Kanika Jain, PhD

• Alfred Lee
• Amar Patel
• Costin Ionescu
• Diane Krause
• Hannah Melchinger
• Hyung Chun
• Janice Jin Hwang
• Jeffrey Testani
• Jennifer M. Kwan MD, PhD
• Jing Du
• John Hwa
• Kathleen Martin
• Raimund Herzog
• Sean Gu
• Stephanie Halene
• Tarun Tyagi
• Timur Yarovinsky
• Vivian Gu

Aging; Blood Platelets; Cardiovascular Diseases; Diabetes Mellitus; Parkinson Disease; Protein Folding; Oxidative Stress; Protein Aggregation, Pathological; Proteostasis

• A guide to molecular and functional investigations of platelets to bridge basic and clinical sciencesTyagi, T., Jain, K., Gu, S.X. et al. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nat Cardiovasc Res 1, 223–237 (2022). https://doi.org/10.1038/s44161-022-00021-z
• Unfolded Protein Response Differentially Modulates the Platelet Phenotype.Jain K, Tyagi T, Du J, Hu X, Patell K, Martin KA, Hwa J. Unfolded Protein Response Differentially Modulates the Platelet Phenotype. Circulation Research 2022, 131: 290-307. PMID: 35862006, PMCID: PMC9357223, DOI: 10.1161/CIRCRESAHA.121.320530.
• Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews. Cardiology 2021, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
• "CO"ping With a Sticky Situation.Jain K, Tyagi T, Hwa J. "CO"ping With a Sticky Situation. Arteriosclerosis, Thrombosis, And Vascular Biology 2020, 40: 2344-2345. PMID: 32966131, PMCID: PMC7517721, DOI: 10.1161/ATVBAHA.120.315158.
• Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients.Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.
• Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.Lee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ, Atteya G, Jaji Z, Tyagi T, Kim WH, Herzog RI, Patel A, Ionescu CN, Martin KA, Hwa J. Mitochondrial MsrB2 serves as a switch and transducer for mitophagy. EMBO Molecular Medicine 2019, 11: e10409. PMID: 31282614, PMCID: PMC6685081, DOI: 10.15252/emmm.201910409.
• Role of Platelet Mitochondria: Life in a Nucleus-Free Zone.Melchinger H, Jain K, Tyagi T, Hwa J. Role of Platelet Mitochondria: Life in a Nucleus-Free Zone. Frontiers In Cardiovascular Medicine 2019, 6: 153. PMID: 31737646, PMCID: PMC6828734, DOI: 10.3389/fcvm.2019.00153.
• Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.Jain K, Suryakumar G, Ganju L, Singh SB. Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α. Vascular Pharmacology 2016, 83: 36-46. PMID: 27058435, DOI: 10.1016/j.vph.2016.03.004.
• Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress.Jain K, Suryakumar G, Prasad R, Singh SN, Ganju L. Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress. Biochimie 2013, 95: 1897-908. PMID: 23816873, DOI: 10.1016/j.biochi.2013.06.018.