Jui Dave, PhD

• Daniel Greif
• Erica Herzog
• Inderjit Singh
• John Hwa
• Kathleen Martin
• Maor Sauler
• Patrick Gallagher
• W. Mark Saltzman
• William Sessa
• Wonnie Ryu

Aorta; Aortic Diseases; Blood-Brain Barrier; Cardiovascular Diseases; Cerebral Hemorrhage; Elastin; Infant Mortality; Infant, Newborn, Diseases; Muscle, Smooth, Vascular; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Pericytes; Genetic Diseases, Inborn; Vascular Malformations

• Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. Circulation 2022, 101161CIRCULATIONAHA121057599. PMID: 35502657, DOI: 10.1161/CIRCULATIONAHA.121.057599.
• JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. The Journal Of Clinical Investigation 2022, 132 PMID: 34990407, PMCID: PMC8884911, DOI: 10.1172/JCI142338.
• Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension.Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6 PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
• Targeting smooth muscle cell phenotypic switching in vascular disease.Chakraborty R, Chatterjee P, Dave JM, Ostriker AC, Greif DM, Rzucidlo EM, Martin KA. Targeting smooth muscle cell phenotypic switching in vascular disease. Journal Of Vascular Surgery. Vascular Science 2021, 2: 79-94. PMID: 34617061, PMCID: PMC8489222, DOI: 10.1016/j.jvssci.2021.04.001.
• Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain.Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 44: 665-678.e6. PMID: 29456135, PMCID: PMC5871595, DOI: 10.1016/j.devcel.2018.01.018.
• Vascular Cells in Blood Vessel Wall Development and Disease.Mazurek R, Dave JM, Chandran RR, Misra A, Sheikh AQ, Greif DM. Vascular Cells in Blood Vessel Wall Development and Disease. Advances In Pharmacology (San Diego, Calif.) 2017, 78: 323-350. PMID: 28212800, PMCID: PMC5559712, DOI: 10.1016/bs.apha.2016.08.001.
• Molecular Regulation of Sprouting Angiogenesis.Duran CL, Howell DW, Dave JM, Smith RL, Torrie ME, Essner JJ, Bayless KJ. Molecular Regulation of Sprouting Angiogenesis. Comprehensive Physiology 2017, 8: 153-235. PMID: 29357127, DOI: 10.1002/cphy.c160048.
• Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.Dave JM, Abbey CA, Duran CL, Seo H, Johnson GA, Bayless KJ. Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase. Journal Of Cell Science 2016, 129: 743-56. PMID: 26769900, PMCID: PMC4760372, DOI: 10.1242/jcs.170571.
• High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop.Qiu C, Erinne OC, Dave JM, Cui P, Jin H, Muthukrishnan N, Tang LK, Babu SG, Lam KC, Vandeventer PJ, Strohner R, Van den Brulle J, Sze SH, Kaplan CD. High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop. PLoS Genetics 2016, 12: e1006321. PMID: 27898685, PMCID: PMC5127505, DOI: 10.1371/journal.pgen.1006321.
• Vimentin as an integral regulator of cell adhesion and endothelial sprouting.Dave JM, Bayless KJ. Vimentin as an integral regulator of cell adhesion and endothelial sprouting. Microcirculation (New York, N.Y. : 1994) 2014, 21: 333-44. PMID: 24387004, DOI: 10.1111/micc.12111.
• Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK).Dave JM, Kang H, Abbey CA, Maxwell SA, Bayless KJ. Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). The Journal Of Biological Chemistry 2013, 288: 30720-33. PMID: 24005669, PMCID: PMC3798542, DOI: 10.1074/jbc.M113.512467.
• Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.Kwak HI, Kang H, Dave JM, Mendoza EA, Su SC, Maxwell SA, Bayless KJ. Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. Angiogenesis 2012, 15: 287-303. PMID: 22407449, PMCID: PMC3338915, DOI: 10.1007/s10456-012-9262-4.