Jui Dave, PhD
Research & Publications
Biography
News
Extensive Research Description
Current project is aimed at understanding key molecular mechanisms responsible for intracerebral hemorrhage (ICH) and elucidating the role of transforming growth factor beta-mediated signaling in this vascular disorder. ICH is caused by a marked disruption of the blood brain barrier, which in the murine embryonic brain, is comprised of endothelial cells, basement membrane and mural cells known as pericytes. The overall goal of this project is to identify molecular targets and devise novel therapeutic strategies to reduce the incidence and morbidity of neonatal ICH.
Coauthors
Research Interests
Aorta; Aortic Diseases; Blood-Brain Barrier; Cardiovascular Diseases; Cerebral Hemorrhage; Elastin; Infant Mortality; Infant, Newborn, Diseases; Muscle, Smooth, Vascular; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Pericytes; Genetic Diseases, Inborn; Vascular Malformations
Selected Publications
- Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension.Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6.
- Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain.Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 44:665-678.e6.
- Vascular Cells in Blood Vessel Wall Development and Disease.Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM. Vascular Cells in Blood Vessel Wall Development and Disease. Advances In Pharmacology (San Diego, Calif.) 2017, 78:323-350.
- Molecular Regulation of Sprouting Angiogenesis.Duran CL, Howell DW, Dave JM, Smith RL, Torrie ME, Essner JJ, Bayless KJ. Molecular Regulation of Sprouting Angiogenesis. Comprehensive Physiology 2017, 8:153-235.
- Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.Dave JM, Abbey CA, Duran CL, Seo H, Johnson GA, Bayless KJ. Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase. Journal Of Cell Science 2016, 129:743-56.
- High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop.Qiu C, Erinne OC, Dave JM, Cui P, Jin H, Muthukrishnan N, Tang LK, Babu SG, Lam KC, Vandeventer PJ, Strohner R, Van den Brulle J, Sze SH, Kaplan CD. High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop. PLoS Genetics 2016, 12:e1006321.
- Vimentin as an integral regulator of cell adhesion and endothelial sprouting.Dave JM, Bayless KJ. Vimentin as an integral regulator of cell adhesion and endothelial sprouting. Microcirculation (New York, N.Y. : 1994) 2014, 21:333-44.
- Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK).Dave JM, Kang H, Abbey CA, Maxwell SA, Bayless KJ. Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). The Journal Of Biological Chemistry 2013, 288:30720-33.
- Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.Kwak HI, Kang H, Dave JM, Mendoza EA, Su SC, Maxwell SA, Bayless KJ. Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. Angiogenesis 2012, 15:287-303.