Kanika Jain, PhD
Associate Research Scientist
Research & Publications
Biography
News
Coauthors
Research Interests
Aging; Blood Platelets; Cardiovascular Diseases; Diabetes Mellitus; Oxidative Stress; Protein Aggregation, Pathological; Proteostasis
Research Image
Figure from Jain et al. 2019, eBiomedicine (https://doi.org/10.1016/j.ebiom.2019.05.022)
Platelet phenotype differs distinctly with age and is likely due to the age associated adaptive changes in platelet antioxidant levels.
Selected Publications
- Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients.Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44:28-40.
- Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.Lee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ, Atteya G, Jaji Z, Tyagi T, Kim WH, Herzog RI, Patel A, Ionescu CN, Martin KA, Hwa J. Mitochondrial MsrB2 serves as a switch and transducer for mitophagy. EMBO Molecular Medicine 2019, 11:e10409.
- "CO"ping With a Sticky Situation.Jain K, Tyagi T, Hwa J. "CO"ping With a Sticky Situation. Arteriosclerosis, Thrombosis, And Vascular Biology 2020, 40:2344-2345.
- Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews. Cardiology 2021, 18:194-209.
- Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.Jain K, Suryakumar G, Ganju L, Singh SB. Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α. Vascul Pharmacol 2016, 83:36-46.