Karel Liem Jr
Research & Publications
Biography
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Research Summary
The Liem lab studies mutations that affect the development of the mammalian embryo. The lab uses forward genetics and other approaches in the mouse to identify novel genes and signaling pathways that are required for sculpting the body plan and for proper organ development. The lab is especially interested in mutations that cause developmental defects of the central nervous system and in mutations that affect the development of cilia, microtubule-based organelles on the surface of most cells. Current projects include (1) the role of cilia in molecular signaling in Polycystic Kidney Disease and other “Ciliopathies” (2) the cellular and molecular basis of “Tubulinopathies” including the neurodegenerative disorder H-ABC.
Research Interests
Congenital Abnormalities; Ciliary Motility Disorders; Demyelinating Diseases; Embryonic Structures; Kidney Diseases; Nervous System Malformations; Nervous System Diseases; Neurodegenerative Diseases; Heterotaxy Syndrome
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Selected Publications
- The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.Goetz SC, Liem KF, Anderson KV. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell 2012, 151:847-858.
- The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.Liem KF, Ashe A, He M, Satir P, Moran J, Beier D, Wicking C, Anderson KV. The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. The Journal Of Cell Biology 2012, 197:789-800.
- Global control of motor neuron topography mediated by the repressive actions of a single hox gene.Jung H, Lacombe J, Mazzoni EO, Liem KF, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron 2010, 67:781-96.
- Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.Liem KF, He M, Ocbina PJ, Anderson KV. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106:13377-82.
- A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord.Liem KF, Tremml G, Jessell TM. A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord. Cell 1997, 91:127-38.
- Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm.Liem KF, Tremml G, Roelink H, Jessell TM. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 1995, 82:969-79.