Jung Kim, MD
Professor Emeritus of and Senior Research Scientist in Pathology
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Extensive Research Description
Hippocampal sclerosis (neuronal loss and gliosis) plays a complicated role in epilepsy: hippocampal sclerosis occurs due to epilepsy, but, in turn, the sclerotic hippocampus appears to be responsible for epileptogenesis. We are looking into the role of hippocampal neurons and glial cells in epilepy through neuronal and glial density studies in surgically resected hippocampi from intractable epilepsy patients. My second research interest is the role of calpains in CNS degenerative disorders, epilepsy and AIDS. All three conditions just mentioned are believed to have neuronal damages, at least in part, due to excitotoxicity, which may acitivate calpains, a family of Ca++ dependant proteases. Calpains, once activated, cleave spectrin, generating the spectrin breakdown product (BDP), and involvement of calpains is determined by detecting spectrin BDP in the CNS tissue.
Coauthors
Selected Publications
- Pathology of epilepsy.Kim JH. Pathology of epilepsy. Experimental And Molecular Pathology 2001, 70: 345-67. PMID: 11418013, DOI: 10.1006/exmp.2001.2372.
- Characteristics of an explosive blast-induced brain injury in an experimental model.de Lanerolle NC, Bandak F, Kang D, Li AY, Du F, Swauger P, Parks S, Ling G, Kim JH. Characteristics of an explosive blast-induced brain injury in an experimental model. Journal Of Neuropathology And Experimental Neurology 2011, 70: 1046-57. PMID: 22002430, DOI: 10.1097/NEN.0b013e318235bef2.
- Calpain proteolysis of alpha II-spectrin in the normal adult human brain.Huh GY, Glantz SB, Je S, Morrow JS, Kim JH. Calpain proteolysis of alpha II-spectrin in the normal adult human brain. Neuroscience Letters 2001, 316: 41-4. PMID: 11720774.
- Expression of endothelial cell angiogenesis receptors in human cerebrovascular malformations.Uranishi R, Baev NI, Ng PY, Kim JH, Awad IA. Expression of endothelial cell angiogenesis receptors in human cerebrovascular malformations. Neurosurgery 2001, 48: 359-67; discussion 367-8. PMID: 11220380.
- Differential neuronal and glial relations with parameters of ictal discharge in mesial temporal lobe epilepsy.Spencer SS, Kim J, deLanerolle N, Spencer DD. Differential neuronal and glial relations with parameters of ictal discharge in mesial temporal lobe epilepsy. Epilepsia 1999, 40: 708-12. PMID: 10368067.