Jung Kim, MD
Professor Emeritus of and Senior Research Scientist in Pathology
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Extensive Research Description
Hippocampal sclerosis (neuronal loss and gliosis) plays a complicated role in epilepsy: hippocampal sclerosis occurs due to epilepsy, but, in turn, the sclerotic hippocampus appears to be responsible for epileptogenesis. We are looking into the role of hippocampal neurons and glial cells in epilepy through neuronal and glial density studies in surgically resected hippocampi from intractable epilepsy patients. My second research interest is the role of calpains in CNS degenerative disorders, epilepsy and AIDS. All three conditions just mentioned are believed to have neuronal damages, at least in part, due to excitotoxicity, which may acitivate calpains, a family of Ca++ dependant proteases. Calpains, once activated, cleave spectrin, generating the spectrin breakdown product (BDP), and involvement of calpains is determined by detecting spectrin BDP in the CNS tissue.
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Selected Publications
- Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Modelde Lanerolle NC, Bandak F, Kang D, Li AY, Du F, Swauger P, Parks S, Ling G, Kim JH. Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model. Journal Of Neuropathology & Experimental Neurology 2011, 70: 1046-1057. PMID: 22002430, DOI: 10.1097/nen.0b013e318235bef2.
- Pathology of epilepsy.Kim JH. Pathology of epilepsy. Experimental And Molecular Pathology 2001, 70: 345-67. PMID: 11418013, DOI: 10.1006/exmp.2001.2372.
- Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe EpilepsySpencer S, Kim J, DeLanerolle N, Spencer D. Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy. Epilepsia 1999, 40: 708-712. PMID: 10368067, DOI: 10.1111/j.1528-1157.1999.tb00767.x.