Justin Belsky, MD, MPH
Research & Publications
Biography
Research Summary
My goal is to provide a platform to diagnose patients with serious bacterial infections prior to organ damage and to risk stratify those who are sick. This is accomplished through Emergency Department screening protocols and with biomarkers. My research interest is in the role of Thymosin Beta 4 and Actin proteins in the pathogenesis of sepsis.
As the Yale site principal investigator for the clinical trial VICTAS, a multicentered study comparing the efficacy of Vitamin C, Thiamine, and Hydrocortisone in patients with septic shock, it is my hope to bring new treatments to those patients suffering with serious infections.
Coauthors
Research Interests
Shock, Septic; Urinary Tract Infections; Wound Infection; Bacteremia; Pneumonia, Bacterial; Sepsis; Personal Protective Equipment
Selected Publications
- Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW, VICTAS Investigators.. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA 2021, 325:742-750.
- Antibiotic Delays and Feasibility of a 1-Hour-From-Triage Antibiotic Requirement: Analysis of an Emergency Department Sepsis Quality Improvement Database.Filbin MR, Thorsen JE, Zachary TM, Lynch JC, Matsushima M, Belsky JB, Heldt T, Reisner AT. Antibiotic Delays and Feasibility of a 1-Hour-From-Triage Antibiotic Requirement: Analysis of an Emergency Department Sepsis Quality Improvement Database. Annals Of Emergency Medicine 2020, 75:93-99.
- F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis.Belsky JB, Filbin MR, Rivers EP, Bobbitt KR, Jaehne AK, Wisnik CA, Maciejewski KR, Li F, Morris DC. F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis. Biomarkers : Biochemical Indicators Of Exposure, Response, And Susceptibility To Chemicals 2020, 25:391-396.
- The Decline of Basic Science Publications in Major Emergency Medicine Journals and Research Conferences.Jacob V, Belsky J, Cone D. The Decline of Basic Science Publications in Major Emergency Medicine Journals and Research Conferences. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2018, 25:705-707.
- Thymosin beta 4 regulation of actin in sepsis.Belsky JB, Rivers EP, Filbin MR, Lee PJ, Morris DC. Thymosin beta 4 regulation of actin in sepsis. Expert Opinion On Biological Therapy 2018, 18:193-197.
- A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.Belsky JB, Wira CR, Jacob V, Sather JE, Lee PJ. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutrition Research Reviews 2018, 31:281-290.
- Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.Belsky JB, Morris DC, Bouchebl R, Filbin MR, Bobbitt KR, Jaehne AK, Rivers EP. Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock. Biomarkers : Biochemical Indicators Of Exposure, Response, And Susceptibility To Chemicals 2016, 21:180-5.
- Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Critical Care (London, England) 2016, 20:160.
Clinical Trials
Conditions | Study Title |
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Diseases of the Blood; Infectious Diseases | Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) |