Research & Publications
Extensive Research Description
Current project is aimed at understanding key molecular mechanisms responsible for intracerebral hemorrhage (ICH) and elucidating the role of transforming growth factor beta-mediated signaling in this vascular disorder. ICH is caused by a marked disruption of the blood brain barrier, which in the murine embryonic brain, is comprised of endothelial cells, basement membrane and mural cells known as pericytes. The overall goal of this project is to identify molecular targets and devise novel therapeutic strategies to reduce the incidence and morbidity of neonatal ICH.
Aorta; Aortic Diseases; Blood-Brain Barrier; Cardiovascular Diseases; Cerebral Hemorrhage; Elastin; Infant Mortality; Infant, Newborn, Diseases; Muscle, Smooth, Vascular; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Pericytes; Genetic Diseases, Inborn; Vascular Malformations