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JungHo Back, PhD

Associate Research Scientist

Contact Information

JungHo Back, PhD

Mailing Address

  • Orthopaedics & Rehabilitation

    789 Howard Ave, Tompkins Memorial Pavilion

    New Haven, CT 06520-8071

    United States

Research Summary

Our laboratory focuses on the role of MAP kinase in bone inflammation. We investigate the novel molecular therapeutic target to prevent or reduce imbalance of osteoclast/osteoblast differentiation by breast cancer metastasis and bacteria infection. To study these processes, we use a translational approach, combining the analysis of human samples and the use of experimental model systems by various immunological and molecular biology state-of-the-art techniques.

Extensive Research Description

The goal of the our research is to introduce a new way of combinational therapy for breast cancer metastasis to bone. Pathologic bone loss related to metastatic cancers and severe osteoporosis affect more than 50% of Americans over the age of fifty. Currently available anti-resorptive drugs such as bisphosphonates do not always effectively preserve or restore bone from the entire array of osteolytic disorders. This presents a barrier which needs to be overcome in order to enhance bone health. Our study enhances the health of patients with severe pathologic bone loss and will create new strategies for treatment of bone metastasis cancers.


Research Interests

Diseases; Chemicals and Drugs

Public Health Interests

Cancer; Infectious Diseases

Research Image

Selected Publications