1002/(SICI)1098-2795(199701)46:1<104::AID-MRD16>3.0.CO;2-2.
- Parathyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy.Sun BH, Mitnick M, Eielson C, Yao GQ, Paliwal I, Insogna K. Parathyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy. Endocrinology 1997, 138: 3918-24. PMID: 9275082, DOI: 10.1210/endo.138.9.5421.
- Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor-1 gene in murine osteoblasts.Kaplan DL, Eielson CM, Horowitz MC, Insogna KL, Weir EC. Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor-1 gene in murine osteoblasts. Journal Of Cellular Physiology 1996, 168: 199-208. PMID: 8647916, DOI: 10.1002/(SICI)1097-4652(199607)168:1<199::AID-JCP24>3.0.CO;2-1.
- Effects of continuous glucocorticoid infusion on bone metabolism in the rat.King CS, Weir EC, Gundberg CW, Fox J, Insogna KL. Effects of continuous glucocorticoid infusion on bone metabolism in the rat. Calcified Tissue International 1996, 59: 184-91. PMID: 8694896.
- 24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets--a clinical research center study.Carpenter TO, Keller M, Schwartz D, Mitnick M, Smith C, Ellison A, Carey D, Comite F, Horst R, Travers R, Glorieux FH, Gundberg CM, Poole AR, Insogna KL. 24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets--a clinical research center study. The Journal Of Clinical Endocrinology And Metabolism 1996, 81: 2381-8. PMID: 8964881, DOI: 10.1210/jcem.81.6.8964881.
- The effects of dairy products on body composition, bone mineralization, and weight in adolescent girls (Nutr Rev 1996;54:64-65)Kerstetter J, Insogna K. The effects of dairy products on body composition, bone mineralization, and weight in adolescent girls (Nutr Rev 1996;54:64-65) Nutrition Reviews 1996, 54: 66. PMID: 9053828, DOI: 10.1111/j.1753-4887.1996.tb03860.x.
- Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary hyperparathyroidism and correlate with markers of bone resorption--a clinical research center study.Grey A, Mitnick MA, Shapses S, Ellison A, Gundberg C, Insogna K. Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary hyperparathyroidism and correlate with markers of bone resorption--a clinical research center study. The Journal Of Clinical Endocrinology And Metabolism 1996, 81: 3450-4. PMID: 8855783, DOI: 10.1210/jcem.81.10.8855783.
- Boning up on estrogen: new options, new concerns.Insogna K, Concato J, Henrich J. Boning up on estrogen: new options, new concerns. JAMA 1996, 276: 1430-2. PMID: 8892721.
- Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein.Weir EC, Lowik CW, Paliwal I, Insogna KL. Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1996, 11: 1474-81. PMID: 8889847, DOI: 10.1002/jbmr.5650111014.
- Dietary hypercalciuria in patients with calcium oxalate kidney stones.Burtis WJ, Gay L, Insogna KL, Ellison A, Broadus AE. Dietary hypercalciuria in patients with calcium oxalate kidney stones. The American Journal Of Clinical Nutrition 1994, 60: 424-9. PMID: 8074077, DOI: 10.1093/ajcn/60.3.424.
- Nocturnal hyperparathyroidism: a frequent feature of X-linked hypophosphatemia.Carpenter TO, Mitnick MA, Ellison A, Smith C, Insogna KL. Nocturnal hyperparathyroidism: a frequent feature of X-linked hypophosphatemia. The Journal Of Clinical Endocrinology And Metabolism 1994, 78: 1378-83. PMID: 8200940, DOI: 10.1210/jcem.78.6.8200940.
- Estrogen modulates parathyroid hormone-induced fibronectin production in human and rat osteoblast-like cells.Eielson C, Kaplan D, Mitnick MA, Paliwal I, Insogna K. Estrogen modulates parathyroid hormone-induced fibronectin production in human and rat osteoblast-like cells. Endocrinology 1994, 135: 1639-44. PMID: 7925127, DOI: 10.1210/endo.135.4.7925127.
- Osteoporosis and aging: the continuing crisis.Insogna K. Osteoporosis and aging: the continuing crisis. Aging (Milan, Italy) 1994, 6: 65-7. PMID: 7918732.
- Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing.Yang KH, dePapp AE, Soifer NE, Dreyer BE, Wu TL, Porter SE, Bellantoni M, Burtis WJ, Insogna KL, Broadus AE. Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing. Biochemistry 1994, 33: 7460-9. PMID: 8003511.
- Macrophage colony-stimulating factor release and receptor expression in bone cells.Weir EC, Horowitz MC, Baron R, Centrella M, Kacinski BM, Insogna KL. Macrophage colony-stimulating factor release and receptor expression in bone cells. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1993, 8: 1507-18. PMID: 8304053, DOI: 10.1002/jbmr.5650081214.
- Secondary hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids.Milstone LM, Bale SJ, Insogna KL. Secondary hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids. Archives Of Dermatology 1993, 129: 648. PMID: 8481031.
- Calcium and kidney stones.Burtis WJ, Broadus AE, Insogna KL. Calcium and kidney stones. The New England Journal Of Medicine 1993, 329: 508-9. PMID: 8332168, DOI: 10.1056/NEJM199308123290716.
- Human granulosa-luteal cells secrete parathyroid hormone-related protein in vivo and in vitro.Gutmann JN, Burtis WJ, Dreyer BE, Andrade-Gordon P, Penzias AS, Polan ML, Insogna KL. Human granulosa-luteal cells secrete parathyroid hormone-related protein in vivo and in vitro. The Journal Of Clinical Endocrinology And Metabolism 1993, 76: 1314-8. PMID: 8496323, DOI: 10.1210/jcem.76.5.8496323.
- Synthetic parathyroid hormone-like protein (1-74) is anabolic for bone in vivo.Weir EC, Terwilliger G, Sartori L, Insogna KL. Synthetic parathyroid hormone-like protein (1-74) is anabolic for bone in vivo. Calcified Tissue International 1992, 51: 30-4. PMID: 1393774.
- Parathyroid hormone-related protein stimulates prostaglandin E2 release from human osteoblast-like cells: modulating effect of peptide length.Mitnick M, Isales C, Paliwal I, Insogna K. Parathyroid hormone-related protein stimulates prostaglandin E2 release from human osteoblast-like cells: modulating effect of peptide length. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1992, 7: 887-96. PMID: 1332431, DOI: 10.1002/jbmr.5650070805.
- Cross-cultural association between dietary animal protein and hip fracture: a hypothesis.Abelow BJ, Holford TR, Insogna KL. Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcified Tissue International 1992, 50: 14-8. PMID: 1739864.
- Serum parathyroid hormone level is elevated in some patients with disorders of keratinization.Milstone LM, Ellison AF, Insogna KL. Serum parathyroid hormone level is elevated in some patients with disorders of keratinization. Archives Of Dermatology 1992, 128: 926-30. PMID: 1320849.
- A prospective trial of phosphate and 1,25-dihydroxyvitamin D3 therapy in symptomatic adults with X-linked hypophosphatemic rickets.Sullivan W, Carpenter T, Glorieux F, Travers R, Insogna K. A prospective trial of phosphate and 1,25-dihydroxyvitamin D3 therapy in symptomatic adults with X-linked hypophosphatemic rickets. The Journal Of Clinical Endocrinology And Metabolism 1992, 75: 879-85. PMID: 1517380, DOI: 10.1210/jcem.75.3.1517380.
- Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types.Soifer NE, Dee KE, Insogna KL, Burtis WJ, Matovcik LM, Wu TL, Milstone LM, Broadus AE, Philbrick WM, Stewart AF. Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types. The Journal Of Biological Chemistry 1992, 267: 18236-43. PMID: 1517251.
- Treatment of sarcoidosis-associated hypercalcemia with ketoconazole.Bia MJ, Insogna K. Treatment of sarcoidosis-associated hypercalcemia with ketoconazole. American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation 1991, 18: 702-5. PMID: 1962657, DOI: 10.1016/s0272-6386(12)80613-5.
- Immunoaffinity purification of parathyroid hormone-related protein from bovine milk and human keratinocyte-conditioned medium.Stewart AF, Wu TL, Insogna KL, Milstone LM, Burtis WJ. Immunoaffinity purification of parathyroid hormone-related protein from bovine milk and human keratinocyte-conditioned medium. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1991, 6: 305-11. PMID: 2035357, DOI: 10.1002/jbmr.5650060313.
- The parathyroid hormone-related protein stimulates human osteoblast-like cells to secrete a 9,000 dalton bone-resorbing protein.Morris CA, Mitnick ME, Weir EC, Horowitz M, Kreider BL, Insogna KL. The parathyroid hormone-related protein stimulates human osteoblast-like cells to secrete a 9,000 dalton bone-resorbing protein. Endocrinology 1990, 126: 1783-5. PMID: 2307127, DOI: 10.1210/endo-126-3-1783.
- Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase.Brown GM, Morris CA, Mitnick MA, Insogna KL. Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1990, 5: 1037-41. PMID: 1964358, DOI: 10.1002/jbmr.5650051007.
- Vitamin D metabolism in chronic childhood hypoparathyroidism: evidence for a direct regulatory effect of calcium.Carpenter TO, Insogna KL, Boulware SD, Mitnick MA. Vitamin D metabolism in chronic childhood hypoparathyroidism: evidence for a direct regulatory effect of calcium. The Journal Of Pediatrics 1990, 116: 252-7. PMID: 2299496.
- Humoral hypercalcemia of malignancy. The role of parathyroid hormone-related protein.Insogna KL. Humoral hypercalcemia of malignancy. The role of parathyroid hormone-related protein. Endocrinology And Metabolism Clinics Of North America 1989, 18: 779-94. PMID: 2673773.
- Synthetic parathyroid hormone-like protein-(1-74): biochemical and physiological characterization.Stewart AF, Elliot J, Burtis WJ, Wu T, Insogna KL. Synthetic parathyroid hormone-like protein-(1-74): biochemical and physiological characterization. Endocrinology 1989, 124: 642-8. PMID: 2912692, DOI: 10.1210/endo-124-2-642.
- Synthesis of a gene encoding parathyroid hormone-like protein-(1-141): purification and biological characterization of the expressed protein.Thorikay M, Kramer S, Reynolds FH, Sorvillo JM, Doescher L, Wu T, Morris CA, Burtis WJ, Insogna KL, Valenzuela DM. Synthesis of a gene encoding parathyroid hormone-like protein-(1-141): purification and biological characterization of the expressed protein. Endocrinology 1989, 124: 111-8. PMID: 2535801, DOI: 10.1210/endo-124-1-111.
- Parathyroid hormone-related protein modulates the effect of transforming growth factor-beta on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells.Centrella M, Canalis E, McCarthy TL, Stewart AF, Orloff JJ, Insogna KL. Parathyroid hormone-related protein modulates the effect of transforming growth factor-beta on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells. Endocrinology 1989, 125: 199-208. PMID: 2737143, DOI: 10.1210/endo-125-1-199.
- Osteoblast-like cells secrete granulocyte-macrophage colony-stimulating factor in response to parathyroid hormone and lipopolysaccharide.Weir EC, Insogna KL, Horowitz MC. Osteoblast-like cells secrete granulocyte-macrophage colony-stimulating factor in response to parathyroid hormone and lipopolysaccharide. Endocrinology 1989, 124: 899-904. PMID: 2643512, DOI: 10.1210/endo-124-2-899.
- Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties.Insogna KL, Stewart AF, Morris CA, Hough LM, Milstone LM, Centrella M. Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties. The Journal Of Clinical Investigation 1989, 83: 1057-60. PMID: 2537846, PMCID: PMC303783, DOI: 10.1172/JCI113947.
- Trichlormethiazide and oral phosphate therapy in patients with absorptive hypercalciuria.Insogna KL, Ellison AS, Burtis WJ, Sartori L, Lang RL, Broadus AE. Trichlormethiazide and oral phosphate therapy in patients with absorptive hypercalciuria. The Journal Of Urology 1989, 141: 269-74. PMID: 2913343.
- Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.Stewart AF, Mangin M, Wu T, Goumas D, Insogna KL, Burtis WJ, Broadus AE. Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. The Journal Of Clinical Investigation 1988, 81: 596-600. PMID: 3339131, PMCID: PMC329608, DOI: 10.1172/JCI113358.
- Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac.Weir EC, Centrella M, Matus RE, Brooks ML, Wu T, Insogna KL. Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac. Calcified Tissue International 1988, 43: 359-65. PMID: 3146425.
- Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy.Ikeda K, Mangin M, Dreyer BE, Webb AC, Posillico JT, Stewart AF, Bander NH, Weir EC, Insogna KL, Broadus AE. Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. The Journal Of Clinical Investigation 1988, 81: 2010-4. PMID: 2454953, PMCID: PMC442656, DOI: 10.1172/JCI113551.
- Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy.Weir EC, Burtis WJ, Morris CA, Brady TG, Insogna KL. Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy. Endocrinology 1988, 123: 2744-51. PMID: 3197642, DOI: 10.1210/endo-123-6-2744.
- Renal phosphate transport in humoral hypercalcemia of malignancy.Sartori L, Insogna KL, Barrett PQ. Renal phosphate transport in humoral hypercalcemia of malignancy. The American Journal Of Physiology 1988, 255: F1078-84. PMID: 2974244, DOI: 10.1152/ajprenal.1988.255.6.F1078.
- Synthetic and partially-purified adenylate cyclase-stimulating proteins from tumors associated with humoral hypercalcemia of malignancy inhibit phosphate transport in a PTH-responsive renal cell line.Sartori L, Weir EC, Stewart AF, Broadus AE, Mangin M, Barrett PQ, Insogna KL. Synthetic and partially-purified adenylate cyclase-stimulating proteins from tumors associated with humoral hypercalcemia of malignancy inhibit phosphate transport in a PTH-responsive renal cell line. The Journal Of Clinical Endocrinology And Metabolism 1988, 66: 459-61. PMID: 3339117, DOI: 10.1210/jcem-66-2-459.
- Humoral hypercalcemia of malignancy in canine lymphosarcoma.Weir EC, Norrdin RW, Matus RE, Brooks MB, Broadus AE, Mitnick M, Johnston SD, Insogna KL. Humoral hypercalcemia of malignancy in canine lymphosarcoma. Endocrinology 1988, 122: 602-8. PMID: 2828006, DOI: 10.1210/endo-122-2-602.
- Effect of short-term somatostatin and long-term triiodothyronine administration in a child with nontumorous inappropriate thyrotropin secretion.Isales CM, Tamborlane W, Gertner JM, Genel M, Insogna KL. Effect of short-term somatostatin and long-term triiodothyronine administration in a child with nontumorous inappropriate thyrotropin secretion. The Journal Of Pediatrics 1988, 112: 51-5. PMID: 2891806.
- Characterization of a parathyroid hormonelike peptide secreted by human keratinocytes.Insogna KL, Stewart AF, Ikeda K, Centrella M, Milstone LM. Characterization of a parathyroid hormonelike peptide secreted by human keratinocytes. Annals Of The New York Academy Of Sciences 1988, 548: 146-59. PMID: 2470290.
- Enhanced production rate of 1,25-dihydroxyvitamin D in sarcoidosis.Insogna KL, Dreyer BE, Mitnick M, Ellison AF, Broadus AE. Enhanced production rate of 1,25-dihydroxyvitamin D in sarcoidosis. The Journal Of Clinical Endocrinology And Metabolism 1988, 66: 72-5. PMID: 3335611, DOI: 10.1210/jcem-66-1-72.
- In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice.Weir EC, Insogna KL, Brownstein DG, Bander NH, Broadus AE. In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice. The Journal Of Clinical Investigation 1988, 81: 818-21. PMID: 3343341, PMCID: PMC442531, DOI: 10.1172/JCI113389.
- Influence of furosemide on parathyroid hormone levels in hyperparathyroidism.Petit WA, Henrich J, Insogna KL, Mitnick ME, Broadus AE. Influence of furosemide on parathyroid hormone levels in hyperparathyroidism. The New England Journal Of Medicine 1988, 318: 644-5. PMID: 3344015.
- Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide.Broadus AE, Mangin M, Ikeda K, Insogna KL, Weir EC, Burtis WJ, Stewart AF. Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. The New England Journal Of Medicine 1988, 319: 556-63. PMID: 3043221, DOI: 10.1056/NEJM198809013190906.
- Humoral hypercalcemia of malignancy.Burtis WJ, Wu TL, Insogna KL, Stewart AF. Humoral hypercalcemia of malignancy. Annals Of Internal Medicine 1988, 108: 454-7. PMID: 3277518, DOI: 10.7326/0003-4819-108-3-454.
- Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.Wu TL, Insogna KL, Hough LM, Milstone L, Stewart AF. Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins. The Journal Of Clinical Endocrinology And Metabolism 1987, 65: 105-9. PMID: 3034948, DOI: 10.1210/jcem-65-1-105.
- Co-purification of transforming growth factor beta-like activity with PTH-like and bone-resorbing activities from a tumor associated with humoral hypercalcemia of malignancy.Insogna KL, Weir EC, Wu TL, Stewart AF, Broadus AE, Burtis WJ, Centrella M. Co-purification of transforming growth factor beta-like activity with PTH-like and bone-resorbing activities from a tumor associated with humoral hypercalcemia of malignancy. Endocrinology 1987, 120: 2183-5. PMID: 3494596, DOI: 10.1210/endo-120-5-2183.
- Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. The Journal Of Biological Chemistry 1987, 262: 7151-6. PMID: 3584110.
- Concerning the pathogenesis of idiopathic hypercalciuria.Broadus AE, Burtis WJ, Oren DA, Sartori L, Gay L, Ellison AF, Insogna KL. Concerning the pathogenesis of idiopathic hypercalciuria. Contributions To Nephrology 1987, 58: 127-36. PMID: 3691116.
- The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.Stewart AF, Wu T, Burtis WJ, Weir EC, Broadus AE, Insogna KL. The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1987, 2: 37-43. PMID: 3455155, DOI: 10.1002/jbmr.5650020107.
- Hypercalcemia of malignancy.Insogna KL, Broadus AE. Hypercalcemia of malignancy. Annual Review Of Medicine 1987, 38: 241-56. PMID: 3555293, DOI: 10.1146/annurev.me.38.020187.001325.
- A parathyroid hormone-like protein from cultured human keratinocytes.Merendino JJ, Insogna KL, Milstone LM, Broadus AE, Stewart AF. A parathyroid hormone-like protein from cultured human keratinocytes. Science (New York, N.Y.) 1986, 231: 388-90. PMID: 2417317.
- Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy.Burtis WJ, Broadus AE, Insogna KL, Weir EC, Stewart AF. Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy. Endocrinology 1986, 118: 1982-8. PMID: 3009144, DOI: 10.1210/endo-118-5-1982.
- Primary hyperparathyroidism in a dog: biochemical, bone histomorphometric, and pathologic findings.Weir EC, Norrdin RW, Barthold SW, Meuten DJ, Pond MJ, Insogna KL. Primary hyperparathyroidism in a dog: biochemical, bone histomorphometric, and pathologic findings. Journal Of The American Veterinary Medical Association 1986, 189: 1471-4. PMID: 3804843.
- Frequency and partial characterization of adenylate cyclase-stimulating activity in tumors associated with humoral hypercalcemia of malignancy.Stewart AF, Insogna KL, Burtis WJ, Aminiafshar A, Wu T, Weir EC, Broadus AE. Frequency and partial characterization of adenylate cyclase-stimulating activity in tumors associated with humoral hypercalcemia of malignancy. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 1986, 1: 267-76. PMID: 2845726, DOI: 10.1002/jbmr.5650010305.
- Nephrogenous cyclic AMP, adenylate cyclase-stimulating activity, and the humoral hypercalcemia of malignancy.Godsall JW, Burtis WJ, Insogna KL, Broadus AE, Stewart AF. Nephrogenous cyclic AMP, adenylate cyclase-stimulating activity, and the humoral hypercalcemia of malignancy. Recent Progress In Hormone Research 1986, 42: 705-50. PMID: 3016837.
- Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated hypercalcemia.Rosenthal N, Insogna KL, Godsall JW, Smaldone L, Waldron JA, Stewart AF. Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated hypercalcemia. The Journal Of Clinical Endocrinology And Metabolism 1985, 60: 29-33. PMID: 3871092, DOI: 10.1210/jcem-60-1-29.
- Elevated production rate of 1,25-dihydroxyvitamin D in patients with absorptive hypercalciuria.Insogna KL, Broadus AE, Dreyer BE, Ellison AF, Gertner JM. Elevated production rate of 1,25-dihydroxyvitamin D in patients with absorptive hypercalciuria. The Journal Of Clinical Endocrinology And Metabolism 1985, 61: 490-5. PMID: 2991323, DOI: 10.1210/jcem-61-3-490.
- Sensitivity of the parathyroid hormone-1,25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism.Insogna KL, Mitnick ME, Stewart AF, Burtis WJ, Mallette LE, Broadus AE. Sensitivity of the parathyroid hormone-1,25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism. The New England Journal Of Medicine 1985, 313: 1126-30. PMID: 2995810, DOI: 10.1056/NEJM198510313131805.
- Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia.Godsall JW, Baron R, Insogna KL. Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia. The American Journal Of Medicine 1984, 77: 747-50. PMID: 6486152.
- Hypercalciuria as a metabolic disease.Insogna KL, Broadus AE. Hypercalciuria as a metabolic disease. Seminars In Urology 1984, 2: 20-33. PMID: 6463459.
- Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria.Broadus AE, Insogna KL, Lang R, Ellison AF, Dreyer BE. Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria. The New England Journal Of Medicine 1984, 311: 73-80. PMID: 6330548, DOI: 10.1056/NEJM198407123110201.
- Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy.Insogna KL, Stewart AF, Vignery AM, Weir EC, Namnum PA, Baron RE, Kirkwood JM, Deftos LM, Broadus AE. Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. Endocrinology 1984, 114: 888-96. PMID: 6546543, DOI: 10.1210/endo-114-3-888.
- A consideration of the hormonal basis and phosphate leak hypothesis of absorptive hypercalciuria.Broadus AE, Insogna KL, Lang R, Mallette LE, Oren DA, Gertner JM, Kliger AS, Ellison AF. A consideration of the hormonal basis and phosphate leak hypothesis of absorptive hypercalciuria. The Journal Of Clinical Endocrinology And Metabolism 1984, 58: 161-9. PMID: 6546292, DOI: 10.1210/jcem-58-1-161.
- Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.Stewart AF, Insogna KL, Goltzman D, Broadus AE. Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 1454-8. PMID: 6298791, PMCID: PMC393616.
- Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.Rodan SB, Insogna KL, Vignery AM, Stewart AF, Broadus AE, D'Souza SM, Bertolini DR, Mundy GR, Rodan GA. Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. The Journal Of Clinical Investigation 1983, 72: 1511-5. PMID: 6685137, PMCID: PMC370436, DOI: 10.1172/JCI111108.
- Impaired phosphorus conservation and 1,25 dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets.Insogna KL, Broadus AE, Gertner JM. Impaired phosphorus conservation and 1,25 dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets. The Journal Of Clinical Investigation 1983, 71: 1562-9. PMID: 6306051, PMCID: PMC370362.
- Evidence for bidirectional net movement of creatinine in the rat kidney.Namnum P, Insogna K, Baggish D, Hayslett JP. Evidence for bidirectional net movement of creatinine in the rat kidney. The American Journal Of Physiology 1983, 244: F719-23. PMID: 6859263, DOI: 10.1152/ajprenal.1983.244.6.F719.
- Influence of pregnancy on immunoreactive parathyroid hormone levels.Gillette ME, Insogna KL, Lewis AM, Baran DT. Influence of pregnancy on immunoreactive parathyroid hormone levels. Calcified Tissue International 1982, 34: 9-12. PMID: 6279256.
- Effect of age on serum immunoreactive parathyroid hormone and its biological effects.Insogna KL, Lewis AM, Lipinski BA, Bryant C, Baran DT. Effect of age on serum immunoreactive parathyroid hormone and its biological effects. The Journal Of Clinical Endocrinology And Metabolism 1981, 53: 1072-5. PMID: 6270181, DOI: 10.1210/jcem-53-5-1072.
- Osteomalacia and weakness from excessive antacid ingestion.Insogna KL, Bordley DR, Caro JF, Lockwood DH. Osteomalacia and weakness from excessive antacid ingestion. JAMA 1980, 244: 2544-6. PMID: 7431592.
- An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone.Walker JM, Yao GQ, Siu E, Zhu M, Sun BH, Simpson C, Insogna KL. An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone. Endocrinology 2021, 162 PMID: 33640975, PMCID: PMC8095390, DOI: 10.1210/endocr/bqab042.
- Reply to: Burosumab for Tumor-Induced Osteomalacia: not Enough of a Good Thing.Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, Martin JS, Carpenter TO. Reply to: Burosumab for Tumor-Induced Osteomalacia: not Enough of a Good Thing. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2021, 36: 2455-2456. PMID: 34030212, DOI: 10.1002/jbmr.4317.
- Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension.Briot K, Portale AA, Brandi ML, Carpenter TO, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Ing S, Insogna K, Ito N, Jan de Beur S, Javaid MK, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Nixon A, Nixon M, Sun W, Williams A, Imel EA. Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension. RMD Open 2021, 7 PMID: 34548383, PMCID: PMC8458321, DOI: 10.1136/rmdopen-2021-001714.
- Musculoskeletal Features in Adults With X-linked Hypophosphatemia: An Analysis of Clinical Trial and Survey Data.Javaid MK, Ward L, Pinedo-Villanueva R, Rylands AJ, Williams A, Insogna K, Imel EA. Musculoskeletal Features in Adults With X-linked Hypophosphatemia: An Analysis of Clinical Trial and Survey Data. The Journal Of Clinical Endocrinology And Metabolism 2022, 107: e1249-e1262. PMID: 34636401, PMCID: PMC8852215, DOI: 10.1210/clinem/dgab739.
- Update on Osteoporosis Screening and Management.Anam AK, Insogna K. Update on Osteoporosis Screening and Management. The Medical Clinics Of North America 2021, 105: 1117-1134. PMID: 34688418, DOI: 10.1016/j.mcna.2021.05.016.
- Corticosteroid use in chronic dermatologic disorders and osteoporosis.Lupsa BC, Insogna KL, Micheletti RG, Caplan A. Corticosteroid use in chronic dermatologic disorders and osteoporosis. International Journal Of Women's Dermatology 2021, 7: 545-551. PMID: 35024411, PMCID: PMC8721058, DOI: 10.1016/j.ijwd.2021.07.014.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Musculoskeletal System | Examining the Effect of Burosumab on Muscle Function |
Diseases of the Kidney & Urinary Tract | The Impact of Phosphate Metabolism on Healthy Aging |